The investigation of asthma phenotypes

Current Opinion in Allergy and Clinical Immunology

Volumn 11, Issue 5, 2011, Pages 393-399

  Siroux, Valérie ^a,b   Garcia Aymerich, Judith ^c,d,e,f  

^a INSTITUT ALBERT BONNIOT   (France)

^b UNIV GRENOBLE ALPES   (France)

^c CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^d HOSPITAL DEL MAR   (Spain)

^e UNIVERSITAT POMPEU FABRA   (Spain)

^f CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

Author keywords

asthma; classification; endotype; phenotype; severe asthma

Indexed keywords

ALGORITHM; ALLERGIC ASTHMA; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; DISEASE SEVERITY; ENVIRONMENTAL FACTOR; GENETIC RISK; GENETIC VARIABILITY; HUMAN; ONSET AGE; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SOCIOECONOMICS; WHEEZING;

ADULT; ASTHMA; CHILD; DISEASE PROGRESSION; EVIDENCE-BASED MEDICINE; HUMANS; PHENOTYPE; SEVERITY OF ILLNESS INDEX; SOCIOECONOMIC FACTORS;

EID: 80052503816     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0b013e32834a955a     Document Type: Review

References (29)

1. Rice JP, Saccone NL, Rasmussen E. Definition of the phenotype. Adv Genet 2001; 42:69-76
2. Han MK, Agusti A, Calverley PM, et al. Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med 2010; 182:598-604
3. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003; 160:636-645 (Pubitemid 41079594)
4. Weiss ST, Raby BA, Rogers A. Asthma genetics and genomics. Curr Opin Genet Dev 2009; 19:279-282
5. Postma DS, Koppelman GH. Genetics of asthma: where are we and where do we go? Proc Am Thorac Soc 2009; 6:283-287
6. Manolio TA, Collins FS, Cox NJ, et al. Finding the missing heritability of complex diseases. Nature 2009; 461:747-753
7. Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008; 8:169-182 (Pubitemid 351323288)
8. Freimer N, Sabatti C. The human phenome project. Nat Genet 2003; 34:15-21 (Pubitemid 36548781)
9. Bouzigon E, Corda E, Aschard H, et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 2008; 359:1985-1994
10. Moffatt MF, Gut IG, Demenais F, et al. Alarge-scale, consortium-based genomewide association study of asthma. N Engl J Med 2010; 363:1211-1221
11. Wenzel SE. Severe asthma in adults. Exp Lung Res 2005; 31 (Suppl 1):22 (Pubitemid 41361778)
12. Nair P, Pizzichini MM, Kjarsgaard M, et al. Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. N Engl J Med 2009; 360:985-993
13. Haldar P, Brightling CE, Hargadon B, et al. Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med 2009; 360:973-984
14. Bradding P, Green RH. Subclinical phenotypes of asthma. Curr Opin Allergy Clin Immunol 2010; 10:54-59
15. Bel EH. Clinical phenotypes of asthma. Curr Opin Pulm Med 2004; 10:44-50 (Pubitemid 38045900)
16. Spycher BD, Silverman M, Kuehni CE. Phenotypes of childhood asthma: are they real? Clin Exp Allergy 2010; 40:1130-1141
17. Bousquet J, Mantzouranis E, Cruz AA, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol 2010; 126:926-938
18. Bel EH, Sousa A, Fleming L, et al. Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI). Thorax 2010. [Epub ahead of print]
19. Lotvall J, Akdis CA, Bacharier LB, et al. Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol 2011; 127:355-360
20. Wardlaw AJ, Silverman M, Siva R, et al. Multidimensional phenotyping: towards a new taxonomy for airway disease. Clin Exp Allergy 2005; 35: 1254-1262
21. Fitzpatrick AM, Teague WG, Meyers DA, et al. Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program. J Allergy Clin Immunol 2011; 127:382-389
22. Benton AS, Wang Z, Lerner J, et al. Overcoming heterogeneity in pediatric asthma: tobacco smoke and asthma characteristics within phenotypic clusters in an African American cohort. J Asthma 2010; 47:728-734
23. Henderson J, Granell R, Heron J, et al. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax 2008; 63:974-980
24. Savenije OE, Granell R, Caudri D, et al. Comparison of childhood wheezing phenotypes in 2 birth cohorts: ALSPAC and PIAMA. J Allergy Clin Immunol 2011. [Epub ahead of print]
25. Martinez FD, Wright AL, Taussig LM, et al. Asthma and wheezing in the first six years of life: the Group Health Medical Associates. N Engl J Med 1995; 332:133-138
26. Haldar P, Pavord ID, Shaw DE, et al. Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 2008; 178:218-224
27. MooreWC, Meyers DA, Wenzel SE, et al. Identification of asthma phenotypes using cluster analysis in the severe asthma research program. Am J Respir Crit Care Med 2010; 181:315-323
28. Siroux V, Basagana X, Boudier A, et al. Identifying adult asthma phenotypes using a clustering approach. Eur Respir J 2011. [Epub ahead of print]
29. Bousquet J, Anto J, Auffray C, et al. MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine. Allergy 2011; 66:596-604