Stable heterodimers from remodeling the domain interface of a homodimer using a phage display library

Journal of Molecular Biology

Volumn 270, Issue 1, 1997, Pages 26-35

  Atwell, Shane ^a,b   Ridgway, John B B ^a   Wells, James A ^a   Carter, Paul ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antibody C(H)3 domains; Bispecific antibody; Domain interface engineering; Heterodimer; Phage display

Indexed keywords

ADHESIN; ANTIBODY; DIMER; GUANIDINE; HYBRID PROTEIN; MUTANT PROTEIN; THREONINE; TRYPTOPHAN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBODY PRODUCTION; ARTICLE; BACTERIOPHAGE M13; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ESCHERICHIA COLI; GENETIC ENGINEERING; GENETIC TRANSFECTION; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN SECRETION; RANDOMIZATION; THERMOSTABILITY;

ESCHERICHIA COLI;

EID: 0031552589     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1997.1116     Document Type: Article

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