Polymorphisms in the IL4, IL4RA, and FCERIB genes and asthma severity

Journal of Allergy and Clinical Immunology

Volumn 106, Issue 1 I, 2000, Pages 135-140

  Sandford, Andrew J ^a   Chagani, Tabassum ^a   Zhu, Shoukang ^a   Weir, Tracey D ^a   Bai, Tony R ^a   Spinelli, John J ^a   Fitzgerald, J Mark ^b   Behbehani, Nasser A ^c   Tan, Wan C ^d   Paré, Peter D ^a  

^a ST PAUL S HOSPITAL   (Canada)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

^c KUWAIT UNIVERSITY   (Kuwait)

^d NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

Asthma; IgE receptor; IL 4; IL 4 receptor; Severity

Indexed keywords

DNA; IMMUNOGLOBULIN E RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR;

ADULT; AIRWAY OBSTRUCTION; AMINO ACID SUBSTITUTION; ARTICLE; ASTHMA; CONTROLLED STUDY; DISEASE SEVERITY; FATALITY; FEMALE; FORCED EXPIRATORY VOLUME; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR;

EID: 18744429855     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1067/mai.2000.107926     Document Type: Article

References (35)

1. Sandford A, Weir T, Paré P. The genetics of asthma. Am J Respir Crit Care Med 1996;153:1749-65.
2. Sarafino EP, Goldfedder J. Genetic factors in the presence, severity, and triggers of asthma. Arch Dis Child 1995;73:112-6.
3. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, et al. Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994;264:1152-6.
4. Meyers DA, Postma DS, Panhuysen CI, Xu J, Amelung PJ, Levitt RC, et al. Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics 1994;23:464-70.
5. Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M, et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995;25:74-8.
6. Noguchi E, Shibasaki M, Arinami T, Takeda K, Yokouchi Y, Kawashima T, et al. Association of asthma and the interleukin-4 promoter gene in Japanese. Clin Exp Allergy 1998;28:449-53.
7. Walley AJ, Cookson WOCM. Investigation of an interleukin-4 promoter polymorphism for associations with asthma and atopy. J Med Genet 1996;33:689-92.
8. Zhu S, Chan-Yeung M, Becker AB, Dimich-Ward H, Ferguson AC, Manfreda J, et al. Polymorphisms of the IL4, TNFα and FcεRIβ genes and the risk of allergic disorders in at-risk infants. Am J Respir Crit Care Med 2000;161:1655-9.
9. 1 in asthma. Am J Respir Crit Care Med 1999;160:919-22.
10. Hershey GK, Friedrich MF, Esswein LA, Thomas ML, Chatila TA. The association of atopy with a gain-of-function mutation in the α subunit of the interleukin-4 receptor. N Engl J Med 1997;337:1720-5.
11. Deichmann KA, Heinzmann A, Forster J, Dischinger S, Mehl C, Brueggenolte E, et al. Linkage and allelic association of atopy and markers flanking the IL4-receptor gene. Clin Exp Allergy 1998;28:151-5.
12. Rosa-Rosa L, Zimmermann N, Bernstein JA, Rothenberg ME, Khurana-Hershey GK. The R576 IL-4 receptor α allele correlates with asthma severity. J Allergy Clin Immunol 1999;104:1008-14.
13. Sandford AJ, Shirakawa T, Moffatt MF, Daniels SE, Ra C, Faux JA, et al. Localisation of atopy and β subunit of high-affinity IgE receptor (FcεRI) on chromosome 11q. Lancet 1993;341:332-4.
14. Young RP, Sharp PA, Lynch JR, Faux JA, Lathrop GM, Cookson WOCM, et al. Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. J Med Genet 1992;29:236-8.
15. Shirakawa T, Hashimoto T, Furuyama J, Takeshita T, Morimoto K. Linkage between severe atopy and chromosome 11q13 in Japanese families. Clin Genet 1994;46:228-32.
16. Hill MR, Cookson WOCM. A new variant of the β subunit of the high-affinity receptor for immunoglobulin E (FcεRI-β E237G): associations with measures of atopy and bronchial hyper-responsive ness. Hum Mol Genet 1996;5:959-62.
17. Shirakawa T, Mao XQ, Sasaki S, Enomoto T, Kawai M, Morimoto K, et al. Association between atopic asthma and a coding variant of FcεRI β in a Japanese population. Hum Mol Genet 1996;5:1129-30.
18. Crapo RO, Morris AH, Gardner RM. Reference spirometric values using techniques and equipment that meet ATS recommendations. Am Rev Respi rDis 1981;123:659-64.
19. Cooper CS, Stratton MR. Extraction and enzymatic amplification of DNA from paraffin-embedded specimens. In: Matthew C, ed. Methods in molecular biology, vol 9: protocols in human molecular genetics. Clifton (NJ): The Humana Press Inc; 1991. p. 133-40.
20. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning. A laboratory manual. 2nd ed. Cold Spring Harbor (NY): Cold Spring Harbor Press; 1989.
21. Hecker KH, Roux KH. High and low annealing temperatures increase both specificity and yield in touchdown and stepdown PCR. Biotechniques 1996;20:478-85.
22. Dawson-Saunders B, Trapp RG. Basic and clinical bio statistics. 2nd ed. Norwalk (CT): Appleton and Lange; 1994.
23. Kelly WJW, Hudson I, Phelan PD, Pain MCF, Olinsky A. Atopy in subjects with asthma followed to the age of 28 years. J Allergy Clin Immunol 1990;85:548-57.
24. Zimmerman B, Feanny S, Reisman J, Hak H, Rashed N, McLaughlin FJ, et al. Allergy in asthma. I. The dose relationship of allergy to severity of childhood asthma. J Allergy Clin Immunol 1988;81:63-70.
25. Pollart SM, Reid MJ, Fling JA, Chapman MD, Platts-Mills TA. Epidemiology of emergency room asthma in northern California: association with IgE antibody to ryegrass pollen. J Allergy Clin Immunol 1988;82:224-30.
26. Pollart SM, Chapman MD, Fiocco GP, Rose G, Platts-Mills TAE. Epidemiology of acute asthma: IgE antibodies to common inhalant allergens as a risk factor for emergency room visits. J Allergy Clin Immunol 1989; 83:875-82.
27. LeSon S, Gershwin ME. Risk factors for asthmatic patients requiring intubation. III. Observations in young adults. J Asthma 1996;33:27-35.
28. British Thoracic Society. Comparison of atopic and non-atopic patients dying of asthma. Br J Dis Chest 1987;81:30-4.
29. Peat JK, Tovey E, Gray EJ, Mellis CM, Woolcock AJ. Asthma severity and morbidity in a population sample of Sydney schoolchildren: Part II -importance of house dust mite allergens. Aust NZ J Med 1994;24:270-6.
30. O'Hollaren MT, Yunginger JW, Offord KP, Somers MJ, O'Connell EJ, Ballard DJ, et al. Exposure to an aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma. N Engl J Med 1991;324:359-63.
31. Call RS, Ward G, Jackson S, Platts-Mills TA. Investigating severe and fatal asthma. J Allergy Clin Immunol 1994;94:1065-72.
32. Mitsuyasu H, Izuhara K, Mao XQ, Gao PS, Arinobu Y, Enomoto T, et al. Ile50Val variant of IL4Rα upregulates IgE synthesis and associates with atopic asthma. Nat Genet 1998;19:119-20.
33. Leung DY, Martin RJ, Szefler SJ, Sher ER, Ying S, Kay AB, et al. Dysregulation of interleukin 4, interleukin 5, and interferon gamma gene expression in steroid-resistant asthma. J Exp Med 1995;181:33-40.
34. Sher ER, Leung DY, Surs W, Kam JC, Zieg G, Kamada AK, et al. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 1994;93:33-9.
35. Deichmann K, Bardutzky J, Forster J, Heinzmann A, Kuehr J. Common polymorphisms in the coding part of the IL4-receptor gene. Biochem Biophys Res Commun 1997;231:696-7.