Naringenin induces apoptosis through downregulation of Akt and caspase-3 activation in human leukemia THP-1 cells

Food and Chemical Toxicology

Volumn 46, Issue 12, 2008, Pages 3684-3690

  Park, Joon Hee ^a   Jin, Cheng Yun ^a   Lee, Bok Kyu ^a   Kim, Gi Young ^b   Choi, Yung Hyun ^a,c   Jeong, Yong Kee ^d  

^a Dong Eui University   (South Korea)

^b Jeju National University   (South Korea)

^c Dong Eui University   (South Korea)

^d Dong A University   (South Korea)

Author keywords

Akt; Apoptosis; Bcl 2; Caspase; Naringenin; THP 1

Indexed keywords

CASPASE; CASPASE 3; FLAVONOID; NARINGENIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B;

APOPTOSIS; ARTICLE; CANCER PREVENTION; CELL DEATH; CITRUS FRUIT; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA; LEUKEMIA CELL LINE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN FUNCTION;

APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; ESTROGEN ANTAGONISTS; FLAVANONES; FLOW CYTOMETRY; FLUORESCENT DYES; GENES, BCL-2; HUMANS; INDICATORS AND REAGENTS; INDOLES; LEUKEMIA; MEMBRANE POTENTIALS; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; ONCOGENE PROTEIN V-AKT; SIGNAL TRANSDUCTION;

CITRUS;

EID: 55949118960     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2008.09.056     Document Type: Article

References (28)

1. Adams J.M., and Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 281 (1998) 1322-1326
2. Barragan M., Bellosillo B., Campas C., Colomer D., Pons G., and Gil J. Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. Blood 99 (2002) 2969-2976
3. Chen D., Chen M.S., Cui Q.C., Yang H., and Dou Q.P. Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells. Front. Biosci. 12 (2007) 1935-1945
4. Chen Y.C., Shen S.C., and Lin H.Y. Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids. Biochem. Pharmacol. 66 (2003) 1139-1150
5. Datta S.R., Brunet A., and Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev. 13 (1999) 2905-2927
6. Dlugosz P.J., Billen L.P., Annis M.G., Zhu W., Zhang Z., Lin J., Leber B., and Andrews D.W. Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J. 25 (2006) 2287-2296
7. Fernandes-Alnemri T., Litwack G., and Alnemri E.S. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 β-converting enzyme. J. Biol. Chem. 269 (1994) 30761-30764
8. Hengartner M.O. The biochemistry of apoptosis. Nature 407 (2000) 770-776
9. Jacobson M.D., Burne J.F., and Raff M.C. Mechanisms of programmed cell death and Bcl-2 protection. Biochem. Soc. Trans. 22 (1994) 600-602
10. Jin C.Y., Moon D.O., Lee J.D., Heo MS., Choi Y.H., Lee C.M., Park Y.M., and Kim G.Y. Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis through downregulation of ERK and Akt in lung adenocarcinoma A549 cells. Carcinogenesis 28 (2007) 1058-1066
11. Kanno S., Shouji A., Asou K., and Ishikawa M. Effects of naringin on hydrogen peroxide-induced cytotoxicity and apoptosis in P388 cells. J. Pharmacol. Sci. 92 (2003) 66-70
12. Kanno S., Shouji A., Hirata R., Asou K., and Ishikawa M. Effects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells. Life Sci. 75 (2004) 353-365
13. Kanno S., Tomizawa A., Ohtake T., Koiwai K., Ujibe M., and Ishikawa M. Naringenin-induced apoptosis via activation of NF-kappaB and necrosis involving the loss of ATP in human promyeloleukemia HL-60 cells. Toxicol. Lett. 166 (2006) 131-139
14. Kawaii S., Tomono Y., Katase E., Ogawa K., and Yano M. HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from citrus juices. J. Agric. Food Chem. 47 (1999) 128-135
15. Kennedy S.G., Wagner A.J., Conzen S.D., Jordán J., Bellacosa A., Tsichlis P.N., and Hay N. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev. 11 (1997) 701-713
16. Kluck R.M., Bossy-Wetzel E., Green D.R., and Newmeyer D.D. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275 (1997) 1132-1136
17. McConkey D.J. Therapy-induced apoptosis in primary tumors. Adv. Exp. Med. Biol. 608 (2007) 31-51
18. Mow B.M., Blajeski A.L., Chandra J., and Kaufmann S.H. Apoptosis and the response to anticancer therapy. Curr. Opin. Oncol. 13 (2001) 453-462
19. Murph A.N., Bredesen D.N., Cortopassi G., Wang E., and Fiskum G. Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria. Proc. Natl. Acad. Sci. USA 93 (1996) 9893-9898
20. Nicholson K.M., and Anderson N.G. The protein kinase B/Akt signaling pathway in human malignancy. Cell. Signal. 14 (2002) 381-395
21. Oliver F.J., de la Rubia G., Rolli V., Ruiz-Ruiz M.C., de Murcia G., and Murcia J.M. Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant. J. Biol. Chem. 273 (1998) 33533-33539
22. Qiao X., Chen X., Wu D., Ding R., Wang J., Hong Q., Shi S., Li J., Xie Y., Lu Y., and Wang Z. Mitochondrial pathway is responsible for aging-related increase of tubular cell apoptosis in renal ischemia/reperfusion injury. J. Gerontol. A Biol. Sci. Med. Sci. 60 (2005) 830-839
23. Rahmani M., Reese E., Dai Y., Bauer C., Payne S.G., Dent P., Spiegel S., and Grant S. Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species. Cancer Res. 65 (2005) 2422-2432
24. Stennicke H.R., and Salvesen G.S. Properties of the caspases. Biochim. Biophys. Acta 1387 (1998) 17-31
25. Thees S., Hubbard G.B., Winckler J., Schultz C., and Rami A. Specific alteration of the Bax/Bcl2 ratio and cytochrome c without execution of apoptosis in the hippocampus of aged baboons. Restor. Neurol. Neurosci. 23 (2005) 1-9
26. Wang B.D., Yang Z.Y., Wang Q., Cai T.K., and Crewdson P. Synthesis, characterization, cytotoxic activities, and DNA-binding properties of the La(III) complex with naringenin schiff-base. Bioorg. Med. Chem. 14 (2006) 1880-1888
27. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331
28. Yu C., Mao X., and Li W.X. Inhibition of the PI3K pathway sensitizes fludarabine-induced apoptosis in human leukemic cells through an inactivation of MAPK-dependent pathway. Biochem. Biophys. Res. Commun. 331 (2005) 391-397