Protein engineering and the use of molecular modeling and simulation: The case of heterodimeric Fc engineering

Methods

Volumn 65, Issue 1, 2014, Pages 77-94

  Spreter Von Kreudenstein, Thomas ^a   Lario, Paula I ^a   Dixit, Surjit B ^a  

^a Zymeworks Inc   (Canada)

Author keywords

Antibody engineering; Bispecific antibody; Computational protein engineering; Fc engineering; Heterodimeric antibody

Indexed keywords

BISPECIFIC ANTIBODY; FC RECEPTOR; HETERODIMER; HOMODIMER; IMMUNOGLOBULIN G1;

ANTIBODY ENGINEERING; ARTICLE; COMPARATIVE STUDY; COMPUTER MODEL; COMPUTER SIMULATION; HEAVY CHAIN; LIGHT CHAIN; MOLECULAR DYNAMICS; MOLECULAR MODEL; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN PURIFICATION; STRUCTURE ACTIVITY RELATION;

ANTIBODY ENGINEERING; BISPECIFIC ANTIBODY; CCSD; CHARGE INVERSION; CI; CLOSE CONTACT SURFACE DENSITY (ΔΣ(TOT)); COMPUTATIONAL PROTEIN ENGINEERING; ELEC; ELECTROSTATIC CONTRIBUTIONS; FC ENGINEERING; H-BOND; HETERODIMERIC ANTIBODY; HPHOBIC; HYDROGEN BOND; HYDROPHOBIC; KBP; KIH; KNOB IN HOLE; KNOWLEDGE BASED POTENTIAL; LENNARD-JONES CONTRIBUTIONS; LJ; MD; MOLECULAR DYNAMICS; RADIAL DISTRIBUTION FUNCTION; RDF; RMSD; RMSF; ROOT MEAN SQUARED DEVIATION; ROOT MEAN SQUARED FLUCTUATION; SASA; SOLVENT EXPOSED SURFACE AREA; THERMAL MELTING TEMPERATURE; TM; VAN DER WAALS INTERACTION; VDW;

AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODY SPECIFICITY; BINDING SITES; HUMANS; HYDROGEN BONDING; IMMUNOGLOBULIN FC FRAGMENTS; MOLECULAR DYNAMICS SIMULATION; PROTEIN ENGINEERING; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY;

EID: 84891601553     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2013.10.016     Document Type: Article

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