Bcl-2 changes conformation to inhibit Bax oligomerization

EMBO Journal

Volumn 25, Issue 11, 2006, Pages 2287-2296

  Dlugosz, Paulina J ^a   Billen, Lieven P ^a   Annis, Matthew G ^a   Zhu, Weijia ^a   Zhang, Zhi ^b   Lin, Jialing ^b   Leber, Brian ^a   Andrews, David W ^a  

^a MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Apoptosis; Bax; Bcl 2; Membrane topology; tBid

Indexed keywords

CYSTEINE; CYTOCHROME C; MONOMER; MUTANT PROTEIN; OLIGOMER; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID;

ALPHA HELIX; APOPTOSIS; ARTICLE; CELL DEATH; CELL ISOLATION; CELL MEMBRANE PERMEABILITY; CELL MOTILITY; CONFORMATIONAL TRANSITION; DISULFIDE BOND; ENZYME RELEASE; GENETIC TRANSFECTION; MEMBRANE STRUCTURE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; OLIGOMERIZATION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN SECRETION;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CELL LINE; CELL MEMBRANE; CYTOCHROMES C; HUMANS; MITOCHONDRIA; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS;

EID: 33745755472     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601126     Document Type: Article

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