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Volumn 7, Issue 26, 2012, Pages 2051-2062

Neuroprotection and its molecular mechanism following spinal cord injury

Author keywords

Apoptosis; Glucocorticoid receptor; Inflammation; MicroRNAs; Neuroprotection; Oxidation; Phospolipase A2; Signaling pathway; Spinal cord injury

Indexed keywords


EID: 84892679943     PISSN: 16735374     EISSN: 18767958     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2012.26.007     Document Type: Article
Times cited : (63)

References (99)
  • 1
    • 33645774598 scopus 로고    scopus 로고
    • Phospholipase A2 and spinal cord injury: A novel target for therapeutic intervention
    • [1] Olivas AD, Noble-Haeusslein LJ. Phospholipase A2 and spinal cord injury: a novel target for therapeutic intervention. Ann Neurol. 2006;59:577-579.
    • (2006) Ann Neurol , vol.59 , pp. 577-579
    • Olivas, A.D.1    Noble-Haeusslein, L.J.2
  • 2
    • 3042816808 scopus 로고    scopus 로고
    • The role of excitotoxicity in secondary mechanisms of spinal cord injury: A review with an emphasis on the implications for white matter degeneration
    • [2] Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma. 2004;21: 754-774.
    • (2004) J Neurotrauma , vol.21 , pp. 754-774
    • Park, E.1    Velumian, A.A.2    Fehlings, M.G.3
  • 3
    • 17444392322 scopus 로고    scopus 로고
    • Neuroprotection and acute spinal cord injury: A reappraisal
    • [3] Hall ED, Springer JE. Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx. 2004;1:80-100.
    • (2004) Neurorx , vol.1 , pp. 80-100
    • Hall, E.D.1    Springer, J.E.2
  • 4
    • 0032079920 scopus 로고    scopus 로고
    • Acute inflammatory response in spinal cord following impact injury
    • [4] Carlson SL, Parrish ME, Springer JE, et al. Acute inflammatory response in spinal cord following impact injury. Exp Neurol. 1998;151:77-88.
    • (1998) Exp Neurol , vol.151 , pp. 77-88
    • Carlson, S.L.1    Parrish, M.E.2    Springer, J.E.3
  • 5
    • 0033920448 scopus 로고    scopus 로고
    • Vascular events after spinal cord injury: Contribution to secondary pathogenesis
    • [5] Mautes AE, Weinzierl MR, Donovan F, et al. Vascular events after spinal cord injury: contribution to secondary pathogenesis. Phys Ther. 2000;80:673-687.
    • (2000) Phys Ther , vol.80 , pp. 673-687
    • Mautes, A.E.1    Weinzierl, M.R.2    Donovan, F.3
  • 6
    • 0031013236 scopus 로고    scopus 로고
    • Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats
    • [6] Popovich PG, Wei P, Stokes BT. Cellular inflammatory response after spinal cord injury in Sprague-Dawley and Lewis rats. J Comp Neurol. 1997;377:443-464.
    • (1997) J Comp Neurol , vol.377 , pp. 443-464
    • Popovich, P.G.1    Wei, P.2    Stokes, B.T.3
  • 7
    • 0035851791 scopus 로고    scopus 로고
    • Regional and temporal changes in prostaglandin E2 and thromboxane B2 concentrations after spinal cord injury
    • [7] Resnick DK, Nguyen P, Cechvala CF. Regional and temporal changes in prostaglandin E2 and thromboxane B2 concentrations after spinal cord injury. Spine J. 2001;1:432-436.
    • (2001) Spine J , vol.1 , pp. 432-436
    • Resnick, D.K.1    Nguyen, P.2    Cechvala, C.F.3
  • 8
    • 0031815256 scopus 로고    scopus 로고
    • Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis
    • [8] Streit WJ, Semple-Rowland SL, Hurley SD, et al. Cytokine mRNA profiles in contused spinal cord and axotomized facial nucleus suggest a beneficial role for inflammation and gliosis. Exp Neurol. 1998;152:74-87.
    • (1998) Exp Neurol , vol.152 , pp. 74-87
    • Streit, W.J.1    Semple-Rowland, S.L.2    Hurley, S.D.3
  • 9
    • 0032929318 scopus 로고    scopus 로고
    • Possible involvement of interleukin-1 in cyclooxygenase-2 induction after spinal cord injury in rats
    • [9] Tonai T, Taketani Y, Ueda N, et al. Possible involvement of interleukin-1 in cyclooxygenase-2 induction after spinal cord injury in rats. J Neurochem. 1999;72:302-309.
    • (1999) J Neurochem , vol.72 , pp. 302-309
    • Tonai, T.1    Taketani, Y.2    Ueda, N.3
  • 10
    • 0030610578 scopus 로고    scopus 로고
    • Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat
    • [10] Wang CX, Olschowka JA, Wrathall JR. Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat. Brain Res. 1997;759:190-196.
    • (1997) Brain Res , vol.759 , pp. 190-196
    • Wang, C.X.1    Olschowka, J.A.2    Wrathall, J.R.3
  • 11
    • 0032584936 scopus 로고    scopus 로고
    • Methylprednisolone inhibition of TNF-alpha expression and NF-kB activation after spinal cord injury in rats
    • [11] Xu J, Fan G, Chen S, et al. Methylprednisolone inhibition of TNF-alpha expression and NF-kB activation after spinal cord injury in rats. Brain Res Mol Brain Res. 1998;59: 135-142.
    • (1998) Brain Res Mol Brain Res , vol.59 , pp. 135-142
    • Xu, J.1    Fan, G.2    Chen, S.3
  • 12
    • 0028326548 scopus 로고
    • Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
    • [12] Dusart I, Schwab ME. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur J Neurosci. 1994;6:712-724.
    • (1994) Eur J Neurosci , vol.6 , pp. 712-724
    • Dusart, I.1    Schwab, M.E.2
  • 13
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases
    • [13] Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med. 1997;336:1066-1071.
    • (1997) N Engl J Med , vol.336 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 15
    • 0035144802 scopus 로고    scopus 로고
    • Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury
    • [15] Xu J, Kim GM, Ahmed SH, et al. Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury. J Neurosci. 2001;21:92-97.
    • (2001) J Neurosci , vol.21 , pp. 92-97
    • Xu, J.1    Kim, G.M.2    Ahmed, S.H.3
  • 16
    • 0032080219 scopus 로고    scopus 로고
    • Traumatic spinal cord injury induces nuclear factor-kappaB activation
    • [16] Bethea JR, Castro M, Keane RW, et al. Traumatic spinal cord injury induces nuclear factor-kappaB activation. J Neurosci. 1998;18:3251-3260.
    • (1998) J Neurosci , vol.18 , pp. 3251-3260
    • Bethea, J.R.1    Castro, M.2    Keane, R.W.3
  • 17
    • 0023782359 scopus 로고
    • The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes
    • [17] Chiu R, Boyle WJ, Meek J, et al. The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell. 1988;54:541-552.
    • (1988) Cell , vol.54 , pp. 541-552
    • Chiu, R.1    Boyle, W.J.2    Meek, J.3
  • 18
    • 0023771685 scopus 로고
    • C-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities
    • [18] Halazonetis TD, Georgopoulos K, Greenberg ME, et al. c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell. 1988;55:917-924.
    • (1988) Cell , vol.55 , pp. 917-924
    • Halazonetis, T.D.1    Georgopoulos, K.2    Greenberg, M.E.3
  • 19
    • 84870199424 scopus 로고    scopus 로고
    • NF-kappaB as a target for modulating inflammatory responses
    • [19] Gasparini C, Feldmann M. NF-kappaB as a target for modulating inflammatory responses. Curr Pharm Des. 2012.
    • (2012) Curr Pharm Des
    • Gasparini, C.1    Feldmann, M.2
  • 20
    • 0033595590 scopus 로고    scopus 로고
    • Nuclear factor kappa B activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts
    • [20] Bond M, Baker AH, Newby AC. Nuclear factor kappa B activity is essential for matrix metalloproteinase-1 and -3 upregulation in rabbit dermal fibroblasts. Biochem Biophys Res Commun. 1999;264:561-567.
    • (1999) Biochem Biophys Res Commun , vol.264 , pp. 561-567
    • Bond, M.1    Baker, A.H.2    Newby, A.C.3
  • 21
    • 0031596140 scopus 로고    scopus 로고
    • Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1betastimulated synovial fibroblasts
    • [21] Vincenti MP, Coon CI, Brinckerhoff CE. Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1betastimulated synovial fibroblasts. Arthritis Rheum. 1998;41:1987-1994.
    • (1998) Arthritis Rheum , vol.41 , pp. 1987-1994
    • Vincenti, M.P.1    Coon, C.I.2    Brinckerhoff, C.E.3
  • 22
    • 0030062901 scopus 로고    scopus 로고
    • Dual regulation of IL-1 beta-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-kappa B and AP-1
    • [22] Yokoo T, Kitamura M. Dual regulation of IL-1 beta-mediated matrix metalloproteinase-9 expression in mesangial cells by NF-kappa B and AP-1. Am J Physiol. 1996;270:F123-130.
    • (1996) Am J Physiol , vol.270 , pp. F123-F130
    • Yokoo, T.1    Kitamura, M.2
  • 23
    • 0032508674 scopus 로고    scopus 로고
    • Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: An absolute requirement for transcription factor NF-kappa B
    • [23] Bond M, Fabunmi RP, Baker AH, et al. Synergistic upregulation of metalloproteinase-9 by growth factors and inflammatory cytokines: an absolute requirement for transcription factor NF-kappa B. FEBS Lett. 1998;435: 29-34.
    • (1998) FEBS Lett , vol.435 , pp. 29-34
    • Bond, M.1    Fabunmi, R.P.2    Baker, A.H.3
  • 24
    • 0032006878 scopus 로고    scopus 로고
    • Matrix metalloproteinases and diseases of the CNS
    • [24] Yong VW, Krekoski CA, Forsyth PA, et al. Matrix metalloproteinases and diseases of the CNS. Trends Neurosci. 1998;21:75-80.
    • (1998) Trends Neurosci , vol.21 , pp. 75-80
    • Yong, V.W.1    Krekoski, C.A.2    Forsyth, P.A.3
  • 25
    • 0021971033 scopus 로고
    • Vascular permeability in experimental spinal cord injury
    • [25] Hsu CY, Hogan EL, Gadsden RH Sr, et al. Vascular permeability in experimental spinal cord injury. J Neurol Sci. 1985;70:275-282.
    • (1985) J Neurol Sci , vol.70 , pp. 275-282
    • Hsu, C.Y.1    Hogan, E.L.2    Gadsden, R.H.3
  • 26
    • 84155162481 scopus 로고    scopus 로고
    • Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
    • [26] Smith JA, Das A, Ray SK, et al. Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull. 2012;87:10-20.
    • (2012) Brain Res Bull , vol.87 , pp. 10-20
    • Smith, J.A.1    Das, A.2    Ray, S.K.3
  • 27
    • 0028597564 scopus 로고
    • Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury
    • [27] Yakovlev AG, Faden AI. Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury. Mol Chem Neuropathol. 1994;23:179-190.
    • (1994) Mol Chem Neuropathol , vol.23 , pp. 179-190
    • Yakovlev, A.G.1    Faden, A.I.2
  • 28
    • 0030249926 scopus 로고    scopus 로고
    • Production of tumor necrosis factor in spinal cord following traumatic injury in rats
    • [28] Wang CX, Nuttin B, Heremans H, et al. Production of tumor necrosis factor in spinal cord following traumatic injury in rats. J Neuroimmunol. 1996;69:151-156.
    • (1996) J Neuroimmunol , vol.69 , pp. 151-156
    • Wang, C.X.1    Nuttin, B.2    Heremans, H.3
  • 29
    • 0030842973 scopus 로고    scopus 로고
    • Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: An in situ hybridization study
    • [29] Bartholdi D, Schwab ME. Expression of pro-inflammatory cytokine and chemokine mRNA upon experimental spinal cord injury in mouse: an in situ hybridization study. Eur J Neurosci. 1997;9:1422-1438.
    • (1997) Eur J Neurosci , vol.9 , pp. 1422-1438
    • Bartholdi, D.1    Schwab, M.E.2
  • 30
    • 0035006281 scopus 로고    scopus 로고
    • Cellular localization of tumor necrosis factor-alpha following acute spinal cord injury in adult rats
    • [30] Yan P, Li Q, Kim GM, et al. Cellular localization of tumor necrosis factor-alpha following acute spinal cord injury in adult rats. J Neurotrauma. 2001;18:563-568.
    • (2001) J Neurotrauma , vol.18 , pp. 563-568
    • Yan, P.1    Li, Q.2    Kim, G.M.3
  • 31
    • 0141783952 scopus 로고    scopus 로고
    • Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats
    • [31] Yan P, Liu N, Kim GM, et al. Expression of the type 1 and type 2 receptors for tumor necrosis factor after traumatic spinal cord injury in adult rats. Exp Neurol. 2003;183: 286-297.
    • (2003) Exp Neurol , vol.183 , pp. 286-297
    • Yan, P.1    Liu, N.2    Kim, G.M.3
  • 32
    • 0035449479 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury
    • [32] Kim GM, Xu J, Song SK, et al. Tumor necrosis factor receptor deletion reduces nuclear factor-kappaB activation, cellular inhibitor of apoptosis protein 2 expression, and functional recovery after traumatic spinal cord injury. J Neurosci. 2001;21:6617-6625.
    • (2001) J Neurosci , vol.21 , pp. 6617-6625
    • Kim, G.M.1    Xu, J.2    Song, S.K.3
  • 33
    • 0027954265 scopus 로고
    • The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats
    • [33] Constantini S, Young W. The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg. 1994;80:97-111.
    • (1994) J Neurosurg , vol.80 , pp. 97-111
    • Constantini, S.1    Young, W.2
  • 34
    • 0033049143 scopus 로고    scopus 로고
    • Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy
    • [34] Moalem G, Leibowitz-Amit R, Yoles E, et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med. 1999;5:49-55.
    • (1999) Nat Med , vol.5 , pp. 49-55
    • Moalem, G.1    Leibowitz-Amit, R.2    Yoles, E.3
  • 35
    • 0031849511 scopus 로고    scopus 로고
    • Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats
    • [35] Rapalino O, Lazarov-Spiegler O, Agranov E, et al. Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat Med. 1998;4:814-821.
    • (1998) Nat Med , vol.4 , pp. 814-821
    • Rapalino, O.1    Lazarov-Spiegler, O.2    Agranov, E.3
  • 36
    • 0031005797 scopus 로고    scopus 로고
    • TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice
    • [36] Nawashiro H, Tasaki K, Ruetzler CA, et al. TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 1997;17:483-490.
    • (1997) J Cereb Blood Flow Metab , vol.17 , pp. 483-490
    • Nawashiro, H.1    Tasaki, K.2    Ruetzler, C.A.3
  • 37
    • 0031798012 scopus 로고    scopus 로고
    • Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor
    • [37] Gary DS, Bruce-Keller AJ, Kindy MS, et al. Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor. J Cereb Blood Flow Metab. 1998;18:1283-1287.
    • (1998) J Cereb Blood Flow Metab , vol.18 , pp. 1283-1287
    • Gary, D.S.1    Bruce-Keller, A.J.2    Kindy, M.S.3
  • 38
    • 0029899586 scopus 로고    scopus 로고
    • Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
    • [38] Bruce AJ, Boling W, Kindy MS, et al. Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med. 1996;2: 788-794.
    • (1996) Nat Med , vol.2 , pp. 788-794
    • Bruce, A.J.1    Boling, W.2    Kindy, M.S.3
  • 39
    • 0033232751 scopus 로고    scopus 로고
    • Glucocorticoid receptor expression in the spinal cord after traumatic injury in adult rats
    • [39] Yan P, Xu J, Li Q, et al. Glucocorticoid receptor expression in the spinal cord after traumatic injury in adult rats. J Neurosci. 1999;19:9355-9363.
    • (1999) J Neurosci , vol.19 , pp. 9355-9363
    • Yan, P.1    Xu, J.2    Li, Q.3
  • 40
    • 0028174061 scopus 로고
    • Function and activation of NF-kappa B in the immune system
    • [40] Baeuerle PA, Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol. 1994;12:141-179.
    • (1994) Annu Rev Immunol , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 41
    • 0029985953 scopus 로고    scopus 로고
    • Methylprednisolone administration improves axonal regeneration into Schwann cell grafts in transected adult rat thoracic spinal cord
    • [41] Chen A, Xu XM, Kleitman N, et al. Methylprednisolone administration improves axonal regeneration into Schwann cell grafts in transected adult rat thoracic spinal cord. Exp Neurol. 1996;138:261-276.
    • (1996) Exp Neurol , vol.138 , pp. 261-276
    • Chen, A.1    Xu, X.M.2    Kleitman, N.3
  • 42
    • 0028867899 scopus 로고
    • Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
    • [42] Auphan N, DiDonato JA, Rosette C, et al. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science. 1995;270:286-290.
    • (1995) Science , vol.270 , pp. 286-290
    • Auphan, N.1    Didonato, J.A.2    Rosette, C.3
  • 43
    • 0031862891 scopus 로고    scopus 로고
    • Anti-inflammatory actions of glucocorticoids: Molecular mechanisms
    • [43] Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci (Lond). 1998;94:557-572.
    • (1998) Clin Sci (Lond) , vol.94 , pp. 557-572
    • Barnes, P.J.1
  • 44
    • 4644263340 scopus 로고    scopus 로고
    • Effects of glucocorticoids on gene transcription
    • [44] Hayashi R, Wada H, Ito K, et al. Effects of glucocorticoids on gene transcription. Eur J Pharmacol. 2004;500:51-62.
    • (2004) Eur J Pharmacol , vol.500 , pp. 51-62
    • Hayashi, R.1    Wada, H.2    Ito, K.3
  • 45
    • 30444439723 scopus 로고    scopus 로고
    • Glucocorticoids: Exemplars of multi-tasking
    • [45] Buckingham JC. Glucocorticoids: exemplars of multi-tasking. Br J Pharmacol. 2006;147 Suppl 1: S258-268.
    • (2006) Br J Pharmacol , vol.147 , Issue.1 , pp. S258-S268
    • Buckingham, J.C.1
  • 46
    • 84886639785 scopus 로고
    • Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor
    • [46] Fuxe K, Harfstrand A, Agnati LF, et al. Immunocytochemical studies on the localization of glucocorticoid receptor immunoreactive nerve cells in the lower brain stem and spinal cord of the male rat using a monoclonal antibody against rat liver glucocorticoid receptor. Neurosci Lett. 1985;60:1-6.
    • (1985) Neurosci Lett , vol.60 , pp. 1-6
    • Fuxe, K.1    Harfstrand, A.2    Agnati, L.F.3
  • 47
    • 0025649124 scopus 로고
    • Charting of type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system
    • [47] Ahima RS, Harlan RE. Charting of type II glucocorticoid receptor-like immunoreactivity in the rat central nervous system. Neuroscience. 1990;39:579-604.
    • (1990) Neuroscience , vol.39 , pp. 579-604
    • Ahima, R.S.1    Harlan, R.E.2
  • 48
    • 3242742080 scopus 로고    scopus 로고
    • Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats
    • [48] Liu N, Han S, Lu PH, et al. Upregulation of annexins I, II, and V after traumatic spinal cord injury in adult rats. J Neurosci Res. 2004;77:391-401.
    • (2004) J Neurosci Res , vol.77 , pp. 391-401
    • Liu, N.1    Han, S.2    Lu, P.H.3
  • 49
    • 34948894950 scopus 로고    scopus 로고
    • Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury
    • [49] Liu NK, Zhang YP, Han S, et al. Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. J Neuropathol Exp Neurol. 2007;66:932-943.
    • (2007) J Neuropathol Exp Neurol , vol.66 , pp. 932-943
    • Liu, N.K.1    Zhang, Y.P.2    Han, S.3
  • 50
    • 0032819394 scopus 로고    scopus 로고
    • Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction
    • [50] Liu D, Liu J, Wen J. Elevation of hydrogen peroxide after spinal cord injury detected by using the Fenton reaction. Free Radic Biol Med. 1999;27:478-482.
    • (1999) Free Radic Biol Med , vol.27 , pp. 478-482
    • Liu, D.1    Liu, J.2    Wen, J.3
  • 51
    • 18744418274 scopus 로고    scopus 로고
    • Superoxide production after spinal injury detected by microperfusion of cytochrome c
    • [51] Liu D, Sybert TE, Qian H, et al. Superoxide production after spinal injury detected by microperfusion of cytochrome c. Free Radic Biol Med. 1998;25:298-304.
    • (1998) Free Radic Biol Med , vol.25 , pp. 298-304
    • Liu, D.1    Sybert, T.E.2    Qian, H.3
  • 52
    • 2942695288 scopus 로고    scopus 로고
    • The time course of hydroxyl radical formation following spinal cord injury: The possible role of the iron-catalyzed Haber-Weiss reaction
    • [52] Liu D, Liu J, Sun D, et al. The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction. J Neurotrauma. 2004;21:805-816.
    • (2004) J Neurotrauma , vol.21 , pp. 805-816
    • Liu, D.1    Liu, J.2    Sun, D.3
  • 53
    • 14744272784 scopus 로고    scopus 로고
    • Uric acid protects against secondary damage after spinal cord injury
    • [53] Scott GS, Cuzzocrea S, Genovese T, et al. Uric acid protects against secondary damage after spinal cord injury. Proc Natl Acad Sci U S A. 2005;102:3483-3488.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 3483-3488
    • Scott, G.S.1    Cuzzocrea, S.2    Genovese, T.3
  • 54
    • 0027496238 scopus 로고
    • A radical hypothesis for neurodegeneration
    • [54] Olanow CW. A radical hypothesis for neurodegeneration. Trends Neurosci. 1993;16:439-444.
    • (1993) Trends Neurosci , vol.16 , pp. 439-444
    • Olanow, C.W.1
  • 55
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
    • [55] Beckman JS, Koppenol WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol. 1996;271:C1424-1437.
    • (1996) Am J Physiol , vol.271 , pp. C1424-C1437
    • Beckman, J.S.1    Koppenol, W.H.2
  • 56
    • 0034996414 scopus 로고    scopus 로고
    • INOS and nitrotyrosine expression after spinal cord injury
    • [56] Xu J, Kim GM, Chen S, et al. iNOS and nitrotyrosine expression after spinal cord injury. J Neurotrauma. 2001; 18:523-532.
    • (2001) J Neurotrauma , vol.18 , pp. 523-532
    • Xu, J.1    Kim, G.M.2    Chen, S.3
  • 57
    • 0029966320 scopus 로고    scopus 로고
    • Involvement of nitric oxide in acute spinal cord injury: An immunocytochemical study using light and electron microscopy in the rat
    • [57] Sharma HS, Westman J, Olsson Y, et al. Involvement of nitric oxide in acute spinal cord injury: an immunocytochemical study using light and electron microscopy in the rat. Neurosci Res. 1996;24:373-384.
    • (1996) Neurosci Res , vol.24 , pp. 373-384
    • Sharma, H.S.1    Westman, J.2    Olsson, Y.3
  • 58
    • 0035181410 scopus 로고    scopus 로고
    • Improved recovery after spinal cord injury in neuronal nitric oxide synthase-deficient mice but not in TNF-alpha-deficient mice
    • [58] Farooque M, Isaksson J, Olsson Y. Improved recovery after spinal cord injury in neuronal nitric oxide synthase-deficient mice but not in TNF-alpha-deficient mice. J Neurotrauma. 2001;18:105-114.
    • (2001) J Neurotrauma , vol.18 , pp. 105-114
    • Farooque, M.1    Isaksson, J.2    Olsson, Y.3
  • 59
    • 16944363478 scopus 로고    scopus 로고
    • Neuronal and glial apoptosis after traumatic spinal cord injury
    • [59] Liu XZ, Xu XM, Hu R, et al. Neuronal and glial apoptosis after traumatic spinal cord injury. J Neurosci. 1997;17: 5395-5406.
    • (1997) J Neurosci , vol.17 , pp. 5395-5406
    • Liu, X.Z.1    Xu, X.M.2    Hu, R.3
  • 60
    • 0031015075 scopus 로고    scopus 로고
    • Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
    • [60] Crowe MJ, Bresnahan JC, Shuman SL, et al. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med. 1997;3:73-76.
    • (1997) Nat Med , vol.3 , pp. 73-76
    • Crowe, M.J.1    Bresnahan, J.C.2    Shuman, S.L.3
  • 61
    • 77955086151 scopus 로고    scopus 로고
    • Phospholipase A2 and its molecular mechanism after spinal cord injury
    • [61] Liu NK, Xu XM.: Phospholipase A2 and its molecular mechanism after spinal cord injury. Mol Neurobiol. 2010;41:197-205.
    • (2010) Mol Neurobiol , vol.41 , pp. 197-205
    • Liu, N.K.1    Xu, X.M.2
  • 63
    • 48249106275 scopus 로고    scopus 로고
    • Role of secretory phospholipase a(2) in CNS inflammation: Implications in traumatic spinal cord injury
    • [63] Titsworth WL, Liu NK, Xu XM. Role of secretory phospholipase a(2) in CNS inflammation: implications in traumatic spinal cord injury. CNS Neurol Disord Drug Targets. 2008;7:254-269.
    • (2008) CNS Neurol Disord Drug Targets , vol.7 , pp. 254-269
    • Titsworth, W.L.1    Liu, N.K.2    Xu, X.M.3
  • 64
    • 33645786025 scopus 로고    scopus 로고
    • A novel role of phospholipase A2 in mediating spinal cord secondary injury
    • [64] Liu NK, Zhang YP, Titsworth WL, et al. A novel role of phospholipase A2 in mediating spinal cord secondary injury. Ann Neurol. 2006;59:606-619.
    • (2006) Ann Neurol , vol.59 , pp. 606-619
    • Liu, N.K.1    Zhang, Y.P.2    Titsworth, W.L.3
  • 65
    • 70450220984 scopus 로고    scopus 로고
    • Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death
    • [65] Titsworth WL, Cheng X, Ke Y, et al. Differential expression of sPLA2 following spinal cord injury and a functional role for sPLA2-IIA in mediating oligodendrocyte death. Glia. 2009;57:1521-1537.
    • (2009) Glia , vol.57 , pp. 1521-1537
    • Titsworth, W.L.1    Cheng, X.2    Ke, Y.3
  • 66
    • 83355166855 scopus 로고    scopus 로고
    • Characterizing phospholipase A2-induced spinal cord injury—A comparison with contusive spinal cord injury in adult rats
    • [66] Liu NK, Titsworth WL, Zhang YP, et al. Characterizing phospholipase A2-induced spinal cord injury—A comparison with contusive spinal cord injury in adult rats. Transl Stroke Res. 2011;2:608-618.
    • (2011) Transl Stroke Res , vol.2 , pp. 608-618
    • Liu, N.K.1    Titsworth, W.L.2    Zhang, Y.P.3
  • 67
    • 34548295575 scopus 로고    scopus 로고
    • Focal phospholipases A2 group III injections induce cervical white matter injury and functional deficits with delayed recovery concomitant with Schwann cell remyelination
    • [67] Titsworth WL, Onifer SM, Liu NK, et al. Focal phospholipases A2 group III injections induce cervical white matter injury and functional deficits with delayed recovery concomitant with Schwann cell remyelination. Exp Neurol. 2007;207:150-162.
    • (2007) Exp Neurol , vol.207 , pp. 150-162
    • Titsworth, W.L.1    Onifer, S.M.2    Liu, N.K.3
  • 68
    • 79952445447 scopus 로고    scopus 로고
    • Inhibition of cPLA2 activation by Ginkgo biloba extract protects spinal cord neurons from glutamate excitotoxicity and oxidative stress-induced cell death
    • [68] Zhao Z, Liu N, Huang J, et al. Inhibition of cPLA2 activation by Ginkgo biloba extract protects spinal cord neurons from glutamate excitotoxicity and oxidative stress-induced cell death. J Neurochem. 2011;116: 1057-1065.
    • (2011) J Neurochem , vol.116 , pp. 1057-1065
    • Zhao, Z.1    Liu, N.2    Huang, J.3
  • 69
    • 77950858614 scopus 로고    scopus 로고
    • PTEN/mTOR and axon regeneration
    • [69] Park KK, Liu K, Hu Y, et al. PTEN/mTOR and axon regeneration. Exp Neurol. 2010;223:45-50.
    • (2010) Exp Neurol , vol.223 , pp. 45-50
    • Park, K.K.1    Liu, K.2    Hu, Y.3
  • 70
    • 55849108858 scopus 로고    scopus 로고
    • Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway
    • [70] Park KK, Liu K, Hu Y, et al. Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway. Science. 2008;322:963-966.
    • (2008) Science , vol.322 , pp. 963-966
    • Park, K.K.1    Liu, K.2    Hu, Y.3
  • 71
    • 78449258688 scopus 로고    scopus 로고
    • ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons
    • [71] Song W, Volosin M, Cragnolini AB, et al. ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons. J Neurosci. 2010;30: 15608-15615.
    • (2010) J Neurosci , vol.30 , pp. 15608-15615
    • Song, W.1    Volosin, M.2    Cragnolini, A.B.3
  • 72
    • 33846457396 scopus 로고    scopus 로고
    • Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury
    • [72] Zhang QG, Wu DN, Han D, et al. Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury. FEBS Lett. 2007;581:495-505.
    • (2007) FEBS Lett , vol.581 , pp. 495-505
    • Zhang, Q.G.1    Wu, D.N.2    Han, D.3
  • 73
    • 78349308125 scopus 로고    scopus 로고
    • Restoration of Akt activity by the bisperoxovanadium compound bpV(Pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis
    • [73] Sury MD, Vorlet-Fawer L, Agarinis C, et al. Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiol Dis. 2011;41:201-208.
    • (2011) Neurobiol Dis , vol.41 , pp. 201-208
    • Sury, M.D.1    Vorlet-Fawer, L.2    Agarinis, C.3
  • 74
    • 84855588783 scopus 로고    scopus 로고
    • Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury
    • [74] Walker CL, Walker MJ, Liu NK, et al. Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury. PLoS One. 2012;7:e30012.
    • (2012) Plos One , vol.7
    • Walker, C.L.1    Walker, M.J.2    Liu, N.K.3
  • 75
    • 15844365303 scopus 로고    scopus 로고
    • GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
    • [75] Jing S, Wen D, Yu Y, et al. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF. Cell. 1996;85:1113-1124.
    • (1996) Cell , vol.85 , pp. 1113-1124
    • Jing, S.1    Wen, D.2    Yu, Y.3
  • 76
    • 15844418441 scopus 로고    scopus 로고
    • Characterization of a multicomponent receptor for GDNF
    • [76] Treanor JJ, Goodman L, de Sauvage F, et al. Characterization of a multicomponent receptor for GDNF. Nature. 1996;382:80-83.
    • (1996) Nature , vol.382 , pp. 80-83
    • Treanor, J.J.1    Goodman, L.2    De Sauvage, F.3
  • 77
    • 15844406351 scopus 로고    scopus 로고
    • Functional receptor for GDNF encoded by the c-ret proto-oncogene
    • [77] Trupp M, Arenas E, Fainzilber M, et al. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature. 1996;381:785-789.
    • (1996) Nature , vol.381 , pp. 785-789
    • Trupp, M.1    Arenas, E.2    Fainzilber, M.3
  • 78
    • 0031805128 scopus 로고    scopus 로고
    • Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase
    • [78] Trupp M, Raynoschek C, Belluardo N, et al. Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase. Mol Cell Neurosci. 1998;11:47-63.
    • (1998) Mol Cell Neurosci , vol.11 , pp. 47-63
    • Trupp, M.1    Raynoschek, C.2    Belluardo, N.3
  • 79
    • 4544308191 scopus 로고    scopus 로고
    • A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury
    • [79] Iannotti C, Ping Zhang Y, Shields CB, et al. A neuroprotective role of glial cell line-derived neurotrophic factor following moderate spinal cord contusion injury. Exp Neurol. 2004;189:317-332.
    • (2004) Exp Neurol , vol.189 , pp. 317-332
    • Iannotti, C.1    Ping Zhang, Y.2    Shields, C.B.3
  • 80
    • 0036682288 scopus 로고    scopus 로고
    • Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury
    • [80] Cheng H, Wu JP, Tzeng SF. Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury. J Neurosci Res. 2002;69: 397-405.
    • (2002) J Neurosci Res , vol.69 , pp. 397-405
    • Cheng, H.1    Wu, J.P.2    Tzeng, S.F.3
  • 81
    • 67349227134 scopus 로고    scopus 로고
    • Neuroprotective actions of androgens on motoneurons
    • [81] Fargo KN, Foecking EM, Jones KJ, et al. Neuroprotective actions of androgens on motoneurons. Front Neuroendocrinol. 2009;30:130-141.
    • (2009) Front Neuroendocrinol , vol.30 , pp. 130-141
    • Fargo, K.N.1    Foecking, E.M.2    Jones, K.J.3
  • 82
    • 0346786559 scopus 로고    scopus 로고
    • Testosterone manipulation protects motoneurons from dendritic atrophy after contralateral motoneuron depletion
    • [82] Fargo KN, Sengelaub DR. Testosterone manipulation protects motoneurons from dendritic atrophy after contralateral motoneuron depletion. J Comp Neurol. 2004;469:96-106.
    • (2004) J Comp Neurol , vol.469 , pp. 96-106
    • Fargo, K.N.1    Sengelaub, D.R.2
  • 83
    • 3543131334 scopus 로고    scopus 로고
    • Exogenous testosterone prevents motoneuron atrophy induced by contralateral motoneuron depletion
    • [83] Fargo KN, Sengelaub DR. Exogenous testosterone prevents motoneuron atrophy induced by contralateral motoneuron depletion. J Neurobiol. 2004;60:348-359.
    • (2004) J Neurobiol , vol.60 , pp. 348-359
    • Fargo, K.N.1    Sengelaub, D.R.2
  • 84
    • 0030986794 scopus 로고    scopus 로고
    • Gonadal steroid preservation of central synaptic input to hamster facial motoneurons following peripheral axotomy
    • [84] Jones KJ, Durica TE, Jacob SK. Gonadal steroid preservation of central synaptic input to hamster facial motoneurons following peripheral axotomy. J Neurocytol. 1997;26:257-266.
    • (1997) J Neurocytol , vol.26 , pp. 257-266
    • Jones, K.J.1    Durica, T.E.2    Jacob, S.K.3
  • 85
    • 41349084631 scopus 로고    scopus 로고
    • Testosterone replacement therapy and motor function in men with spinal cord injury: A retrospective analysis
    • [85] Clark MJ, Petroski GF, Mazurek MO, et al. Testosterone replacement therapy and motor function in men with spinal cord injury: a retrospective analysis. Am J Phys Med Rehabil. 2008;87:281-284.
    • (2008) Am J Phys Med Rehabil , vol.87 , pp. 281-284
    • Clark, M.J.1    Petroski, G.F.2    Mazurek, M.O.3
  • 86
    • 84862130602 scopus 로고    scopus 로고
    • Neuroprotective effects of testosterone on motoneuron and muscle morphology following spinal cord injury
    • [86] Byers JS, Huguenard AL, Kuruppu D, et al. Neuroprotective effects of testosterone on motoneuron and muscle morphology following spinal cord injury. J Comp Neurol. 2012;520:2683-2696.
    • (2012) J Comp Neurol , vol.520 , pp. 2683-2696
    • Byers, J.S.1    Huguenard, A.L.2    Kuruppu, D.3
  • 87
    • 79957640347 scopus 로고    scopus 로고
    • MicroRNA in central nervous system trauma and degenerative disorders
    • [87] Liu NK, Xu XM. MicroRNA in central nervous system trauma and degenerative disorders. Physiol Genomics. 2011;43:571-580.
    • (2011) Physiol Genomics , vol.43 , pp. 571-580
    • Liu, N.K.1    Xu, X.M.2
  • 88
    • 37249042389 scopus 로고    scopus 로고
    • MicroRNA profiling: From dark matter to white matter, or identifying new players in neurobiology
    • [88] Krichevsky AM. MicroRNA profiling: from dark matter to white matter, or identifying new players in neurobiology. ScientificWorldJournal. 2007;7:155-166.
    • (2007) Scientificworldjournal , vol.7 , pp. 155-166
    • Krichevsky, A.M.1
  • 89
    • 40449124713 scopus 로고    scopus 로고
    • MicroRNA expression in the adult mouse central nervous system
    • [89] Bak M, Silahtaroglu A, Moller M, et al. MicroRNA expression in the adult mouse central nervous system. RNA. 2008;14:432-444.
    • (2008) RNA , vol.14 , pp. 432-444
    • Bak, M.1    Silahtaroglu, A.2    Moller, M.3
  • 90
    • 33751254116 scopus 로고    scopus 로고
    • The neuronal microRNA system
    • [90] Kosik KS. The neuronal microRNA system. Nat Rev Neurosci. 2006;7:911-920.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 911-920
    • Kosik, K.S.1
  • 91
    • 5344273958 scopus 로고    scopus 로고
    • Microarray analysis of microRNA expression in the developing mammalian brain
    • [91] Miska EA, Alvarez-Saavedra E, Townsend M, et al. Microarray analysis of microRNA expression in the developing mammalian brain. Genome Biol. 2004;5:R68.
    • (2004) Genome Biol , vol.5 , pp. R68
    • Miska, E.A.1    Alvarez-Saavedra, E.2    Townsend, M.3
  • 92
    • 69749105831 scopus 로고    scopus 로고
    • Altered microRNA expression following traumatic spinal cord injury
    • [92] Liu NK, Wang XF, Lu QB, et al. Altered microRNA expression following traumatic spinal cord injury. Exp Neurol. 2009;219:424-429.
    • (2009) Exp Neurol , vol.219 , pp. 424-429
    • Liu, N.K.1    Wang, X.F.2    Lu, Q.B.3
  • 93
    • 79957972917 scopus 로고    scopus 로고
    • MicroRNA dysregulation following spinal cord contusion: Implications for neural plasticity and repair
    • [93] Strickland ER, Hook MA, Balaraman S, et al. MicroRNA dysregulation following spinal cord contusion: implications for neural plasticity and repair. Neuroscience. 2011;186: 146-160.
    • (2011) Neuroscience , vol.186 , pp. 146-160
    • Strickland, E.R.1    Hook, M.A.2    Balaraman, S.3
  • 94
    • 84870985082 scopus 로고    scopus 로고
    • MicroRNA dysregulation in the spinal cord following traumatic injury
    • [94] Yunta M, Nieto-Diaz M, Esteban FJ, et al. MicroRNA dysregulation in the spinal cord following traumatic injury. PLoS One. 2012;7:e34534.
    • (2012) Plos One , vol.7
    • Yunta, M.1    Nieto-Diaz, M.2    Esteban, F.J.3
  • 95
    • 34248634004 scopus 로고    scopus 로고
    • Therapeutic potential for microRNAs
    • [95] Esau CC, Monia BP. Therapeutic potential for microRNAs. Adv Drug Deliv Rev. 2007;59:101-114.
    • (2007) Adv Drug Deliv Rev , vol.59 , pp. 101-114
    • Esau, C.C.1    Monia, B.P.2
  • 96
    • 60849101337 scopus 로고    scopus 로고
    • MicroRNAs: Key players in carcinogenesis and novel therapeutic targets
    • [96] Mirnezami AH, Pickard K, Zhang L, et al. MicroRNAs: key players in carcinogenesis and novel therapeutic targets. Eur J Surg Oncol. 2009;35:339-347.
    • (2009) Eur J Surg Oncol , vol.35 , pp. 339-347
    • Mirnezami, A.H.1    Pickard, K.2    Zhang, L.3
  • 97
    • 33645135862 scopus 로고    scopus 로고
    • Anti-miRNA oligonucleotides (AMOs): Ammunition to target miRNAs implicated in human disease?
    • [97] Weiler J, Hunziker J, Hall J. Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther. 2006;13:496-502.
    • (2006) Gene Ther , vol.13 , pp. 496-502
    • Weiler, J.1    Hunziker, J.2    Hall, J.3
  • 98
    • 34547524771 scopus 로고    scopus 로고
    • MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer
    • [98] Meng F, Henson R, Wehbe-Janek H, et al. MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology. 2007;133:647-658.
    • (2007) Gastroenterology , vol.133 , pp. 647-658
    • Meng, F.1    Henson, R.2    Wehbe-Janek, H.3
  • 99
    • 58149215787 scopus 로고    scopus 로고
    • Inhibiting microRNA function in vivo
    • [99] Medina PP, Slack FJ. Inhibiting microRNA function in vivo. Nat Methods. 2009;6:37-38.
    • (2009) Nat Methods , vol.6 , pp. 37-38
    • Medina, P.P.1    Slack, F.J.2


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