Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility

Nature Nanotechnology

Volumn 5, Issue 9, 2010, Pages 683-689

  Bai, Yuhong ^a   Zhang, Yi ^a,b   Zhang, Jingping ^a   Mu, Qingxin ^b,c   Zhang, Weidong ^d   Butch, Elizabeth R ^b   Snyder, Scott E ^b   Yan, Bing ^b,c  

^a SHANDONG UNIVERSITY   (China)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c Shandong University   (China)

^d SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONES; MAMMALS; NANOTUBES; YARN;

IMAGING APPLICATIONS; IN-VIVO; INTRAVENOUS INJECTIONS; MALE MOUSE; SEX HORMONES; SOLUBLE CARBON NANOTUBE; WATERSOLUBLE;

MULTIWALLED CARBON NANOTUBES (MWCN);

CARBON NANOTUBE; SEX HORMONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; MALE; MALE FERTILITY; MALE GENITAL TRACT PARAMETERS; MATING; MOUSE; NONHUMAN; OXIDATIVE STRESS; PREGNANCY OUTCOME; PREGNANCY RATE; PRIORITY JOURNAL; REVERSIBLE TESTIS DAMAGE; SEMINIFEROUS TUBULE EPITHELIUM; SOLUBILITY; SPERM INTEGRITY; SPERM QUALITY; SPERMATOZOON COUNT; TESTIS; TESTIS INJURY; TISSUE REPAIR;

EID: 77956442702     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2010.153     Document Type: Article

References (46)

1. Lacerda, L., Bianco, A., Prato, M. & Kostarelos, K. Carbon nanotubes as nanomedicines: from toxicology to pharmacology. Adv. Drug Deliv. Rev. 58, 1460-1470 (2006).
2. Liu, Z. et al. In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice. Nature Nanotech. 2, 47-52 (2007).
3. Usui, Y. et al. Carbon nanotubes with high bone-tissue compatibility and boneformation acceleration effects. Small 4, 240-246 (2008).
4. Chen, J. Y. et al. Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery. J. Am. Chem. Soc. 130, 16778-16785 (2008).
5. Singh, R. et al. Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers. Proc. Natl Acad. Sci. USA 103, 3357-3362 (2006).
6. Yang, S. T. et al. Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice. Toxicol. Lett. 181, 182-189 (2008).
7. Manna, S. K. et al. Single-walled carbon nanotube induces oxidative stress and activates nuclear transcription factor-kappa B in human keratinocytes. Nano Lett. 5, 1676-1684 (2005).
8. Shvedova, A. A. et al. Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress and mutagenesis. Am. J. Physiol. Lung Cell. Mol. Physiol. 295, 552-565 (2008).
9. Ravichandran, P. et al. Induction of apoptosis in rat lung epithelial cells by multiwalled carbon nanotubes. J. Biochem. Mol. Toxicol. 23, 333-344 (2009).
10. Bottini, M. et al. Multi-walled carbon nanotubes induce T lymphocyte apoptosis. Toxicol. Lett. 160, 121-126 (2006).
11. Warheit, D. B. et al. Comparative pulmonary toxicity assessment of single-wall carbon nanotubes in rats. Toxicol. Sci. 77, 117-125 (2004).
12. Li, Z. et al. Cardiovascular effects of pulmonary exposure to single-wall carbon nanotubes. Environ. Health Perspect. 115, 377-382 (2007).
13. Shvedova, A. A. et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 289, 698-708 (2005).
14. Ma-Hock, L. et al. Inhalation toxicity of multiwall carbon nanotubes in rats exposed for 3 months. Toxicol. Sci. 112, 468-481 (2009).
15. Sakamoto, Y. et al. Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats. J. Toxicol. Sci. 34, 65-76 (2009).
16. Miyawaki, J., Yudasaka, M., Azami, T., Kubo, Y. & Iijima, S. Toxicity of singlewalled carbon nanohorns. ACS Nano 2, 213-226 (2008).
17. Bonde, J. P. Male reproductive organs are at risk from environmental hazards. Asian J. Androl. 12, 152-156 (2010).
18. Yoshida, S. et al. Effect of nanoparticles on the male reproductive system of mice. Int. J. Androl. 32, 337-342 (2009).
19. Yoshida, S. et al. Effects of fetal exposure to carbon nanoparticles on reproductive function in male offspring. Fertil. Steril. 93, 1695-1699 (2010).
20. Purvis, K. & Christiansen, E. Male infertility: current concepts. Ann. Med. 24, 259-272 (1992).
21. Howards, S. S. Treatment of male infertility. N. Engl. J. Med. 332, 312-317 (1995).
22. Saleh, R. A. & Agarwal, A. Oxidative stress and male infertility: from research bench to clinical practice. J. Androl. 23, 737-752 (2002). (Pubitemid 36300961)
23. Tremellen, K. Oxidative stress and male infertility-a clinical perspective. Hum. Reprod. Update 14, 243-258 (2008).
24. Xia, T. et al. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett. 6, 1794-1807 (2006).
25. Liu, Z. et al. Drug delivery with carbon nanotubes for in vivo cancer treatment. Cancer Res. 68, 6652-6660 (2008).
26. De Jong, W. H. et al. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 29, 1912-1919 (2008).
27. Kwon, J. T. et al. Body distribution of inhaled fluorescent magnetic nanoparticles in the mice. J. Occup. Health 50, 1-6 (2008).
28. Li, M. W. M., Mruk, D. D., Lee, W. M. & Cheng, C. Y. Cytokines and junction restructuring events during spermatogenesis in the testis: an emerging concept of regulation. Cytokine Growth Factor Rev. 20, 329-338 (2009).
29. Cheng, C. Y. & Mruk, D. D. Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol. Rev. 82, 825-874 (2002).
30. Meistrich, M. L. et al. Rapid recovery of spermatogenesis after mitoxantrone, vincristine, vinblastine and prednisone chemotherapy for Hodgkins disease. J. Clin. Oncol. 15, 3488-3495 (1997)
31. Mandal, T. K. & Das, N. S. Testicular toxicity in cannabis extract treated mice: association with oxidative stress and role of antioxidant enzyme systems. Toxicol. Ind. Health 26, 11-23 (2010).
32. Lacerda, L. et al. Tissue histology and physiology following intravenous administration of different types of functionalized multiwalled carbon nanotubes. Nanomedicine 3, 149-161 (2008).
33. Safe, S. H. Polychlorinated biphenyls (PCBs): environmental impact, biochemical and toxic responses, and implications for risk assessment. Crit. Rev. Toxicol. 24, 87-149 (1994).
34. Rodamilans, M. et al. Lead toxicity on endocrine testicular function in an occupationally exposed population. Hum. Toxicol. 7, 125-128 (1988).
35. Li, C. M. et al. Effects of inhaled nanoparticle-rich diesel exhaust on regulation of testicular function in adult male rats. Inhal. Toxicol. 21, 803-811 (2009).
36. Ramdhan, D. H. et al. Nanoparticle-rich diesel exhaust may disrupt testosterone biosynthesis and metabolism via growth hormone. Toxicol. Lett. 191, 103-108 (2009).
37. Davies, K. J. Oxidative stress: the paradox of aerobic life. Biochem. Soc. Symp. 61, 1-31 (1995).
38. Kazzaz, J. A. et al. Cellular oxygen toxicity: oxidant injury without apoptosis. J. Biol. Chem. 271, 15182-15186 (1996).
39. Alvarez, J. G., Touchstone, J. C., Blasco, L. & Storey, B. T. Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa. Superoxide dismutase as major enzyme protectant against oxygen toxicity. J. Androl. 8, 338-348 (1987).
40. Sergerie, M., Laforest, G., Bujan, L., Bissonnette, F. & Bleau, G. Sperm DNA fragmentation: threshold value in male fertility. Hum. Reprod. 20, 3446-3451 (2005). (Pubitemid 41742526)
41. Calvo, L., Dennison-Lagos, L., Banks, S. M. & Sherins, R. J. Characterization and frequency distribution of sperm acrosome reaction among normal and infertile men. Hum. Reprod. 9, 1875-1879 (1994).
42. Goyal, H. O. et al. Neonatal estrogen exposure of male rats alters reproductive functions at adulthood. Biol. Reprod. 68, 2081-2091 (2003).
43. Zhou, H. Y. et al. A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity and immune response. Nano Lett. 8, 859-865 (2008).
44. Watanabe, T. & Endo, A. Effects of selenium deficiency on sperm morphology and spermatocyte chromosomes in mice. Mutat. Res. 262, 93-99 (1991).
45. Santos, J. R. et al. Probing the structure and function of mammalian sperm using optical and fluorescence microscopy. Mod. Res. Educ. Topics Microsc. 21, 394-402 (2007).
46. Ozaki, T., Takahashi, K., Kanasaki, H. & Miyazaki, K. Evaluation of acrosome reaction and viability of human sperm with two fluorescent dyes. Arch. Gynecol. Obstet. 266, 114-117 (2002).