Folate deficiency triggers an oxidative-nitrosative stress-mediated apoptotic cell death and impedes insulin biosynthesis in RINm5F pancreatic islet β-cells: Relevant to the pathogenesis of diabetes

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Hsu, Hung Chih ^a,b,c   Chiou, Jeng Fong ^d   Wang, Yu Huei ^d   Chen, Chia Hui ^d   Mau, Shin Yi ^d   Ho, Chun Te ^d   Chang, Pey Jium ^a   Liu, Tsan Zon ^d   Chen, Ching Hsein ^e  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL CHIAYI UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GLUTATHIONE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; NITRIC OXIDE; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM DEPLETION; CELL DEATH; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FOLIC ACID DEFICIENCY; INSULIN SYNTHESIS; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PATHOGENESIS; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CALCIUM; DIABETES MELLITUS; FEEDER CELLS; FOLIC ACID DEFICIENCY; GLUTATHIONE; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NITRIC OXIDE; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES;

EID: 84892398606     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077931     Document Type: Article

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