메뉴 건너뛰기




Volumn 4, Issue 11-12, 2013, Pages 460-475

The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation

Author keywords

Ect2; ovarian cancer; Rac; RhoGEF

Indexed keywords

EPITHELIAL CELL TRANSFORMING SEQUENCE 2; GUANOSINE TRIPHOSPHATASE; MESSENGER RNA; RAC PROTEIN; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

EID: 84891531737     PISSN: 19476019     EISSN: 19476027     Source Type: Journal    
DOI: 10.1177/1947601913514851     Document Type: Article
Times cited : (58)

References (82)
  • 1
    • 84870209800 scopus 로고    scopus 로고
    • Rho family GTPases
    • Hall A.Rho family GTPases.Biochem Soc Trans. 2012;40 (6): 1378-82.
    • (2012) Biochem Soc Trans , vol.40 , Issue.6 , pp. 1378-1382
    • Hall, A.1
  • 2
    • 34250737379 scopus 로고    scopus 로고
    • SnapShot: Rho family GTPases
    • Vega FM,Ridley AJ.SnapShot: Rho family GTPases.Cell. 2007 1430;129 (7):.
    • (2007) Cell , vol.129 , Issue.7 , pp. 1430
    • Vega, F.M.1    Ridley, A.J.2
  • 3
    • 0036488510 scopus 로고    scopus 로고
    • RHO-GTPases and cancer
    • Sahai E,Marshall CJ.RHO-GTPases and cancer.Nat Rev Cancer. 2002;2 (2): 133-42.
    • (2002) Nat Rev Cancer , vol.2 , Issue.2 , pp. 133-142
    • Sahai, E.1    Marshall, C.J.2
  • 4
    • 44449178868 scopus 로고    scopus 로고
    • Rho GTPases in cancer cell biology
    • Vega FM,Ridley AJ.Rho GTPases in cancer cell biology.FEBS Lett. 2008;582 (14): 2093-101.
    • (2008) FEBS Lett , vol.582 , Issue.14 , pp. 2093-2101
    • Vega, F.M.1    Ridley, A.J.2
  • 5
    • 36348966706 scopus 로고    scopus 로고
    • Rho GTPases: functions and association with cancer
    • Ellenbroek SI,Collard JG.Rho GTPases: functions and association with cancer.Clin Exp Metastasis. 2007;24 (8): 657-72.
    • (2007) Clin Exp Metastasis , vol.24 , Issue.8 , pp. 657-672
    • Ellenbroek, S.I.1    Collard, J.G.2
  • 6
    • 13444252631 scopus 로고    scopus 로고
    • GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
    • Rossman KL,Der CJ,Sondek J.GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.Nat Rev Mol Cell Biol. 2005;6 (2): 167-80.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.2 , pp. 167-180
    • Rossman, K.L.1    Der, C.J.2    Sondek, J.3
  • 7
    • 0033615978 scopus 로고    scopus 로고
    • Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis
    • Tatsumoto T,Xie X,Blumenthal R,Okamoto I,Miki T.Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.J Cell Biol. 1999;147 (5): 921-8.
    • (1999) J Cell Biol , vol.147 , Issue.5 , pp. 921-928
    • Tatsumoto, T.1    Xie, X.2    Blumenthal, R.3    Okamoto, I.4    Miki, T.5
  • 8
    • 10744225152 scopus 로고    scopus 로고
    • Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation
    • Saito S,Liu XF,Kamijo K, et al.Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.J Biol Chem. 2004;279 (8): 7169-79.
    • (2004) J Biol Chem , vol.279 , Issue.8 , pp. 7169-7179
    • Saito, S.1    Liu, X.F.2    Kamijo, K.3
  • 9
    • 3242702211 scopus 로고    scopus 로고
    • Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity
    • Liu XF,Ishida H,Raziuddin R,Miki T.Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity.Mol Cell Biol. 2004;24 (15): 6665-75.
    • (2004) Mol Cell Biol , vol.24 , Issue.15 , pp. 6665-6675
    • Liu, X.F.1    Ishida, H.2    Raziuddin, R.3    Miki, T.4
  • 10
    • 0034625353 scopus 로고    scopus 로고
    • Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation
    • Kimura K,Tsuji T,Takada Y,Miki T,Narumiya S.Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation.J Biol Chem. 2000;275 (23): 17233-6.
    • (2000) J Biol Chem , vol.275 , Issue.23 , pp. 17233-17236
    • Kimura, K.1    Tsuji, T.2    Takada, Y.3    Miki, T.4    Narumiya, S.5
  • 11
    • 38749123941 scopus 로고    scopus 로고
    • Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells
    • Kanada M,Nagasaki A,Uyeda TQ.Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells.Mol Biol Cell. 2008;19 (1): 8-16.
    • (2008) Mol Biol Cell , vol.19 , Issue.1 , pp. 8-16
    • Kanada, M.1    Nagasaki, A.2    Uyeda, T.Q.3
  • 12
    • 77955299128 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer
    • Fields AP,Justilien V.The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.Adv Enzyme Regul. 2009;50 (1): 190-200.
    • (2009) Adv Enzyme Regul , vol.50 , Issue.1 , pp. 190-200
    • Fields, A.P.1    Justilien, V.2
  • 13
    • 84864115184 scopus 로고    scopus 로고
    • ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells
    • Weeks A,Okolowsky N,Golbourn B,Ivanchuk S,Smith C,Rutka JT.ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells.Am J Pathol. 2012;181 (2): 662-74.
    • (2012) Am J Pathol , vol.181 , Issue.2 , pp. 662-674
    • Weeks, A.1    Okolowsky, N.2    Golbourn, B.3    Ivanchuk, S.4    Smith, C.5    Rutka, J.T.6
  • 14
    • 84864011846 scopus 로고    scopus 로고
    • Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells
    • Fortin SP,Ennis MJ,Schumacher CA, et al.Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.Mol Cancer Res. 2012;10 (7): 958-68.
    • (2012) Mol Cancer Res , vol.10 , Issue.7 , pp. 958-968
    • Fortin, S.P.1    Ennis, M.J.2    Schumacher, C.A.3
  • 15
    • 70350074501 scopus 로고    scopus 로고
    • Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
    • Justilien V,Fields AP.Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.Oncogene. 2009;28 (41): 3597-607.
    • (2009) Oncogene , vol.28 , Issue.41 , pp. 3597-3607
    • Justilien, V.1    Fields, A.P.2
  • 16
    • 77951022275 scopus 로고    scopus 로고
    • The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3
    • Wang H,Linghu H,Wang J, et al.The role of Crk/Dock180/Rac1 pathway in the malignant behavior of human ovarian cancer cell SKOV3.Tumour Biol. 2010;31 (1): 59-67.
    • (2010) Tumour Biol , vol.31 , Issue.1 , pp. 59-67
    • Wang, H.1    Linghu, H.2    Wang, J.3
  • 17
    • 15744404625 scopus 로고    scopus 로고
    • Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression
    • Bourguignon LY,Gilad E,Rothman K,Peyrollier K.Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression.J Biol Chem. 2005;280 (12): 11961-72.
    • (2005) J Biol Chem , vol.280 , Issue.12 , pp. 11961-11972
    • Bourguignon, L.Y.1    Gilad, E.2    Rothman, K.3    Peyrollier, K.4
  • 18
    • 75749092545 scopus 로고    scopus 로고
    • RhoC expression level is correlated with the clinicopathological characteristics of ovarian cancer and the expression levels of ROCK-I, VEGF, and MMP9
    • Zhao Y,Zong ZH,Xu HM.RhoC expression level is correlated with the clinicopathological characteristics of ovarian cancer and the expression levels of ROCK-I, VEGF, and MMP9.Gynecol Oncol. 2009;116 (3): 563-71.
    • (2009) Gynecol Oncol , vol.116 , Issue.3 , pp. 563-571
    • Zhao, Y.1    Zong, Z.H.2    Xu, H.M.3
  • 19
    • 57349135304 scopus 로고    scopus 로고
    • Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer
    • Horiuchi A,Kikuchi N,Osada R, et al.Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer.Cancer Sci. 2008;99 (12): 2532-9.
    • (2008) Cancer Sci , vol.99 , Issue.12 , pp. 2532-2539
    • Horiuchi, A.1    Kikuchi, N.2    Osada, R.3
  • 20
    • 0028978027 scopus 로고
    • Chromosomal localization of the human ECT2 proto-oncogene to 3q26.1→q26.2 by somatic cell analysis and fluorescence in situ hybridization
    • Takai S,Long JE,Yamada K,Miki T.Chromosomal localization of the human ECT2 proto-oncogene to 3q26.1→q26.2 by somatic cell analysis and fluorescence in situ hybridization.Genomics. 1995;27 (1): 220-2.
    • (1995) Genomics , vol.27 , Issue.1 , pp. 220-222
    • Takai, S.1    Long, J.E.2    Yamada, K.3    Miki, T.4
  • 21
    • 0034307169 scopus 로고    scopus 로고
    • An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer
    • Suzuki S,Moore DH,Ginzinger DG, et al.An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer.Cancer Res. 2000;60 (19): 5382-5.
    • (2000) Cancer Res , vol.60 , Issue.19 , pp. 5382-5385
    • Suzuki, S.1    Moore, D.H.2    Ginzinger, D.G.3
  • 22
    • 67949106468 scopus 로고    scopus 로고
    • High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors
    • Haverty PM,Hon LS,Kaminker JS,Chant J,Zhang Z.High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors.BMC Med Genomics. 2009;2:21.
    • (2009) BMC Med Genomics , vol.2 , pp. 21
    • Haverty, P.M.1    Hon, L.S.2    Kaminker, J.S.3    Chant, J.4    Zhang, Z.5
  • 23
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data
    • Cerami E,Gao J,Dogrusoz U, et al.The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.Cancer Discov. 2012;2 (5): 401-4.
    • (2012) Cancer Discov , vol.2 , Issue.5 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3
  • 24
    • 79959838081 scopus 로고    scopus 로고
    • Nature
    • Nature. 2011;474 (7353): 609-15.
    • (2011) , vol.474 , Issue.7353 , pp. 609-615
  • 25
    • 0242526719 scopus 로고    scopus 로고
    • Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains
    • Saito S,Tatsumoto T,Lorenzi MV, et al.Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.J Cell Biochem. 2003;90 (4): 819-36.
    • (2003) J Cell Biochem , vol.90 , Issue.4 , pp. 819-836
    • Saito, S.1    Tatsumoto, T.2    Lorenzi, M.V.3
  • 26
    • 33750361148 scopus 로고    scopus 로고
    • Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma
    • Rosen DG,Cai KQ,Luthra R,Liu J.Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma.Mod Pathol. 2006;19 (11): 1414-20.
    • (2006) Mod Pathol , vol.19 , Issue.11 , pp. 1414-1420
    • Rosen, D.G.1    Cai, K.Q.2    Luthra, R.3    Liu, J.4
  • 27
    • 33751575658 scopus 로고    scopus 로고
    • The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis
    • Rosen DG,Mercado-Uribe I,Yang G, et al.The role of constitutively active signal transducer and activator of transcription 3 in ovarian tumorigenesis and prognosis.Cancer. 2006;107 (11): 2730-40.
    • (2006) Cancer , vol.107 , Issue.11 , pp. 2730-2740
    • Rosen, D.G.1    Mercado-Uribe, I.2    Yang, G.3
  • 28
    • 33646374432 scopus 로고    scopus 로고
    • Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma
    • Rosen DG,Yang G,Deavers MT, et al.Cyclin E expression is correlated with tumor progression and predicts a poor prognosis in patients with ovarian carcinoma.Cancer. 2006;106 (9): 1925-32.
    • (2006) Cancer , vol.106 , Issue.9 , pp. 1925-1932
    • Rosen, D.G.1    Yang, G.2    Deavers, M.T.3
  • 29
    • 80053299540 scopus 로고    scopus 로고
    • RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis
    • Stevens EV,Banet N,Onesto C, et al.RhoGDI2 antagonizes ovarian carcinoma growth, invasion and metastasis.Small GTPases. 2011;2 (4): 202-10.
    • (2011) Small GTPases , vol.2 , Issue.4 , pp. 202-210
    • Stevens, E.V.1    Banet, N.2    Onesto, C.3
  • 30
    • 0016318441 scopus 로고
    • Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium
    • Freedman VH,Shin SI.Cellular tumorigenicity in nude mice: correlation with cell growth in semi-solid medium.Cell. 1974;3 (4): 355-9.
    • (1974) Cell , vol.3 , Issue.4 , pp. 355-359
    • Freedman, V.H.1    Shin, S.I.2
  • 31
    • 77949902198 scopus 로고    scopus 로고
    • Cytokinesis and cancer: polo loves ROCK'n' Rho(A)
    • Li J,Wang J,Jiao H,Liao J,Xu X.Cytokinesis and cancer: polo loves ROCK'n' Rho(A).J Genet Genomics. 2010;37 (3): 159-72.
    • (2010) J Genet Genomics , vol.37 , Issue.3 , pp. 159-172
    • Li, J.1    Wang, J.2    Jiao, H.3    Liao, J.4    Xu, X.5
  • 32
    • 0142027035 scopus 로고    scopus 로고
    • The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences
    • Williams CL.The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences.Cell Signal. 2003;15 (12): 1071-80.
    • (2003) Cell Signal , vol.15 , Issue.12 , pp. 1071-1080
    • Williams, C.L.1
  • 33
    • 0038485593 scopus 로고    scopus 로고
    • Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1
    • Lanning CC,Ruiz-Velasco R,Williams CL.Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1.J Biol Chem. 2003;278 (14): 12495-506.
    • (2003) J Biol Chem , vol.278 , Issue.14 , pp. 12495-12506
    • Lanning, C.C.1    Ruiz-Velasco, R.2    Williams, C.L.3
  • 34
    • 43149116339 scopus 로고    scopus 로고
    • Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division
    • Michaelson D,Abidi W,Guardavaccaro D, et al.Rac1 accumulates in the nucleus during the G2 phase of the cell cycle and promotes cell division.J Cell Biol. 2008;181 (3): 485-96.
    • (2008) J Cell Biol , vol.181 , Issue.3 , pp. 485-496
    • Michaelson, D.1    Abidi, W.2    Guardavaccaro, D.3
  • 35
    • 77951240109 scopus 로고    scopus 로고
    • Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype
    • Borikova AL,Dibble CF,Sciaky N, et al.Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype.J Biol Chem. 2010;285 (16): 11760-4.
    • (2010) J Biol Chem , vol.285 , Issue.16 , pp. 11760-11764
    • Borikova, A.L.1    Dibble, C.F.2    Sciaky, N.3
  • 36
    • 79952084024 scopus 로고    scopus 로고
    • The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals
    • Dubash AD,Guilluy C,Srougi MC,Boulter E,Burridge K,Garcia-Mata R.The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.PLoS One. 2011;6 (2): e17380.
    • (2011) PLoS One , vol.6 , Issue.2
    • Dubash, A.D.1    Guilluy, C.2    Srougi, M.C.3    Boulter, E.4    Burridge, K.5    Garcia-Mata, R.6
  • 37
    • 31544476883 scopus 로고    scopus 로고
    • Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase
    • Hara T,Abe M,Inoue H, et al.Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase.Oncogene. 2006;25 (4): 566-78.
    • (2006) Oncogene , vol.25 , Issue.4 , pp. 566-578
    • Hara, T.1    Abe, M.2    Inoue, H.3
  • 38
    • 84861738385 scopus 로고    scopus 로고
    • Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus
    • Guilluy C,Dubash AD,Garcia-Mata R.Analysis of RhoA and Rho GEF activity in whole cells and the cell nucleus.Nat Protoc. 2011;6 (12): 2050-60.
    • (2011) Nat Protoc , vol.6 , Issue.12 , pp. 2050-2060
    • Guilluy, C.1    Dubash, A.D.2    Garcia-Mata, R.3
  • 40
    • 0037044785 scopus 로고    scopus 로고
    • XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC
    • Arthur WT,Ellerbroek SM,Der CJ,Burridge K,Wennerberg K.XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.J Biol Chem. 2002;277 (45): 42964-72.
    • (2002) J Biol Chem , vol.277 , Issue.45 , pp. 42964-42972
    • Arthur, W.T.1    Ellerbroek, S.M.2    Der, C.J.3    Burridge, K.4    Wennerberg, K.5
  • 41
    • 3042801758 scopus 로고    scopus 로고
    • SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis
    • Ellerbroek SM,Wennerberg K,Arthur WT, et al.SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis.Mol Biol Cell. 2004;15 (7): 3309-19.
    • (2004) Mol Biol Cell , vol.15 , Issue.7 , pp. 3309-3319
    • Ellerbroek, S.M.1    Wennerberg, K.2    Arthur, W.T.3
  • 42
    • 0036091925 scopus 로고    scopus 로고
    • Ras signalling on the endoplasmic reticulum and the Golgi
    • Chiu VK,Bivona T,Hach A, et al.Ras signalling on the endoplasmic reticulum and the Golgi.Nat Cell Biol. 2002;4 (5): 343-50.
    • (2002) Nat Cell Biol , vol.4 , Issue.5 , pp. 343-350
    • Chiu, V.K.1    Bivona, T.2    Hach, A.3
  • 43
    • 33744531777 scopus 로고    scopus 로고
    • Analysis of Ras activation in living cells with GFP-RBD
    • Bivona TG,Quatela S,Philips MR.Analysis of Ras activation in living cells with GFP-RBD.Methods Enzymol. 2006;407:128-43.
    • (2006) Methods Enzymol , vol.407 , pp. 128-143
    • Bivona, T.G.1    Quatela, S.2    Philips, M.R.3
  • 44
    • 0041488671 scopus 로고    scopus 로고
    • Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1
    • Bivona TG,Perez De Castro I,Ahearn IM, et al.Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1.Nature. 2003;424 (6949): 694-8.
    • (2003) Nature , vol.424 , Issue.6949 , pp. 694-698
    • Bivona, T.G.1    Perez de Castro, I.2    Ahearn, I.M.3
  • 45
    • 77956633945 scopus 로고    scopus 로고
    • Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src
    • Alan JK,Berzat AC,Dewar BJ,Graves LM,Cox AD.Regulation of the Rho family small GTPase Wrch-1/RhoU by C-terminal tyrosine phosphorylation requires Src.Mol Cell Biol. 2010;30 (17): 4324-38.
    • (2010) Mol Cell Biol , vol.30 , Issue.17 , pp. 4324-4338
    • Alan, J.K.1    Berzat, A.C.2    Dewar, B.J.3    Graves, L.M.4    Cox, A.D.5
  • 46
    • 33745599891 scopus 로고    scopus 로고
    • Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity
    • Chenette EJ,Mitin NY,Der CJ.Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity.Mol Biol Cell. 2006;17 (7): 3108-21.
    • (2006) Mol Biol Cell , vol.17 , Issue.7 , pp. 3108-3121
    • Chenette, E.J.1    Mitin, N.Y.2    Der, C.J.3
  • 47
    • 0032473569 scopus 로고    scopus 로고
    • A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways
    • Tapon N,Nagata K,Lamarche N,Hall A.A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways.EMBO J. 1998;17 (5): 1395-404.
    • (1998) EMBO J , vol.17 , Issue.5 , pp. 1395-1404
    • Tapon, N.1    Nagata, K.2    Lamarche, N.3    Hall, A.4
  • 49
    • 11144226356 scopus 로고    scopus 로고
    • Models of the cooperative mechanism for Rho effector recognition: implications for RhoA-mediated effector activation
    • Blumenstein L,Ahmadian MR.Models of the cooperative mechanism for Rho effector recognition: implications for RhoA-mediated effector activation.J Biol Chem. 2004;279 (51): 53419-26.
    • (2004) J Biol Chem , vol.279 , Issue.51 , pp. 53419-53426
    • Blumenstein, L.1    Ahmadian, M.R.2
  • 50
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • Ridley AJ,Hall A.The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.Cell. 1992;70 (3): 389-99.
    • (1992) Cell , vol.70 , Issue.3 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 51
    • 0026654125 scopus 로고
    • The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
    • Ridley AJ,Paterson HF,Johnston CL,Diekmann D,Hall A.The small GTP-binding protein rac regulates growth factor-induced membrane ruffling.Cell. 1992;70 (3): 401-10.
    • (1992) Cell , vol.70 , Issue.3 , pp. 401-410
    • Ridley, A.J.1    Paterson, H.F.2    Johnston, C.L.3    Diekmann, D.4    Hall, A.5
  • 52
    • 0031260578 scopus 로고    scopus 로고
    • A novel Cdc42Hs mutant induces cellular transformation
    • Lin R,Bagrodia S,Cerione R,Manor D.A novel Cdc42Hs mutant induces cellular transformation.Curr Biol. 1997;7 (10): 794-7.
    • (1997) Curr Biol , vol.7 , Issue.10 , pp. 794-797
    • Lin, R.1    Bagrodia, S.2    Cerione, R.3    Manor, D.4
  • 53
    • 0344412931 scopus 로고    scopus 로고
    • Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling
    • Joyce PL,Cox AD.Rac1 and Rac3 are targets for geranylgeranyltransferase I inhibitor-mediated inhibition of signaling, transformation, and membrane ruffling.Cancer Res. 2003;63 (22): 7959-67.
    • (2003) Cancer Res , vol.63 , Issue.22 , pp. 7959-7967
    • Joyce, P.L.1    Cox, A.D.2
  • 54
    • 0021716406 scopus 로고
    • A short amino acid sequence able to specify nuclear location
    • Kalderon D,Roberts BL,Richardson WD,Smith AE.A short amino acid sequence able to specify nuclear location.Cell. 1984;39 (3 Pt 2): 499-509.
    • (1984) Cell , vol.39 , Issue.3 Pt , pp. 499-509
    • Kalderon, D.1    Roberts, B.L.2    Richardson, W.D.3    Smith, A.E.4
  • 55
    • 84864874567 scopus 로고    scopus 로고
    • Centralspindlin and alpha-catenin regulate Rho signalling at the epithelial zonula adherens
    • Ratheesh A,Gomez GA,Priya R, et al.Centralspindlin and alpha-catenin regulate Rho signalling at the epithelial zonula adherens.Nat Cell Biol. 2012;14 (8): 818-28.
    • (2012) Nat Cell Biol , vol.14 , Issue.8 , pp. 818-828
    • Ratheesh, A.1    Gomez, G.A.2    Priya, R.3
  • 56
    • 78649760558 scopus 로고    scopus 로고
    • Epithelial cell transforming sequence 2 in human oral cancer
    • Iyoda M,Kasamatsu A,Ishigami T, et al.Epithelial cell transforming sequence 2 in human oral cancer.PLoS One. 2010;5 (11): e14082.
    • (2010) PLoS One , vol.5 , Issue.11
    • Iyoda, M.1    Kasamatsu, A.2    Ishigami, T.3
  • 57
    • 84868654087 scopus 로고    scopus 로고
    • The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration
    • Cook DR,Solski PA,Bultman SJ, et al.The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.Genes Cancer. 2011;2 (10): 932-42.
    • (2011) Genes Cancer , vol.2 , Issue.10 , pp. 932-942
    • Cook, D.R.1    Solski, P.A.2    Bultman, S.J.3
  • 58
    • 79953154962 scopus 로고    scopus 로고
    • The oncogenic activity of ECT2 is regulated through protein kinase C{iota} mediated phosphorylation
    • Justilien V,Jameison L,Der CJ,Rossman KL,Fields AP.The oncogenic activity of ECT2 is regulated through protein kinase C{iota} mediated phosphorylation.J Biol Chem. 2011;286 (10): 8149-57.
    • (2011) J Biol Chem , vol.286 , Issue.10 , pp. 8149-8157
    • Justilien, V.1    Jameison, L.2    Der, C.J.3    Rossman, K.L.4    Fields, A.P.5
  • 59
    • 58949091881 scopus 로고    scopus 로고
    • Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression
    • Hirata D,Yamabuki T,Miki D, et al.Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression.Clin Cancer Res. 2009;15 (1): 256-66.
    • (2009) Clin Cancer Res , vol.15 , Issue.1 , pp. 256-266
    • Hirata, D.1    Yamabuki, T.2    Miki, D.3
  • 60
    • 57149120776 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma
    • Salhia B,Tran NL,Chan A, et al.The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.Am J Pathol. 2008;173 (6): 1828-38.
    • (2008) Am J Pathol , vol.173 , Issue.6 , pp. 1828-1838
    • Salhia, B.1    Tran, N.L.2    Chan, A.3
  • 61
    • 14044263688 scopus 로고    scopus 로고
    • The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis
    • Kim JE,Billadeau DD,Chen J.The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.J Biol Chem. 2005;280 (7): 5733-9.
    • (2005) J Biol Chem , vol.280 , Issue.7 , pp. 5733-5739
    • Kim, J.E.1    Billadeau, D.D.2    Chen, J.3
  • 62
    • 78649835035 scopus 로고    scopus 로고
    • A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A
    • Lagana A,Dorn JF,De Rop V,Ladouceur AM,Maddox AS,Maddox PS.A small GTPase molecular switch regulates epigenetic centromere maintenance by stabilizing newly incorporated CENP-A.Nat Cell Biol. 2010;12 (12): 1186-93.
    • (2010) Nat Cell Biol , vol.12 , Issue.12 , pp. 1186-1193
    • Lagana, A.1    Dorn, J.F.2    de Rop, V.3    Ladouceur, A.M.4    Maddox, A.S.5    Maddox, P.S.6
  • 63
    • 32544435801 scopus 로고    scopus 로고
    • Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA
    • Niiya F,Tatsumoto T,Lee KS,Miki T.Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.Oncogene. 2006;25 (6): 827-37.
    • (2006) Oncogene , vol.25 , Issue.6 , pp. 827-837
    • Niiya, F.1    Tatsumoto, T.2    Lee, K.S.3    Miki, T.4
  • 64
    • 2942554939 scopus 로고    scopus 로고
    • Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation
    • Solski PA,Wilder RS,Rossman KL, et al.Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.J Biol Chem. 2004;279 (24): 25226-33.
    • (2004) J Biol Chem , vol.279 , Issue.24 , pp. 25226-25233
    • Solski, P.A.1    Wilder, R.S.2    Rossman, K.L.3
  • 65
    • 13844252076 scopus 로고    scopus 로고
    • Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
    • Oceguera-Yanez F,Kimura K,Yasuda S, et al.Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.J Cell Biol. 2005;168 (2): 221-32.
    • (2005) J Cell Biol , vol.168 , Issue.2 , pp. 221-232
    • Oceguera-Yanez, F.1    Kimura, K.2    Yasuda, S.3
  • 66
    • 63049085679 scopus 로고    scopus 로고
    • A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors
    • Kawashima T,Bao YC,Minoshima Y, et al.A Rac GTPase-activating protein, MgcRacGAP, is a nuclear localizing signal-containing nuclear chaperone in the activation of STAT transcription factors.Mol Cell Biol. 2009;29 (7): 1796-813.
    • (2009) Mol Cell Biol , vol.29 , Issue.7 , pp. 1796-1813
    • Kawashima, T.1    Bao, Y.C.2    Minoshima, Y.3
  • 67
    • 80052867878 scopus 로고    scopus 로고
    • Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma
    • Wang SM,Ooi LL,Hui KM.Upregulation of Rac GTPase-activating protein 1 is significantly associated with the early recurrence of human hepatocellular carcinoma.Clin Cancer Res. 2011;17 (18): 6040-51.
    • (2011) Clin Cancer Res , vol.17 , Issue.18 , pp. 6040-6051
    • Wang, S.M.1    Ooi, L.L.2    Hui, K.M.3
  • 68
    • 80052277904 scopus 로고    scopus 로고
    • PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin
    • Tao J,Oladimeji P,Rider L,Diakonova M.PAK1-Nck regulates cyclin D1 promoter activity in response to prolactin.Mol Endocrinol. 2011;25 (9): 1565-78.
    • (2011) Mol Endocrinol , vol.25 , Issue.9 , pp. 1565-1578
    • Tao, J.1    Oladimeji, P.2    Rider, L.3    Diakonova, M.4
  • 69
    • 79952637148 scopus 로고    scopus 로고
    • The F-actin severing protein cofilin-1 is required for RNA polymerase II transcription elongation
    • Obrdlik A,Percipalle P.The F-actin severing protein cofilin-1 is required for RNA polymerase II transcription elongation.Nucleus. 2011;2 (1): 72-9.
    • (2011) Nucleus , vol.2 , Issue.1 , pp. 72-79
    • Obrdlik, A.1    Percipalle, P.2
  • 70
    • 0041438404 scopus 로고    scopus 로고
    • The Group 3 LIM domain protein paxillin potentiates androgen receptor transactivation in prostate cancer cell lines
    • Kasai M,Guerrero-Santoro J,Friedman R,Leman ES,Getzenberg RH,DeFranco DB.The Group 3 LIM domain protein paxillin potentiates androgen receptor transactivation in prostate cancer cell lines.Cancer Res. 2003;63 (16): 4927-35.
    • (2003) Cancer Res , vol.63 , Issue.16 , pp. 4927-4935
    • Kasai, M.1    Guerrero-Santoro, J.2    Friedman, R.3    Leman, E.S.4    Getzenberg, R.H.5    DeFranco, D.B.6
  • 71
    • 78649880786 scopus 로고    scopus 로고
    • p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients
    • Siu MK,Chan HY,Kong DS, et al.p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients.Proc Natl Acad Sci U S A. 2010;107 (43): 18622-7.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.43 , pp. 18622-18627
    • Siu, M.K.1    Chan, H.Y.2    Kong, D.S.3
  • 72
    • 77953465926 scopus 로고    scopus 로고
    • Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion
    • Siu MK,Wong ES,Chan HY, et al.Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion.Int J Cancer. 2010;127 (1): 21-31.
    • (2010) Int J Cancer , vol.127 , Issue.1 , pp. 21-31
    • Siu, M.K.1    Wong, E.S.2    Chan, H.Y.3
  • 73
    • 79960622503 scopus 로고    scopus 로고
    • Biogenesis and function of nuclear bodies
    • Mao YS,Zhang B,Spector DL.Biogenesis and function of nuclear bodies.Trends Genet. 2011;27 (8): 295-306.
    • (2011) Trends Genet , vol.27 , Issue.8 , pp. 295-306
    • Mao, Y.S.1    Zhang, B.2    Spector, D.L.3
  • 74
    • 84866525932 scopus 로고    scopus 로고
    • Charting the landscape of tandem BRCT domain-mediated protein interactions
    • Woods NT,Mesquita RD,Sweet M, et al.Charting the landscape of tandem BRCT domain-mediated protein interactions.Sci Signal. 2012;5 (242): rs6.
    • (2012) Sci Signal , vol.5 , Issue.242
    • Woods, N.T.1    Mesquita, R.D.2    Sweet, M.3
  • 75
    • 79952013333 scopus 로고    scopus 로고
    • The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage
    • Srougi MC,Burridge K.The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.PLoS One. 2011;6 (2): e17108.
    • (2011) PLoS One , vol.6 , Issue.2
    • Srougi, M.C.1    Burridge, K.2
  • 76
    • 34748839538 scopus 로고    scopus 로고
    • Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor
    • Grabocka E,Wedegaertner PB.Disruption of oligomerization induces nucleocytoplasmic shuttling of leukemia-associated rho Guanine-nucleotide exchange factor.Mol Pharmacol. 2007;72 (4): 993-1002.
    • (2007) Mol Pharmacol , vol.72 , Issue.4 , pp. 993-1002
    • Grabocka, E.1    Wedegaertner, P.B.2
  • 77
    • 84856955553 scopus 로고    scopus 로고
    • A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer
    • Rao S,Lyons LS,Fahrenholtz CD, et al.A novel nuclear role for the Vav3 nucleotide exchange factor in androgen receptor coactivation in prostate cancer.Oncogene. 2012;31 (6): 716-27.
    • (2012) Oncogene , vol.31 , Issue.6 , pp. 716-727
    • Rao, S.1    Lyons, L.S.2    Fahrenholtz, C.D.3
  • 78
    • 33645516549 scopus 로고    scopus 로고
    • PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility
    • Fiordalisi JJ,Keller PJ,Cox AD.PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility.Cancer Res. 2006;66 (6): 3153-61.
    • (2006) Cancer Res , vol.66 , Issue.6 , pp. 3153-3161
    • Fiordalisi, J.J.1    Keller, P.J.2    Cox, A.D.3
  • 79
    • 13444311711 scopus 로고    scopus 로고
    • Concentric zones of active RhoA and Cdc42 around single cell wounds
    • Benink HA,Bement WM.Concentric zones of active RhoA and Cdc42 around single cell wounds.J Cell Biol. 2005;168 (3): 429-39.
    • (2005) J Cell Biol , vol.168 , Issue.3 , pp. 429-439
    • Benink, H.A.1    Bement, W.M.2
  • 80
    • 39449083242 scopus 로고    scopus 로고
    • Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells
    • Abdi KM,Bennett V.Adducin promotes micrometer-scale organization of beta2-spectrin in lateral membranes of bronchial epithelial cells.Mol Biol Cell. 2008;19 (2): 536-45.
    • (2008) Mol Biol Cell , vol.19 , Issue.2 , pp. 536-545
    • Abdi, K.M.1    Bennett, V.2
  • 81
    • 59449093560 scopus 로고    scopus 로고
    • The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis
    • Brady DC,Alan JK,Madigan JP,Fanning AS,Cox AD.The transforming Rho family GTPase Wrch-1 disrupts epithelial cell tight junctions and epithelial morphogenesis.Mol Cell Biol. 2009;29 (4): 1035-49.
    • (2009) Mol Cell Biol , vol.29 , Issue.4 , pp. 1035-1049
    • Brady, D.C.1    Alan, J.K.2    Madigan, J.P.3    Fanning, A.S.4    Cox, A.D.5
  • 82
    • 45549103808 scopus 로고    scopus 로고
    • Tools to study the function of the Ras-related, estrogen-regulated growth inhibitor in breast cancer
    • Hanker AB,Morita S,Repasky GA,Ross DT,Seitz RS,Der CJ.Tools to study the function of the Ras-related, estrogen-regulated growth inhibitor in breast cancer.Methods Enzymol. 2008;439:53-72.
    • (2008) Methods Enzymol , vol.439 , pp. 53-72
    • Hanker, A.B.1    Morita, S.2    Repasky, G.A.3    Ross, D.T.4    Seitz, R.S.5    Der, C.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.