Engineering anti-vascular endothelial growth factor single chain disulfide-stabilized antibody variable fragments (sc-dsFv) with phage-displayed sc-dsFv libraries

Journal of Biological Chemistry

Volumn 285, Issue 11, 2010, Pages 7880-7891

  Huang, Yi Jen ^a,b   Chen, Ing Chien ^a   Yu, Chung Ming ^a   Lee, Yu Ching ^a   Hsu, Hung Ju ^a,c   Ching, Anna Tung Ching ^a   Chang, Hung Ju ^a,d   Yang, An Suei ^a  

^a GENOMICS RESEARCH CENTER   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d ACADEMIA SINICA   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-VASCULAR ENDOTHELIAL GROWTH FACTORS; ANTIBODY ENGINEERING; ANTIBODY FRAGMENT; ANTIBODY LIBRARY; BACTERIAL CULTURES; COMBINATORIAL SEARCH; DISULFIDE BONDS; EXPRESSION LEVELS; INTER-DOMAIN; OPTIMUM SIGNALS; ORDERS OF MAGNITUDE; PHAGE DISPLAY; SIGNAL SEQUENCE; SINGLE CHAINS; SOLUBLE PROTEINS; VARIABLE DOMAIN; VARIABLE FRAGMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR; WILD TYPES;

BACTERIOLOGY; BIOACTIVITY; LIBRARIES; PEPTIDES; SELF ASSEMBLY;

ANTIBODIES;

DISULFIDE; HYBRID PROTEIN; SIGNAL PEPTIDE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; VASCULOTROPIN ANTIBODY; IMMUNOGLOBULIN LIGHT CHAIN; PEPTIDE LIBRARY; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANTIBODY ENGINEERING; ANTIBODY LIBRARY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DISULFIDE BOND; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FOLDING; WILD TYPE; CHEMISTRY; DIMERIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; METHODOLOGY; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS;

BACTERIA (MICROORGANISMS);

DIMERIZATION; DISULFIDES; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GENE EXPRESSION; HUMANS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MUTAGENESIS, SITE-DIRECTED; PEPTIDE LIBRARY; PROTEIN ENGINEERING; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77950880605     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.061457     Document Type: Article

References (47)

1. Yokota, T., Milenic, D. E., Whitlow, M., and Schlom, J. (1992) Cancer Res. 52, 3402-3408
2. Michnick, S. W., and Sidhu, S. S. (2008) Nat. Chem. Biol. 4, 326-329
3. Wark, K. L., and Hudson, P. J. (2006) Adv. Drug Deliv. Rev. 58, 657-670
4. Carter, P. J. (2006) Nat. Rev. Immunol. 6, 343-357
5. Hoogenboom, H. R. (2005) Nat. Biotechnol. 23, 1105-1116
6. Holliger, P., and Hudson, P. J. (2005) Nat. Biotechnol. 23, 1126-1136
7. Bradbury, A. R., and Marks, J. D. (2004) J. Immunol. Methods 290, 29-49
8. Winter, G. (1998) FEBS Lett. 430, 92-94
9. Bird, R. E., Hardman, K. D., Jacobson, J. W., Johnson, S., Kaufman, B. M., Lee, S. M., Lee, T., Pope, S. H., Riordan, G. S., and Whitlow, M. (1988) Science 242, 423-426
10. Skerra, A., and Plückthun, A. (1988) Science 240, 1038-1041
11. Huston, J. S., Levinson, D., Mudgett-Hunter, M., Tai, M. S., Novotný, J., Margolies, M. N., Ridge, R. J., Bruccoleri, R. E., Haber, E., and Crea, R. (1988) Proc. Natl. Acad. Sci. U.S.A. 85, 5879-5883
12. McCafferty, J., Griffiths, A. D., Winter, G., and Chiswell, D. J. (1990) Nature 348, 552-554
13. Breitling, F., Dübel, S., Seehaus, T., Klewinghaus, I., and Little, M. (1991) Gene 104, 147-153
14. Hawkins, R. E., Russell, S. J., and Winter, G. (1992) J. Mol. Biol. 226, 889-896
15. Marks, J. D., Griffiths, A. D., Malmqvist, M., Clackson, T. P., Bye, J. M., and Winter, G. (1992) Biotechnology 10, 779-783
16. Raag, R., and Whitlow, M. (1995) FASEB J. 9, 73-80
17. Reiter, Y., Brinkmann, U., Lee, B., and Pastan, I. (1996) Nat. Biotechnol. 14, 1239-1245
18. Hust, M., Jostock, T., Menzel, C., Voedisch, B., Mohr, A., Brenneis, M., Kirsch, M. I., Meier, D., and Dübel, S. (2007) BMC Biotechnol. 7, 14
19. Wörn, A., and Plückthun, A. (2001) J. Mol. Biol. 305, 989-1010
20. Röthlisberger, D., Honegger, A., and Plückthun, A. (2005) J. Mol. Biol. 347, 773-789
21. Brinkmann, U., Chowdhury, P. S., Roscoe, D. M., and Pastan, I. (1995) J. Immunol. Methods 182, 41-50
22. Young, N. M., MacKenzie, C. R., Narang, S. A., Oomen, R. P., and Baenziger, J. E. (1995) FEBS Lett. 377, 135-139
23. Rajagopal, V., Pastan, I., and Kreitman, R. J. (1997) Protein Eng. 10, 1453-1459
24. Wörn, A., and Plückthun, A. (1999) Biochemistry 38, 8739-8750
25. Thie, H., Schirrmann, T., Paschke, M., Dubel, S., and Hust, M. (2008) Nat. Biotechnol. 25, 49-54
26. Clérico, E. M., Maki, J. L., and Gierasch, L. M. (2008) Biopolymers 90, 307-319
27. Steiner, D., Forrer, P., Stumpp, M. T., and Plückthun, A. (2006) Nat. Biotechnol. 24, 823-831
28. Hegde, R. S., and Bernstein, H. D. (2006) Trends Biochem. Sci. 31, 563-571
29. Kim, S. J., Mitra, D., Salerno, J. R., and Hegde, R. S. (2002) Dev. Cell 2, 207-217
30. Martoglio, B., and Dobberstein, B. (1998) Trends Cell Biol. 8, 410-415
31. Jestin, J. L., Volioti, G., and Winter, G. (2001) Res. Microbiol. 152, 187-191
32. Rapoza, M. P., and Webster, R. E. (1993) J. Bacteriol. 175, 1856-1859
33. Fuh, G., Wu, P., Liang, W. C., Ultsch, M., Lee, C. V., Moffat, B., and Wiesmann, C. (2006) J. Biol. Chem. 281, 6625-6631
34. Chen, C. T., Yang, E. W., Hsu, H. J., Sun, Y. K., Hsu, W. L., and Yang, A. S. (2008) Bioinformatics 24, 2691-2697
35. Hoover, D. M., and Lubkowski, J. (2002) Nucleic Acids Res. 30, e43
36. Chang, H. J., Hsu, H. J., Chang, C. F., Peng, H. P., Sun, Y. K., Yu, H. M., Shih, H. C., Song, C. Y., Lin, Y. T., Chen, C. C., Wang, C. H., and Yang, A. S. (2009) Structure 17, 620-631
37. DeLano, W. L., and Cunningham, B. C. (2004) in Phage Display (Clackson, T., and Lowman, H. B., eds) 1st Ed., pp. 85-94, Oxford University Press, New York
38. Kunkel, T. A., Roberts, J. D., and Zakour, R. A. (1987) Methods Enzymol. 154, 367-382
39. Sidhu, S. S., and Weiss, G. A. (2004) in Phage Display (Clackson, T., and Lowman, H. B., eds) 1st Ed., pp. 27-42, Oxford University Press, New York
40. Hsu, H. J., Tsai, K. C., Sun, Y. K., Chang, H. J., Huang, Y. J., Yu, H. M., Lin, C. H., Mao, S. S., and Yang, A. S. (2008) J. Biol. Chem. 283, 12343-12353
41. Reiter, Y., Brinkmann, U., Jung, S. H., Pastan, I., and Lee, B. (1995) Protein Eng. 8, 1323-1331
42. Hsu, H. J., Chang, H. J., Peng, H. P., Huang, S. S., Lin, M. Y., and Yang, A. S. (2006) Structure 14, 1499-1510
43. Emanuelsson, O., Brunak, S., von Heijne, G., and Nielsen, H. (2007) Nat. Protoc. 2, 953-971
44. Zimmer, J., Nam, Y., and Rapoport, T. A. (2008) Nature 455, 936-943
45. Tsukazaki, T., Mori, H., Fukai, S., Ishitani, R., Mori, T., Dohmae, N., Perederina, A., Sugita, Y., Vassylyev, D. G., Ito, K., and Nureki, O. (2008) Nature 455, 988-991
46. Driessen, A. J., and Nouwen, N. (2008) Annu. Rev. Biochem. 77, 643-667
47. Luirink, J., and Sinning, I. (2004) Biochim. Biophys. Acta 1694, 17-35