Nanotechnologies for noninvasive measurement of drug release

Molecular Pharmaceutics

Volumn 11, Issue 1, 2014, Pages 24-39

  Moore, Thomas ^a   Chen, Hongyu ^b   Morrison, Rachel ^a   Wang, Fenglin ^b   Anker, Jeffrey N ^b   Alexis, Frank ^a  

^a AMRL   (United States)

^b CLEMSON UNIVERSITY   (United States)

Author keywords

cancer; imaging delivery; quantitative drug delivery; theranostic nanomedicine

Indexed keywords

NANOPARTICLE; SILICON; SINGLET OXYGEN;

CRYSTAL; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG RELEASE; HUMAN; LUMINESCENCE; NANOMEDICINE; NANOTECHNOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; TUMOR VASCULARIZATION;

ANTINEOPLASTIC AGENTS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; NANOMEDICINE; NANOPARTICLES; NANOTECHNOLOGY; NEOPLASMS;

EID: 84891806486     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp400419k     Document Type: Review

References (148)

1. Howlader, N.; Noone, A. M.; Krapcho, M.; Neyman, N.; Aminou, R.; Altekruse, S. F.; Kosary, C. L.; Ruhl, J.; Tatalovich, Z.; Mariotto, A.; Eisner, M. P.; Lewis, D. R.; Chen, H. S.; Feuer, E. J. SEER Cancer Statistics Review, 1975-2009; National Cancer Institute: Bethesda, MD, 2011.
2. Society, A. C. Cancer Facts & Figures; American Cancer Society: Atlanta, GA, 2012.
3. Green, M. R.; Manikhas, G. M.; Orlov, S.; Afanasyev, B.; Makhson, A. M.; Bhar, P.; Hawkins, M. J. Abraxane, a novel Cremophor-free, albumin-bound particle form of paclitaxel for the treatment of advanced non-small-cell lung cancer Ann. Oncol. 2006, 17 (8) 1263-1268
4. Hrkach, J.; Von Hoff, D.; Ali, M. M.; Andrianova, E.; Auer, J.; Campbell, T.; De Witt, D.; Figa, M.; Figueiredo, M.; Horhota, A.; Low, S.; McDonnell, K.; Peeke, E.; Retnarajan, B.; Sabnis, A.; Schnipper, E.; Song, J. J.; Song, Y. H.; Summa, J.; Tompsett, D.; Troiano, G.; Van Geen Hoven, T.; Wright, J.; LoRusso, P.; Kantoff, P. W.; Bander, N. H.; Sweeney, C.; Farokhzad, O. C.; Langer, R.; Zale, S. Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile Sci. Transl. Med. 2012, 4 (128) 128ra39
5. Kim, D. W.; Kim, S. Y.; Kim, H. K.; Kim, S. W.; Shin, S. W.; Kim, J. S.; Park, K.; Lee, M. Y.; Heo, D. S. Multicenter phase II trial of Genexol-PM, a novel Cremophor-free, polymeric micelle formulation of paclitaxel, with cisplatin in patients with advanced non-small-cell lung cancer Ann. Oncol. 2007, 18 (12) 2009-2014
6. Gradishar, W. J.; Tjulandin, S.; Davidson, N.; Shaw, H.; Desai, N.; Bhar, P.; Hawkins, M.; O'Shaughnessy, J. Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer J. Clin. Oncol. 2005, 23 (31) 7794-803
7. Schiller, J. H.; Harrington, D.; Belani, C. P.; Langer, C.; Sandler, A.; Krook, J.; Zhu, J.; Johnson, D. H. Comparison of Four Chemotherapy Regimens for Advanced Non-Small-Cell Lung Cancer N. Engl. J. Med. 2002, 346 (2) 92-98
8. O'Brien, M. E.; Wigler, N.; Inbar, M.; Rosso, R.; Grischke, E.; Santoro, A.; Catane, R.; Kieback, D. G.; Tomczak, P.; Ackland, S. P.; Orlandi, F.; Mellars, L.; Alland, L.; Tendler, C. Reduced cardiotoxicity and comparable efficacy in a phase III trial of pegylated liposomal doxorubicin HCl (CAELYX/Doxil) versus conventional doxorubicin for first-line treatment of metastatic breast cancer Ann. Oncol. 2004, 15 (3) 440-449
9. Boddy, A. V.; Plummer, E. R.; Todd, R.; Sludden, J.; Griffin, M.; Robson, L.; Cassidy, J.; Bissett, D.; Bernareggi, A.; Verrill, M. W.; Calvert, A. H. A phase I and pharmacokinetic study of paclitaxel poliglumex (XYOTAX), investigating both 3-weekly and 2-weekly schedules Clin. Cancer Res. 2005, 11 (21) 7834-7840
10. Paz-Ares, L.; Ross, H.; O'Brien, M.; Riviere, A.; Gatzemeier, U.; Von Pawel, J.; Kaukel, E.; Freitag, L.; Digel, W.; Bischoff, H.; Garcia-Campelo, R.; Iannotti, N.; Reiterer, P.; Bover, I.; Prendiville, J.; Eisenfeld, A. J.; Oldham, F. B.; Bandstra, B.; Singer, J. W.; Bonomi, P. Phase III trial comparing paclitaxel poliglumex vs docetaxel in the second-line treatment of non-small-cell lung cancer Br. J. Cancer 2008, 98 (10) 1608-1613
11. Weiss, G. J.; Chao, J.; Neidhart, J. D.; Ramanathan, R. K.; Bassett, D.; Neidhart, J. A.; Choi, C. H.; Chow, W.; Chung, V.; Forman, S. J.; Garmey, E.; Hwang, J.; Kalinoski, D. L.; Koczywas, M.; Longmate, J.; Melton, R. J.; Morgan, R.; Oliver, J.; Peterkin, J. J.; Ryan, J. L.; Schluep, T.; Synold, T. W.; Twardowski, P.; Davis, M. E.; Yen, Y. First-in-human phase 1/2a trial of CRLX101, a cyclodextrin-containing polymer-camptothecin nanopharmaceutical in patients with advanced solid tumor malignancies Invest. New Drugs 2013, 31 (4) 986-1000
12. Hamaguchi, T.; Kato, K.; Yasui, H.; Morizane, C.; Ikeda, M.; Ueno, H.; Muro, K.; Yamada, Y.; Okusaka, T.; Shirao, K.; Shimada, Y.; Nakahama, H.; Matsumura, Y. A phase I and pharmacokinetic study of NK105, a paclitaxel-incorporating micellar nanoparticle formulation Br. J. Cancer 2007, 97 (2) 170-176
13. Lee, K. S.; Chung, H. C.; Im, S. A.; Park, Y. H.; Kim, C. S.; Kim, S. B.; Rha, S. Y.; Lee, M. Y.; Ro, J. Multicenter phase II trial of Genexol-PM, a Cremophor-free, polymeric micelle formulation of paclitaxel, in patients with metastatic breast cancer Breast Cancer Res. Treat. 2008, 108 (2) 241-250
14. Allen, T. M.; Cullis, P. R. Drug Delivery Systems: Entering the Mainstream Science 2004, 303 (5665) 1818-1822
15. Wiernik, P. H.; Schwartz, E. L.; Strauman, J. J.; Dutcher, J. P.; Lipton, R. B.; Paietta, E. Phase I clinical and pharmacokinetic study of taxol Cancer Res. 1987, 47 (9) 2486-2493
16. Nyman, D. W.; Campbell, K. J.; Hersh, E.; Long, K.; Richardson, K.; Trieu, V.; Desai, N.; Hawkins, M. J.; Von Hoff, D. D. Phase I and pharmacokinetics trial of ABI-007, a novel nanoparticle formulation of paclitaxel in patients with advanced nonhematologic malignancies J. Clin. Oncol. 2005, 23 (31) 7785-7793
17. Kim, T. Y.; Kim, D. W.; Chung, J. Y.; Shin, S. G.; Kim, S. C.; Heo, D. S.; Kim, N. K.; Bang, Y. J. Phase I and pharmacokinetic study of Genexol-PM, a cremophor-free, polymeric micelle-formulated paclitaxel, in patients with advanced malignancies Clin. Cancer Res. 2004, 10 (11) 3708-3716
18. Maeda, H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting Adv. Enzyme Regul. 2001, 41 (1) 189-207
19. Matsumura, Y.; Maeda, H. A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs Cancer Res. 1986, 46 (12 Part 1) 6387-6392
20. Lammers, T.; Hennink, W. E.; Storm, G. Tumour-targeted nanomedicines: principles and practice Br. J. Cancer 2008, 99 (3) 392-397
21. Lammers, T.; Kiessling, F.; Hennink, W. E.; Storm, G. Nanotheranostics and image-guided drug delivery: current concepts and future directions Mol. Pharmaceutics 2010, 7 (6) 1899-1912
22. Sottoriva, A.; Spiteri, I.; Piccirillo, S. G. M.; Touloumis, A.; Collins, V. P.; Marioni, J. C.; Curtis, C.; Watts, C.; Tavaré, S. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics Proc. Natl. Acad. Sci. U.S.A. 2013, 110 (10) 4009-4014
23. Eisenhauer, E. A.; Therasse, P.; Bogaerts, J.; Schwartz, L. H.; Sargent, D.; Ford, R.; Dancey, J.; Arbuck, S.; Gwyther, S.; Mooney, M.; Rubinstein, L.; Shankar, L.; Dodd, L.; Kaplan, R.; Lacombe, D.; Verweij, J. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) Eur. J. Cancer 2009, 45 (2) 228-247
24. Bigbee, W.; Herberman, R. B., Tumor Markers and Immunodiagnosis. In Cancer Medicine, 6 th ed.; Kufe, D. W.; Pollock, R. E.; Weichselbaum, R. R.; Bast, R. C.; Gansler, T. S.; Holland, J. F.; Frei, E., Eds.; BC Decker: Hamilton, Ontario, 2003; pp 209-220.
25. Kaestner, S. A.; Sewell, G. J. Chemotherapy Dosing Part I: Scientific Basis for Current Practice and Use of Body Surface Area Clin. Oncol. 2007, 19 (1) 23-37
26. Al-Jamal, W. T.; Kostarelos, K. Liposomes: From a Clinically Established Drug Delivery System to a Nanoparticle Platform for Theranostic Nanomedicine Acc. Chem. Res. 2011, 44 (10) 1094-1104
27. Caldorera-Moore, M. E.; Liechty, W. B.; Peppas, N. A. Responsive Theranostic Systems: Integration of Diagnostic Imaging Agents and Responsive Controlled Release Drug Delivery Carriers Acc. Chem. Res. 2011, 44 (10) 1061-1070
28. Cole, A. J.; Yang, V. C.; David, A. E. Cancer theranostics: the rise of targeted magnetic nanoparticles Trends Biotechnol. 2011, 29 (7) 323-332
29. Janib, S. M.; Moses, A. S.; MacKay, J. A. Imaging and drug delivery using theranostic nanoparticles Adv. Drug Delivery Rev. 2010, 62 (11) 1052-1063
30. Lammers, T.; Aime, S.; Hennink, W. E.; Storm, G.; Kiessling, F. Theranostic nanomedicine Acc. Chem. Res. 2011, 44 (10) 1029-1038
31. Majumdar, D.; Peng, X. H.; Shin, D. M. The medicinal chemistry of theragnostics, multimodality imaging and applications of nanotechnology in cancer Curr. Top. Med. Chem. 2010, 10 (12) 1211-26
32. Paulmurugan, R.; Oronsky, B.; Brouse, C. F.; Reid, T.; Knox, S.; Scicinski, J. Real Time Dynamic Imaging and Current Targeted Therapies in the War on Cancer: A New Paradigm Theranostics 2013, 3 (6) 437-447
33. Dames, P.; Gleich, B.; Flemmer, A.; Hajek, K.; Seidl, N.; Wiekhorst, F.; Eberbeck, D.; Bittmann, I.; Bergemann, C.; Weyh, T.; Trahms, L.; Rosenecker, J.; Rudolph, C. Targeted delivery of magnetic aerosol droplets to the lung Nat. Nanotechnol. 2007, 2 (8) 495-499
34. Cole, A. J.; David, A. E.; Wang, J.; Galbán, C. J.; Yang, V. C. Magnetic brain tumor targeting and biodistribution of long-circulating PEG-modified, cross-linked starch-coated iron oxide nanoparticles Biomaterials 2011, 32 (26) 6291-6301
35. Heesakkers, R. A.; Jager, G. J.; Hovels, A. M.; de Hoop, B.; van den Bosch, H. C.; Raat, F.; Witjes, J. A.; Mulders, P. F.; van der Kaa, C. H.; Barentsz, J. O. Prostate cancer: detection of lymph node metastases outside the routine surgical area with ferumoxtran-10-enhanced MR imaging Radiology 2009, 251 (2) 408-414
36. Dilnawaz, F.; Singh, A.; Mohanty, C.; Sahoo, S. K. Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy Biomaterials 2010, 31 (13) 3694-3706
37. Ling, Y.; Wei, K.; Luo, Y.; Gao, X.; Zhong, S. Dual docetaxel/ superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy Biomaterials 2011, 32 (29) 7139-7150
38. Kim, D.; Jeong, Y. Y.; Jon, S. A Drug-Loaded Aptamer-Gold Nanoparticle Bioconjugate for Combined CT Imaging and Therapy of Prostate Cancer ACS Nano 2010, 4 (7) 3689-3696
39. Liu, Z.; Chen, K.; Davis, C.; Sherlock, S.; Cao, Q.; Chen, X.; Dai, H. Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment Cancer Res. 2008, 68 (16) 6652-6660
40. Liu, Z.; Sun, X.; Nakayama-Ratchford, N.; Dai, H. Supramolecular Chemistry on Water-Soluble Carbon Nanotubes for Drug Loading and Delivery ACS Nano 2007, 1 (1) 50-56
41. Welsher, K.; Liu, Z.; Sherlock, S. P.; Robinson, J. T.; Chen, Z.; Daranciang, D.; Dai, H. A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice Nat. Nanotechnol. 2009, 4 (11) 773-780
42. Welsher, K.; Sherlock, S. P.; Dai, H. Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window Proc. Natl. Acad. Sci. U.S.A. 2011, 108 (22) 8943-8948
43. Bagalkot, V.; Zhang, L.; Levy-Nissenbaum, E.; Jon, S.; Kantoff, P. W.; Langer, R.; Farokhzad, O. C. Quantum Dot-Aptamer Conjugates for Synchronous Cancer Imaging, Therapy, and Sensing of Drug Delivery Based on Bi-Fluorescence Resonance Energy Transfer Nano Lett. 2007, 7 (10) 3065-3070
44. Gao, X.; Cui, Y.; Levenson, R. M.; Chung, L. W. K.; Nie, S. In vivo cancer targeting and imaging with semiconductor quantum dots Nat. Biotechnol. 2004, 22 (8) 969-976
45. Huang, C. K.; Lo, C. L.; Chen, H. H.; Hsiue, G. H. Multifunctional Micelles for Cancer Cell Targeting, Distribution Imaging, and Anticancer Drug Delivery Adv. Funct. Mater. 2007, 17 (14) 2291-2297
46. Kim, S.; Lim, C.-K.; Na, J.; Lee, Y.-D.; Kim, K.; Choi, K.; Leary, J. F.; Kwon, I. C. Conjugated polymer nanoparticles for biomedical in vivo imaging Chem. Commun. 2010, 46 (10) 1617-1619
47. Wu, C.; Bull, B.; Szymanski, C.; Christensen, K.; McNeill, J. Multicolor Conjugated Polymer Dots for Biological Fluorescence Imaging ACS Nano 2008, 2 (11) 2415-2423
48. Davis, M. E. Design and development of IT-101, a cyclodextrin-containing polymer conjugate of camptothecin Adv. Drug Delivery Rev. 2009, 61 (13) 1189-1192
49. Schluep, T.; Hwang, J.; Hildebrandt, I. J.; Czernin, J.; Choi, C. H.; Alabi, C. A.; Mack, B. C.; Davis, M. E. Pharmacokinetics and tumor dynamics of the nanoparticle IT-101 from PET imaging and tumor histological measurements Proc. Natl. Acad. Sci. U.S.A. 2009, 106 (27) 11394-11399
50. Young, C.; Schluep, T.; Hwang, J.; Eliasof, S. CRLX101 (formerly IT-101)-A Novel Nanopharmaceutical of Camptothecin in Clinical Development Curr. Bioact. Compd. 2011, 7 (1) 8-14
51. Rapoport, N.; Nam, K.-H.; Gupta, R.; Gao, Z.; Mohan, P.; Payne, A.; Todd, N.; Liu, X.; Kim, T.; Shea, J.; Scaife, C.; Parker, D. L.; Jeong, E.-K.; Kennedy, A. M. Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions J. Controlled Release 2011, 153 (1) 4-15
52. Diamond, K. R.; Malysz, P. P.; Hayward, J. E.; Patterson, M. S. Quantification of fluorophore concentration in vivo using two simple fluorescence-based measurement techniques J. Biomed. Opt. 2005, 10 (2) 024007
53. Mourant, J. R.; Johnson, T. M.; Los, G.; Bigio, I. J. Non-invasive measurement of chemotherapy drug concentrations in tissue: preliminary demonstrations of in vivo measurements Phys. Med. Biol. 1999, 44 (5) 1397-1417
54. Palmer, G. M.; Boruta, R. J.; Viglianti, B. L.; Lan, L.; Spasojevic, I.; Dewhirst, M. W. Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy J. Controlled Release 2010, 142 (3) 457-464
55. Reif, R.; Wang, M.; Joshi, S.; A'Amar, O.; Bigio, I. J. Optical method for real-time monitoring of drug concentrations facilitates the development of novel methods for drug delivery to brain tissue J. Biomed. Opt. 2007, 12 (3) 034036
56. Saager, R. B.; Cuccia, D. J.; Saggese, S.; Kelly, K. M.; Durkin, A. J. Quantitative fluorescence imaging of protoporphyrin IX through determination of tissue optical properties in the spatial frequency domain J. Biomed. Opt. 2011, 16 (12) 126013
57. Chen, H.; Moore, T.; Qi, B.; Colvin, D. C.; Jelen, E. K.; Hitchcock, D. A.; He, J.; Mefford, O. T.; Gore, J. C.; Alexis, F.; Anker, J. N. Monitoring pH-Triggered Drug Release from Radioluminescent Nanocapsules with X-ray Excited Optical Luminescence ACS Nano 2013, 7 (2) 1178-1187
58. Koo, H.; Lee, H.; Lee, S.; Min, K. H.; Kim, M. S.; Lee, D. S.; Choi, Y.; Kwon, I. C.; Kim, K.; Jeong, S. Y. In vivo tumor diagnosis and photodynamic therapy via tumoral pH-responsive polymeric micelles Chem. Commun. 2010, 46 (31) 5668-5670
59. Tian, G.; Ren, W.; Yan, L.; Jian, S.; Gu, Z.; Zhou, L.; Jin, S.; Yin, W.; Li, S.; Zhao, Y. Red-Emitting Upconverting Nanoparticles for Photodynamic Therapy in Cancer Cells Under Near-Infrared Excitation Small 2013, 9 (11) 1929-1938
60. Viglianti, B. L.; Ponce, A. M.; Michelich, C. R.; Yu, D.; Abraham, S. A.; Sanders, L.; Yarmolenko, P. S.; Schroeder, T.; MacFall, J. R.; Barboriak, D. P.; Colvin, O. M.; Bally, M. B.; Dewhirst, M. W. Chemodosimetry of in vivo tumor liposomal drug concentration using MRI Magn. Reson. Med. 2006, 56 (5) 1011-1018
61. Cunin, F.; Schmedake, T. A.; Link, J. R.; Li, Y. Y.; Koh, J.; Bhatia, S. N.; Sailor, M. J. Biomolecular screening with encoded porous-silicon photonic crystals Nat. Mater. 2002, 1 (1) 39-41
62. Wu, E. C.; Andrew, J. S.; Cheng, L.; Freeman, W. R.; Pearson, L.; Sailor, M. J. Real-time monitoring of sustained drug release using the optical properties of porous silicon photonic crystal particles Biomaterials 2011, 32 (7) 1957-1966
63. Doan, V. V.; Sailor, M. J. Luminescent Color Image Generation on Porous Silicon Science 1992, 256 (5065) 1791-1792
64. Park, J.-H.; Gu, L.; von Maltzahn, G.; Ruoslahti, E.; Bhatia, S. N.; Sailor, M. J. Biodegradable luminescent porous silicon nanoparticles for in vivo applications Nat. Mater. 2009, 8 (4) 331-336
65. de Boer, W. D. A. M.; Timmerman, D.; Dohnalova, K.; Yassievich, I. N.; Zhang, H.; Buma, W. J.; Gregorkiewicz, T. Red spectral shift and enhanced quantum efficiency in phonon-free photoluminescence from silicon nanocrystals Nat. Nanotechnol. 2010, 5 (12) 878-884
66. Erogbogbo, F.; Yong, K.-T.; Roy, I.; Hu, R.; Law, W.-C.; Zhao, W.; Ding, H.; Wu, F.; Kumar, R.; Swihart, M. T.; Prasad, P. N. In Vivo Targeted Cancer Imaging, Sentinel Lymph Node Mapping and Multi-Channel Imaging with Biocompatible Silicon Nanocrystals ACS Nano 2010, 5 (1) 413-423
67. Gu, L.; Park, J.-H.; Duong, K. H.; Ruoslahti, E.; Sailor, M. J. Magnetic Luminescent Porous Silicon Microparticles for Localized Delivery of Molecular Drug Payloads Small 2010, 6 (22) 2546-2552
68. Mik, E. G.; Johannes, T.; Zuurbier, C. J.; Heinen, A.; Houben-Weerts, J. H. P. M.; Balestra, G. M.; Stap, J.; Beek, J. F.; Ince, C. In Vivo Mitochondrial Oxygen Tension Measured by a Delayed Fluorescence Lifetime Technique Biophy. J. 2008, 95 (8) 3977-3990
69. Jarvi, M. T.; Niedre, M. J.; Patterson, M. S.; Wilson, B. C. Singlet Oxygen Luminescence Dosimetry (SOLD) for Photodynamic Therapy: Current Status, Challenges and Future Prospects Photochem. Photobiol. 2006, 82 (5) 1198-1210
70. Niedre, M. J.; Yu, C. S.; Patterson, M. S.; Wilson, B. C. Singlet oxygen luminescence as an in vivo photodynamic therapy dose metric: validation in normal mouse skin with topical amino-levulinic acid Br. J. Cancer 2005, 92 (2) 298-304
71. Cheong, W. F.; Prahl, S. A.; Welch, A. J. A review of the optical properties of biological tissues IEEE J. Quantum Electron. 1990, 26 (12) 2166-2185
72. Savla, R.; Taratula, O.; Garbuzenko, O.; Minko, T. Tumor targeted quantum dot-mucin 1 aptamer-doxorubicin conjugate for imaging and treatment of cancer J. Controlled Release 2011, 153 (1) 16-22
73. Hampl, J.; Hall, M.; Mufti, N. A.; Yao, Y.-m. M.; MacQueen, D. B.; Wright, W. H.; Cooper, D. E. Upconverting Phosphor Reporters in Immunochromatographic Assays Anal. Biochem. 2001, 288 (2) 176-187
74. Ukonaho, T.; Rantanen, T.; Jämsen, L.; Kuningas, K.; Päkkilä, H.; Lövgren, T.; Soukka, T. Comparison of infrared-excited up-converting phosphors and europium nanoparticles as labels in a two-site immunoassay Anal. Chim. Acta 2007, 596 (1) 106-115
75. Petoral, R. M.; Söderlind, F.; Klasson, A.; Suska, A.; Fortin, M. A.; Abrikossova, N.; SelegaÌŠrd, L.; Käll, P.-O.; Engström, M.; Uvdal, K. Synthesis and Characterization of Tb3+-Doped Gd2O3 Nanocrystals: A Bifunctional Material with Combined Fluorescent Labeling and MRI Contrast Agent Properties J. Phys. Chem. C 2009, 113 (17) 6913-6920
76. Mader, H. S.; Kele, P.; Saleh, S. M.; Wolfbeis, O. S. Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging Curr. Opin. Chem. Biol. 2010, 14 (5) 582-596
77. Xu, Z.; Gao, Y.; Huang, S.; Ma, P.; Lin, J.; Fang, J. A luminescent and mesoporous core-shell structured Gd2O3: Eu(3+)@nSiO2@mSiO2 nanocomposite as a drug carrier Dalton Trans. 2011, 40 (18) 4846-4854
78. Capozzi, V.; Perna, G.; Carmone, P.; Gallone, A.; Lastella, M.; Mezzenga, E.; Quartucci, G.; Ambrico, M.; Augelli, V.; Biagi, P. F.; Ligonzo, T.; Minafra, A.; Schiavulli, L.; Pallara, M.; Cicero, R. Optical and photoelectronic properties of melanin Thin Solid Films 2006, 511-512 (0) 362-366
79. Sarna, T.; Swartz, H. A. The Physical Properties of Melanins. In The Pigmentary System: Physiology and Pathophysiology, 2 nd edition; Nordlung, J. J.; Boissy, R. E.; Hearing, V. J.; King, R. A.; Oetting, W. S.; Ortonne, J. P., Eds.; Oxford University Press: New York, 1998; pp 311-341.
80. Ortonne, J. P. Photoprotective properties of skin melanin Br. J. Dermatol. 2002, 146 (s61) 7-10
81. de Gruijl, F. R.; van Kranen, H. J.; Mullenders, L. H. F. UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer J. Photochem. Photobiol., B 2001, 63 (1-3) 19-27
82. Stolik, S.; Delgado, J. A.; Pérez, A.; Anasagasti, L. Measurement of the penetration depths of red and near infrared light in human "ex vivo" tissues J. Photochem. Photobiol., B 2000, 57 (2-3) 90-93
83. Chen, H.; Colvin, D. C.; Qi, B.; Moore, T.; He, J.; Mefford, O. T.; Alexis, F.; Gore, J. C.; Anker, J. N. Magnetic and optical properties of multifunctional core-shell radioluminescence nanoparticles J. Mater. Chem. 2012, 22 (25) 12802-12809
84. Gai, S.; Yang, P.; Li, C.; Wang, W.; Dai, Y.; Niu, N.; Lin, J. Synthesis of Magnetic, Up-Conversion Luminescent, and Mesoporous Core-Shell-Structured Nanocomposites as Drug Carriers Adv. Funct. Mater. 2010, 20 (7) 1166-1172
85. Kang, X.; Cheng, Z.; Li, C.; Yang, D.; Shang, M.; Ma, P. Ä.; Li, G.; Liu, N.; Lin, J. Core-Shell Structured Up-Conversion Luminescent and Mesoporous NaYF4:Yb3+/Er3+@nSiO2@mSiO2 Nanospheres as Carriers for Drug Delivery J. Phys. Chem. C 2011, 115 (32) 15801-15811
86. 3+-doped Nanophosphors as Bioimaging Probes Adv. Mater. 2011, 23 (24) H195-H199
87. Champion, J. A.; Mitragotri, S. Role of target geometry in phagocytosis Proc. Natl. Acad. Sci. U.S.A. 2006, 103 (13) 4930-4934
88. Geng, Y.; Dalhaimer, P.; Cai, S.; Tsai, R.; Tewari, M.; Minko, T.; Discher, D. E. Shape effects of filaments versus spherical particles in flow and drug delivery Nat. Nanotechnol. 2007, 2 (4) 249-255
89. Huang, X.; Li, L.; Liu, T.; Hao, N.; Liu, H.; Chen, D.; Tang, F. The shape effect of mesoporous silica nanoparticles on biodistribution, clearance, and biocompatibility in vivo ACS Nano 2011, 5 (7) 5390-5399
90. Ntziachristos, V. Going deeper than microscopy: the optical imaging frontier in biology Nat. Methods 2010, 7 (8) 603
91. Xu, C. T.; Svenmarker, P.; Liu, H.; Wu, X.; Messing, M. E.; Wallenberg, L. R.; Andersson-Engels, S. High-Resolution Fluorescence Diffuse Optical Tomography Developed with Nonlinear Upconverting Nanoparticles ACS Nano 2012, 6 (6) 4788-4795
92. Carpenter, C. M.; Sun, C.; Pratx, G.; Rao, R.; Xing, L. Hybrid x-ray/optical luminescence imaging: characterization of experimental conditions Med. Phys. 2010, 37 (8) 4011-4018
93. Carpenter, C. M.; Pratx, G.; Sun, C.; Xing, L. Limited-angle x-ray luminescence tomography: methodology and feasibility study Phys. Med. Biol. 2011, 56 (12) 3487
94. Chen, D.; Zhu, S.; Yi, H.; Zhang, X.; Chen, D.; Liang, J.; Tian, J. Cone beam x-ray luminescence computed tomography: A feasibility study Med. Phys. 2013, 40 (3) 031111-14
95. Edelman, R. R.; Warach, S. Magnetic Resonance Imaging N. Engl. J. Med. 1993, 328 (10) 708-716
96. Lee, D. C.; Carroll, T. J. Magnetic Resonance Iimaging. In Practical Signal and Image Processing in Clinical Cardiology; Goldberger, J. J.; Ng, J., Eds.; Springer: London, 2010; pp 251-273.
97. Jun, Y. W.; Lee, J. H.; Cheon, J. Chemical design of nanoparticle probes for high-performance magnetic resonance imaging Angew. Chem., Int. Ed. Engl. 2008, 47 (28) 5122-5135
98. Ponce, A. M.; Viglianti, B. L.; Yu, D.; Yarmolenko, P. S.; Michelich, C. R.; Woo, J.; Bally, M. B.; Dewhirst, M. W. Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects J. Natl. Cancer Inst. 2007, 99 (1) 53-63
99. Abraham, S. A.; Edwards, K.; Karlsson, G. r.; MacIntosh, S.; Mayer, L. D.; McKenzie, C.; Bally, M. B. Formation of transition metal-doxorubicin complexes inside liposomes Biochim. Biophys. Acta, Biomembr. 2002, 1565 (1) 41-54
100. Viglianti, B. L.; Abraham, S. A.; Michelich, C. R.; Yarmolenko, P. S.; MacFall, J. R.; Bally, M. B.; Dewhirst, M. W. In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: Illustration of targeted delivery Magn. Reson. Med. 2004, 51 (6) 1153-1162
101. Needham, D.; Anyarambhatla, G.; Kong, G.; Dewhirst, M. W. A New Temperature-sensitive Liposome for Use with Mild Hyperthermia: Characterization and Testing in a Human Tumor Xenograft Model Cancer Res. 2000, 60 (5) 1197-1201
102. Crossgrove, J.; Zheng, W. Manganese toxicity upon overexposure NMR Biomed. 2004, 17 (8) 544-553
103. Parenti, M.; Rusconi, L.; Cappabianca, V.; Parati, E. A.; Groppetti, A. Role of dopamine in manganese neurotoxicity Brain Res. 1988, 473 (2) 236-240
104. Lentschig, M. G.; Reimer, P.; Rausch-Lentschig, U. L.; Allkemper, T.; Oelerich, M.; Laub, G. Breath-hold gadolinium-enhanced MR angiography of the major vessels at 1.0 T: dose-response findings and angiographic correlation Radiology 1998, 208 (2) 353-357
105. de Smet, M.; Langereis, S.; den Bosch, S. v.; Grüll, H. Temperature-sensitive liposomes for doxorubicin delivery under MRI guidance J. Controlled Release 2010, 143 (1) 120-127
106. de Smet, M.; Heijman, E.; Langereis, S.; Hijnen, N. M.; Grüll, H. Magnetic resonance imaging of high intensity focused ultrasound mediated drug delivery from temperature-sensitive liposomes: An in vivo proof-of-concept study J. Controlled Release 2011, 150 (1) 102-110
107. Tagami, T.; Foltz, W. D.; Ernsting, M. J.; Lee, C. M.; Tannock, I. F.; May, J. P.; Li, S. D. MRI monitoring of intratumoral drug delivery and prediction of the therapeutic effect with a multifunctional thermosensitive liposome Biomaterials 2011, 32 (27) 6570-6578
108. Negussie, A. H.; Yarmolenko, P. S.; Partanen, A.; Ranjan, A.; Jacobs, G.; Woods, D.; Bryant, H.; Thomasson, D.; Dewhirst, M. W.; Wood, B. J.; Dreher, M. R. Formulation and characterisation of magnetic resonance imageable thermally sensitive liposomes for use with magnetic resonance-guided high intensity focused ultrasound Int. J. Hyperthermia 2011, 27 (2) 140-155
109. Santra, S.; Jativa, S. D.; Kaittanis, C.; Normand, G.; Grimm, J.; Perez, J. M. Gadolinium-encapsulating iron oxide nanoprobe as activatable NMR/MRI contrast agent ACS Nano 2012, 6 (8) 7281-7294
110. Hardman, R. A toxicologic review of quantum dots: toxicity depends on physicochemical and environmental factors Environ. Health Perspect. 2006, 114 (2) 165-172
111. Derfus, A. M.; Chan, W. C. W.; Bhatia, S. N. Probing the Cytotoxicity of Semiconductor Quantum Dots Nano Lett. 2003, 4 (1) 11-18
112. Ye, L.; Yong, K.-T.; Liu, L.; Roy, I.; Hu, R.; Zhu, J.; Cai, H.; Law, W.-C.; Liu, J.; Wang, K.; Liu, J.; Liu, Y.; Hu, Y.; Zhang, X.; Swihart, M. T.; Prasad, P. N. A pilot study in non-human primates shows no adverse response to intravenous injection of quantum dots Nat. Nanotechnol. 2012, 7 (7) 453-458
113. Yong, K.-T.; Law, W.-C.; Hu, R.; Ye, L.; Liu, L.; Swihart, M. T.; Prasad, P. N. Nanotoxicity assessment of quantum dots: from cellular to primate studies Chem. Soc. Rev. 2013, 42 (3) 1236-1250
114. Liu, J.; Erogbogbo, F.; Yong, K.-T.; Ye, L.; Liu, J.; Hu, R.; Chen, H.; Hu, Y.; Yang, Y.; Yang, J.; Roy, I.; Karker, N. A.; Swihart, M. T.; Prasad, P. N. Assessing Clinical Prospects of Silicon Quantum Dots: Studies in Mice and Monkeys ACS Nano 2013, 7 (8) 7303-7310
115. Cobley, C. M.; Chen, J.; Cho, E. C.; Wang, L. V.; Xia, Y. Gold nanostructures: a class of multifunctional materials for biomedical applications Chem. Soc. Rev. 2011, 40 (1) 44-56
116. Abraham, G. E.; Himmel, P. B. Management of Rheumatoid Arthritis: Rationale for the Use of Colloidal Metallic Gold J. Nutr. Environ. Med. 1997, 7 (4) 295-305
117. The Research Sub-Committee of the Empire Rheumatism Council. Gold Therapy in Rheumatoid Arthritis: Final Report of a Multicentre Controlled Trial. Ann. Rheum. Dis. 1961, 20 (4), 315-334.
118. Stroh, A.; Zimmer, C.; Gutzeit, C.; Jakstadt, M.; Marschinke, F.; Jung, T.; Pilgrimm, H.; Grune, T. Iron oxide particles for molecular magnetic resonance imaging cause transient oxidative stress in rat macrophages Free Radical Biol. Med. 2004, 36 (8) 976-84
119. Chu, K. S.; Hasan, W.; Rawal, S.; Walsh, M. D.; Enlow, E. M.; Luft, J. C.; Bridges, A. S.; Kuijer, J. L.; Napier, M. E.; Zamboni, W. C.; DeSimone, J. M. Plasma, tumor and tissue pharmacokinetics of Docetaxel delivered via nanoparticles of different sizes and shapes in mice bearing SKOV-3 human ovarian carcinoma xenograft Nanomedicine (New York, NY, U.S.) 2013, 9 (5) 686-693
120. Perrault, S. D.; Walkey, C.; Jennings, T.; Fischer, H. C.; Chan, W. C. W. Mediating Tumor Targeting Efficiency of Nanoparticles Through Design Nano Lett. 2009, 9 (5) 1909-1915
121. Kostarelos, K.; Bianco, A.; Prato, M. Promises, facts and challenges for carbon nanotubes in imaging and therapeutics Nat. Nanotechnol. 2009, 4 (10) 627-633
122. Poland, C. A.; Duffin, R.; Kinloch, I.; Maynard, A.; Wallace, W. A. H.; Seaton, A.; Stone, V.; Brown, S.; MacNee, W.; Donaldson, K. Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study Nat. Nanotechnol. 2008, 3 (7) 423-428
123. Schipper, M. L.; Nakayama-Ratchford, N.; Davis, C. R.; Wong Shi Kam, N.; Chu, P.; Zhuang, L.; Xiaoming, S.; Hongjie, D.; Gambhir, S. S. A pilot toxicology study of single-walled carbon nanotubes in a small sample of mice Nat. Nanotechnol. 2008, 3 (4) 216-221
124. Bai, Y.; Zhang, Y.; Zhang, J.; Mu, Q.; Zhang, W.; Butch, E. R.; Snyder, S. E.; Yan, B. Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility Nat. Nanotechnol. 2010, 5 (9) 683-689
125. Lacerda, L.; Ali-Boucetta, H.; Herrero, M. A.; Pastorin, G.; Bianco, A.; Prato, M.; Kostarelos, K. Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes Nanomedicine (London, U.K.) 2008, 3 (2) 149-161
126. Singh, R.; Pantarotto, D.; Lacerda, L.; Pastorin, G.; Klumpp, C. d.; Prato, M.; Bianco, A.; Kostarelos, K. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers Proc. Natl. Acad. Sci. U.S.A. 2006, 103 (9) 3357-3362
127. Murray, A. R.; Kisin, E. R.; Tkach, A. V.; Yanamala, N.; Mercer, R.; Young, S. H.; Fadeel, B.; Kagan, V. E.; Shvedova, A. A. Factoring-in agglomeration of carbon nanotubes and nanofibers for better prediction of their toxicity versus asbestos Part. Fibre Toxicol. 2012, 9, 10
128. Tang, A. C. L.; Hwang, G.-L.; Tsai, S.-J.; Chang, M.-Y.; Tang, Z. C. W.; Tsai, M.-D.; Luo, C.-Y.; Hoffman, A. S.; Hsieh, P. C. H. Biosafety of Non-Surface Modified Carbon Nanocapsules as a Potential Alternative to Carbon Nanotubes for Drug Delivery Purposes PLoS One 2012, 7 (3) e32893
129. Connor, E. E.; Mwamuka, J.; Gole, A.; Murphy, C. J.; Wyatt, M. D. Gold Nanoparticles Are Taken Up by Human Cells but Do Not Cause Acute Cytotoxicity Small 2005, 1 (3) 325-327
130. Niidome, T.; Yamagata, M.; Okamoto, Y.; Akiyama, Y.; Takahashi, H.; Kawano, T.; Katayama, Y.; Niidome, Y. PEG-modified gold nanorods with a stealth character for in vivo applications J. Controlled Release 2006, 114 (3) 343-347
131. Hale, G. M.; Querry, M. R. Optical Constants of Water in the 200-nm to 200-μm Wavelength Region Appl. Opt. 1973, 12 (3) 555-563
132. Lim, Y. T.; Kim, S.; Nakayama, A.; Stott, N. E.; Bawendi, M. G.; Frangioni, J. V. Selection of quantum dot wavelengths for biomedical assays and imaging Mol. Imaging 2003, 2 (1) 50-64
133. Smith, A. M.; Mancini, M. C.; Nie, S. Bioimaging: Second window for in vivo imaging Nat Nanotechnol. 2009, 4 (11) 710-711
134. Won, N.; Jeong, S.; Kim, K.; Kwag, J.; Park, J.; Kim, S. G.; Kim, S. Imaging depths of near-infrared quantum dots in first and second optical windows Mol. Imaging 2012, 11 (4) 338-352
135. Weissleder, R. A clearer vision for in vivo imaging Nat. Biotechnol. 2001, 19 (4) 316-317
136. Li, Y. Y.; Cunin, F.; Link, J. R.; Gao, T.; Betts, R. E.; Reiver, S. H.; Chin, V.; Bhatia, S. N.; Sailor, M. J. Polymer Replicas of Photonic Porous Silicon for Sensing and Drug Delivery Applications Science 2003, 299 (5615) 2045-2047
137. Dolmans, D. E. J. G. J.; Fukumura, D.; Jain, R. K. Photodynamic therapy for cancer Nat. Rev. Cancer 2003, 3 (5) 380-387
138. Burgess, P.; Hutt, P. B.; Farokhzad, O. C.; Langer, R.; Minick, S.; Zale, S. On firm ground: IP protection of therapeutic nanoparticles Nat. Biotechnol. 2010, 28 (12) 1267-1270
139. Kirkpatrick, D. L.; Weiss, M.; Naumov, A.; Bartholomeusz, G.; Weisman, R. B.; Gliko, O. Carbon Nanotubes: Solution for the Therapeutic Delivery of siRNA? Materials 2012, 5 (2) 278-301
140. O'Neal, D. P.; Hirsch, L. R.; Halas, N. J.; Payne, J. D.; West, J. L. Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles Cancer Lett. 2004, 209 (2) 171-176
141. Schwartz, J. A.; Shetty, A. M.; Price, R. E.; Stafford, R. J.; Wang, J. C.; Uthamanthil, R. K.; Pham, K.; McNichols, R. J.; Coleman, C. L.; Payne, J. D. Feasibility study of particle-assisted laser ablation of brain tumors in orthotopic canine model Cancer Res. 2009, 69 (4) 1659-1667
142. Schwartz, J. A.; Price, R. E.; Gill-Sharp, K. L.; Sang, K. L.; Khorchani, J.; Goodwin, B. S.; Payne, J. D. Selective nanoparticle-directed ablation of the canine prostate Lasers Surg. Med. 2011, 43 (3) 213-220
143. Libutti, S. K.; Paciotti, G. F.; Byrnes, A. A.; Alexander, H. R.; Gannon, W. E.; Walker, M.; Seidel, G. D.; Yuldasheva, N.; Tamarkin, L. Phase I and Pharmacokinetic Studies of CYT-6091, a Novel PEGylated Colloidal Gold-rhTNF Nanomedicine Clin. Cancer Res. 2010, 16 (24) 6139-6149
144. Bourrinet, P.; Bengele, H. H.; Bonnemain, B.; Dencausse, A.; Idee, J. M.; Jacobs, P. M.; Lewis, J. M. Preclinical safety and pharmacokinetic profile of ferumoxtran-10, an ultrasmall superparamagnetic iron oxide magnetic resonance contrast agent Invest. Radiol. 2006, 41 (3) 313-324
145. Sharma, R.; Saini, S.; Ros, P. R.; Hahn, P. F.; Small, W. C.; de Lange, E. E.; Stillman, A. E.; Edelman, R. R.; Runge, V. M.; Outwater, E. K.; Morris, M.; Lucas, M. Safety profile of ultrasmall superparamagnetic iron oxide ferumoxtran-10: phase II clinical trial data J. Magn. Reson. Imaging 1999, 9 (2) 291-294
146. Willmann, J. K.; van Bruggen, N.; Dinkelborg, L. M.; Gambhir, S. S. Molecular imaging in drug development Nat. Rev. Drug Discovery 2008, 7, 591-607
147. Gerd, M.; Joel, S. K. Positron emission tomography Phys. Med. Biol. 2006, 51 (13) R117
148. Li, Z.; Conti, P. S. Radiopharmaceutical chemistry for positron emission tomography Adv. Drug Delivery Rev. 2010, 62 (11) 1031-1051