FLZ inhibited γ-secretase selectively and decreased Aβ mitochondrial production in APP-SH-SY5Y cells

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 387, Issue 1, 2014, Pages 75-85

  Ye, Xuan ^a   Tai, Wenjiao ^a   Bao, Xiuqi ^a   Chen, Xiaoguang ^a   Zhang, Dan ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Secretase; COX IV; FLZ; Mitochondria; Notch

Indexed keywords

2 (2,5 DIMETHOXYPHENYL) 3 (4 HYDROXY 3 METHOXYPHENYL) N (4 HYDROXYPHENETHYL) ACRYLAMIDE; ADENOSINE TRIPHOSPHATE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYTOCHROME C OXIDASE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; PRESENILIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANNONA GLABRA; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; PROTEIN EXPRESSION; UPREGULATION;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; BENZENEACETAMIDES; CELL LINE, TUMOR; DOWN-REGULATION; HELA CELLS; HUMANS; MITOCHONDRIA; PHENOLS;

EID: 84891596165     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0918-4     Document Type: Article

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