Novel squamosamide derivative (compound FLZ) attenuates Aβ25-35-induced toxicity in SH-SY5Y cells

Acta Pharmacologica Sinica

Volumn 29, Issue 2, 2008, Pages 152-160

  Fang, Fang ^a,b   Liu, Geng Tao ^a  

^a INSTITUTE OF MATERIA MEDICA   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

amyloid peptide; Apoptosis; Compound FLZ; Oxidative stress; SH SY5Y cells

Indexed keywords

ACRYLAMIDE DERIVATIVE; CYTOCHROME C; GLUTATHIONE; LACTATE DEHYDROGENASE; N [2 (4 HYDROXYPHENYL)ETHYL] 2 (2,5 DIMETHOXYPHENYL) 3 (3 METHOXY 4 HYDROXYPHENYL)ACRYLAMIDE; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SQUAMOSAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ATTENUATION; CELL DAMAGE; CELL VIABILITY; CHEMICAL ANALYSIS; DRUG EFFECT; DRUG MECHANISM; ENZYME RELEASE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; INCUBATION TIME; MITOCHONDRION; NEUROBLASTOMA CELL; NEUROPROTECTION; NEUROTOXICITY; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN SECRETION; WESTERN BLOTTING;

AMYLOID BETA-PROTEIN; APOPTOSIS; BENZENEACETAMIDES; CELL LINE; CELL SURVIVAL; GLUTATHIONE; HUMANS; L-LACTATE DEHYDROGENASE; PEPTIDE FRAGMENTS; PHENOLS; REACTIVE OXYGEN SPECIES;

EID: 38749122873     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00714.x     Document Type: Article

References (47)

1. Famer D, Crisby M. Rosuvastatin reduces caspase-3 activity and up-regulates α-secretase in human neuroblastoma SH-SY5Y cells exposed to Aβ. Neurosci Lett 2004 371 : 209 14.
2. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther, K, et al. Amyloid plaque core protein in Alzheimer's disease and Down syndrome. Proc Natl Acad Sci USA 1985 82 : 4245 9.
3. Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992 256 : 184 5.
4. Selkoe DJ. Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 1996 271 : 18295 8.
5. Butterfiled DA, Castegna A, Lauderback CM, Drake J. Evidence that amyloid β-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death. Neurobiol Aging 2002 23 : 655 64.
6. Wang R, Zhang HY, Tang XC. Huperzine A attenuates cognitive dysfunction and neuronal degeneration caused by β-amyloid protein-(1-40) in rat. Eur J Pharmacol 2001 421 : 149 56.
7. Eckert A, Keil U, Marques CA, Bonert A, Frey C, Schussel K, et al. Mitochondrial dysfunction, apoptotic cell death, and Alzheimer's disease. Biochem Pharmacol 2003 66 : 1627 34.
8. Xu J, Chen S, Ku G, Ahmed SH, Xu J, Chen H, et al. Amyloid β peptide-induced cerebral endothelial cell death involves mitochondrial dysfunction and caspase activation. J Cereb Blood Flow and Metab 2001 21 : 702 10.
9. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW. Apoptosis is induced by β-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 1993 90 : 7951 5.
10. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995 267 : 1456 62.
11. Feng W, Wei H, Liu G. Pharmacological study of the novel compound FLZ against experimental Parkinson's models and its active mechanism. Mol Neurobiol 2005 31 : 295 300.
12. Fang F, Liu GT. Protective effects of compound FLZ on β-amyloid peptide (25-35)-induced mouse hippocampal injury and learning and memory impairment. Acta Pharmacol Sin 2006 27 : 651 8.
13. Zhang D, Zhang JJ, Liu GT. The novel squamosamide derivative (compound FLZ) attenuated 1-methyl, 4-phenyl-pyridinium ion MPP (+)-induced apoptosis and alternations of related signal transduction in SH-SY5Y cells. Neuropharmacology 2007 52 : 423 9.
14. Zeng H, Chen Q, Zhao B. Genistein ameliorates β-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis. Free Radic Biol Med 2004 36 : 180 8.
15. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991 139 : 271 9.
16. Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 1983 130 : 1910 7.
17. Hissin PJ, Hilf RA. Fluorimetric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem 1976 74 : 214 26.
18. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951 193 : 265 75.
19. Jang JH, Surh YJ. Protective effect of resvratrol on β-amyloid- induced oxidative PC12 cell death. Free Radic Biol Med 2003 34 : 1100 10.
20. L. Biol Reprod 2003 68 : 1178 84.
21. Bayer TA, Wirths O, Majtenyi K, Hartmann T, Multhaup G, Beyreuther K, et al. Key factors in Alzheimer's disease: beta amyloid precursor protein processing, metabolism and intraneuronal transport. Brain Pathol 2001 11 : 1 11.
22. Cotman CW, Su JH. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol 1996 6 : 493 506.
23. Stadelmann C, Deckwerth TL, Srinivasan A, Bancher C, Bruck W, Jellinger K, et al. Activation of caspase 3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease. Evidence for apoptotic cell death. Am J Pathol 1999 155 : 1459 66.
24. Watt JA, Pike CJ, Walencewicz-Wasserman AJ, Cotman CW. Ultrastructural analysis of β-amyloid-induced apoptosis in cultured hippocampal neurons. Brain Res 1994 661 : 147 56.
25. Feng Z, Zhang JT. Metatonin reduces amyloid β-induced apoptosis in pheochromeocytoma (PC12) cells. J Pineal Res 2004 37 : 257 66.
26. Li YP, Bushnell AF, Lee CM, Perlmutter LS, Wong SK. Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells. Brain Res 1996 738 : 196 204.
27. Olariu A, Tran MH, Yamada K, Mizuno M, Hefco V, Nabeshima T. Memory deficits and increased emotionality induced β-amyloid (25-35) are correlated with the reduced acetylcholine release and altered phorbol dibutyrate binding in the hippocampus. J Neural Transm 2001 108 : 1065 79.
28. Tohda C, Tamura T, Konatsu K. Repair of amyloid β (25-35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to. Brain Res 2003 990 : 141 7.
29. Bastianitto S, Ramassamy C, Dore S, Christen Y, Poirier J, Quirion R. The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β-amyloid. Eur J Neurosci 2000 12 : 1882 90.
30. Ida N, Masters CL, Beyreuther K. Rapid cellular uptake of Alzheimer amyloid beta A4 peptide by culture human neuroblastoma cells. FEBS Lett 1996 394 : 174 8.
31. Miranda S, Opazo C, Larrondo LF, Munoz FJ, Ruiz F, Leighton F, et al. The role of oxidative stress in the toxicity induced by amyloid β-peptide in Alzheimer's disease. Prog Neurobiol 2000 62 : 633 48.
32. Behl C. Amyloid β-protein toxicity and oxidative stress in Alzheimer's disease. Cell Tissue Res 1997 290 : 471 80.
33. Peng QL, Buzzard AR, Lau BH. Neuroprotective effect of garlic compounds in amyloid β-peptide-induced apoptosis in vitro. Med Sci Monit 2002 8 : BR328 37.
34. Huang X, Atwood CS, Hartshom MA, Multhaup G, Goldstein LE, Scarpa RC, et al. The A beta peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction. Biochemistry 1999 38 : 7609 16.
35. Huang HM, Ou HC, Hsieh SJ. Antioxidants prevent amyloid peptide-induced apoptosis and alteration of calcium homeostasis in cultured cortical neurons. Life Sci 2000 66 : 1879 92.
36. Maurizi CP. Loss of intraventricular fluid melatonin can explain the neuropathology of Alzheimer's disease. Med Hypotheses 1997 49 : 153 8.
37. Cherubini A, Martin A, Andres-Lacueva C, Di Iorio A, Lamponi M, Mecocci P, et al. Vitamine E level, cognitive impairment and dementia in older persons: the InCHIANTI study. Neurobiol Aging 2005 26 : 987 94.
38. Skulachev VP. Cytochrome c in the apoptotic and antioxidant cascades. FEBS Lett 1998 423 : 275 80.
39. Nicholls DG, Budd SL. Mitochondria and neuronal survival. Physicol Rev 2000 80 : 315 60.
40. Jurgensmeier JM, Xie Z, Deveraux Q, Ellerby L, Bredesen D, Reed JC. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 1998 95 : 4997 5002.
41. Shacka JJ, Roth KA. Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications. Curr Drug Targets CNS Neurol disord 2005 4 : 25 39.
42. Kuwana T, Newmeyer DD. Bcl-2-family proteins and the role of mitochondria in apoptosis. Curr Opin Cell Biol 2003 15 : 691 9.
43. L blocks mitochondrial multiple conductance channel activation and inhibits 6-OHDA-induced death in SH-SY5Y cells. J Neurochem 2004 89 : 124 33.
44. Wiedau-Pazos M, Trudell JR, Altenbach C, Kane DJ, Hubbell WL, Bredesen DE. Expression of Bcl-2 inhibits cellular radical generation. Free Radic Res 1996 24 : 205 12.
45. Xie P, Jiao XZ, Liang XT, Feng WH, Wei HL, Liu GT. Synthesis and antioxiactivity of squamosamide cyclic analogs. Acta Acad Med Sin 2004 26 : 372 8.
46. Gilgun-Sherki Y, Melamed E, Offen D. Antioxidant treatment in Alzheimer's disease: current state. J Mol Neurosci 2003 21 : 1 11.
47. Gilgun-Sherki Y, Melamed E, Offen D. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacology 2001 40 : 959 75.