Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death

Free Radical Biology and Medicine

Volumn 68, Issue , 2014, Pages 302-314

  Evans, Myron K ^a   Tovmasyan, Artak ^a   Batinic Haberle, Ines ^a,b   Devi, Gayathri R ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DUKE CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; Ascorbate; H2O2; Inflammatory breast cancer; Manganese porphyrins; MnTE 2 PyP5+; MnTnBuOE 2 PyP5+; ROS; SOD; SUM149; SUM190; XIAP

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIOXIDANT; APOPTOSIS INDUCING FACTOR; ASCORBIC ACID; CASPASE; CATALASE; GLUTATHIONE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOCORTIN 5; METALLOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PORPHYRIN MANGANESE; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CATALYSIS; CATALYST; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; HUMAN; HUMAN CELL; OXIDATION; OXIDATIVE STRESS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING;

APOPTOSIS; ASCORBATE; H(2)O(2); INFLAMMATORY BREAST CANCER; MANGANESE PORPHYRINS; MNTE-2-PYP(5+); MNTNBUOE-2-PYP(5+); ROS; SOD; SUM149; SUM190; XIAP;

APOPTOSIS; ASCORBIC ACID; BREAST NEOPLASMS; CASPASES; FEMALE; HUMANS; HYDROGEN PEROXIDE; METALLOPORPHYRINS; NF-KAPPA B; OXIDATION-REDUCTION; PEROXIDES; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 84892749247     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.11.031     Document Type: Article

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