V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma

Archives of Toxicology

Volumn 88, Issue 1, 2014, Pages 97-107

  Zhang, Yi ^a   Zhao, Li ^a   Li, Xin ^a   Wang, Yajing ^a   Yao, Jing ^a   Wang, Hu ^a   Li, Fanni ^a   Li, Zhiyu ^a   Guo, Qinglong ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Apoptosis; ER stress; Hepatocellular carcinoma; ROS; V8

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 7 [4 [BIS (2 HYDROXYETHYL) AMINO] BUTOXY] 5 HYDROXY 8 METHOXY 2 PHENYL CHROMEN 4 ONE; ACTIVATING TRANSCRIPTION FACTOR 4; ANTINEOPLASTIC AGENT; BH3 PROTEIN; CALCIUM ION; CASPASE 3; CASPASE 9; CYTOCHROME C; FLAVONOID; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; MEMBRANE PROTEIN; PERK PROTEIN; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; V 8; WOGONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME RELEASE; FEMALE; GENE SILENCING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MEDIATOR; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; WESTERN BLOTTING;

MUS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; FEMALE; FLAVANONES; FLAVONES; HEP G2 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; LIVER NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR CHOP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84892572282     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-013-1085-6     Document Type: Article

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