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Volumn 19, Issue 1, 2008, Pages 8-16

Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; EXOENZYME C3; PROTEIN ECT 2; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

EID: 38749123941     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-04-0370     Document Type: Article
Times cited : (27)

References (47)
  • 2
    • 0034799994 scopus 로고    scopus 로고
    • Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods
    • Benard, V., and Bokoch, G. M. (2002). Assay of Cdc42, Rac, and Rho GTPase activation by affinity methods. Methods Enzymol. 345, 349-359.
    • (2002) Methods Enzymol , vol.345 , pp. 349-359
    • Benard, V.1    Bokoch, G.M.2
  • 3
    • 34247615185 scopus 로고    scopus 로고
    • GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases
    • Birkenfeld, J., Nalbant, P., Bohl, B. P., Pertz, O., Hahn, K. M., and Bokoch, G. M. (2007). GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev. Cell 12, 699-712.
    • (2007) Dev. Cell , vol.12 , pp. 699-712
    • Birkenfeld, J.1    Nalbant, P.2    Bohl, B.P.3    Pertz, O.4    Hahn, K.M.5    Bokoch, G.M.6
  • 4
    • 0842281652 scopus 로고    scopus 로고
    • Rho and Rac take center stage
    • Burridge, K., and Wennerberg, K. (2004). Rho and Rac take center stage. Cell 116, 167-179.
    • (2004) Cell , vol.116 , pp. 167-179
    • Burridge, K.1    Wennerberg, K.2
  • 5
    • 0031013074 scopus 로고    scopus 로고
    • Traction forces of cytokinesis measured with optically modified elastic substrata
    • Burton, K., and Taylor, D. L. (1997). Traction forces of cytokinesis measured with optically modified elastic substrata. Nature 385, 450-454.
    • (1997) Nature , vol.385 , pp. 450-454
    • Burton, K.1    Taylor, D.L.2
  • 6
    • 33746826459 scopus 로고    scopus 로고
    • Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission
    • Chalamalasetty, R. B., Hummer, S., Nigg, E. A., and Sillje, H. H. (2006). Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission. J. Cell Sci. 119, 3008-3019.
    • (2006) J. Cell Sci , vol.119 , pp. 3008-3019
    • Chalamalasetty, R.B.1    Hummer, S.2    Nigg, E.A.3    Sillje, H.H.4
  • 7
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville, S., and Hall, A. (2002). Rho GTPases in cell biology. Nature 420, 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 10
    • 15244356577 scopus 로고    scopus 로고
    • The molecular requirements for cytokinesis
    • Glotzer, M. (2005). The molecular requirements for cytokinesis. Science 307, 1735-1739.
    • (2005) Science , vol.307 , pp. 1735-1739
    • Glotzer, M.1
  • 12
  • 13
    • 23044453523 scopus 로고    scopus 로고
    • Adhesion-dependent and contractile ring-independent equatorial furrowing during cytokinesis in mammalian cells
    • Kanada, M., Nagasaki, A., and Uyeda, T.Q.P. (2005). Adhesion-dependent and contractile ring-independent equatorial furrowing during cytokinesis in mammalian cells. Mol. Biol. Cell 16, 3865-3872.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 3865-3872
    • Kanada, M.1    Nagasaki, A.2    Uyeda, T.Q.P.3
  • 14
    • 14044263688 scopus 로고    scopus 로고
    • The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis
    • Kim, J. E., Billadeau, D. D., and Chen, J. (2005). The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J. Biol. Chem. 280, 5733-5739.
    • (2005) J. Biol. Chem , vol.280 , pp. 5733-5739
    • Kim, J.E.1    Billadeau, D.D.2    Chen, J.3
  • 15
    • 9444242736 scopus 로고    scopus 로고
    • Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
    • Kimura, K. et al. (1996). Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 273, 245-248.
    • (1996) Science , vol.273 , pp. 245-248
    • Kimura, K.1
  • 16
    • 0034625353 scopus 로고    scopus 로고
    • Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation
    • Kimura, K., Tsuji, T., Takada, Y., Miki, T., and Narumiya, S. (2000). Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation. J. Biol. Chem. 275, 17233-17236.
    • (2000) J. Biol. Chem , vol.275 , pp. 17233-17236
    • Kimura, K.1    Tsuji, T.2    Takada, Y.3    Miki, T.4    Narumiya, S.5
  • 17
    • 0027509362 scopus 로고
    • Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI)
    • Kishi, K., Sasaki, T., Kuroda, S., Itoh, T., and Takai, Y. (1993). Regulation of cytoplasmic division of Xenopus embryo by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI). J. Cell Biol. 120, 1187-1195.
    • (1993) J. Cell Biol , vol.120 , pp. 1187-1195
    • Kishi, K.1    Sasaki, T.2    Kuroda, S.3    Itoh, T.4    Takai, Y.5
  • 18
    • 0037780973 scopus 로고    scopus 로고
    • The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin
    • Kovar, D. R., Kuhn, J. R., Tichy, A. L., and Pollard, T. D. (2003). The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin. J. Cell Biol. 161, 875-887.
    • (2003) J. Cell Biol , vol.161 , pp. 875-887
    • Kovar, D.R.1    Kuhn, J.R.2    Tichy, A.L.3    Pollard, T.D.4
  • 19
    • 0027691240 scopus 로고
    • A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs
    • Mabuchi, I., Hamaguchi, Y., Fujimoto, H., Morii, N., Mishima, M., and Narumiya, S. (1993). A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs. Zygote 1, 325-331.
    • (1993) Zygote , vol.1 , pp. 325-331
    • Mabuchi, I.1    Hamaguchi, Y.2    Fujimoto, H.3    Morii, N.4    Mishima, M.5    Narumiya, S.6
  • 20
    • 0033974762 scopus 로고    scopus 로고
    • Microtubule-actomyosin interactions in cortical flow and cytokinesis
    • Mandato, C. A., Benink, H. A., and Bement, W. M. (2000). Microtubule-actomyosin interactions in cortical flow and cytokinesis. Cell Motil. Cytoskelet. 45, 87-92.
    • (2000) Cell Motil. Cytoskelet , vol.45 , pp. 87-92
    • Mandato, C.A.1    Benink, H.A.2    Bement, W.M.3
  • 21
    • 21744445075 scopus 로고    scopus 로고
    • Regulation of myosin II during cytokinesis in higher eukaryotes
    • Matsumura, F. (2005). Regulation of myosin II during cytokinesis in higher eukaryotes. Trends Cell Biol. 15, 371-377.
    • (2005) Trends Cell Biol , vol.15 , pp. 371-377
    • Matsumura, F.1
  • 22
    • 0027502565 scopus 로고
    • Oncogene ect2 is related to regulators of small GTP-binding proteins
    • Miki, T., Smith, C. L., Long, J. E., Eva, A., and Fleming, T. P. (1993). Oncogene ect2 is related to regulators of small GTP-binding proteins. Nature 362, 462-465.
    • (1993) Nature , vol.362 , pp. 462-465
    • Miki, T.1    Smith, C.L.2    Long, J.E.3    Eva, A.4    Fleming, T.P.5
  • 23
    • 14844298677 scopus 로고    scopus 로고
    • Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not
    • Mollinari, C., Kleman, J. P., Saoudi, Y., Jablonski, S. A., Perard, J., Yen, T. J., and Margolis, R. L. (2005). Ablation of PRC1 by small interfering RNA demonstrates that cytokinetic abscission requires a central spindle bundle in mammalian cells, whereas completion of furrowing does not. Mol. Biol. Cell 16, 1043-1055.
    • (2005) Mol. Biol. Cell , vol.16 , pp. 1043-1055
    • Mollinari, C.1    Kleman, J.P.2    Saoudi, Y.3    Jablonski, S.A.4    Perard, J.5    Yen, T.J.6    Margolis, R.L.7
  • 24
    • 28544448876 scopus 로고    scopus 로고
    • Morita, K., Hirono, K., and Han, M. (2005). The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells. EMBO Rep. 6, 1163-1168.
    • Morita, K., Hirono, K., and Han, M. (2005). The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells. EMBO Rep. 6, 1163-1168.
  • 25
    • 0037092522 scopus 로고    scopus 로고
    • Genetic and morphological evidence for two parallel pathways of cell-cycle-coupled cytokinesis in Dictyostelium
    • Nagasaki, A., de Hostos, E., and Uyeda, T.Q.P. (2002). Genetic and morphological evidence for two parallel pathways of cell-cycle-coupled cytokinesis in Dictyostelium. J. Cell Sci. 115, 2241-2251.
    • (2002) J. Cell Sci , vol.115 , pp. 2241-2251
    • Nagasaki, A.1    de Hostos, E.2    Uyeda, T.Q.P.3
  • 26
    • 34547793076 scopus 로고    scopus 로고
    • A novel shRNA vector that enables rapid selection and identification of knockdown cells
    • Nagasaki, A., Kanada, M., and Uyeda, T.Q.P. (2007). A novel shRNA vector that enables rapid selection and identification of knockdown cells. Plasmid 58, 190-194.
    • (2007) Plasmid , vol.58 , pp. 190-194
    • Nagasaki, A.1    Kanada, M.2    Uyeda, T.Q.P.3
  • 27
    • 0031049976 scopus 로고    scopus 로고
    • Myosin II-independent processes in mitotic cells of Dictyostelium discoideum: Redistribution of the nuclei, re-arrangement of the actin system, and formation of the cleavage furrow
    • Neujahr, R., Heizer, C., and Gerisch, G. (1997). Myosin II-independent processes in mitotic cells of Dictyostelium discoideum: redistribution of the nuclei, re-arrangement of the actin system, and formation of the cleavage furrow. J. Cell Sci. 110, 123-137.
    • (1997) J. Cell Sci , vol.110 , pp. 123-137
    • Neujahr, R.1    Heizer, C.2    Gerisch, G.3
  • 28
    • 31644438188 scopus 로고    scopus 로고
    • Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis
    • Nishimura, Y., and Yonemura, S. (2006). Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis. J. Cell Sci. 119, 104-114.
    • (2006) J. Cell Sci , vol.119 , pp. 104-114
    • Nishimura, Y.1    Yonemura, S.2
  • 29
    • 0033601744 scopus 로고    scopus 로고
    • The small GTP-binding protein Rho regulates cortical activities in cultured cells during division
    • O'Connell, C. B., Wheatley, S. P., Ahmed, S., and Wang, Y. L. (1999). The small GTP-binding protein Rho regulates cortical activities in cultured cells during division. J. Cell Biol. 144, 305-313.
    • (1999) J. Cell Biol , vol.144 , pp. 305-313
    • O'Connell, C.B.1    Wheatley, S.P.2    Ahmed, S.3    Wang, Y.L.4
  • 30
    • 0034907213 scopus 로고    scopus 로고
    • mDia mediates Rho-regulated formation and orientation of stable microtubules
    • Palazzo, A. F., Cook, T. A., Alberts, A. S., and Gundersen, G. G. (2001). mDia mediates Rho-regulated formation and orientation of stable microtubules. Nat. Cell Biol. 3, 723-729.
    • (2001) Nat. Cell Biol , vol.3 , pp. 723-729
    • Palazzo, A.F.1    Cook, T.A.2    Alberts, A.S.3    Gundersen, G.G.4
  • 31
    • 33646197411 scopus 로고    scopus 로고
    • Spatiotemporal dynamics of RhoA activity in migrating cells
    • Pertz, O., Hodgson, L., Klemke, R. L., and Hahn, K. M. (2006). Spatiotemporal dynamics of RhoA activity in migrating cells. Nature 440, 1069-1072.
    • (2006) Nature , vol.440 , pp. 1069-1072
    • Pertz, O.1    Hodgson, L.2    Klemke, R.L.3    Hahn, K.M.4
  • 32
    • 0036591960 scopus 로고    scopus 로고
    • Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo
    • Piekny, A. J., and Mains, P. E. (2002). Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo. J. Cell Sci. 115, 2271-2282.
    • (2002) J. Cell Sci , vol.115 , pp. 2271-2282
    • Piekny, A.J.1    Mains, P.E.2
  • 33
    • 0033200353 scopus 로고    scopus 로고
    • A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila
    • Prokopenko, S. N., Brumby, A., O'Keefe, L., Prior, L., He, Y., Saint, R., and Bellen, H. J. (1999). A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila. Genes Dev. 13, 2301-2314.
    • (1999) Genes Dev , vol.13 , pp. 2301-2314
    • Prokopenko, S.N.1    Brumby, A.2    O'Keefe, L.3    Prior, L.4    He, Y.5    Saint, R.6    Bellen, H.J.7
  • 34
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • Raftopoulou, M., and Hall, A. (2004). Cell migration: Rho GTPases lead the way. Dev. Biol. 265, 23-32.
    • (2004) Dev. Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 35
    • 0016373845 scopus 로고
    • Characterization of a newly derived human sarcoma cell line (HT-1080)
    • Rasheed, S., Nelson-Rees, W. A., Toth, E. M., Arnstein, P., and Gardner, M. B. (1974). Characterization of a newly derived human sarcoma cell line (HT-1080). Cancer 33, 1027-1033.
    • (1974) Cancer , vol.33 , pp. 1027-1033
    • Rasheed, S.1    Nelson-Rees, W.A.2    Toth, E.M.3    Arnstein, P.4    Gardner, M.B.5
  • 36
    • 0033777071 scopus 로고    scopus 로고
    • Determination of GTP loading on Rho
    • Ren, X. D., and Schwartz, M. A. (2000). Determination of GTP loading on Rho. Methods Enzymol. 325, 264-272.
    • (2000) Methods Enzymol , vol.325 , pp. 264-272
    • Ren, X.D.1    Schwartz, M.A.2
  • 37
    • 0036049615 scopus 로고    scopus 로고
    • An actin nucleation mechanism mediated by Bni1 and profilin
    • Sagot, I., Rodal, A. A., Moseley, J., Goode, B. L., and Pellman, D. (2002). An actin nucleation mechanism mediated by Bni1 and profilin. Nat. Cell Biol. 4, 626-631.
    • (2002) Nat. Cell Biol , vol.4 , pp. 626-631
    • Sagot, I.1    Rodal, A.A.2    Moseley, J.3    Goode, B.L.4    Pellman, D.5
  • 38
    • 10744225152 scopus 로고    scopus 로고
    • Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation
    • Saito, S. et al. (2004). Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation. J. Biol. Chem. 279, 7169-7179.
    • (2004) J. Biol. Chem , vol.279 , pp. 7169-7179
    • Saito, S.1
  • 39
    • 11144267737 scopus 로고    scopus 로고
    • Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein
    • Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N., Palmer, A. E., and Tsien, R. Y. (2004). Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat. Biotechnol. 22, 1567-1572.
    • (2004) Nat. Biotechnol , vol.22 , pp. 1567-1572
    • Shaner, N.C.1    Campbell, R.E.2    Steinbach, P.A.3    Giepmans, B.N.4    Palmer, A.E.5    Tsien, R.Y.6
  • 40
    • 0033615978 scopus 로고    scopus 로고
    • Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis
    • Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I., and Miki, T. (1999). Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J. Cell Biol. 147, 921-928.
    • (1999) J. Cell Biol , vol.147 , pp. 921-928
    • Tatsumoto, T.1    Xie, X.2    Blumenthal, R.3    Okamoto, I.4    Miki, T.5
  • 41
    • 8844261079 scopus 로고    scopus 로고
    • Multiple parallelisms in animal cytokinesis
    • Uyeda, T.Q.P., Nagasaki, A., and Yumura, S. (2004). Multiple parallelisms in animal cytokinesis. Int. Rev. Cytol. 240, 377-432.
    • (2004) Int. Rev. Cytol , vol.240 , pp. 377-432
    • Uyeda, T.Q.P.1    Nagasaki, A.2    Yumura, S.3
  • 42
    • 0032479167 scopus 로고    scopus 로고
    • Westwick, J. K., Lee, R. J., Lambert, Q. T., Symons, M., Pestell, R. G., Der, C. J., and Whitehead, I. P. (1998). Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. J. Biol. Chem. 273, 16739-16747.
    • Westwick, J. K., Lee, R. J., Lambert, Q. T., Symons, M., Pestell, R. G., Der, C. J., and Whitehead, I. P. (1998). Transforming potential of Dbl family proteins correlates with transcription from the cyclin D1 promoter but not with activation of Jun NH2-terminal kinase, p38/Mpk2, serum response factor, or c-Jun. J. Biol. Chem. 273, 16739-16747.
  • 43
    • 33744914052 scopus 로고    scopus 로고
    • A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis
    • Wu, D., Asiedu, M., Adelstein, R. S., and Wei, Q. (2006). A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis. Cell Cycle 5, 1234-1239.
    • (2006) Cell Cycle , vol.5 , pp. 1234-1239
    • Wu, D.1    Asiedu, M.2    Adelstein, R.S.3    Wei, Q.4
  • 46
    • 23944499922 scopus 로고    scopus 로고
    • An ECT2-centralspindlin complex regulates the localization and function of RhoA
    • Yuce, O., Piekny, A., and Glotzer, M. (2005). An ECT2-centralspindlin complex regulates the localization and function of RhoA. J. Cell Biol. 170, 571-582.
    • (2005) J. Cell Biol , vol.170 , pp. 571-582
    • Yuce, O.1    Piekny, A.2    Glotzer, M.3
  • 47
    • 0030690360 scopus 로고    scopus 로고
    • On the role of myosin-II in cytokinesis: Division of Dictyostelium cells under adhesive and nonadhesive conditions
    • Zang, J. H., Cavet, G., Sabry, J. H., Wagner, P., Moores, S. L., and Spudich, J. A. (1997). On the role of myosin-II in cytokinesis: division of Dictyostelium cells under adhesive and nonadhesive conditions. Mol. Biol. Cell 8, 2617-2629.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 2617-2629
    • Zang, J.H.1    Cavet, G.2    Sabry, J.H.3    Wagner, P.4    Moores, S.L.5    Spudich, J.A.6


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