Homocysteine Induces Programmed Cell Death in Human Vascular Endothelial Cells through Activation of the Unfolded Protein Response

Journal of Biological Chemistry

Volumn 276, Issue 38, 2001, Pages 35867-35874

  Zhang, Chun ^a   Cai, Yong ^a   Adachi, Mimi T ^a   Oshiro, Satoru ^a   Aso, Teijiro ^b   Kaufman, Randal J ^c   Kitajima, Shigetaka ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b CANCER INSTITUTE   (Japan)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ASSAYS; CHEMICAL ACTIVATION; DNA; HUMAN ENGINEERING; PROTEINS;

SIGNAL TRANSDUCTION;

BIOCHEMISTRY;

CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; GLUCOSE REGULATED PROTEIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HOMOCYSTEINE; PROTEIN KINASE; PROTEIN KINASE IRE1ALPHA; PROTEIN KINASE IRE1BETA; RIBONUCLEASE; UNCLASSIFIED DRUG; CARRIER PROTEIN; CASP3 PROTEIN, HUMAN; CASPASE; CCAAT ENHANCER BINDING PROTEIN; CHAPERONE; DDIT3 PROTEIN, HUMAN; HEAT SHOCK PROTEIN; MOLECULAR CHAPERONE GRP78; MUSCLE PROTEIN; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; HUMAN CELL; HYPERHOMOCYSTEINEMIA; NICK END LABELING; OXIDATIVE STRESS; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FOLDING; SIGNAL TRANSDUCTION; UMBILICAL VEIN; UNFOLDED PROTEIN RESPONSE; VASCULAR ENDOTHELIUM; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM;

APOPTOSIS; CARRIER PROTEINS; CASPASE 3; CASPASES; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; ENDOPLASMIC RETICULUM; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HEAT-SHOCK PROTEINS; HOMOCYSTEINE; HUMANS; MOLECULAR CHAPERONES; MUSCLE PROTEINS; PROTEIN FOLDING; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR CHOP; TRANSCRIPTION FACTORS;

EID: 0035929641     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M100747200     Document Type: Article

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