Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons

British Journal of Pharmacology

Volumn 162, Issue 1, 2011, Pages 175-192

  Choi, Hye Joung ^a   Kang, Ki Sung ^a   Fukui, Masayuki ^a   Zhu, Bao Ting ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

glutamate; hippocampal neuronal cells; JNK p53 GADD45 apoptotic cascade; oxidative cytotoxicity

Indexed keywords

ACETYLCYSTEINE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GLUTAMIC ACID; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45 ALPHA; KAINIC ACID; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; BRAIN TISSUE; CONTROLLED STUDY; GENE EXPRESSION; GENE SILENCING; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVE CELL NECROSIS; NEUROPATHOLOGY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; KAINIC ACID; MAP KINASE KINASE 4; MICE; MICROSCOPY, FLUORESCENCE; NEURONS; NUCLEAR PROTEINS; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; RATS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 78650110549     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01041.x     Document Type: Article

References (43)

1. Alexander SPH, Mathie A, Peters JA, (2009). Guide to Receptors and Channels (GRAC), 4th edn. Br J Pharmacol 158 (Suppl. 1): S1-S254.
2. Andersen JK, (2004). Oxidative stress in neurodegeneration: cause or consequence? Nat Med 10 (suppl.): S18-S25.
3. Carrier F, Georgel PT, Pourquier P, Blake M, Kontny HU, Antinore MJ, et al. (1999). Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin. Mol Cell Biol 19: 1673-1685.
4. Chen F, Demers LM, Vallyathan V, Ding M, Lu Y, Castranova V, et al. (1999). Vanadate induction of NF-kappaB involves IkappaB kinase beta and SAPK/ERK kinase 1 in macrophages. J Biol Chem 274: 20307-20312.
5. Choi DW, (1990). Methods for antagonizing glutamate neurotoxicity. Cerebrovasc Brain Metab Rev 2: 105-147.
6. Coyle JT, Puttfarcken P, (1993). Oxidative stress, glutamate, and neurodegenerative disorders. Science 262: 689-695.
7. Culmsee C, Zhu X, Yu QS, Chan SL, Camandola S, Guo Z, et al. (2001). A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. J Neurochem 77: 220-228.
8. Davis JB, Maher P, (1994). Protein kinase C activation inhibits glutamate-induced cytotoxicity in a neuronal cell line. Brain Res 652: 169-173.
9. Erdö SL, Michler A, Wolff JR, Tytko H, (1990). Lack of excitotoxic cell death in serum-free cultures of rat cerebral cortex. Brain Res 526: 328-332.
10. Floyd RA, (1999). Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 222: 236-245.
11. Froissard P, Duval D, (1994). Cytotoxic effects of glutamic acid on PC12 cells. Neurochem Int 24: 485-493.
12. Fukui M, Song JH, Choi J, Choi HJ, Zhu BT, (2009). Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. Eur J Pharmacol 617: 1-11.
13. Harman D, (1981). The aging process. Proc Natl Acad Sci USA 78: 7124-7128.
14. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ, (1993). The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75: 805-816.
15. He X, Jenner AM, Ong WY, Farooqui AA, Patel SC, (2006). Lovastatin modulates increased cholesterol and oxysterol levels and has a neuroprotective effect on rat hippocampal neurons after kainate injury. J Neuropathol Exp Neurol 65: 652-663.
16. Kastan MB, Zhan Q, El-Deiry WS, Carrier F, Jacks T, Walsh WV, et al. (1992). A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597.
17. Kovalsky O, Lung FD, Roller PP, Fornace AJ Jr, (2001). Oligomerization of human Gadd45α protein. J Biol Chem 276: 39330-39339.
18. Laabich A, Li G, Cooper NG, (2001). Characterization of apoptosis-genes associated with NMDA mediated cell death in the adult rat retina. Brain Res Mol Brain Res 91: 34-42.
19. Li Y, Maher P, Schubert D, (1997). A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. Neuron 19: 453-463. (Pubitemid 27374242)
20. -ΔΔCT method. Methods 25: 402-408.
21. Min JY, Park MH, Park KW, Lee NW, Kim TH, Kim J, et al. (2006). Staurosporin induces neurite outgrowth through ROS generation in NH33 hippocampal cell lines. J Neural Transm 113: 1821-1826.
22. Mita H, Tsutsui J, Takekawa M, Witten EA, Saito H, (2002). Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mol Cell Biol 22: 4544-4555.
23. 2+ homeostasis in hippocampal neurons in vitro. Mol Pharmacol 35: 671-180.
24. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, et al. (2001). Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60: 759-767.
25. Oka A, Belliveau MJ, Rosenberg PA, Volpe JJ, (1993). Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J Neurosci 13: 1441-1453.
26. Paxinos G, Watson C, (1997). The Rat Brain in Stereotaxic Coordinates, 3rd edit. Academic Press: San Diego.
27. Pereira C, Paveto C, Espinosa J, Alonso G, Flawiá MM, Torres HN, (1997). Control of Trypanosoma cruzi epimastigote motility through the nitric oxide pathway. J Eukaryot Microbiol 44: 155-156.
28. Sagara J, Makino N, Bannai S, (1996). Glutathione efflux from cultured astrocytes. J Neurochem 66: 1876-1881.
29. Salvador JM, Hollander MC, Nguyen AT, Kopp JB, Barisoni L, Moore JK, et al. (2002). Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 16: 499-508.
30. Samet JM, Graves LM, Quay J, Dailey LA, Devlin RB, Ghio AJ, et al. (1998). Activation of MAPKs in human bronchial epithelial cells exposed to metals. Am J Physiol 275 (3 Pt 1): L551-L558.
31. Sarter M, Bodewitz G, Stephens DN, (1988). Attenuation of scopolamine-induced impairment of spontaneous alternation behavior by antagonist but not inverse agonist and β-carboline. Psychopharmacology 94: 491-495.
32. Sayre LM, Smith MA, Perry G, (2001). Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Curr Med Chem 8: 721-738.
33. Sayre LM, Perry G, Smith MA, (2008). Oxidative stress and neurotoxicity. Chem Res Toxicol 21: 172-188.
34. Schmued LC, Hopkins KJ, (2000). Fluoro-Jade: novel fluorochromes for detecting toxicant-induced neuronal degeneration. Toxicol Pathol 28: 91-99.
35. Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, et al. (1994). Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266: 1376-1380.
36. Takahashi S, Saito S, Ohtani N, Sakai T, (2001). Involvement of the Oct-1 regulatory element of the gadd45 promoter in the p53-independent response to ultraviolet irradiation. Cancer Res 61: 1187-1195.
37. Takekawa M, Saito H, (1998). A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95: 521-530.
38. Tan S, Wood M, Maher P, (1998). Oxidative stress induces a form of programmed cell death with characteristics of both apoptosis and necrosis in neuronal cells. J Neurochem 71: 95-105.
39. Tao H, Umek RM, (1999). Reciprocal regulation of gadd45 by C/EBP alpha and c-Myc. DNA Cell Biol 18: 75-84.
40. Thyss R, Virolle V, Imbert V, Peyron JF, Aberdam D, Virolle T, (2005). NF-kappaB/Egr-1/Gadd45 are sequentially activated upon UVB irradiation to mediate epidermal cell death. EMBO J 24: 128-137.
41. Tran H, Brunet A, Grenier JM, Datta SR, Fornace AJ Jr, DiStefano PS, et al. (2002). DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein. Science 19: 530-534.
42. Zhan Q, Bae I, Kastan MB, Fornace AJ Jr, (1994). The p53-dependent gamma-ray response of GADD45. Cancer Res 54: 2755-2760.
43. Zhu RL, Graham SH, Jin J, Stetler RA, Simon RP, Chen J, (1997). Kainate induces the expression of the DNA damage-inducible gene, GADD45, in the rat brain. Neuroscience 81: 707-720.