Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats

Journal of Ethnopharmacology

Volumn 144, Issue 1, 2012, Pages 195-200

  Zhang, Jun ^a   Li, Chang Yin ^a   Xu, Mei Juan ^a   Wu, Ting ^a   Chu, Ji Hong ^a   Liu, Shi Jia ^a   Ju, Wen Zheng ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Bioavailability; Celastrol; Gender difference; LC MS MS; Pharmacokinetics

Indexed keywords

CELASTROL; GLYCYRRHETINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG MONITORING; DRUG STRUCTURE; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; NONHUMAN; RAT; SENSITIVITY ANALYSIS; SEX DIFFERENCE; SUSPENSION; TABLET; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; FEMALE; MALE; MEDICINE, CHINESE TRADITIONAL; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; TABLETS; TRIPTERYGIUM; TRITERPENES;

RATTUS;

EID: 84867524649     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.09.005     Document Type: Article

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