Celastrol attenuates hypertension-induced inflammation and oxidative stress in vascular smooth muscle cells via induction of heme oxygenase-1

American Journal of Hypertension

Volumn 23, Issue 8, 2010, Pages 895-903

  Yu, Xiao ^a   Tao, Weiwei ^a   Jiang, Fengrong ^a   Li, Chaojun ^b   Lin, Jiandie ^c   Liu, Chang ^a  

^a NANJING NORMAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

blood pressure; celastrol; heme oxygenase 1; hypertension; inflammation; oxidative stress; vascular smooth muscle cells

Indexed keywords

CELASTROL; CYTOKINE; DICHLORODIHYDROFLUORESCEIN DIACETATE; FRUCTOSE; HEME OXYGENASE 1; HEME OXYGENASE INHIBITOR; INSULIN; LUCIGENIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZINC PROTOPORPHYRIN 9; HEME OXYGENASE; HMOX1 PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; TRIPTERINE; TRITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ATTENUATION; BLOOD SAMPLING; CELL CULTURE; CHEMOLUMINESCENCE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEEDING; GLUCOSE TOLERANCE; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INSULIN SENSITIVITY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SYSTOLIC BLOOD PRESSURE; TAIL FLICK TEST; TISSUE CULTURE; TISSUE HOMOGENATE; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD; BLOOD PRESSURE; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BLOOD PRESSURE; CELLS, CULTURED; CYTOKINES; ENZYME ACTIVATION; FRUCTOSE; HEME OXYGENASE (DECYCLIZING); HYPERTENSION; INFLAMMATION; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; TRITERPENES;

EID: 77955771876     PISSN: 08957061     EISSN: None     Source Type: Journal    
DOI: 10.1038/ajh.2010.75     Document Type: Article

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