메뉴 건너뛰기




Volumn 66, Issue 4, 2009, Pages 208-215

Oxidative and nitrosative stress in β-cell apoptosis: Their contribution to β-cell loss in type 1 diabetes mellitus

Author keywords

Apoptosis; Diabetes mellitus; Nitric oxide; Oxidative stress

Indexed keywords

GAMMA INTERFERON; N(G) METHYLARGININE; TUMOR NECROSIS FACTOR ALPHA;

EID: 75649107661     PISSN: 09674845     EISSN: None     Source Type: Journal    
DOI: 10.1080/09674845.2009.11730278     Document Type: Review
Times cited : (19)

References (79)
  • 1
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death - the signal transduction of immune-mediated beta-cell apoptosis
    • Eizirik DL, Mandrup-Poulsen T. A choice of death - the signal transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001; 44: 2115-33.
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.L.1    Mandrup-Poulsen, T.2
  • 2
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes - many differences, few similarities
    • Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes - many differences, few similarities. Diabetes 2005; 54: (Suppl 2): S97-S107.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Cnop, M.1    Welsh, N.2    Jonas, J.C.3    Jorns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 4
    • 0028345818 scopus 로고
    • The role of cytokines in the regulation of pancreatic beta cell function
    • Sandler S, Eizirik DL, Sternesjö J, Welsh N. The role of cytokines in the regulation of pancreatic beta cell function. Biochem Soc Trans 1994; 22: 26-30.
    • (1994) Biochem Soc Trans , vol.22 , pp. 26-30
    • Sandler, S.1    Eizirik, D.L.2    Sternesjö, J.3    Welsh, N.4
  • 5
    • 75649144401 scopus 로고
    • Human interleukin 1 is cytotoxic to insulin and glucagon-producing islets of Langerhans
    • Bendtzen K, Mandrup-Poulsen T, Dinarello CA et al. Human interleukin 1 is cytotoxic to insulin and glucagon-producing islets of Langerhans. Eur J Clin Invest 1986; 16: A40.
    • (1986) Eur J Clin Invest , vol.16
    • Bendtzen, K.1    Mandrup-Poulsen, T.2    Dinarello, C.A.3
  • 7
    • 0028633557 scopus 로고
    • Cytokines, nitric oxide and insulin-secreting cells
    • Cunningham JM, Green IC. Cytokines, nitric oxide and insulin-secreting cells. Growth Regul 1994; 4: 173-80.
    • (1994) Growth Regul , vol.4 , pp. 173-180
    • Cunningham, J.M.1    Green, I.C.2
  • 8
    • 0027934873 scopus 로고
    • TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide
    • Cetkovic-Cvrlje M, Eizirik DL. TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 1994; 6: 399-406
    • (1994) Cytokine , vol.6 , pp. 399-406
    • Cetkovic-Cvrlje, M.1    Eizirik, D.L.2
  • 9
    • 0029817047 scopus 로고    scopus 로고
    • The role of interleukin-1 in the pathogenesis of IDDM
    • Mandrup-Poulsen T. The role of interleukin-1 in the pathogenesis of IDDM. Diabetologia 1996; 39: 1005-29
    • (1996) Diabetologia , vol.39 , pp. 1005-1029
    • Mandrup-Poulsen, T.1
  • 10
    • 0032523104 scopus 로고    scopus 로고
    • Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus
    • Rabinovitch A, Suarez-Pinzon WL. Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus. Biochem Pharmacol 1998; 55 (8): 1139-49.
    • (1998) Biochem Pharmacol , vol.55 , Issue.8 , pp. 1139-1149
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2
  • 12
    • 0035928391 scopus 로고    scopus 로고
    • Type 1 diabetes: New perspectives on disease pathogenesis and treatment
    • Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001; 358: 221-9.
    • (2001) Lancet , vol.358 , pp. 221-229
    • Atkinson, M.A.1    Eisenbarth, G.S.2
  • 13
    • 0035856952 scopus 로고    scopus 로고
    • Beta cell death during progression to diabetes
    • Mathis D, Vence L, Benoist C. Beta cell death during progression to diabetes. Nature 2001; 414: 792-8.
    • (2001) Nature , vol.414 , pp. 792-798
    • Mathis, D.1    Vence, L.2    Benoist, C.3
  • 14
    • 50949092228 scopus 로고    scopus 로고
    • Autoimmune mechanisms in type 1 diabetes
    • Knip M, Siljander H. Autoimmune mechanisms in type 1 diabetes. Autoimmunity 2008; 7 (7): 550-7.
    • (2008) Autoimmunity , vol.7 , Issue.7 , pp. 550-557
    • Knip, M.1    Siljander, H.2
  • 15
    • 0035966006 scopus 로고    scopus 로고
    • A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta cells
    • Cardozo AK, Heimberg H, HeremansY et al. A comprehensive analysis of cytokine-induced and nuclear factor-kappa B-dependent genes in primary rat pancreatic beta cells. J Biol Chem 2001; 276: 48879-86.
    • (2001) J Biol Chem , vol.276 , pp. 48879-48886
    • Cardozo, A.K.1    Heimberg, H.2    HeremansY3
  • 16
    • 0035029867 scopus 로고    scopus 로고
    • Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays
    • Cardozo AK, Kruhoffer M, Leeman R, Orntoft T, Eizirik DL. Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays. Diabetes 2001; 50: 909-20.
    • (2001) Diabetes , vol.50 , pp. 909-920
    • Cardozo, A.K.1    Kruhoffer, M.2    Leeman, R.3    Orntoft, T.4    Eizirik, D.L.5
  • 17
    • 0035488777 scopus 로고    scopus 로고
    • Inhibition of cytokine-induced NF-kappa B activation by adenovirus-mediated expression of a NF-kappa B super-repressor prevents beta-cell apoptosis
    • Heimberg H, Heremans Y, Jobin C et al. Inhibition of cytokine-induced NF-kappa B activation by adenovirus-mediated expression of a NF-kappa B super-repressor prevents beta-cell apoptosis. Diabetes 2001; 50: 2219-24.
    • (2001) Diabetes , vol.50 , pp. 2219-2224
    • Heimberg, H.1    Heremans, Y.2    Jobin, C.3
  • 18
    • 0033755391 scopus 로고    scopus 로고
    • Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans
    • John NE, Andersen HU, Fey SJ et al. Cytokine- or chemically derived nitric oxide alters the expression of proteins detected by two-dimensional gel electrophoresis in neonatal rat islets of Langerhans. Diabetes 2000; 49: 1819-29.
    • (2000) Diabetes , vol.49 , pp. 1819-1829
    • John, N.E.1    Andersen, H.U.2    Fey, S.J.3
  • 19
    • 33644905017 scopus 로고    scopus 로고
    • Beta cell cytoprotective strategies: Establishing the relative roles for iNOS and ROS
    • McCabe C, Samali A, O'Brien T. Beta cell cytoprotective strategies: establishing the relative roles for iNOS and ROS. Biochem Biophys Res Comm 2006; 342: 1240-8.
    • (2006) Biochem Biophys Res Comm , vol.342 , pp. 1240-1248
    • McCabe, C.1    Samali, A.2    O'Brien, T.3
  • 20
    • 33646533330 scopus 로고    scopus 로고
    • Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms
    • Pirot P, Eizirik DL, Cardozo AK. Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms. Diabetologia 2006; 49: 1229-36.
    • (2006) Diabetologia , vol.49 , pp. 1229-1236
    • Pirot, P.1    Eizirik, D.L.2    Cardozo, A.K.3
  • 21
    • 0035079807 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells
    • Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL. Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1 beta-exposed human and rat islet cells. Diabetologia 2001; 44: 325-32.
    • (2001) Diabetologia , vol.44 , pp. 325-332
    • Chen, M.C.1    Proost, P.2    Gysemans, C.3    Mathieu, C.4    Eizirik, D.L.5
  • 22
    • 44749083828 scopus 로고    scopus 로고
    • Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells
    • Ortis F, Pirot P, Naamane N et al. Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia 2008; 51 (7): 1213-25
    • (2008) Diabetologia , vol.51 , Issue.7 , pp. 1213-1225
    • Ortis, F.1    Pirot, P.2    Naamane, N.3
  • 23
    • 67349121629 scopus 로고    scopus 로고
    • Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B signalling in human islets and in a mouse beta cell line
    • Sarkar SA, Kutlu B, Velmurugan K et al. Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B signalling in human islets and in a mouse beta cell line. Diabetologia 2009; 52: 1092-101.
    • (2009) Diabetologia , vol.52 , pp. 1092-1101
    • Sarkar, S.A.1    Kutlu, B.2    Velmurugan, K.3
  • 24
    • 0030689041 scopus 로고    scopus 로고
    • Relation between antioxidant enzyme gene expression and antioxidative defence status of insulin-producing cells
    • Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defence status of insulin-producing cells. Diabetes 1997; 46: 1733-42.
    • (1997) Diabetes , vol.46 , pp. 1733-1742
    • Tiedge, M.1    Lortz, S.2    Drinkgern, J.3    Lenzen, S.4
  • 25
    • 0034949349 scopus 로고    scopus 로고
    • An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice
    • Suarez-Pinzon WL, Mabley JG, Strynadka K, Power RF, Szabo C, Rabinovitch A. An inhibitor of inducible nitric oxide synthase and scavenger of peroxynitrite prevents diabetes development in NOD mice. J Autoimmun 2001; 16: 449-55.
    • (2001) J Autoimmun , vol.16 , pp. 449-455
    • Suarez-Pinzon, W.L.1    Mabley, J.G.2    Strynadka, K.3    Power, R.F.4    Szabo, C.5    Rabinovitch, A.6
  • 26
    • 0025685395 scopus 로고
    • Inhibition of insulin secretion by interleukin-1-beta and tumour necrosis factor-alpha via an L-arginine- dependent nitric oxide-generating mechanism
    • Southern C, Schulster D, Green IC. Inhibition of insulin secretion by interleukin-1-beta and tumour necrosis factor-alpha via an L-arginine- dependent nitric oxide-generating mechanism. FEBS Lett 1990; 276: 42-4.
    • (1990) FEBS Lett , vol.276 , pp. 42-44
    • Southern, C.1    Schulster, D.2    Green, I.C.3
  • 27
    • 0028179849 scopus 로고
    • Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic Rinm5F cells
    • Ankarcrona M, Dypbukt JM., Brune B, Nicotera P. Interleukin-1 beta-induced nitric oxide production activates apoptosis in pancreatic Rinm5F cells. Exp Cell Res 1994; 213: 172-7.
    • (1994) Exp Cell Res , vol.213 , pp. 172-177
    • Ankarcrona, M.1    Dypbukt, J.M.2    Brune, B.3    Nicotera, P.4
  • 28
    • 0029093781 scopus 로고
    • Apoptotic cell death triggered by nitric oxide in pancreatic beta cells
    • Kaneto H, Fujii J, Seo HG et al. Apoptotic cell death triggered by nitric oxide in pancreatic beta cells. Diabetes 1995; 44: 733-8.
    • (1995) Diabetes , vol.44 , pp. 733-738
    • Kaneto, H.1    Fujii, J.2    Seo, H.G.3
  • 29
    • 0029795599 scopus 로고    scopus 로고
    • Human pancreatic islet beta-cell destruction by cytokines involves oxygen-free radicals and aldehyde production
    • Rabinovitch A, Suarez-Pinzon WL, Strynadka K, Lakey JRT, Rajotte RV. Human pancreatic islet beta-cell destruction by cytokines involves oxygen-free radicals and aldehyde production. J Clin Endocrinol Metab 1996; 81: 3197-202.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3197-3202
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Strynadka, K.3    Lakey, J.R.T.4    Rajotte, R.V.5
  • 30
    • 0028109668 scopus 로고
    • Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production
    • Rabinovitch A, Suarez-Pinzon WL, Strynadka K et al. Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production. J Clin Endocrinol Metab 1994; 79 (4): 1058-62.
    • (1994) J Clin Endocrinol Metab , vol.79 , Issue.4 , pp. 1058-1062
    • Rabinovitch, A.1    Suarez-Pinzon, W.L.2    Strynadka, K.3
  • 31
    • 0028296629 scopus 로고
    • Cytokines suppress human islet function irrespective of their effects on nitric oxide generation
    • Eizirik DL, Sandler S, Welsh N et al. Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. J Clin Invest 1994; 93: 1968-74.
    • (1994) J Clin Invest , vol.93 , pp. 1968-1974
    • Eizirik, D.L.1    Sandler, S.2    Welsh, N.3
  • 32
    • 0029401861 scopus 로고
    • Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets - implications for the pathogenesis of insulin-dependent diabetes mellitus
    • Welsh N, Margulis B, Borg LAH et al. Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets - implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol Med 1995; 1: 806-20.
    • (1995) Mol Med , vol.1 , pp. 806-820
    • Welsh, N.1    Margulis, B.2    Borg, L.A.H.3
  • 33
    • 0029915909 scopus 로고    scopus 로고
    • Nitric oxide donors decrease the function and survival of human pancreatic islets
    • Eizirik DL, Delaney CA, Green MHL et al. Nitric oxide donors decrease the function and survival of human pancreatic islets. Mol Cell Endocrinol 1996; 118: 71-83.
    • (1996) Mol Cell Endocrinol , vol.118 , pp. 71-83
    • Eizirik, D.L.1    Delaney, C.A.2    Green, M.H.L.3
  • 34
    • 0030731917 scopus 로고    scopus 로고
    • Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus
    • Stassi G, De Maria R, Trucco G et al. Nitric oxide primes pancreatic beta cells for Fas-mediated destruction in insulin-dependent diabetes mellitus. J Exp Med 1997; 186 (8): 1193-200.
    • (1997) J Exp Med , vol.186 , Issue.8 , pp. 1193-1200
    • Stassi, G.1    De Maria, R.2    Trucco, G.3
  • 35
    • 26244436171 scopus 로고    scopus 로고
    • Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt
    • Storling J, Binzer J, Anderson AK et al. Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt. Diabetologia 2005; 48: 2039-50.
    • (2005) Diabetologia , vol.48 , pp. 2039-2050
    • Storling, J.1    Binzer, J.2    Anderson, A.K.3
  • 36
    • 0001462775 scopus 로고    scopus 로고
    • A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic beta-cell dysfunction and destruction
    • McDaniel ML, Corbett JA, Kwon G, Hill JR. A role for nitric oxide and other inflammatory mediators in cytokine-induced pancreatic beta-cell dysfunction and destruction. Adv Exp Med Biol 1997; 426: 313-9.
    • (1997) Adv Exp Med Biol , vol.426 , pp. 313-319
    • McDaniel, M.L.1    Corbett, J.A.2    Kwon, G.3    Hill, J.R.4
  • 38
    • 0030573997 scopus 로고    scopus 로고
    • Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death
    • Delaney CA, Tyrberg B, Bouwens L, Vaghef H, Hellman B, Eizirik DL. Sensitivity of human pancreatic islets to peroxynitrite-induced cell dysfunction and death. FEBS Lett 1996; 394: 300-6.
    • (1996) FEBS Lett , vol.394 , pp. 300-306
    • Delaney, C.A.1    Tyrberg, B.2    Bouwens, L.3    Vaghef, H.4    Hellman, B.5    Eizirik, D.L.6
  • 39
    • 46449092492 scopus 로고    scopus 로고
    • iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis
    • Li F, Mahato RI. iNOS gene silencing prevents inflammatory cytokine-induced beta-cell apoptosis. Mol Pharm 2008; 5: 407-17.
    • (2008) Mol Pharm , vol.5 , pp. 407-417
    • Li, F.1    Mahato, R.I.2
  • 40
    • 0036097472 scopus 로고    scopus 로고
    • Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia
    • Biarnes M, Montolio M, Nacher V, Raurell M, Soler J, Montanya E. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 2002; 51: 66-72.
    • (2002) Diabetes , vol.51 , pp. 66-72
    • Biarnes, M.1    Montolio, M.2    Nacher, V.3    Raurell, M.4    Soler, J.5    Montanya, E.6
  • 41
    • 33846826610 scopus 로고    scopus 로고
    • Adenoviral overproduction of interleukin-1 receptor antagonist increases beta-cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome
    • Tellez N, Montolio M, Estilles E, Escoriza J, Soler J, Montanya E. Adenoviral overproduction of interleukin-1 receptor antagonist increases beta-cell replication and mass in syngeneically transplanted islets, and improves metabolic outcome. Diabetologia 2007; 50: 602-11.
    • (2007) Diabetologia , vol.50 , pp. 602-611
    • Tellez, N.1    Montolio, M.2    Estilles, E.3    Escoriza, J.4    Soler, J.5    Montanya, E.6
  • 42
    • 55349094344 scopus 로고    scopus 로고
    • Encapsulation of human islets in novel inhomogeneous alginate-Ca2+/Ba2+ microbeads: In vitro and in vivo function
    • Qi M, Strand BL, Morch Y et al. Encapsulation of human islets in novel inhomogeneous alginate-Ca2+/Ba2+ microbeads: in vitro and in vivo function. Artif Cells Blood Substit Immobil Biotechnol 2008; 36: 403-20.
    • (2008) Artif Cells Blood Substit Immobil Biotechnol , vol.36 , pp. 403-420
    • Qi, M.1    Strand, B.L.2    Morch, Y.3
  • 43
    • 33947391397 scopus 로고    scopus 로고
    • Interleukin-1 beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation
    • Montolio M, Biarnes M, Tellez N, Escoriza J, Soler J, Montanya E. Interleukin-1 beta and inducible form of nitric oxide synthase expression in early syngeneic islet transplantation. J Endocrinol 2007; 192: 169-77.
    • (2007) J Endocrinol , vol.192 , pp. 169-177
    • Montolio, M.1    Biarnes, M.2    Tellez, N.3    Escoriza, J.4    Soler, J.5    Montanya, E.6
  • 44
    • 0346728620 scopus 로고    scopus 로고
    • Cytokines and nitric oxide inhibit the enzyme activity of catalase but not its protein or mRNA expression in insulin-producing cells
    • Sigfrid LA, Cunningham JM, Beeharry N et al. Cytokines and nitric oxide inhibit the enzyme activity of catalase but not its protein or mRNA expression in insulin-producing cells. J Mol Endocrinol 2003; 31: 509-18.
    • (2003) J Mol Endocrinol , vol.31 , pp. 509-518
    • Sigfrid, L.A.1    Cunningham, J.M.2    Beeharry, N.3
  • 45
    • 0025916445 scopus 로고
    • Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line
    • Nose K, Shibanuma M, Kikuchi K. Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. Eur J Biochem 1991; 201: 99-106
    • (1991) Eur J Biochem , vol.201 , pp. 99-106
    • Nose, K.1    Shibanuma, M.2    Kikuchi, K.3
  • 46
    • 0025739254 scopus 로고
    • Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-κB transcription factor and HIV-1
    • 2247?58
    • Schreck R, Rieber P, Baeuerle PA. Reactive oxygen intermediates as apparently widely used messengers in the activation of NF-κB transcription factor and HIV-1. EMBO J 1991; 10: 2247?58.
    • (1991) EMBO J , vol.10
    • Schreck, R.1    Rieber, P.2    Baeuerle, P.A.3
  • 47
    • 0033921459 scopus 로고    scopus 로고
    • Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes
    • Lortz S, Tiedge M, Nachtwey T, Karlsen AE, Nerup J, Lenzen S. Protection of insulin-producing RINm5F cells against cytokine-mediated toxicity through overexpression of antioxidant enzymes. Diabetes 2000; 49: 1123-30.
    • (2000) Diabetes , vol.49 , pp. 1123-1130
    • Lortz, S.1    Tiedge, M.2    Nachtwey, T.3    Karlsen, A.E.4    Nerup, J.5    Lenzen, S.6
  • 48
    • 0032791152 scopus 로고    scopus 로고
    • Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells
    • Tiedge M, Lortz J, Munday R, Lenzen S. Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells. Diabetologia 1999; 42: 849-55.
    • (1999) Diabetologia , vol.42 , pp. 849-855
    • Tiedge, M.1    Lortz, J.2    Munday, R.3    Lenzen, S.4
  • 49
    • 4344716628 scopus 로고    scopus 로고
    • Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines
    • Gurgul E, Lortz S, Tiedge M, Jorns A, Lenzen S. Mitochondrial catalase overexpression protects insulin-producing cells against toxicity of reactive oxygen species and proinflammatory cytokines. Diabetes 2004; 53: 2271-80.
    • (2004) Diabetes , vol.53 , pp. 2271-2280
    • Gurgul, E.1    Lortz, S.2    Tiedge, M.3    Jorns, A.4    Lenzen, S.5
  • 50
    • 1342282935 scopus 로고    scopus 로고
    • Role for oxidative stress in the regeneration of islet beta cells?
    • Haskins K, Kench J, Powers K et al. Role for oxidative stress in the regeneration of islet beta cells? J Investig Med 2004; 52 (1): 45-9.
    • (2004) J Investig Med , vol.52 , Issue.1 , pp. 45-49
    • Haskins, K.1    Kench, J.2    Powers, K.3
  • 52
    • 0030923812 scopus 로고    scopus 로고
    • Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells
    • Delaney CA, Pavlovic D, Hoorens A, Pipeleers DG, Eizirik DL. Cytokines induce deoxyribonucleic acid strand breaks and apoptosis in human pancreatic islet cells. Endocrinology 1997; 138: 2610-4.
    • (1997) Endocrinology , vol.138 , pp. 2610-2614
    • Delaney, C.A.1    Pavlovic, D.2    Hoorens, A.3    Pipeleers, D.G.4    Eizirik, D.L.5
  • 53
    • 17844367636 scopus 로고    scopus 로고
    • MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity
    • Chen HN, Li XY, Epstein PN. MnSOD and catalase transgenes demonstrate that protection of islets from oxidative stress does not alter cytokine toxicity. Diabetes 2005; 54: 1437-46.
    • (2005) Diabetes , vol.54 , pp. 1437-1446
    • Chen, H.N.1    Li, X.Y.2    Epstein, P.N.3
  • 54
    • 23844470618 scopus 로고    scopus 로고
    • Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines
    • Lortz S, Gurgul-Convey E, Lenzen S, Tiedge M. Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines. Diabetologia 2005; 48: 1541-8.
    • (2005) Diabetologia , vol.48 , pp. 1541-1548
    • Lortz, S.1    Gurgul-Convey, E.2    Lenzen, S.3    Tiedge, M.4
  • 55
    • 42449154297 scopus 로고    scopus 로고
    • Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells
    • Souza KLA, Gurgul-Convey E, Eisner M, Lenzen S. Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells. J Endocrinol 2008; 197: 139-50.
    • (2008) J Endocrinol , vol.197 , pp. 139-150
    • Souza, K.L.A.1    Gurgul-Convey, E.2    Eisner, M.3    Lenzen, S.4
  • 56
    • 0035845568 scopus 로고    scopus 로고
    • Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
    • Oyadomari S, Takeda K, Takiguchi M et al. Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Natl Acad Sci USA 2001; 98: 10845-50.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10845-10850
    • Oyadomari, S.1    Takeda, K.2    Takiguchi, M.3
  • 57
    • 19944432792 scopus 로고    scopus 로고
    • Cytokines down-regulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
    • Cardozo AK, Ortis F, Storling J et al. Cytokines down-regulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005; 54: 452-61.
    • (2005) Diabetes , vol.54 , pp. 452-461
    • Cardozo, A.K.1    Ortis, F.2    Storling, J.3
  • 59
    • 0033510053 scopus 로고    scopus 로고
    • Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6
    • Nakata M, Uto N, Maruyama I, Yada T. Nitric oxide induces apoptosis via Ca2+-dependent processes in the pancreatic beta-cell line MIN6. Cell Struct Funct 1999; 24: 451-5.
    • (1999) Cell Struct Funct , vol.24 , pp. 451-455
    • Nakata, M.1    Uto, N.2    Maruyama, I.3    Yada, T.4
  • 60
    • 0029089864 scopus 로고
    • Nitric oxide induces intracellular Ca2+ mobilization and increases secretion of incorporated 5-hydroxytryptamine in rat pancreatic beta cells
    • Willmott NJ, Galione A, Smith PA. Nitric oxide induces intracellular Ca2+ mobilization and increases secretion of incorporated 5-hydroxytryptamine in rat pancreatic beta cells. FEBS Lett 1995; 371: 99-104.
    • (1995) FEBS Lett , vol.371 , pp. 99-104
    • Willmott, N.J.1    Galione, A.2    Smith, P.A.3
  • 61
    • 0029981670 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose
    • Lizasoain I, Moro MA, Knowles RG, Darley Usmar V, Moncada S. Nitric oxide and peroxynitrite exert distinct effects on mitochondrial respiration which are differentially blocked by glutathione or glucose. Biochem J 1996; 314: 877-80.
    • (1996) Biochem J , vol.314 , pp. 877-880
    • Lizasoain, I.1    Moro, M.A.2    Knowles, R.G.3    Darley Usmar, V.4    Moncada, S.5
  • 64
    • 42349110538 scopus 로고    scopus 로고
    • Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L
    • Holohan C, Szegezdi E, Ritter T, O'Brien T, Samali A. Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L. J Cell Mol Med 2008; 12: 591-606.
    • (2008) J Cell Mol Med , vol.12 , pp. 591-606
    • Holohan, C.1    Szegezdi, E.2    Ritter, T.3    O'Brien, T.4    Samali, A.5
  • 65
    • 0345161818 scopus 로고    scopus 로고
    • Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta cells from cytokine-induced destruction
    • Rabinovitch A, Suarez-Pinzon W, Strynadka K et al. Transfection of human pancreatic islets with an anti-apoptotic gene (bcl-2) protects beta cells from cytokine-induced destruction. Diabetes 1999; 48 (6): 1223-9.
    • (1999) Diabetes , vol.48 , Issue.6 , pp. 1223-1229
    • Rabinovitch, A.1    Suarez-Pinzon, W.2    Strynadka, K.3
  • 66
    • 2442645184 scopus 로고    scopus 로고
    • Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha
    • Chang I, Cho NJ, Kim S et al. Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha. J Immunol 2004; 172: 7008-14.
    • (2004) J Immunol , vol.172 , pp. 7008-7014
    • Chang, I.1    Cho, N.J.2    Kim, S.3
  • 67
    • 0028973059 scopus 로고
    • Regulation of Ikb-alpha phosphorylation by PKC-dependent and Ca2+-dependent signal-transduction pathways
    • Steffan NM, Bren GD, Frantz B, Tocci MJ, Oneill EA, Paya CV. Regulation of Ikb-alpha phosphorylation by PKC-dependent and Ca2+-dependent signal-transduction pathways. J Immunol 1995; 155: 4685-91.
    • (1995) J Immunol , vol.155 , pp. 4685-4691
    • Steffan, N.M.1    Bren, G.D.2    Frantz, B.3    Tocci, M.J.4    Oneill, E.A.5    Paya, C.V.6
  • 68
    • 0032830978 scopus 로고    scopus 로고
    • Effects of calcium channel antagonists on LPS-induced hepatic iNOS expression
    • Mustafa SB, Olson MS. Effects of calcium channel antagonists on LPS-induced hepatic iNOS expression. Am J Physiol 1999; 277 (2 pt 1): G351-60.
    • (1999) Am J Physiol , vol.277 , Issue.2 PART 1
    • Mustafa, S.B.1    Olson, M.S.2
  • 69
    • 39049113549 scopus 로고    scopus 로고
    • Role of oxidative stress in the development of vascular injury and its therapeutic intervention by nifedipine
    • Yamagishi S, Nakamura K, Matsui T. Role of oxidative stress in the development of vascular injury and its therapeutic intervention by nifedipine. Curr Med Chem 2008; 15: 172-7.
    • (2008) Curr Med Chem , vol.15 , pp. 172-177
    • Yamagishi, S.1    Nakamura, K.2    Matsui, T.3
  • 70
    • 63249083149 scopus 로고    scopus 로고
    • Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death
    • Luciani DS, Gwiazda KS, Yang TLB et al. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death. Diabetes 2009; 58: 422-32.
    • (2009) Diabetes , vol.58 , pp. 422-432
    • Luciani, D.S.1    Gwiazda, K.S.2    Yang, T.L.B.3
  • 71
    • 2642573270 scopus 로고    scopus 로고
    • Ryanodine receptors in human pancreatic beta cells: Localization and effects on insulin secretion
    • Johnson JD, Kuang SH, Misler S, Polonsky KS. Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion. FASEB J 2004; 18: 878-84.
    • (2004) FASEB J , vol.18 , pp. 878-884
    • Johnson, J.D.1    Kuang, S.H.2    Misler, S.3    Polonsky, K.S.4
  • 72
    • 0037288692 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and diabetes mellitus
    • Araki E, Oyadomari S, Mori M. Endoplasmic reticulum stress and diabetes mellitus. Intern Med 2003; 42: 7-14.
    • (2003) Intern Med , vol.42 , pp. 7-14
    • Araki, E.1    Oyadomari, S.2    Mori, M.3
  • 73
    • 33748789479 scopus 로고    scopus 로고
    • Mediators of endoplasmic reticulum stress-induced apoptosis
    • Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006; 7: 880-5.
    • (2006) EMBO Rep , vol.7 , pp. 880-885
    • Szegezdi, E.1    Logue, S.E.2    Gorman, A.M.3    Samali, A.4
  • 74
    • 33947510911 scopus 로고    scopus 로고
    • Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis
    • Cnop M, Ladriere L, Hekerman P et al. Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. J Biol Chem 2007; 282: 3989-97.
    • (2007) J Biol Chem , vol.282 , pp. 3989-3997
    • Cnop, M.1    Ladriere, L.2    Hekerman, P.3
  • 75
    • 44949214679 scopus 로고    scopus 로고
    • Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids
    • Diakogiannaki E, Welters HJ, Morgan NG. Differential regulation of the endoplasmic reticulum stress response in pancreatic beta-cells exposed to long-chain saturated and monounsaturated fatty acids. J Endocrinol 2008; 197: 553-63.
    • (2008) J Endocrinol , vol.197 , pp. 553-563
    • Diakogiannaki, E.1    Welters, H.J.2    Morgan, N.G.3
  • 76
    • 58149337392 scopus 로고    scopus 로고
    • Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signalling
    • Akerfeldt MC, Howes J, Chan JY et al. Cytokine-induced beta-cell death is independent of endoplasmic reticulum stress signalling. Diabetes 2008; 57: 3034-44.
    • (2008) Diabetes , vol.57 , pp. 3034-3044
    • Akerfeldt, M.C.1    Howes, J.2    Chan, J.Y.3
  • 77
    • 38449122843 scopus 로고    scopus 로고
    • The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death
    • Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA. The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes 2008; 57: 124-32.
    • (2008) Diabetes , vol.57 , pp. 124-132
    • Chambers, K.T.1    Unverferth, J.A.2    Weber, S.M.3    Wek, R.C.4    Urano, F.5    Corbett, J.A.6
  • 78
    • 1842843855 scopus 로고    scopus 로고
    • Roles of CHOP/GADD153 in endoplasmic reticulum stress
    • Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 2004; 11: 381-9.
    • (2004) Cell Death Differ , vol.11 , pp. 381-389
    • Oyadomari, S.1    Mori, M.2
  • 79
    • 0036175128 scopus 로고    scopus 로고
    • Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
    • Oyadomari S, Koizumi A, Takeda K et al. Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest 2002; 109: 525-32.
    • (2002) J Clin Invest , vol.109 , pp. 525-532
    • Oyadomari, S.1    Koizumi, A.2    Takeda, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.