Homocysteine thiolactone induces apoptotic DNA damage mediated by increased intracellular hydrogen peroxide and caspase 3 activation in HL-60 cells

Life Sciences

Volumn 68, Issue 25, 2001, Pages 2799-2811

  Huang, Rwei Fen S ^a   Huang, Sheu Mai ^a   Lin, Bou Shu ^a   Wei, Jeng Shu ^b   Liu, Tsan Zon ^c,d  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c YUAN'S GENERAL HOSPITAL   (Taiwan)

^d FOOYIN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase 3; Homocysteine thiolactone; Hydrogen peroxide

Indexed keywords

CASPASE 3; CATALASE; DNA; DNA FRAGMENT; ENZYME PRECURSOR; HOMOCYSTEINE THIOLACTONE; HYDROGEN PEROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME METABOLISM; GENOTOXICITY; HUMAN; HUMAN CELL; TIME;

APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL SURVIVAL; DNA; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; ENZYME ACTIVATION; FLOW CYTOMETRY; HL-60 CELLS; HOMOCYSTEINE; HUMANS; HYDROGEN PEROXIDE; MUTAGENICITY TESTS; MUTAGENS; REACTIVE OXYGEN SPECIES;

EID: 0035844038     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01066-9     Document Type: Article

References (47)

1. McCully KS. Homocysteine thiolactone metabolism in malignant cells. Cancer Research 1976;36:3198-202.
2. Olszewski AJ, McCully KS. Homocysteine metabolism and the oxidative modification of proteins and lipids. Free Radical Biology & Medicine 1993;14:683-93.
3. Jones BG, Rose FA, Tudball N. Lipid peroxidation and homocysteine induced toxicity. Atherosclerosis 1994;105:165-70.
4. Jakubowski H. Metabolism of homocysteine thiolactone in human cell culture. Journal of Biological Chemistry 1997;272(3):1935-42.
5. 12, homocysteine status and chromosome damage rate in lymphocytes of older men. Carcinogenesis 1997;18(7):1329-36.
6. 12, homocysteine status and DNA damage in young Australian adults. Carcinogenesis 1998; 19(7): 1163-71.
7. Jacob RA, Gretz DM, Taylor PC, JAmes J, Pogribny IP, Miller BJ, Henning SM, Swendseid ME. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. Journal of Nutrition 1998;128:1204-12.
8. McCully KS, Vezeridis MP. Histopathological effects of Homocysteine thiolactone on epithelial and stromal tissues. Experimental Molecular Pathology 1989;51:159-17.
9. Mucully KS. Chemical pathology of Homocysteine thiolactone theory of atherogenesis and carcinogenesis. Annals of Clinical and Laboratory Science 1993;24:27-59.
10. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. Journal of Clinical Investigation 1996;98(1):5-7.
11. Hultberg B, Andersson A, Isaksson A. The cell-damaging effects of low amounts of homocysteine and copper ions in human cell line cultures are caused by oxidative stress. Toxicology 1997;123:33-40.
12. Upchurch GRJr, Welch GN, Fabian AJ, Freedmant JE, Johnson JL, Keaney JFJr, Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. Journal of Biological Chemistry 1997;272(27):17012-7.
13. Starkebaum G, Harlan JM. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine. Journal of Clinical Investigation 1986;77:1370-6.
14. Wall RT, Harlan JM, Harker LA, Striker GE. Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury. Thrombosis Research 1980;18:113-21.
15. Kirkland JB. Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: Role of activation of poly(ADP-ribose)polymerase. Biochimica Biophysica Acta 1991;1092(3);319-25.
16. Halliwell B, Aruoma OI. DNA damage by oxygen-derived species. FEBS Letters 1991;281(1):9-19.
17. Duthie SJ, Collins AR. The influence of cell growth, detoxifying enzymes and DNA repair on hydrogen peroxide-mediated DNA damage (measured using the comet assay) in human cells. Free Radical Biology & Medicine 1997;22 (4):717-24.
18. Jonas SK, Riley PA, Wilson RL. Hydrogen peroxide cytotoxicity, low-temperature enhancement by ascorbate or reduced lipoate. Biochemical Journal 1989;264(3):651-5.
19. Markesbery WR. Oxidative stress hypothesis in Alzherimer's disease. Free Radical Biology & Medicine 1997;23(1):134-47.
20. Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunology Today 1994;15:7-10.
21. Rudin CM, Thompson CB. (1997) Apoptosis and disease: Regulation and clinical relevance of programmed cell death. Annual Review Medicine 1997;48:267-81.
22. Granville DJ, Carthy CM, Hunt DWC, McManus BM. Apoptosis: Molecular aspects of cell death and disease. Laboratory Investigation 1998;78(8):893-913.
23. Wyllie AH, Kerr JFR, Currie AR. Cell death: The significance of apoptosis. International Review of Cytology 1980;68:251-306.
24. Wyllie AH. Apoptosis: Cell death in tissue regulation. Journal of Pathology 1987;153:313-6.
25. Vanags DM, Porn-Ares MI, Coppola S, Burgess DH, Orrenius S. Protease involvement in fodrin cleavage and phosphatidylserine exposure in apoptosis. Journal of Biological Chemistry 1996:271:31075-85.
26. Nunez G, Benedict MA, Hu Y, Inohara N. Caspases: The proteases of the apoptotic pathway. Oncogen 1998;17(25):3237-45.
27. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senalki G, Howard T, Lowe SW, Mak TW. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes & Development 1998;12:806-19.
28. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 1998;391:43-50.
29. Collins SJ. The HL-60 promyelocytic leukemia cell line: Proliferation, differentiation, and cellular oncogene expression. Blood 1987;70(5):1233-44.
30. Huang RFS, Ho YH, Lin HL, Wei JS, Liu TZ. Folate deficiency induces a cell cycle-specific apoptosis in HepG2 cells. Journal of Nutrition 1999;129:25-31.
31. Endresen PC, Prytz PS, Lysne S, Aarbakke J. Homocysteine increases the relative number of apoptotic cells and reduces the relative number of apoptotic bodies in HL-60 cells treated with 3-deazaadenosine. Journal of Pharmacology and Experimental Therapeutics 1994;269(3):1245-53.
32. Robinson JP, Carter WO, Narayanan PK. Oxidative product formation analysis by flow cytometry. Methods in Cell Biology 1994;41:437-47.
33. DiPietrantonio AM, Hsieh TC, Wu JM. Activation of caspase 3 in HL-60 cells exposed to hydrogen peroxide. Biochemical and Biophysical Research Communications 1999;255:477-82.
34. Blundell G, Jones BG, Rose FA, Tudball N. Homocysteine mediated endothelial cell toxicity and its amelioration. Atherosclerosis 1996;122:163-72.
35. Tsai JC, Perrella MA, Yoshizumi M, Hsieh CM, Haber E, Schlegel R, Lee ME. Promotion of vascular smooth muscle cell growth by homocysteine: A link to atherosclerosis. Proceedings of the National Academy of Sciences of USA 1994;91:6369-73.
36. Fell D, Selhub J. Disruption of thymidylate synthesis and glycine-serine interconversion by L-methionine and L-homocystine in Raji cells. Biochimica et Biophysica Acta 1990;1033:80-4.
37. Kokame K, Kato H, Miyata T. Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. Journal of Biological Chemistry 1996;271(47):29659-65.
38. Austin RC, Sood SK, Dorward AM, Singh G, Shaughnessy SG, Pamid S, Outinen PA, Weitz JI. Homocysteine-dependent alterations in mitochoncrial gene expression, function and structure. Journal of Biological Chemistry 1998;273(46):30808-17.
39. Suzuki Y, Lorenzi MV, Shi SS, Day RM, Blumberg JB. Homocysteine exerts cell type-specific inhibition of AP-1 transcription factor. Free Radical Biology & Medicine 2000;28(1):39-45.
40. Dalton ML, Gadson PFJr, Wrenn RW, Rosenquist TH. Homocysteine signal cascade: Production of phospholipids, activation of protein kinase C, and the induction of c-fos and c-myb in smooth muscle cells. FASEB Journal 1997;11:703-11.
41. Endresen PC, Eide TJ, Aarbakke J. Cell death initiated by 3-deazaadenosine in HL-60 cells is apoptosis and is partially inhibited by Homocysteine. Biochemical Pharmacology 1993;46(11): 1893-1901.
42. Suzuki Y, Ono Y, Hirabayashi Y. Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas-mediated apoptosis. FEBS Letters 1998;425:209-12.
43. Tada-Oikawa S, Oikawa S, Kawanisuhi M, Yamada M, Kawanishi S. Generation of hydrogen peroxide precedes loss of mitochondrial membrane potential during DNA alkylation induced apoptosis. FEBS Letters 1999;442(1):65-9.
44. Kroemer G, Zazami N, Susin SA. Mitochondrial control of apoptosis. Immunology Today 1997;18(1):44-51.
45. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X. Cytochrome c and dATP-dependent formation of apaf-1/caspase-9 complex initiates and apoptotic protease cascade. Cell 1997;91: 479-89.
46. Hankey GJ, Eikelboom JW. Homocysteine and vascular disease. Lancet 1999;354:407-13.
47. Sinelshchikova TA, Lvova, GN, Shoniya, NN, Zasukhina, GD. Defective DNA excision repair in cells of patients with homocystinuria. Mutation Research 1987;184:265-70.