Th2 cytokines IL-4 and IL-13 downregulate paxillin expression in bronchial airway epithelial cells

Journal of Clinical Immunology

Volumn 24, Issue 4, 2004, Pages 426-434

  Ramirez Icaza, Gail ^a,b   Mohammed, Kamal A ^a,c   Nasreen, Najmunnisa ^a,c   Van Horn, Robert D ^a   Hardwick, Joyce A ^a   Sanders, Kerry L ^a   Tian, Jun ^a   Ramirez Icaza, Carlos ^a   Johnson, Mary T ^b   Antony, Veena B ^a,c  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Asthma; Epithelial denudation; IL 13; IL 4; Permeability; Th2

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; PAXILLIN;

ARTICLE; BRONCHUS MUCOSA; CELL ADHESION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IMPEDANCE; MUCOSA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH2 CELL; WESTERN BLOTTING;

BRONCHI; CELL ADHESION; CELLS, CULTURED; CYTOSKELETAL PROTEINS; DOWN-REGULATION; EPITHELIAL CELLS; HUMANS; INTERLEUKIN-13; INTERLEUKIN-4; PAXILLIN; PERMEABILITY; PHOSPHOPROTEINS; TH2 CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 3442888383     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOCI.0000029111.27168.c6     Document Type: Article

References (34)

1. Venkayya R, Lam M, Willkom M, Granig G, Corry DB, Erle DJ: The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol 26:202-208, 2002
2. Hamilton LM, Davies DE, Wilson SJ, Kimber I, Dearman RJ, Holgate ST: The bronchial epithelium in asthma-much more than a passive barrier. Monaldi Arch Chest Dis 56:48-54, 2001
3. Holgate ST: Epithelial damage and response. Clin Exp Allergy 30(Suppl 1):37-41, 2000
4. Oddera S, Silvestri M, Balbo A, Jovovich BO, Penna R, Crimi E, Rossi GA: Airway eosinophilic inflammation, epithelial damage, and bronchial hyperresponsiveness in patients with mild-moderate, stable asthma. Allergy 51:100-107, 1996
5. Vignola AM, Chanez P, Campbell AM, Souques F, Lebel B, Enander I, Bousquet J: Airway inflammation in mild intermittent and in persistent asthma. Am J Respir Crit Care Med 157:403-409, 1998
6. Ahdieh M, Vandenbos T, Youakim A: Lung epithelial barrier function and wound healing are decreased by IL-4 and IL-13 and enhanced by IFN-gamma. Am J Physiol Cell Physiol 281:C2029-C2038, 2001
7. Ordonez C, Ferrando R, Hyde DM, Wong HH Fahy JV: Epithelial desquamation in asthma: Artifact or pathology? Am J Respir Crit Care Med 162:2324-2329, 2000
8. Houston JC, De Navasquez S, Trounce JR: A clinical and pathological study of fatal cases of status asthmaticus. Thorax 8:207-213, 1953
9. Naylor B: The shedding of the mucosa of the bronchial tree in asthma. Thorax 17:69-72, 1962
10. Demoly P, Simony-Lafontaine J, Chanez P, Pujol JL, Lequeux N, Michel FB, Bousquet J: Cell proliferation in the bronchial mucosa of asthmatics and chronic bronchitics. Am J Respir Crit Care Med 150:214-217, 1994
11. Montefort S, Roche WR, Holgate ST: Bronchial epithelial shedding in asthmatics and non-asthmatics. Respir Med 87(Suppl B):9-11, 1993
12. Montefort S, Roberts JA, Beasley R, Holgate ST, Roche WR: The site of disruption of the bronchial epithelium in asthmatic and non-asthmatic subjects. Thorax 47:499-503, 1992
13. Montefort S, Djukanovic R, Holgate ST, Roche WR: Ciliated cell damage in the bronchial epithelium of asthmatics and non-asthmatics. Clin Exp Allergy 23:185-189, 1993
14. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD: Interleukin-13: Central mediator of allergic asthma. Science 282:2258-2261, 1998
15. Renauld JC: New insights into the role of cytokines in asthma. J Clin Pathol 54:577-589, 2001
16. Mattes J, Yang M, Siqueira A, Clark K, MacKenzie J, McKenzie AN, Webb DC, Matthaei KI, Foster PS: IL-13 induces airways hyperreactivity independently of the IL-4R alpha chain in the allergic lung. J Immunol 167:1683-1692, 2001
17. Mathew A, MacLean JA, DeHaan E, Tager AM, Green FH, Luster AD: Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J Exp Med 193:1087-1096, 2001
18. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z: New insights into the pathogenesis of asthma. J Clin Invest 111:291-297, 2003
19. Shirakawa I, Deichmann KA, Izuhara I, Mao I, Adra CN, Hopkin JM: Atopy and asthma: Genetic variants of IL-4 and IL-13 signalling. Immunol Today 21:60-64, 2000
20. McKenzie AN: Regulation of T helper type 2 cell immunity by interleukin-4 and interleukin-13. Pharmacol Ther 88:143-151, 2000
21. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Cony DB: Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282:2261-2263, 1998
22. Sastry SK, Burridge K: Focal adhesions: A nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res 261:25-36, 2000
23. Petit V, Thiery JP: Focal adhesions: Structure and dynamics. Biol Cell 92:477-494, 2000
24. Ishida T, Ishida M, Suera J, Takahashi M, Berk BC: Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. J Clin Invest 103:789-797, 1999
25. Turner CE: Paxillin and focal adhesion signalling. Nat Cell Biol 2:E231-E236, 2000
26. Schaller MD: Paxillin: A focal adhesion-associated adaptor protein. Oncogene 20:6459-6472, 2001
27. McDonald DM: Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am J Respir Crit Care Med 164:S39-S45, 2001
28. Cohen AW, Carbajal JM, Schaeffer RC Jr: VEGF stimulates tyrosine phosphorylation of beta-catenin and small-pore endothelial barrier dysfunction. Am J Physiol 277:H2038-H2049, 1999
29. Boussat S, Eddahibi S, Coste A, Fataccioli V, Gouge M, Housset B, Adnot S, Maitre B: Expression and regulation of vascular endothelial growth factor in human pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol 279:L371-L378, 2000
30. Antony AB, Tepper RS, Mohammed KA: Cockroach extract antigen increases bronchial airway epithelial permeability. J Allergy Clin Immunol 110:589-595, 2002
31. Shim SR, Kook S, Kim JI, Song WK: Degradation of focal adhesion proteins paxillin and p130cas by caspases or calpains in apoptotic rat-1 and L929 cells. Biochem Biophys Res Commun 286:601-608, 2001
32. Zhou Y, McLane M, Levitt RC: Th2 cytokines and asthma. interleukin-9 as a therapeutic target for asthma. Respir Res 2:80-84, 2001
33. Ober C, Cox NJ, Abney M, Di Rienzo A, Lander ES, Changyaleket B, Gidley H, Kurtz B, Lee J, Nance M, Pettersson A, Prescott J, Richardson A, Schlenker E, Summerhill E, Willadsen S, Parry R: Genome-wide search for asthma susceptibility loci in a founder population. The collaborative study on the genetics of asthma. Hum Mol Genet 7:1393-1398, 1998
34. Izuhara K, Shirakawa T: Signal transduction via the interleukin-4 receptor and its correlation with atopy. Int J Mol Med 3:3-10, 1999