Structure-based improvement of the biophysical properties of immunoglobulin VH domains with a generalizable approach

Biochemistry

Volumn 42, Issue 6, 2003, Pages 1517-1528

  Ewert, Stefan ^a,b   Honegger, Annemarie ^a   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b ESBATech AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BINDING ENERGY; CONFORMATIONS; GENETIC ENGINEERING; HYDROPHOBICITY; IMMUNOLOGY; MOLECULAR BIOLOGY; MOLECULAR STRUCTURE;

BIOPHYSICAL PROPERTIES;

BIOCHEMISTRY;

ANTIBODY; IMMUNOGLOBULIN; IMMUNOGLOBULIN V; UNCLASSIFIED DRUG;

ANTIBODY ENGINEERING; ARTICLE; BETA SHEET; BINDING AFFINITY; BIOPHYSICS; GENE EXPRESSION; GENE LIBRARY; GENE MUTATION; GENETIC VARIABILITY; GERM LINE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; IMMUNOGLOBULIN STRUCTURE; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FOLDING; SURFACE CHARGE; THERMODYNAMICS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES, ANTIBODY; COMBINATORIAL CHEMISTRY TECHNIQUES; CONSENSUS SEQUENCE; HORSES; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS, SITE-DIRECTED; PEPTIDE LIBRARY; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

EID: 0037452533     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026448p     Document Type: Article

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