Celastrol acts as a potent antimetastatic agent targeting β1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 334, Issue 2, 2010, Pages 489-499

  Zhu, Hong ^a   Liu, Xiao Wen ^a   Cai, Tian Yu ^a   Cao, Ji ^a   Tu, Chong Xing ^a   Lu, Wei ^b   He, Qiao Jun ^a   Yang, Bo ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIMETASTATIC AGENT; BETA1 INTEGRIN; CELASTROL; CELL ADHESION MOLECULE; FIBRONECTIN; FOCAL ADHESION KINASE; GREEN FLUORESCENT PROTEIN; SYNAPTOPHYSIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ADHESION; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; FOCAL ADHESION; LUNG METASTASIS; METASTASIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD29; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; FIBRONECTINS; HUMANS; MICE; MICE, INBRED C57BL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 77954917015     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.165654     Document Type: Article

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