Loop-sequence features and stability determinants in antibody variable domains by high-throughput experiments

Structure

Volumn 22, Issue 1, 2014, Pages 9-21

  Chang, Hung Ju ^a,b,c   Jian, Jhih Wei ^a,d,e   Hsu, Hung Ju ^a   Lee, Yu Ching ^a   Chen, Hong Sen ^a   You, Jhong Jhe ^a   Hou, Shin Chen ^a   Shao, Chih Yun ^a,c   Chen, Yen Ju ^a,c   Chiu, Kuo Ping ^a   Peng, Hung Pin ^a,d,e   Lee, Kuo Hao ^a   Yang, An Suei ^a  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e INSTITUTE OF INFORMATION SCIENCE   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN A; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; VASCULOTROPIN ANTIBODY; VASCULOTROPIN;

AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ANTIGEN BINDING; ARTICLE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; HYDROPHOBICITY; PHAGE DISPLAY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN LOOP; PROTEIN STABILITY; PROTEIN STRUCTURE; SEQUENCE DATABASE; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY; HIGH THROUGHPUT SEQUENCING; PROTEIN BINDING; PROTEIN INTERACTION; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SINGLE-CHAIN ANTIBODIES; STAPHYLOCOCCAL PROTEIN A; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84891885359     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2013.10.005     Document Type: Article

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