Conservation of folding and stability within a protein family: The Tyrosine corner as an evolutionary cul-de-sac

Journal of Molecular Biology

Volumn 295, Issue 3, 2000, Pages 641-649

  Hamill, Stefan J ^a   Cota, Ernesto ^a   Chothia, Cyrus ^b   Clarke, Jane ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

Evolution; Fibronectin type III; Immunoglobulin; Protein folding; Tyrosine corner

Indexed keywords

FIBRONECTIN; IMMUNOGLOBULIN; M PROTEIN;

ARTICLE; MOLECULAR EVOLUTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN STABILITY; STRUCTURE ANALYSIS;

EID: 0034695407     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3360     Document Type: Article

References (42)

1. Equilibrium folding intermediates of a Greek key beta-barrel protein
2. Pfam 3.1: 1313 multiple alignments match the majority of proteins
3. Bound water-molecules and conformational stabilization help mediate an antigen-antibody association
4. The immunoglobulin fold. Structural classification, sequence patterns and common core
5. Structural and energetic responses to cavity creating mutations in hydrophobic cores: Observation of a buried water molecule and the hydrophilic nature of such hydrophobic cavities
6. One thousand families for the molecular biologist
7. Structural determinants in the sequences of immunoglobulin variable domain
8. Folding and stability of a fibronectin type III domain of human tenascin
9. Folding studies of immunoglobulin-like β-sandwich proteins suggest that they share a common folding pathway
10. Folding of beta-sandwich proteins: Three-state transition of a fibronectin type III module
11. Crystal structure of the tenth type III cell adhesion module of human fibronectin
12. Structure of domain 1 of rat T lymphocyte CD2 antigen
13. Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect
14. The folding of an enzyme. I. Theory of protein engineering analysis of stability and pathway of protein folding
15. Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans
16. A structural census of the current population of protein sequences
17. The effect of boundary selection on the stability and folding of the third fibronectin type III domain from human tenascin
18. Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains
19. The tyrosine corner: A feature of most Greek key beta-barrel proteins
20. How do small single-domain proteins fold?
21. Crystal structure at 2.8 Å resolution of a soluble form of the cell adhesion molecule CD2
22. The sequences of small proteins are not extensively optimized for rapid folding by natural selection
23. MolScript, a program to produce both detailed and schematic plots of protein structures
24. Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein
25. How different amino acid sequences determine similar protein structures: The structure and evolutionary dynamics of the globins
26. Effects of core mutations on the folding of a beta-sheet protein: Implications for backbone organization in the I-State
27. The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions
28. How evolution makes proteins fold quickly
29. One sequence, two folds: A metastable structure of CD2
30. Determination and analysis of urea and guanidinium denaturation curves
31. Amide backbone and water-related H/D isotope effects on the dynamics of a protein folding reaction
32. An integrated kinetic analysis of intermediates and transition states in protein folding reactions
33. Rapid refolding of a proline-rich all-β-sheet fibronectin type III module
34. Protein folding and protein evolution: Common folding nucleus in different subfamilies of c-type cytochromes?
35. Correlation of observed fold frequency with the occurrence of local structural motifs
36. Conserved residues and the mechanism of protein folding
37. Accomodating sequence changes in beta-hairpins in proteins
38. Refined crystal structure of the influenza virus-N9 neuraminidase NC41 FAB complex
39. Bactericidal antibody recognition of a PorA epitope of Neisseria meningitidis: Crystal structure of a Fab fragment in complex with a fluorescein-conjugated peptide
40. The immunoglobulin superfamily-domains for cell surface recognition