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Volumn 48, Issue 1, 2015, Pages 84-96

Immunobiology of Critical Pediatric Asthma

Author keywords

Airway epithelial cells; Asthma phenotypes; Biological response modifier therapy; Dendritic cells; Eosinophilic asthma; Eosinophils; Immunotherapy; Innate immunity; Leukotrienes; Prostaglandins; Severe asthma; T helper cells; TH2 cells; Thymic stromal lymphopoietin; Toll like receptors; Vitamin D

Indexed keywords

CYTOKINE; LEUKOTRIENE; TOLL LIKE RECEPTOR;

EID: 84892579068     PISSN: 10800549     EISSN: 15590267     Source Type: Journal    
DOI: 10.1007/s12016-014-8409-z     Document Type: Review
Times cited : (6)

References (139)
  • 1
    • 84878465431 scopus 로고    scopus 로고
    • Phenotypes and endotypes of severe asthma in children
    • COI: 1:CAS:528:DC%2BC3sXhtV2mtbvJ, PID: 23741231
    • Yoo Y (2013) Phenotypes and endotypes of severe asthma in children. Korean J Pediatr 56(5):191–5
    • (2013) Korean J Pediatr , vol.56 , Issue.5 , pp. 191-195
    • Yoo, Y.1
  • 2
    • 33845987340 scopus 로고    scopus 로고
    • Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute’s Severe Asthma Research Program
    • PID: 17291857
    • Moore WC et al (2007) Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute’s Severe Asthma Research Program. J Allergy Clin Immunol 119(2):405–13
    • (2007) J Allergy Clin Immunol , vol.119 , Issue.2 , pp. 405-413
    • Moore, W.C.1
  • 3
    • 77954366044 scopus 로고    scopus 로고
    • Phenotypes of childhood asthma: are they real?
    • COI: 1:STN:280:DC%2BC3cnpt1ahtw%3D%3D, PID: 20545704
    • Spycher BD, Silverman M, Kuehni CE (2010) Phenotypes of childhood asthma: are they real? Clin Exp Allergy 40(8):1130–41
    • (2010) Clin Exp Allergy , vol.40 , Issue.8 , pp. 1130-1141
    • Spycher, B.D.1    Silverman, M.2    Kuehni, C.E.3
  • 5
    • 84877250200 scopus 로고    scopus 로고
    • A comparison of immunotherapy delivery methods for allergen immunotherapy
    • COI: 1:CAS:528:DC%2BC3sXmvVSmsbo%3D, PID: 23634740, quiz 475
    • Klimek L, Pfaar O (2013) A comparison of immunotherapy delivery methods for allergen immunotherapy. Expert Rev Clin Immunol 9(5):465–74, quiz 475
    • (2013) Expert Rev Clin Immunol , vol.9 , Issue.5 , pp. 465-474
    • Klimek, L.1    Pfaar, O.2
  • 6
    • 84871005335 scopus 로고    scopus 로고
    • Asthma in children and adolescents: a comprehensive approach to diagnosis and management
    • PID: 22187333
    • Chang C (2012) Asthma in children and adolescents: a comprehensive approach to diagnosis and management. Clin Rev Allergy Immunol 43(1–2):98–137
    • (2012) Clin Rev Allergy Immunol , vol.43 , Issue.1-2 , pp. 98-137
    • Chang, C.1
  • 7
    • 83455217697 scopus 로고    scopus 로고
    • Asthma: developments in targeted therapy
    • PID: 22149334
    • Matucci A et al (2012) Asthma: developments in targeted therapy. Expert Rev Clin Immunol 8(1):13–5
    • (2012) Expert Rev Clin Immunol , vol.8 , Issue.1 , pp. 13-15
    • Matucci, A.1
  • 8
    • 84867335084 scopus 로고    scopus 로고
    • Asthma and pregnancy
    • COI: 1:CAS:528:DC%2BC38Xht1egtrnL, PID: 21858482
    • Vatti RR, Teuber SS (2012) Asthma and pregnancy. Clin Rev Allergy Immunol 43(1–2):45–56
    • (2012) Clin Rev Allergy Immunol , vol.43 , Issue.1-2 , pp. 45-56
    • Vatti, R.R.1    Teuber, S.S.2
  • 9
    • 84871651905 scopus 로고    scopus 로고
    • The critically ill asthmatic—from ICU to discharge
    • COI: 1:CAS:528:DC%2BC38Xht1egtrnI, PID: 21573915
    • Louie S et al (2012) The critically ill asthmatic—from ICU to discharge. Clin Rev Allergy Immunol 43(1–2):30–44
    • (2012) Clin Rev Allergy Immunol , vol.43 , Issue.1-2 , pp. 30-44
    • Louie, S.1
  • 10
    • 84871647696 scopus 로고    scopus 로고
    • The challenge of asthma in minority populations
    • PID: 21538075
    • Leong AB, Ramsey CD, Celedon JC (2012) The challenge of asthma in minority populations. Clin Rev Allergy Immunol 43(1–2):156–83
    • (2012) Clin Rev Allergy Immunol , vol.43 , Issue.1-2 , pp. 156-183
    • Leong, A.B.1    Ramsey, C.D.2    Celedon, J.C.3
  • 11
    • 84887780131 scopus 로고    scopus 로고
    • Management of critical asthma syndrome during pregnancy. Clin Rev Allergy Immunol
    • Chan A L et al (2013) Management of critical asthma syndrome during pregnancy. Clin Rev Allergy Immunol. doi:10.1007/s12016-013-8397-4
    • (2013) doi:10.1007/s12016-013-8397-4
    • Chan, A.L.1
  • 12
    • 84887314458 scopus 로고    scopus 로고
    • Critical asthma syndrome in the ICU. Clin Rev Allergy Immunol
    • Schivo M et al (2013) Critical asthma syndrome in the ICU. Clin Rev Allergy Immunol. doi:10.1007/s12016-013-8394-7
    • (2013) doi:10.1007/s12016-013-8394-7
    • Schivo, M.1
  • 13
    • 84886962242 scopus 로고    scopus 로고
    • Definition of Critical Asthma Syndromes. Clin Rev Allergy Immunol
    • Kenyon N et al (2013) Definition of Critical Asthma Syndromes. Clin Rev Allergy Immunol. doi:10.1007/s12016-013-8395-6
    • (2013) doi:10.1007/s12016-013-8395-6
    • Kenyon, N.1
  • 15
    • 52049087356 scopus 로고    scopus 로고
    • Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease
    • PID: 18805339
    • Anderson GP (2008) Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease. Lancet 372(9643):1107–19
    • (2008) Lancet , vol.372 , Issue.9643 , pp. 1107-1119
    • Anderson, G.P.1
  • 16
    • 79551505136 scopus 로고    scopus 로고
    • Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome
    • PID: 21281866
    • Lotvall J et al (2011) Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 127(2):355–60
    • (2011) J Allergy Clin Immunol , vol.127 , Issue.2 , pp. 355-360
    • Lotvall, J.1
  • 17
    • 84856845581 scopus 로고    scopus 로고
    • Severe asthma: from characteristics to phenotypes to endotypes
    • COI: 1:CAS:528:DC%2BC38Xpt12htL8%3D, PID: 22251060
    • Wenzel S (2012) Severe asthma: from characteristics to phenotypes to endotypes. Clin Exp Allergy 42(5):650–8
    • (2012) Clin Exp Allergy , vol.42 , Issue.5 , pp. 650-658
    • Wenzel, S.1
  • 18
    • 77953794345 scopus 로고    scopus 로고
    • The many paths to asthma: phenotype shaped by innate and adaptive immunity
    • COI: 1:CAS:528:DC%2BC3cXns1Gjurw%3D, PID: 20562844
    • Kim HY, DeKruyff RH, Umetsu DT (2010) The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol 11(7):577–84
    • (2010) Nat Immunol , vol.11 , Issue.7 , pp. 577-584
    • Kim, H.Y.1    DeKruyff, R.H.2    Umetsu, D.T.3
  • 19
    • 84860691114 scopus 로고    scopus 로고
    • The airway epithelium in asthma
    • COI: 1:CAS:528:DC%2BC38XmsFOqt7w%3D, PID: 22561832
    • Lambrecht BN, Hammad H (2012) The airway epithelium in asthma. Nat Med 18(5):684–92
    • (2012) Nat Med , vol.18 , Issue.5 , pp. 684-692
    • Lambrecht, B.N.1    Hammad, H.2
  • 20
    • 84877052896 scopus 로고    scopus 로고
    • Evolution of immune systems: specificity and autoreactivity
    • COI: 1:CAS:528:DC%2BC38XhvVaqu7rF, PID: 23201916
    • Bailey M, Christoforidou Z, Lewis M (2013) Evolution of immune systems: specificity and autoreactivity. Autoimmun Rev 12(6):643–7
    • (2013) Autoimmun Rev , vol.12 , Issue.6 , pp. 643-647
    • Bailey, M.1    Christoforidou, Z.2    Lewis, M.3
  • 21
    • 64149087970 scopus 로고    scopus 로고
    • House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells
    • COI: 1:CAS:528:DC%2BD1MXjslartrY%3D, PID: 19330007
    • Hammad H et al (2009) House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med 15(4):410–6
    • (2009) Nat Med , vol.15 , Issue.4 , pp. 410-416
    • Hammad, H.1
  • 22
    • 59049100417 scopus 로고    scopus 로고
    • Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein
    • COI: 1:CAS:528:DC%2BD1MXhtFOmtr8%3D, PID: 19060881
    • Trompette A et al (2009) Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 457(7229):585–8
    • (2009) Nature , vol.457 , Issue.7229 , pp. 585-588
    • Trompette, A.1
  • 23
    • 44849090900 scopus 로고    scopus 로고
    • Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells
    • COI: 1:CAS:528:DC%2BD1cXotVeht7w%3D, PID: 18217953
    • Pace E et al (2008) Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells. Immunology 124(3):401–11
    • (2008) Immunology , vol.124 , Issue.3 , pp. 401-411
    • Pace, E.1
  • 24
    • 0347362785 scopus 로고    scopus 로고
    • Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin
    • COI: 1:CAS:528:DC%2BD3sXpvFGjtbg%3D, PID: 14565959
    • Monick MM et al (2003) Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem 278(52):53035–44
    • (2003) J Biol Chem , vol.278 , Issue.52 , pp. 53035-53044
    • Monick, M.M.1
  • 25
    • 77951817294 scopus 로고    scopus 로고
    • IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses
    • COI: 1:CAS:528:DC%2BC3cXivVCiu7w%3D, PID: 20200520
    • Saenz SA et al (2010) IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responses. Nature 464(7293):1362–6
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1362-1366
    • Saenz, S.A.1
  • 26
    • 77951817855 scopus 로고    scopus 로고
    • Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
    • COI: 1:CAS:528:DC%2BC3cXivVCiur4%3D, PID: 20200518
    • Neill DR et al (2010) Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity. Nature 464(7293):1367–70
    • (2010) Nature , vol.464 , Issue.7293 , pp. 1367-1370
    • Neill, D.R.1
  • 27
    • 18244405108 scopus 로고    scopus 로고
    • IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo
    • COI: 1:CAS:528:DC%2BD38Xhsl2ksA%3D%3D, PID: 11754819
    • Fort MM et al (2001) IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo. Immunity 15(6):985–95
    • (2001) Immunity , vol.15 , Issue.6 , pp. 985-995
    • Fort, M.M.1
  • 28
    • 70349337464 scopus 로고    scopus 로고
    • IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production
    • COI: 1:CAS:528:DC%2BD1MXhtVOmurrP, PID: 19684081
    • Schneider E et al (2009) IL-33 activates unprimed murine basophils directly in vitro and induces their in vivo expansion indirectly by promoting hematopoietic growth factor production. J Immunol 183(6):3591–7
    • (2009) J Immunol , vol.183 , Issue.6 , pp. 3591-3597
    • Schneider, E.1
  • 29
    • 0034680145 scopus 로고    scopus 로고
    • Toll-like receptors in the induction of the innate immune response
    • COI: 1:STN:280:DC%2BD3cvjtVOhuw%3D%3D, PID: 10963608
    • Aderem A, Ulevitch RJ (2000) Toll-like receptors in the induction of the innate immune response. Nature 406(6797):782–7
    • (2000) Nature , vol.406 , Issue.6797 , pp. 782-787
    • Aderem, A.1    Ulevitch, R.J.2
  • 30
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • COI: 1:CAS:528:DyaK2sXkvVChurc%3D, PID: 9237759
    • Medzhitov R, Preston-Hurlburt P, Janeway CA Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388(6640):394–7
    • (1997) Nature , vol.388 , Issue.6640 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway, C.A.3
  • 31
    • 0034303250 scopus 로고    scopus 로고
    • Toll-like receptor family and signalling pathway
    • COI: 1:CAS:528:DC%2BD3cXotFykt70%3D, PID: 11044375
    • Muzio M et al (2000) Toll-like receptor family and signalling pathway. Biochem Soc Trans 28(5):563–6
    • (2000) Biochem Soc Trans , vol.28 , Issue.5 , pp. 563-566
    • Muzio, M.1
  • 32
    • 0036569813 scopus 로고    scopus 로고
    • Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells
    • COI: 1:CAS:528:DC%2BD38Xjt12jt7g%3D, PID: 11970998
    • Dabbagh K et al (2002) Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J Immunol 168(9):4524–30
    • (2002) J Immunol , vol.168 , Issue.9 , pp. 4524-4530
    • Dabbagh, K.1
  • 33
    • 0033983004 scopus 로고    scopus 로고
    • Viral and bacterial infections in the development and progression of asthma
    • COI: 1:STN:280:DC%2BD3c7kvVKqsQ%3D%3D, PID: 10669531
    • Gern JE (2000) Viral and bacterial infections in the development and progression of asthma. J Allergy Clin Immunol 105(2 Pt 2):S497–502
    • (2000) J Allergy Clin Immunol , vol.105 , Issue.2 , pp. S497-S502
    • Gern, J.E.1
  • 34
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    • COI: 1:CAS:528:DC%2BD3cXnvVGht78%3D, PID: 11062499
    • Kurt-Jones EA et al (2000) Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 1(5):398–401
    • (2000) Nat Immunol , vol.1 , Issue.5 , pp. 398-401
    • Kurt-Jones, E.A.1
  • 35
    • 84859126022 scopus 로고    scopus 로고
    • The role of dendritic cells in asthma
    • COI: 1:CAS:528:DC%2BC38XkvFSlsLo%3D, PID: 22464668
    • Gill MA (2012) The role of dendritic cells in asthma. J Allergy Clin Immunol 129(4):889–901
    • (2012) J Allergy Clin Immunol , vol.129 , Issue.4 , pp. 889-901
    • Gill, M.A.1
  • 36
    • 80051707475 scopus 로고    scopus 로고
    • Polymorphisms in toll-like receptor 4 gene are associated with asthma severity but not susceptibility in a Chinese Han population
    • COI: 1:CAS:528:DC%2BC3MXhsVWkurfF, PID: 21905500
    • Zhang Q et al (2011) Polymorphisms in toll-like receptor 4 gene are associated with asthma severity but not susceptibility in a Chinese Han population. J investig allergol Clin Immunol 21(5):370–7
    • (2011) J investig allergol Clin Immunol , vol.21 , Issue.5 , pp. 370-377
    • Zhang, Q.1
  • 37
    • 27844508633 scopus 로고    scopus 로고
    • The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma
    • COI: 1:CAS:528:DC%2BD2MXhtlSitrzJ, PID: 16266379
    • Sackesen C et al (2005) The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma. Allergy 60(12):1485–92
    • (2005) Allergy , vol.60 , Issue.12 , pp. 1485-1492
    • Sackesen, C.1
  • 38
    • 84875219804 scopus 로고    scopus 로고
    • The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma
    • COI: 1:CAS:528:DC%2BC3sXitFKms74%3D, PID: 23384679
    • Beeh KM et al (2013) The novel TLR-9 agonist QbG10 shows clinical efficacy in persistent allergic asthma. J Allergy Clin Immunol 131(3):866–74
    • (2013) J Allergy Clin Immunol , vol.131 , Issue.3 , pp. 866-874
    • Beeh, K.M.1
  • 39
    • 34247485053 scopus 로고    scopus 로고
    • Noneosinophilic asthma: a distinct clinical and pathologic phenotype
    • COI: 1:CAS:528:DC%2BD2sXkslektL4%3D, PID: 17472810, quiz 1053–4
    • Haldar P, Pavord ID (2007) Noneosinophilic asthma: a distinct clinical and pathologic phenotype. J Allergy Clin Immunol 119(5):1043–52, quiz 1053–4
    • (2007) J Allergy Clin Immunol , vol.119 , Issue.5 , pp. 1043-1052
    • Haldar, P.1    Pavord, I.D.2
  • 40
    • 0023831561 scopus 로고
    • Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity
    • COI: 1:STN:280:DyaL1c7gsV2jtA%3D%3D, PID: 2447813
    • Wardlaw AJ et al (1988) Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 137(1):62–9
    • (1988) Am Rev Respir Dis , vol.137 , Issue.1 , pp. 62-69
    • Wardlaw, A.J.1
  • 41
    • 0025037094 scopus 로고
    • Eosinophilic inflammation in asthma
    • COI: 1:STN:280:DyaK3M%2FhsFajsw%3D%3D, PID: 2215562
    • Bousquet J et al (1990) Eosinophilic inflammation in asthma. N Engl J Med 323(15):1033–9
    • (1990) N Engl J Med , vol.323 , Issue.15 , pp. 1033-1039
    • Bousquet, J.1
  • 42
    • 0030048946 scopus 로고    scopus 로고
    • Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa
    • COI: 1:STN:280:DyaK287mtVGlsA%3D%3D, PID: 8564096
    • Bentley AM et al (1996) Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med 153(2):551–6
    • (1996) Am J Respir Crit Care Med , vol.153 , Issue.2 , pp. 551-556
    • Bentley, A.M.1
  • 43
    • 0024545977 scopus 로고
    • Cellular events in the bronchi in mild asthma and after bronchial provocation
    • COI: 1:STN:280:DyaL1M7msFShuw%3D%3D, PID: 2923380
    • Beasley R et al (1989) Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139(3):806–17
    • (1989) Am Rev Respir Dis , vol.139 , Issue.3 , pp. 806-817
    • Beasley, R.1
  • 44
    • 0036165793 scopus 로고    scopus 로고
    • Eosinophilic bronchitis: clinical manifestations and implications for treatment
    • COI: 1:STN:280:DC%2BD387htV2nsQ%3D%3D, PID: 11828051
    • Gibson PG, Fujimura M, Niimi A (2002) Eosinophilic bronchitis: clinical manifestations and implications for treatment. Thorax 57(2):178–82
    • (2002) Thorax , vol.57 , Issue.2 , pp. 178-182
    • Gibson, P.G.1    Fujimura, M.2    Niimi, A.3
  • 45
    • 0035888740 scopus 로고    scopus 로고
    • Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone
    • COI: 1:STN:280:DC%2BD3Mnlt1Slsw%3D%3D, PID: 11704581
    • Payne DN et al (2001) Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med 164(8 Pt 1):1376–81
    • (2001) Am J Respir Crit Care Med , vol.164 , Issue.8 , pp. 1376-1381
    • Payne, D.N.1
  • 46
    • 0035043059 scopus 로고    scopus 로고
    • The labyrinth of asthma phenotypes and exhaled NO
    • COI: 1:STN:280:DC%2BD3M3it1CqsA%3D%3D, PID: 11312396
    • Baraldi E, Zanconato S (2001) The labyrinth of asthma phenotypes and exhaled NO. Thorax 56(5):333–5
    • (2001) Thorax , vol.56 , Issue.5 , pp. 333-335
    • Baraldi, E.1    Zanconato, S.2
  • 47
    • 80052438246 scopus 로고    scopus 로고
    • An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications
    • COI: 1:CAS:528:DC%2BC3MXhtlWqtrfM, PID: 21885636
    • Dweik RA et al (2011) An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 184(5):602–15
    • (2011) Am J Respir Crit Care Med , vol.184 , Issue.5 , pp. 602-615
    • Dweik, R.A.1
  • 48
    • 67049144615 scopus 로고    scopus 로고
    • Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies
    • COI: 1:CAS:528:DC%2BD1MXmtFeiu7k%3D, PID: 19387026
    • Fahy JV (2009) Eosinophilic and neutrophilic inflammation in asthma: insights from clinical studies. Proc Am Thorac Soc 6(3):256–9
    • (2009) Proc Am Thorac Soc , vol.6 , Issue.3 , pp. 256-259
    • Fahy, J.V.1
  • 49
    • 0035177659 scopus 로고    scopus 로고
    • Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma
    • COI: 1:STN:280:DC%2BD3MnktVOhtw%3D%3D, PID: 11692100
    • Woodruff PG et al (2001) Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol 108(5):753–8
    • (2001) J Allergy Clin Immunol , vol.108 , Issue.5 , pp. 753-758
    • Woodruff, P.G.1
  • 50
    • 0030859389 scopus 로고    scopus 로고
    • Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids
    • COI: 1:STN:280:DyaK2svlsFOltA%3D%3D, PID: 9309987
    • Wenzel SE et al (1997) Bronchoscopic evaluation of severe asthma. Persistent inflammation associated with high dose glucocorticoids. Am J Respir Crit Care Med 156(3 Pt 1):737–43
    • (1997) Am J Respir Crit Care Med , vol.156 , Issue.3 , pp. 737-743
    • Wenzel, S.E.1
  • 51
    • 0032875377 scopus 로고    scopus 로고
    • Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics
    • COI: 1:STN:280:DyaK1Mvgtlanuw%3D%3D, PID: 10471631
    • Wenzel SE et al (1999) Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am J Respir Crit Care Med 160(3):1001–8
    • (1999) Am J Respir Crit Care Med , vol.160 , Issue.3 , pp. 1001-1008
    • Wenzel, S.E.1
  • 52
    • 0034942124 scopus 로고    scopus 로고
    • Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8
    • COI: 1:CAS:528:DC%2BD3MXktlekur4%3D, PID: 11348936
    • Gibson PG, Simpson JL, Saltos N (2001) Heterogeneity of airway inflammation in persistent asthma: evidence of neutrophilic inflammation and increased sputum interleukin-8. Chest 119(5):1329–36
    • (2001) Chest , vol.119 , Issue.5 , pp. 1329-1336
    • Gibson, P.G.1    Simpson, J.L.2    Saltos, N.3
  • 53
    • 36749095585 scopus 로고    scopus 로고
    • Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma
    • PID: 17356056
    • Berry M et al (2007) Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 62(12):1043–9
    • (2007) Thorax , vol.62 , Issue.12 , pp. 1043-1049
    • Berry, M.1
  • 54
    • 0037202790 scopus 로고    scopus 로고
    • Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
    • PID: 12480423
    • Green RH et al (2002) Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet 360(9347):1715–21
    • (2002) Lancet , vol.360 , Issue.9347 , pp. 1715-1721
    • Green, R.H.1
  • 55
    • 33344476409 scopus 로고    scopus 로고
    • Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations
    • COI: 1:STN:280:DC%2BD287itVKlug%3D%3D, PID: 16507847
    • Jayaram L et al (2006) Determining asthma treatment by monitoring sputum cell counts: effect on exacerbations. Eur Respir J 27(3):483–94
    • (2006) Eur Respir J , vol.27 , Issue.3 , pp. 483-494
    • Jayaram, L.1
  • 56
    • 0000606763 scopus 로고
    • Treatment of chronic asthma with prednisolone; significance of eosinophils in the sputum
    • COI: 1:STN:280:DyaG1M%2FktFOjuw%3D%3D, PID: 13612182
    • Brown HM (1958) Treatment of chronic asthma with prednisolone; significance of eosinophils in the sputum. Lancet 2(7059):1245–7
    • (1958) Lancet , vol.2 , Issue.7059 , pp. 1245-1247
    • Brown, H.M.1
  • 57
    • 0033606539 scopus 로고    scopus 로고
    • Non-eosinophilic corticosteroid unresponsive asthma
    • COI: 1:STN:280:DyaK1MzitVWltg%3D%3D, PID: 10392993
    • Pavord ID et al (1999) Non-eosinophilic corticosteroid unresponsive asthma. Lancet 353(9171):2213–4
    • (1999) Lancet , vol.353 , Issue.9171 , pp. 2213-2214
    • Pavord, I.D.1
  • 58
    • 0037111588 scopus 로고    scopus 로고
    • Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in a mouse model of asthma
    • PID: 12393720
    • van Rijt LS et al (2002) Allergen-induced accumulation of airway dendritic cells is supported by an increase in CD31(hi)Ly-6C(neg) bone marrow precursors in a mouse model of asthma. Blood 100(10):3663–71
    • (2002) Blood , vol.100 , Issue.10 , pp. 3663-3671
    • van Rijt, L.S.1
  • 59
    • 0033144464 scopus 로고    scopus 로고
    • Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats
    • COI: 1:CAS:528:DyaK1MXjvF2jsr4%3D, PID: 10340935
    • Lambrecht BN et al (1999) Allergen-induced changes in bone-marrow progenitor and airway dendritic cells in sensitized rats. Am J Respir Cell Mol Biol 20(6):1165–74
    • (1999) Am J Respir Cell Mol Biol , vol.20 , Issue.6 , pp. 1165-1174
    • Lambrecht, B.N.1
  • 60
    • 0033855772 scopus 로고    scopus 로고
    • Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation
    • COI: 1:CAS:528:DC%2BD3cXlvFClur4%3D, PID: 10953030
    • Lambrecht BN et al (2000) Myeloid dendritic cells induce Th2 responses to inhaled antigen, leading to eosinophilic airway inflammation. J Clin Invest 106(4):551–9
    • (2000) J Clin Invest , vol.106 , Issue.4 , pp. 551-559
    • Lambrecht, B.N.1
  • 61
    • 0035863826 scopus 로고    scopus 로고
    • Intratracheal priming with ovalbumin- and ovalbumin 323–339 peptide-pulsed dendritic cells induces airway hyperresponsiveness, lung eosinophilia, goblet cell hyperplasia, and inflammation
    • COI: 1:CAS:528:DC%2BD3MXlvVWmtg%3D%3D, PID: 11145709
    • Sung S, Rose CE, Fu SM (2001) Intratracheal priming with ovalbumin- and ovalbumin 323–339 peptide-pulsed dendritic cells induces airway hyperresponsiveness, lung eosinophilia, goblet cell hyperplasia, and inflammation. J Immunol 166(2):1261–71
    • (2001) J Immunol , vol.166 , Issue.2 , pp. 1261-1271
    • Sung, S.1    Rose, C.E.2    Fu, S.M.3
  • 62
    • 17644372733 scopus 로고    scopus 로고
    • IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • COI: 1:CAS:528:DC%2BD2MXktFOjur4%3D, PID: 15771572
    • Liu YJ (2005) IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 23:275–306
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 63
    • 77953404932 scopus 로고    scopus 로고
    • Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells
    • COI: 1:CAS:528:DC%2BC3cXmtFyqsLo%3D, PID: 20410486
    • Gill MA et al (2010) Counterregulation between the FcepsilonRI pathway and antiviral responses in human plasmacytoid dendritic cells. J Immunol 184(11):5999–6006
    • (2010) J Immunol , vol.184 , Issue.11 , pp. 5999-6006
    • Gill, M.A.1
  • 64
    • 33644781574 scopus 로고    scopus 로고
    • Impaired virus-induced interferon-alpha2 release in adult asthmatic patients
    • COI: 1:CAS:528:DC%2BD28XjtlGms7s%3D, PID: 16499644
    • Gehlhar K et al (2006) Impaired virus-induced interferon-alpha2 release in adult asthmatic patients. Clin Exp Allergy 36(3):331–7
    • (2006) Clin Exp Allergy , vol.36 , Issue.3 , pp. 331-337
    • Gehlhar, K.1
  • 65
    • 0036118734 scopus 로고    scopus 로고
    • Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release
    • COI: 1:CAS:528:DC%2BD38XhvVSksb8%3D, PID: 11893858
    • Bufe A et al (2002) Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release. Int Arch Allergy Immunol 127(1):82–8
    • (2002) Int Arch Allergy Immunol , vol.127 , Issue.1 , pp. 82-88
    • Bufe, A.1
  • 66
    • 77955503273 scopus 로고    scopus 로고
    • Cutting edge: type I IFN reverses human Th2 commitment and stability by suppressing GATA3
    • COI: 1:CAS:528:DC%2BC3cXotlymu7s%3D, PID: 20554961
    • Huber JP et al (2010) Cutting edge: type I IFN reverses human Th2 commitment and stability by suppressing GATA3. J Immunol 185(2):813–7
    • (2010) J Immunol , vol.185 , Issue.2 , pp. 813-817
    • Huber, J.P.1
  • 67
    • 52749084284 scopus 로고    scopus 로고
    • Interferon-alpha controls IL-17 expression in vitro and in vivo
    • COI: 1:CAS:528:DC%2BD1cXhtlCgt7%2FJ, PID: 18926293
    • Moschen AR et al (2008) Interferon-alpha controls IL-17 expression in vitro and in vivo. Immunobiology 213(9–10):779–87
    • (2008) Immunobiology , vol.213 , Issue.9-10 , pp. 779-787
    • Moschen, A.R.1
  • 68
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • COI: 1:CAS:528:DC%2BD2MXhtFamsb7J, PID: 16200070
    • Harrington LE et al (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11):1123–32
    • (2005) Nat Immunol , vol.6 , Issue.11 , pp. 1123-1132
    • Harrington, L.E.1
  • 69
    • 33847134006 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells
    • COI: 1:CAS:528:DC%2BD2sXitVekt7s%3D, PID: 17242164
    • Allakhverdi Z et al (2007) Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J Exp Med 204(2):253–8
    • (2007) J Exp Med , vol.204 , Issue.2 , pp. 253-258
    • Allakhverdi, Z.1
  • 70
    • 34247891512 scopus 로고    scopus 로고
    • TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
    • COI: 1:CAS:528:DC%2BD2sXltlagu7s%3D, PID: 17129180
    • Liu YJ et al (2007) TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol 25:193–219
    • (2007) Annu Rev Immunol , vol.25 , pp. 193-219
    • Liu, Y.J.1
  • 71
    • 20444365526 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity
    • COI: 1:CAS:528:DC%2BD2MXkvVOlsLc%3D, PID: 15944327
    • Ying S et al (2005) Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of Th2-attracting chemokines and disease severity. J Immunol 174(12):8183–90
    • (2005) J Immunol , vol.174 , Issue.12 , pp. 8183-8190
    • Ying, S.1
  • 72
    • 25844515028 scopus 로고    scopus 로고
    • Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice
    • COI: 1:CAS:528:DC%2BD2MXhtVajs7fF, PID: 16142237
    • Zhou B et al (2005) Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice. Nat Immunol 6(10):1047–53
    • (2005) Nat Immunol , vol.6 , Issue.10 , pp. 1047-1053
    • Zhou, B.1
  • 73
    • 77952770768 scopus 로고    scopus 로고
    • The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease
    • COI: 1:CAS:528:DC%2BC3cXjtFyjsbk%3D
    • Fang C et al (2010) The role of thymic stromal lymphopoietin in allergic inflammation and chronic obstructive pulmonary disease. Arch Immunol Ther Exp (Warsz) 58(2):81–90
    • (2010) Arch Immunol Ther Exp (Warsz) , vol.58 , Issue.2 , pp. 81-90
    • Fang, C.1
  • 74
    • 55649112317 scopus 로고    scopus 로고
    • [Signal transduction in respiratory syncytial virus infection-induced thymic stromal lymphopoietin expression in human epithelial cells]
    • COI: 1:CAS:528:DC%2BD2sXhtlGqsbzM, PID: 17959543
    • Tu HY, Chen X, Li J (2007) [Signal transduction in respiratory syncytial virus infection-induced thymic stromal lymphopoietin expression in human epithelial cells]. Nan Fang Yi Ke Da Xue Xue Bao 27(10):1581–3
    • (2007) Nan Fang Yi Ke Da Xue Xue Bao , vol.27 , Issue.10 , pp. 1581-1583
    • Tu, H.Y.1    Chen, X.2    Li, J.3
  • 75
    • 0026610142 scopus 로고
    • Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
    • COI: 1:STN:280:DyaK387gtVWnsQ%3D%3D, PID: 1530827
    • Robinson DS et al (1992) Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 326(5):298–304
    • (1992) N Engl J Med , vol.326 , Issue.5 , pp. 298-304
    • Robinson, D.S.1
  • 76
    • 0035719975 scopus 로고    scopus 로고
    • Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
    • COI: 1:CAS:528:DC%2BD3MXosVeqtrY%3D, PID: 11686867
    • Steinke JW, Borish L (2001) Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir Res 2(2):66–70
    • (2001) Respir Res , vol.2 , Issue.2 , pp. 66-70
    • Steinke, J.W.1    Borish, L.2
  • 77
    • 0035722930 scopus 로고    scopus 로고
    • Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease
    • COI: 1:CAS:528:DC%2BD3MXosVeqt74%3D, PID: 11686868
    • Greenfeder S et al (2001) Th2 cytokines and asthma. The role of interleukin-5 in allergic eosinophilic disease. Respir Res 2(2):71–9
    • (2001) Respir Res , vol.2 , Issue.2 , pp. 71-79
    • Greenfeder, S.1
  • 78
    • 0033024432 scopus 로고    scopus 로고
    • IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders
    • COI: 1:CAS:528:DyaK1MXjsl2ksbk%3D, PID: 10329852
    • Levitt RC et al (1999) IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders. J Allergy Clin Immunol 103(5 Pt 2):S485–91
    • (1999) J Allergy Clin Immunol , vol.103 , Issue.5 , pp. S485-S491
    • Levitt, R.C.1
  • 79
    • 0027376039 scopus 로고
    • Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases
    • COI: 1:CAS:528:DyaK2cXlt1ejsA%3D%3D, PID: 7691943
    • Eklund KK et al (1993) Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases. J Immunol 151(8):4266–73
    • (1993) J Immunol , vol.151 , Issue.8 , pp. 4266-4273
    • Eklund, K.K.1
  • 80
    • 0029039388 scopus 로고
    • IL-9 induces expression of granzymes and high-affinity IgE receptor in murine T helper clones
    • COI: 1:CAS:528:DyaK2MXlsVyksbg%3D, PID: 7730612
    • Louahed J et al (1995) IL-9 induces expression of granzymes and high-affinity IgE receptor in murine T helper clones. J Immunol 154(10):5061–70
    • (1995) J Immunol , vol.154 , Issue.10 , pp. 5061-5070
    • Louahed, J.1
  • 81
    • 0025090799 scopus 로고
    • Mast cell growth-enhancing activity (MEA) stimulates interleukin 6 production in a mouse bone marrow-derived mast cell line and a malignant subline
    • COI: 1:STN:280:DyaK3czltlCltg%3D%3D, PID: 2117548
    • Hultner L, Moeller J (1990) Mast cell growth-enhancing activity (MEA) stimulates interleukin 6 production in a mouse bone marrow-derived mast cell line and a malignant subline. Exp Hematol 18(8):873–7
    • (1990) Exp Hematol , vol.18 , Issue.8 , pp. 873-877
    • Hultner, L.1    Moeller, J.2
  • 82
    • 0027197714 scopus 로고
    • Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes
    • COI: 1:CAS:528:DyaK3sXlslyqtbY%3D, PID: 7686859
    • Dugas B et al (1993) Interleukin-9 potentiates the interleukin-4-induced immunoglobulin (IgG, IgM and IgE) production by normal human B lymphocytes. Eur J Immunol 23(7):1687–92
    • (1993) Eur J Immunol , vol.23 , Issue.7 , pp. 1687-1692
    • Dugas, B.1
  • 83
    • 0027180597 scopus 로고
    • Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes
    • COI: 1:CAS:528:DyaK3sXkt1Knsbg%3D, PID: 8509135
    • Petit-Frere C et al (1993) Interleukin-9 potentiates the interleukin-4-induced IgE and IgG1 release from murine B lymphocytes. Immunology 79(1):146–51
    • (1993) Immunology , vol.79 , Issue.1 , pp. 146-151
    • Petit-Frere, C.1
  • 84
    • 0026051430 scopus 로고
    • Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children
    • COI: 1:STN:280:DyaK3MzmslaisA%3D%3D, PID: 1891008
    • Sears MR et al (1991) Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 325(15):1067–71
    • (1991) N Engl J Med , vol.325 , Issue.15 , pp. 1067-1071
    • Sears, M.R.1
  • 85
    • 0032545213 scopus 로고    scopus 로고
    • Interleukin-13: central mediator of allergic asthma
    • COI: 1:CAS:528:DyaK1cXotFGjsLk%3D, PID: 9856949
    • Wills-Karp M et al (1998) Interleukin-13: central mediator of allergic asthma. Science 282(5397):2258–61
    • (1998) Science , vol.282 , Issue.5397 , pp. 2258-2261
    • Wills-Karp, M.1
  • 86
    • 0032545433 scopus 로고    scopus 로고
    • Requirement for IL-13 independently of IL-4 in experimental asthma
    • COI: 1:CAS:528:DyaK1cXotFGjsbw%3D, PID: 9856950
    • Grunig G et al (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282(5397):2261–3
    • (1998) Science , vol.282 , Issue.5397 , pp. 2261-2263
    • Grunig, G.1
  • 87
    • 0034769498 scopus 로고    scopus 로고
    • IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism
    • COI: 1:CAS:528:DC%2BD3MXotFSqsro%3D, PID: 11590387
    • Pope SM et al (2001) IL-13 induces eosinophil recruitment into the lung by an IL-5- and eotaxin-dependent mechanism. J Allergy Clin Immunol 108(4):594–601
    • (2001) J Allergy Clin Immunol , vol.108 , Issue.4 , pp. 594-601
    • Pope, S.M.1
  • 88
    • 78751483763 scopus 로고    scopus 로고
    • The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1)
    • COI: 1:CAS:528:DC%2BC3MXlsFSlsg%3D%3D, PID: 21097505
    • Martinez-Nunez RT, Louafi F, Sanchez-Elsner T (2011) The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1). J Biol Chem 286(3):1786–94
    • (2011) J Biol Chem , vol.286 , Issue.3 , pp. 1786-1794
    • Martinez-Nunez, R.T.1    Louafi, F.2    Sanchez-Elsner, T.3
  • 89
    • 3442888383 scopus 로고    scopus 로고
    • Th2 cytokines IL-4 and IL-13 downregulate paxillin expression in bronchial airway epithelial cells
    • COI: 1:CAS:528:DC%2BD2cXkt1OmsLs%3D, PID: 15163899
    • Ramirez-Icaza G et al (2004) Th2 cytokines IL-4 and IL-13 downregulate paxillin expression in bronchial airway epithelial cells. J Clin Immunol 24(4):426–34
    • (2004) J Clin Immunol , vol.24 , Issue.4 , pp. 426-434
    • Ramirez-Icaza, G.1
  • 90
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • COI: 1:CAS:528:DyaK1MXhvFaku70%3D, PID: 10079098
    • Zhu Z et al (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103(6):779–88
    • (1999) J Clin Invest , vol.103 , Issue.6 , pp. 779-788
    • Zhu, Z.1
  • 91
    • 44249117365 scopus 로고    scopus 로고
    • IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells
    • COI: 1:CAS:528:DC%2BD1cXotVOhtLw%3D, PID: 18384429
    • Chibana K et al (2008) IL-13 induced increases in nitrite levels are primarily driven by increases in inducible nitric oxide synthase as compared with effects on arginases in human primary bronchial epithelial cells. Clin Exp Allergy 38(6):936–46
    • (2008) Clin Exp Allergy , vol.38 , Issue.6 , pp. 936-946
    • Chibana, K.1
  • 92
    • 0036344597 scopus 로고    scopus 로고
    • Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma
    • COI: 1:CAS:528:DC%2BD38Xls12msb4%3D, PID: 12091879
    • Kuperman DA et al (2002) Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8(8):885–9
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 885-889
    • Kuperman, D.A.1
  • 93
    • 34447281733 scopus 로고    scopus 로고
    • Interleukin 25 promotes the initiation of proallergic type 2 responses
    • COI: 1:CAS:528:DC%2BD2sXnslymu7g%3D, PID: 17562814
    • Angkasekwinai P et al (2007) Interleukin 25 promotes the initiation of proallergic type 2 responses. J Exp Med 204(7):1509–17
    • (2007) J Exp Med , vol.204 , Issue.7 , pp. 1509-1517
    • Angkasekwinai, P.1
  • 94
    • 77953795713 scopus 로고    scopus 로고
    • Pulmonary IL-17E (IL-25) production and IL-17RB + myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease
    • COI: 1:CAS:528:DC%2BD1MXht1ymtbjK, PID: 19828636
    • Dolgachev V et al (2009) Pulmonary IL-17E (IL-25) production and IL-17RB + myeloid cell-derived Th2 cytokine production are dependent upon stem cell factor-induced responses during chronic allergic pulmonary disease. J Immunol 183(9):5705–15
    • (2009) J Immunol , vol.183 , Issue.9 , pp. 5705-5715
    • Dolgachev, V.1
  • 95
    • 33748064320 scopus 로고    scopus 로고
    • IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice
    • COI: 1:CAS:528:DC%2BD28XpsVWmtrg%3D, PID: 16950278
    • Tamachi T et al (2006) IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J Allergy Clin Immunol 118(3):606–14
    • (2006) J Allergy Clin Immunol , vol.118 , Issue.3 , pp. 606-614
    • Tamachi, T.1
  • 96
    • 36749051929 scopus 로고    scopus 로고
    • Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma
    • COI: 1:CAS:528:DC%2BD2sXhsVSmtb3M, PID: 17889290
    • Ballantyne SJ et al (2007) Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma. J Allergy Clin Immunol 120(6):1324–31
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.6 , pp. 1324-1331
    • Ballantyne, S.J.1
  • 97
    • 75549087056 scopus 로고    scopus 로고
    • Disease-associated functions of IL-33: the new kid in the IL-1 family
    • COI: 1:CAS:528:DC%2BC3cXntVCrtg%3D%3D, PID: 20081870
    • Liew FY, Pitman NI, McInnes IB (2010) Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol 10(2):103–10
    • (2010) Nat Rev Immunol , vol.10 , Issue.2 , pp. 103-110
    • Liew, F.Y.1    Pitman, N.I.2    McInnes, I.B.3
  • 98
    • 77949261590 scopus 로고    scopus 로고
    • IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation
    • COI: 1:CAS:528:DC%2BC3cXhs1ejtr0%3D, PID: 19763788
    • Silver MR et al (2010) IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation. Inflamm Res 59(3):207–18
    • (2010) Inflamm Res , vol.59 , Issue.3 , pp. 207-218
    • Silver, M.R.1
  • 99
    • 44649129170 scopus 로고    scopus 로고
    • A novel IL-1 family cytokine, IL-33, potently activates human eosinophils
    • COI: 1:CAS:528:DC%2BD1cXmvV2rs74%3D, PID: 18539196
    • Cherry WB et al (2008) A novel IL-1 family cytokine, IL-33, potently activates human eosinophils. J Allergy Clin Immunol 121(6):1484–90
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.6 , pp. 1484-1490
    • Cherry, W.B.1
  • 100
    • 65549152797 scopus 로고    scopus 로고
    • Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway
    • COI: 1:CAS:528:DC%2BD1MXmtFeitbc%3D, PID: 19179489
    • Kearley J et al (2009) Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Am J Respir Crit Care Med 179(9):772–81
    • (2009) Am J Respir Crit Care Med , vol.179 , Issue.9 , pp. 772-781
    • Kearley, J.1
  • 101
    • 75549085516 scopus 로고    scopus 로고
    • IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation
    • COI: 1:CAS:528:DC%2BD1MXhtlKhsbfE, PID: 19841166
    • Kurowska-Stolarska M et al (2009) IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J Immunol 183(10):6469–77
    • (2009) J Immunol , vol.183 , Issue.10 , pp. 6469-6477
    • Kurowska-Stolarska, M.1
  • 102
    • 0033523665 scopus 로고    scopus 로고
    • Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses
    • COI: 1:CAS:528:DyaK1MXmsVCltrs%3D, PID: 10510079
    • Coyle AJ et al (1999) Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med 190(7):895–902
    • (1999) J Exp Med , vol.190 , Issue.7 , pp. 895-902
    • Coyle, A.J.1
  • 103
    • 67649207586 scopus 로고    scopus 로고
    • Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma
    • COI: 1:CAS:528:DC%2BD1MXnvVaguro%3D, PID: 19508862
    • Liu X et al (2009) Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma. Biochem Biophys Res Commun 386(1):181–5
    • (2009) Biochem Biophys Res Commun , vol.386 , Issue.1 , pp. 181-185
    • Liu, X.1
  • 104
    • 0037636682 scopus 로고    scopus 로고
    • Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine
    • COI: 1:STN:280:DC%2BD3s3os1Kitw%3D%3D, PID: 12814161
    • Barczyk A, Pierzchala W, Sozanska E (2003) Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med 97(6):726–33
    • (2003) Respir Med , vol.97 , Issue.6 , pp. 726-733
    • Barczyk, A.1    Pierzchala, W.2    Sozanska, E.3
  • 105
    • 70349871248 scopus 로고    scopus 로고
    • Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness
    • COI: 1:CAS:528:DC%2BD1MXhtlGgtbjE, PID: 19661246
    • Wilson RH et al (2009) Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am J Respir Crit Care Med 180(8):720–30
    • (2009) Am J Respir Crit Care Med , vol.180 , Issue.8 , pp. 720-730
    • Wilson, R.H.1
  • 106
    • 84873742238 scopus 로고    scopus 로고
    • The role of Th17/IL-17 on eosinophilic inflammation
    • COI: 1:CAS:528:DC%2BC38Xht1aktL3M, PID: 22906357
    • Dias PM, Banerjee G (2013) The role of Th17/IL-17 on eosinophilic inflammation. J Autoimmun 40:9–20
    • (2013) J Autoimmun , vol.40 , pp. 9-20
    • Dias, P.M.1    Banerjee, G.2
  • 107
    • 0036754255 scopus 로고    scopus 로고
    • Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses
    • COI: 1:CAS:528:DC%2BD38XnsFGrsLg%3D, PID: 12354389
    • Nakae S et al (2002) Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17(3):375–87
    • (2002) Immunity , vol.17 , Issue.3 , pp. 375-387
    • Nakae, S.1
  • 108
    • 39549106479 scopus 로고    scopus 로고
    • Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17
    • COI: 1:CAS:528:DC%2BD1cXisVehtL0%3D, PID: 18250191
    • Pichavant M et al (2008) Ozone exposure in a mouse model induces airway hyperreactivity that requires the presence of natural killer T cells and IL-17. J Exp Med 205(2):385–93
    • (2008) J Exp Med , vol.205 , Issue.2 , pp. 385-393
    • Pichavant, M.1
  • 109
    • 77950296391 scopus 로고    scopus 로고
    • Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization
    • COI: 1:CAS:528:DC%2BC3cXktlGju7Y%3D, PID: 20132969
    • Schroeder JT et al (2010) Decreases in human dendritic cell-dependent T(H)2-like responses after acute in vivo IgE neutralization. J Allergy Clin Immunol 125(4):896–901 e6
    • (2010) J Allergy Clin Immunol , vol.125 , Issue.4 , pp. 890-896
    • Schroeder, J.T.1
  • 110
    • 84870244915 scopus 로고    scopus 로고
    • Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature
    • COI: 1:CAS:528:DC%2BC38XhtFaht7fM, PID: 22776787
    • Antico A et al (2012) Can supplementation with vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature. Autoimmun Rev 12(2):127–36
    • (2012) Autoimmun Rev , vol.12 , Issue.2 , pp. 127-136
    • Antico, A.1
  • 111
    • 84858155296 scopus 로고    scopus 로고
    • Vitamin D deficiency as a risk factor for childhood allergic disease and asthma
    • COI: 1:CAS:528:DC%2BC38Xjt1CktLY%3D, PID: 22266772
    • Litonjua AA (2012) Vitamin D deficiency as a risk factor for childhood allergic disease and asthma. Curr Opin Allergy Clin Immunol 12(2):179–85
    • (2012) Curr Opin Allergy Clin Immunol , vol.12 , Issue.2 , pp. 179-185
    • Litonjua, A.A.1
  • 112
    • 79851516692 scopus 로고    scopus 로고
    • Vitamin D and the anti-viral state
    • COI: 1:CAS:528:DC%2BC3MXhvVyqsrs%3D, PID: 21242105
    • Beard JA, Bearden A, Striker R (2011) Vitamin D and the anti-viral state. J Clin Virol 50(3):194–200
    • (2011) J Clin Virol , vol.50 , Issue.3 , pp. 194-200
    • Beard, J.A.1    Bearden, A.2    Striker, R.3
  • 113
    • 68049147287 scopus 로고    scopus 로고
    • Childhood asthma may be a consequence of vitamin D deficiency
    • COI: 1:CAS:528:DC%2BD1MXnt1ygtrc%3D, PID: 19365260
    • Litonjua AA (2009) Childhood asthma may be a consequence of vitamin D deficiency. Curr Opin Allergy Clin Immunol 9(3):202–7
    • (2009) Curr Opin Allergy Clin Immunol , vol.9 , Issue.3 , pp. 202-207
    • Litonjua, A.A.1
  • 114
    • 77953945880 scopus 로고    scopus 로고
    • Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study
    • COI: 1:CAS:528:DC%2BC3cXosVGrt78%3D, PID: 20538327
    • Brehm JM et al (2010) Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study. J Allergy Clin Immunol 126(1):52–8 e5
    • (2010) J Allergy Clin Immunol , vol.126 , Issue.1 , pp. 50-51
    • Brehm, J.M.1
  • 115
    • 77952291218 scopus 로고    scopus 로고
    • High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC
    • PID: 20236657
    • Freishtat RJ et al (2010) High prevalence of vitamin D deficiency among inner-city African American youth with asthma in Washington, DC. J Pediatr 156(6):948–52
    • (2010) J Pediatr , vol.156 , Issue.6 , pp. 948-952
    • Freishtat, R.J.1
  • 116
    • 80053471811 scopus 로고    scopus 로고
    • Vitamin D deficiency as a strong predictor of asthma in children
    • COI: 1:CAS:528:DC%2BC38XhvFantLg%3D, PID: 21986034
    • Bener A et al (2012) Vitamin D deficiency as a strong predictor of asthma in children. Int Arch Allergy Immunol 157(2):168–75
    • (2012) Int Arch Allergy Immunol , vol.157 , Issue.2 , pp. 168-175
    • Bener, A.1
  • 117
    • 83655193284 scopus 로고    scopus 로고
    • The relationship between serum 25 hydroxy vitamin d levels and asthma in children
    • COI: 1:CAS:528:DC%2BC3MXhtlGisrvK, PID: 21966605
    • Alyasin S et al (2011) The relationship between serum 25 hydroxy vitamin d levels and asthma in children. Allergy Asthma Immunol Res 3(4):251–5
    • (2011) Allergy Asthma Immunol Res , vol.3 , Issue.4 , pp. 251-255
    • Alyasin, S.1
  • 118
    • 79960981595 scopus 로고    scopus 로고
    • Age- and atopy-dependent effects of vitamin D on wheeze and asthma
    • PID: 21807254
    • Keet CA et al (2011) Age- and atopy-dependent effects of vitamin D on wheeze and asthma. J Allergy Clin Immunol 128(2):414–16 e5
    • (2011) J Allergy Clin Immunol , vol.128 , Issue.2 , pp. 410-414
    • Keet, C.A.1
  • 119
    • 82455192232 scopus 로고    scopus 로고
    • Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study
    • PID: 21929603
    • van Oeffelen AA et al (2011) Serum micronutrient concentrations and childhood asthma: the PIAMA birth cohort study. Pediatr Allergy Immunol 22(8):784–93
    • (2011) Pediatr Allergy Immunol , vol.22 , Issue.8 , pp. 784-793
    • van Oeffelen, A.A.1
  • 120
    • 0034613767 scopus 로고    scopus 로고
    • Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells
    • COI: 1:CAS:528:DC%2BD3cXnvFWgt74%3D, PID: 11067871
    • Jonuleit H et al (2000) Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med 192(9):1213–22
    • (2000) J Exp Med , vol.192 , Issue.9 , pp. 1213-1222
    • Jonuleit, H.1
  • 121
    • 0034890907 scopus 로고    scopus 로고
    • Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen
    • COI: 1:CAS:528:DC%2BD3MXlslGgt7g%3D, PID: 11477409
    • Akbari O, DeKruyff RH, Umetsu DT (2001) Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat Immunol 2(8):725–31
    • (2001) Nat Immunol , vol.2 , Issue.8 , pp. 725-731
    • Akbari, O.1    DeKruyff, R.H.2    Umetsu, D.T.3
  • 122
    • 0032128421 scopus 로고    scopus 로고
    • Role of interleukin 10 in specific immunotherapy
    • COI: 1:CAS:528:DyaK1cXktlWhtbk%3D, PID: 9649562
    • Akdis CA et al (1998) Role of interleukin 10 in specific immunotherapy. J Clin Invest 102(1):98–106
    • (1998) J Clin Invest , vol.102 , Issue.1 , pp. 98-106
    • Akdis, C.A.1
  • 123
    • 10744232817 scopus 로고    scopus 로고
    • Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity
    • COI: 1:CAS:528:DC%2BD2cXhsVCqsLk%3D, PID: 14978133
    • Nouri-Aria KT et al (2004) Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. J Immunol 172(5):3252–9
    • (2004) J Immunol , vol.172 , Issue.5 , pp. 3252-3259
    • Nouri-Aria, K.T.1
  • 124
    • 0027222095 scopus 로고
    • Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses
    • COI: 1:STN:280:DyaK3szlt1yjtQ%3D%3D, PID: 8349803
    • Varney VA et al (1993) Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses. J Clin Invest 92(2):644–51
    • (1993) J Clin Invest , vol.92 , Issue.2 , pp. 644-651
    • Varney, V.A.1
  • 125
    • 0027443372 scopus 로고
    • Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals
    • COI: 1:CAS:528:DyaK3sXmtFKqtLc%3D, PID: 7902409
    • Secrist H et al (1993) Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals. J Exp Med 178(6):2123–30
    • (1993) J Exp Med , vol.178 , Issue.6 , pp. 2123-2130
    • Secrist, H.1
  • 126
    • 9844266243 scopus 로고    scopus 로고
    • Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen
    • COI: 1:CAS:528:DyaK2sXmsFGkt7k%3D, PID: 9678832
    • Ebner C et al (1997) Immunological changes during specific immunotherapy of grass pollen allergy: reduced lymphoproliferative responses to allergen and shift from TH2 to TH1 in T-cell clones specific for Phl p 1, a major grass pollen allergen. Clin Exp Allergy 27(9):1007–15
    • (1997) Clin Exp Allergy , vol.27 , Issue.9 , pp. 1007-1015
    • Ebner, C.1
  • 127
    • 0043264799 scopus 로고    scopus 로고
    • Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies
    • COI: 1:CAS:528:DC%2BD3sXotFahur8%3D, PID: 12956739
    • Mothes N et al (2003) Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 33(9):1198–208
    • (2003) Clin Exp Allergy , vol.33 , Issue.9 , pp. 1198-1208
    • Mothes, N.1
  • 128
    • 8944234849 scopus 로고    scopus 로고
    • Human IgG monoclonal antibodies that modulate the binding of specific IgE to birch pollen Bet v 1
    • COI: 1:CAS:528:DyaK28XktVymu70%3D, PID: 8752951
    • Visco V et al (1996) Human IgG monoclonal antibodies that modulate the binding of specific IgE to birch pollen Bet v 1. J Immunol 157(2):956–62
    • (1996) J Immunol , vol.157 , Issue.2 , pp. 956-962
    • Visco, V.1
  • 129
    • 0036170801 scopus 로고    scopus 로고
    • Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study)
    • PID: 11842293
    • Moller C et al (2002) Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 109(2):251–6
    • (2002) J Allergy Clin Immunol , vol.109 , Issue.2 , pp. 251-256
    • Moller, C.1
  • 130
    • 84875700570 scopus 로고    scopus 로고
    • Can certain genotypes predispose to poor asthma control in children? A pharmacogenetic study of 9 candidate genes in children with difficult asthma
    • COI: 1:CAS:528:DC%2BC3sXmtFWqsr0%3D, PID: 23573270
    • Almomani B et al (2013) Can certain genotypes predispose to poor asthma control in children? A pharmacogenetic study of 9 candidate genes in children with difficult asthma. PloS one 8(4):e60592
    • (2013) PloS one , vol.8 , Issue.4 , pp. e60592
    • Almomani, B.1
  • 131
    • 0032860829 scopus 로고    scopus 로고
    • Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma
    • COI: 1:STN:280:DyaK1MvgtlagtQ%3D%3D, PID: 10471619
    • Burchard EG et al (1999) Association between a sequence variant in the IL-4 gene promoter and FEV(1) in asthma. Am J Respir Crit Care Med 160(3):919–22
    • (1999) Am J Respir Crit Care Med , vol.160 , Issue.3 , pp. 919-922
    • Burchard, E.G.1
  • 132
    • 18744429855 scopus 로고    scopus 로고
    • Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity
    • COI: 1:CAS:528:DC%2BD3cXlslajtbg%3D, PID: 10887316
    • Sandford AJ et al (2000) Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity. J Allergy Clin Immunol 106(1 Pt 1):135–40
    • (2000) J Allergy Clin Immunol , vol.106 , Issue.1 , pp. 135-140
    • Sandford, A.J.1
  • 133
    • 3242687981 scopus 로고    scopus 로고
    • Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids
    • COI: 1:CAS:528:DC%2BD2cXkvVSrsLw%3D
    • Tantisira KG et al (2004) Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroids. Human Mol Genet 13(13):1353–9
    • (2004) Human Mol Genet , vol.13 , Issue.13 , pp. 1353-1359
    • Tantisira, K.G.1
  • 134
    • 32644490529 scopus 로고    scopus 로고
    • Evidence of a role of tumor necrosis factor alpha in refractory asthma
    • COI: 1:CAS:528:DC%2BD28XhsVWktLY%3D, PID: 16481637
    • Berry MA et al (2006) Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med 354(7):697–708
    • (2006) N Engl J Med , vol.354 , Issue.7 , pp. 697-708
    • Berry, M.A.1
  • 135
    • 0028432821 scopus 로고
    • Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines
    • COI: 1:CAS:528:DyaK2cXktVOhsrw%3D, PID: 8179909
    • Bradding P et al (1994) Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines. Am J Respir Cell Mol Biol 10(5):471–80
    • (1994) Am J Respir Cell Mol Biol , vol.10 , Issue.5 , pp. 471-480
    • Bradding, P.1
  • 136
    • 74849096564 scopus 로고    scopus 로고
    • The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis
    • Holgate ST et al (2009) The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proc Am Thorac Soc 6(8):655–9
    • (2009) Proc Am Thorac Soc , vol.6 , Issue.8 , pp. 655-659
    • Holgate, S.T.1
  • 137
    • 84873448028 scopus 로고    scopus 로고
    • Does IFN-gamma play a role on the pathogenesis of non-atopic asthma in Latin America children?
    • Figueiredo CA et al (2012) Does IFN-gamma play a role on the pathogenesis of non-atopic asthma in Latin America children? Allergy Asthma Clin Immunol 8(1):18
    • (2012) Allergy Asthma Clin Immunol , vol.8 , Issue.1 , pp. 18
    • Figueiredo, C.A.1
  • 138
    • 34250797912 scopus 로고    scopus 로고
    • Filaggrin null mutations are associated with increased asthma severity in children and young adults
    • Palmer CN et al (2007) Filaggrin null mutations are associated with increased asthma severity in children and young adults. J Allergy Clin Immunol 120(1):64–8
    • (2007) J Allergy Clin Immunol , vol.120 , Issue.1 , pp. 64-68
    • Palmer, C.N.1
  • 139
    • 0041427913 scopus 로고    scopus 로고
    • The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children
    • Leung TF et al (2003) The C-159T polymorphism in the CD14 promoter is associated with serum total IgE concentration in atopic Chinese children. Pediatr Allergy Immunol 14(4):255–60
    • (2003) Pediatr Allergy Immunol , vol.14 , Issue.4 , pp. 255-260
    • Leung, T.F.1


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