Responsive theranostic systems: Integration of diagnostic imaging agents and responsive controlled release drug delivery carriers

Accounts of Chemical Research

Volumn 44, Issue 10, 2011, Pages 1061-1070

  Caldorera Moore, Mary E ^a   Liechty, William B ^a   Peppas, Nicholas A ^a,b  

^a The University of Texas at Austin   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIAGNOSTIC AGENT; DRUG CARRIER; NANOPARTICLE;

ANIMAL; ARTICLE; CHEMISTRY; DELAYED RELEASE FORMULATION; DIAGNOSTIC IMAGING; HUMAN; METHODOLOGY; MOLECULARLY TARGETED THERAPY; NANOMEDICINE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; DELAYED-ACTION PREPARATIONS; DIAGNOSTIC IMAGING; DRUG CARRIERS; HUMANS; MOLECULAR TARGETED THERAPY; NANOMEDICINE; NANOPARTICLES;

EID: 80054769452     PISSN: 00014842     EISSN: 15204898     Source Type: Journal    
DOI: 10.1021/ar2001777     Document Type: Article

References (53)

1. Xie, J.; Chen, K.; Huang, J.; Lee, S.; Wang, J. H.; Gao, J.; Li, X. G.; Chen, X. Y. PET/NIRF/MRI triple functional iron oxide nanoparticles Biomaterials 2010, 31, 3016-3022
2. Islam, T.; Josephson, L. Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticles Cancer Biomarkers 2009, 5, 99-107
3. Thorek, D. L. J.; Chen, A.; Czupryna, J.; Tsourkas, A. Superparamagnetic iron oxide nanoparticle probes for molecular imaging Ann. Biomed. Eng. 2006, 34, 23-38
4. Caldorera-Moore, M.; Peppas, N. A. Micro- and nanotechnologies for intelligent and responsive biomaterial-based medical systems Adv. Drug Delivery Rev. 2009, 61, 1391-1401
5. Liechty, W. B.; Kryscio, D. R.; Slaughter, B. V.; Peppas, N. A. Polymers for drug delivery systems Annu. Rev. Chem. Biomol. Eng. 2010, 1, 149-173
6. Liechty, W. B.; Caldorera-Moore, M.; Phillips, M. A.; Schoener, C.; Peppas, N. A. Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics. J. Controlled Release 2011, in press.
7. Zalipsky, S.; Qazen, M.; Walker, J. A.; Mullah, N.; Quinn, Y. P.; Huang, S. K. New detachable poly(ethylene glycol) conjugates: Cysteine-cleavable lipopolymers regenerating natural phospholipid, diacyl phosphatidylethanolamine Bioconjugate Chem. 1999, 10, 703-707 (Pubitemid 29456355)
8. Owens, D. E.; Eby, J. K.; Jian, Y.; Peppas, N. A. Temperature-responsive polymer-gold nanocomposites as intelligent therapeutic systems J. Biomed. Mater. Res., Part A 2007, 83A, 692-695 (Pubitemid 350086295)
9. Owens, D. E.; Jian, Y. C.; Fang, J. E.; Slaughter, B. V.; Chen, Y. H.; Peppas, N. A. Thermally responsive swelling properties of polyacrylamide/ poly(acrylic acid) interpenetrating polymer network nanoparticles Macromolecules 2007, 40, 7306-7310 (Pubitemid 47583080)
10. Zou, P.; Yu, Y.; Wang, Y. A.; Zhong, Y.; Welton, A.; GalbaÌn, C.; Wang, S.; Sun, D. Superparamagnetic iron oxide nanotheranostics for targeted cancer cell imaging and pH-dependent intracellular drug release Mol. Pharmaceutics 2010, 7, 1974-1984
11. Bikram, M.; Gobin, A. M.; Whitmire, R. E.; West, J. L. Temperature-sensitive hydrogels with SiO2-Au nanoshells for controlled drug delivery J. Controlled Release 2007, 123, 219-227 (Pubitemid 350007822)
12. El-Sayed, I. H.; Huang, X.; El-Sayed, M. A. Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in Oral Cancer Nano Lett. 2005, 5, 829-834 (Pubitemid 40749040)
13. Huang, X.; El-Sayed, I. H.; Qian, W.; El-Sayed, M. A. Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods J. Am. Chem. Soc. 2006, 128, 2115-2120 (Pubitemid 43277351)
14. Homan, K.; Shah, J.; Gomez, S.; Gensler, H.; Karpiouk, A.; Brannon-Peppas, L.; Emelianov, S. Silver nanosystems for photoacoustic imaging and image-guided therapy J. Biomed. Opt. 2010, 15 021316
15. Janib, S. M.; Moses, A. S.; MacKay, J. A. Imaging and drug delivery using theranostic nanoparticles Adv. Drug Delivery Rev. 2010, 62, 1052-1063
16. El-Sayed, I. H.; Huang, X.; El-Sayed, M. A. Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles Cancer Lett. 2006, 239, 129-135 (Pubitemid 43946581)
17. Gannon, C.; Patra, C.; Bhattacharya, R.; Mukherjee, P.; Curley, S. Intracellular gold nanoparticles enhance non-invasive radiofrequency thermal destruction of human gastrointestinal cancer cells J. Nanobiotechnol. 2008, 6 2
18. Curley, S. A.; Cherukuri, P.; Briggs, K.; Patra, C. R.; Upton, M.; Dolson, E.; Mukherjee, P. Noninvasive radiofrequency field-induced hyperthermic cytotoxicity in human cancer cells using cetuximab-targeted gold nanoparticles J. Exp. Ther. Oncol. 2008, 7, 313-326
19. Matsumura, Y.; Maeda, H. A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent Smancs Cancer Res. 1986, 46, 6387-6392 (Pubitemid 17221789)
20. Guthi, J. S.; Yang, S. G.; Huang, G.; Li, S. Z.; Khemtong, C.; Kessinger, C. W.; Peyton, M.; Minna, J. D.; Brown, K. C.; Gao, J. M. MRI-visible micellar nanomedicine for targeted drug delivery to lung cancer cells Mol. Pharmaceutics 2010, 7, 32-40
21. Barth, B. M.; Sharma, R.; Altinoglu, E. I.; Morgan, T. T.; Shanmugavelandy, S. S.; Kaiser, J. M.; McGovern, C.; Matters, G. L.; Smith, J. P.; Kester, M.; Adair, J. H. Bioconjugation of calcium phosphosilicate composite nanoparticles for selective targeting of human breast and pancreatic cancers in vivo ACS Nano 2010, 4, 1279-1287
22. Colombo, M.; Corsi, F.; Foschi, D.; Mazzantini, E.; Mazzucchelli, S.; Morasso, C.; Occhipinti, E.; Polito, L.; Prosperi, D.; Ronchi, S.; Verderio, P. HER2 targeting as a two-sided strategy for breast cancer diagnosis and treatment: Outlook and recent implications in nanomedical approaches Pharmacol. Res. 2010, 62, 150-165
23. Lee, J. H.; Yigit, M. V.; Mazumdar, D.; Lu, Y. Molecular diagnostic and drug delivery agents based on aptamer-nanomaterial conjugates Adv. Drug Delivery Rev. 2010, 62, 592-605
24. Lemarchand, C.; Gref, R.; Couvreur, P. Polysaccharide-decorated nanoparticles Eur. J. Pharm. Biopharm. 2004, 58, 327-341 (Pubitemid 39037239)
25. Santra, S.; Kaittanis, C.; Grimm, J.; Perez, J. M. Drug/dye-loaded, multifunctional iron oxide nanoparticles for combined targeted cancer therapy and dual optical/magnetic resonance imaging Small 2009, 5, 1862-1868
26. Bartlett, D. W.; Su, H.; Hildebrandt, I. J.; Weber, W. A.; Davis, M. E. Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 15549-15554 (Pubitemid 47502954)
27. Slaughter, B. V.; Khurshid, S. S.; Fisher, O. Z.; Khademhosseini, A.; Peppas, N. A. Hydrogels in Regenerative Medicine Adv. Mater. 2009, 21, 3307-3329
28. McCarthy, J. R.; Jaffer, F. A.; Weissleder, R. A macrophage-targeted theranostic nanoparticle for biomedical applications Small 2006, 2, 983-987 (Pubitemid 44230996)
29. McCarthy, J. R.; Korngold, E.; Weissleder, R.; Jaffer, F. A. A light-activated theranostic nanoagent for targeted macrophage ablation in inflammatory atherosclerosis Small 2010, 6, 2041-2049
30. Medarova, Z.; Rashkovetsky, L.; Pantazopoulos, P.; Moore, A. Multiparametric monitoring of tumor response to chemotherapy by noninvasive imaging Cancer Res. 2009, 69, 1182-1189
31. Kumar, M.; Yigit, M.; Dai, G. P.; Moore, A.; Medarova, Z. Image-guided breast tumor therapy using a small interfering RNA nanodrug Cancer Res. 2010, 70, 7553-7561
32. Mok, H.; Veiseh, O.; Fang, C.; Kievit, F. M.; Wang, F. Y.; Park, J. O.; Zhang, M. Q. pH-sensitive siRNA nanovector for targeted gene silencing and cytotoxic effect in cancer cells Mol. Pharmaceutics 2010, 7, 1930-1939
33. Veiseh, O.; Kievit, F. M.; Fang, C.; Mu, N.; Jana, S.; Leung, M. C.; Mok, H.; Ellenbogen, R. G.; Park, J. O.; Zhang, M. Q. Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery Biomaterials 2010, 31, 8032-8042
34. Kievit, F. M.; Veiseh, O.; Fang, C.; Bhattarai, N.; Lee, D.; Ellenbogen, R. G.; Zhang, M. Q. Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma ACS Nano 2010, 4, 4587-4594
35. Yang, X. Q.; Grailer, J. J.; Rowland, I. J.; Javadi, A.; Hurley, S. A.; Steeber, D. A.; Gong, S. Q. Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging Biomaterials 2010, 31, 9065-9073
36. Das, M.; Mishra, D.; Dhak, P.; Gupta, S.; Maiti, T. K.; Basak, A.; Pramanik, P. Biofunctionalized, phosphonate-grafted, ultrasmall iron oxide nanoparticles for combined targeted cancer therapy and multimodal imaging Small 2009, 5, 2883-2893
37. Winter, P. M.; Caruthers, S. D.; Zhang, H. Y.; Williams, T. A.; Wickline, S. A.; Lanza, G. M. Antiangiogenic synergism of integrin-targeted fumagillin nanoparticles and atorvastatin in atherosclerosis JACC: Cardiovasc. Imaging 2008, 1, 624-634
38. Felding-Habermann, B. Integrin adhesion receptors in tumor metastasis Clin. Exp. Metastasis 2003, 20, 203-213 (Pubitemid 36513225)
39. Lijowski, M.; Caruthers, S.; Hu, G.; Zhang, H. Y.; Scott, M. J.; Williams, T.; Erpelding, T.; Schmieder, A. H.; Kiefer, G.; Gulyas, G.; Athey, P. S.; Gaffney, P. J.; Wickline, S. A.; Lanza, G. M. High sensitivity high-resolution SPECT-CT/MR molecular imaging of angiogenesis in the Vx2Model Invest. Radiol. 2009, 44, 15-22
40. Mulder, W. J. M.; Koole, R.; Brandwijk, R. J.; Storm, G.; Chin, P. T. K.; Strijkers, G. J.; Donega, C. D.; Nicolay, K.; Griffioen, A. W. Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe Nano Lett. 2006, 6, 1-6 (Pubitemid 43166093)
41. Lee, H.-Y.; Li, Z.; Chen, K.; Hsu, A. R.; Xu, C.; Xie, J.; Sun, S.; Chen, X. PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD) conjugated radiolabeled iron oxide nanoparticles J. Nucl. Med. 2008, 49, 1371-1379
42. 3-rich tumor cells J. Am. Chem. Soc. 2008, 130, 7542-7543 (Pubitemid 351842107)
43. Medarova, Z.; Pham, W.; Kim, Y.; Dai, G. P.; Moore, A. In vivo imaging of tumor response to therapy using a dual-modality imaging strategy Int. J. Cancer 2006, 118, 2796-2802 (Pubitemid 43673359)
44. Medarova, Z.; Pham, W.; Farrar, C.; Petkova, V.; Moore, A. In vivo imaging of siRNA delivery and silencing in tumors Nat. Med. 2007, 13, 372-377 (Pubitemid 46376679)
45. Daniels, T. R.; Delgado, T.; Helguera, G.; Penichet, M. L. The transferrin receptor part II: Targeted delivery of therapeutic agents into cancer cells Clin. Immunol. 2006, 121, 159-176 (Pubitemid 44572972)
46. Kester, M.; Heakal, Y.; Fox, T.; Sharma, A.; Robertson, G. P.; Morgan, T. T.; Altinoglu, E. I.; Tabakovic, A.; Parette, M. R.; Rouse, S. M.; Ruiz-Velasco, V.; Adair, J. H. Calcium phosphate nanocomposite particles for in vitro imaging and encapsulated chemotherapeutic drug delivery to cancer cells Nano Lett. 2008, 8, 4116-4121
47. Yoo, H. S.; Park, T. G. Folate-receptor-targeted delivery of doxorubicin nano-aggregates stabilized by doxorubicin-PEG-folate conjugate J. Controlled Release 2004, 100, 247-256 (Pubitemid 39491276)
48. Prabaharan, M.; Grailer, J. J.; Pilla, S.; Steeber, D. A.; Gong, S. Q. Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery Biomaterials 2009, 30, 6065-6075
49. Li, X.; Zhou, H. Y.; Yang, L.; Du, G. Q.; Pai-Panandiker, A. S.; Huang, X. F.; Yan, B. Enhancement of cell recognition in vitro by dual-ligand cancer targeting gold nanoparticles Biomaterials 2011, 32, 2540-2545
50. Das, M.; Mishra, D.; Maiti, T. K.; Basak, A.; Pramanik, P. Bio-functionalization of magnetite nanoparticles using an aminophosphonic acid coupling agent: new, ultradispersed, iron-oxide folate nanoconjugates for cancer-specific targeting Nanotechnology 2009, 20 189801
51. Hu, G.; Lijowski, M.; Zhang, H. Y.; Partlow, K. C.; Caruthers, S. D.; Kiefer, G.; Gulyas, G.; Athey, P.; Scott, M. J.; Wickline, S. A.; Lanza, G. M. Imaging of Vx-2 rabbit tumors with alpha v beta(3)-integrin-targeted In-111 nanoparticles Int. J. Cancer 2007, 120, 1951-1957 (Pubitemid 46418372)
52. Winter, P. M.; Cai, K. J.; Chen, J.; Adair, C. R.; Kiefer, G. E.; Athey, P. S.; Gaffney, P. J.; Buff, C. E.; Robertson, J. D.; Caruthers, S. D.; Wickline, S. A.; Lanza, G. M. Targeted PARACEST nanoparticle contrast agent for the detection of fibrin Magn. Reson. Med. 2006, 56, 1384-1388 (Pubitemid 44865324)
53. Winter, P. M.; Neubauer, A. M.; Caruthers, S. D.; Harris, T. D.; Robertson, J. D.; Williams, T. A.; Schmieder, A. H.; Hu, G.; Allen, J. S.; Lacy, E. K.; Zhang, H. Y.; Wickline, S. A.; Lanza, G. M. Endothelial alpha(v)beta(3) integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis Arterioscler., Thromb., Vasc. Biol. 2006, 26, 2103-2109 (Pubitemid 44253795)