Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy

Journal of Controlled Release

Volumn 142, Issue 3, 2010, Pages 457-464

  Palmer, Gregory M ^a   Boruta, Richard J ^a   Viglianti, Benjamin L ^b   Lan, Lan ^a   Spasojevic, Ivan ^a   Dewhirst, Mark W ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Doxorubicin; Drug delivery; Fluorescence spectroscopy; Liposome; Pharmacokinetics

Indexed keywords

DOXORUBICIN; DRUG CONCENTRATION; FLUORESCENCE PROPERTIES; FLUORESCENCE TECHNIQUE; HAZARD RATIO; HEMOGLOBIN SATURATION; IN-VIVO; LIPOSOMAL DOXORUBICIN; LIPOSOMAL FORMULATION; LOW TEMPERATURES; MODELING TECHNIQUE; MONTE CARLO; NON-INVASIVE MONITORING; OPTICAL SPECTROSCOPY; PRE-TREATMENT; PRECLINICAL STUDIES; TARGETED DELIVERY; TREATMENT RESPONSE; TUMOR GROWTH; TUMOR PHYSIOLOGY;

CLUSTER ANALYSIS; DRUG DELIVERY; FLUORESCENCE; FLUORESCENCE SPECTROSCOPY; GROUP DELAY; HEMOGLOBIN; PHARMACOKINETICS; TUMORS;

HYPERTHERMIA THERAPY;

2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; DIPALMITOYLPHOSPHATIDYLETHANOLAMINE; DOXORUBICIN; HEMOGLOBIN; LIPOSOME; MACROGOL 2000; PENTOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLUSTER ANALYSIS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG FORMULATION; DRUG TUMOR LEVEL; FEMALE; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYPERTHERMIC THERAPY; IN VIVO STUDY; MONTE CARLO METHOD; MOUSE; NON INVASIVE MEASUREMENT; NONHUMAN; OVARY CANCER; PATIENT MONITORING; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; SPECTROSCOPY; TREATMENT OUTCOME; TUMOR GROWTH; TUMOR VOLUME;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG EVALUATION, PRECLINICAL; DRUG MONITORING; FIBER OPTIC TECHNOLOGY; HYPERTHERMIA, INDUCED; LIPOSOMES; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MONTE CARLO METHOD; NEOPLASMS, EXPERIMENTAL; SPECTROMETRY, FLUORESCENCE;

EID: 77349113992     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.10.034     Document Type: Article

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