Antibody variable domain interface and framework sequence requirements for stability and function by high-throughput experiments

Structure

Volumn 22, Issue 1, 2014, Pages 22-34

  Hsu, Hung Ju ^a,b   Lee, Kuo Hao ^b   Jian, Jhih Wei ^b,c,d   Chang, Hung Ju ^b,e,f   Yu, Chung Ming ^b   Lee, Yu Ching ^b   Chen, Ing Chien ^b   Peng, Hung Pin ^b,c,d   Wu, Chih Yuan ^b   Huang, Yu Feng ^b   Shao, Chih Yun ^b,e   Chiu, Kuo Ping ^b   Yang, An Suei ^a,b  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b GENOMICS RESEARCH CENTER   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d INSTITUTE OF INFORMATION SCIENCE   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f ACADEMIA SINICA   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; ANTIBODY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY COMBINING SITE; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING SITE; CONSENSUS SEQUENCE; HIGH THROUGHPUT SEQUENCING; HYDROGEN BOND; HYDROPHOBICITY; MUTAGENESIS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PYROSEQUENCING; SEQUENCE DATABASE; STATIC ELECTRICITY; THERMOSTABILITY; COMPLEMENTARITY DETERMINING REGION; POSITION WEIGHT MATRIX; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN ENGINEERING; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; HYDROGEN BONDING; IMMUNOGLOBULIN VARIABLE REGION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SINGLE-CHAIN ANTIBODIES; STAPHYLOCOCCAL PROTEIN A; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84891857423     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2013.10.006     Document Type: Article

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