Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype

Journal of Biological Chemistry

Volumn 285, Issue 16, 2010, Pages 11760-11764

  Borikova, Asya L ^a   Dibble, Christopher F ^a   Sciaky, Noah ^a   Welch, Christopher M ^a   Abell, Amy N ^a   Bencharit, Sompop ^b   Johnson, Gary L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL INHIBITION; CYTOSOLS; EXTRACELLULAR MATRICES; KINASE INHIBITION; LIVE-CELL IMAGING; MYOSIN LIGHT CHAINS; PROTEIN EXPRESSIONS; PROTEIN FUNCTIONS; SHORT HAIRPIN RNA; SIGNALING NETWORKS; THERAPEUTIC TARGETS; TUBE FORMATION; VASCULAR ENDOTHELIAL CELLS; VASCULAR LESIONS;

BIOSENSORS; BLOOD VESSEL PROSTHESES; ENZYME INHIBITION; PHOSPHORYLATION; PROTEINS; RNA; SELF ASSEMBLY; SIGNALING;

ENDOTHELIAL CELLS;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; BRAIN PROTEIN; CEREBRAL CAVERNOUS MALFORMATION 1 PROTEIN; CEREBRAL CAVERNOUS MALFORMATION 2 PROTEIN; CEREBRAL CAVERNOUS MALFORMATION 3 PROTEIN; MYOSIN LIGHT CHAIN 2; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOSENSOR; CELL INVASION; CELL NUCLEUS; CEREBRAL CAVERNOUS MALFORMATION; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; EMBRYO; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMIDES; APOPTOSIS REGULATORY PROTEINS; BIOSENSING TECHNIQUES; CARDIAC MYOSINS; CARRIER PROTEINS; CELL LINE; ENDOTHELIAL CELLS; HEMANGIOMA, CAVERNOUS, CENTRAL NERVOUS SYSTEM; HUMANS; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MYOSIN LIGHT CHAINS; PHENOTYPE; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; PYRIDINES; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA INTERFERENCE;

EID: 77951240109     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C109.097220     Document Type: Article

References (19)

1. Plummer, N. W., Zawistowski, J. S., and Marchuk, D. A. (2005) Curr. Neurol. Neurosci. Rep. 5, 391-396
2. Laberge-le Couteulx, S., Jung, H. H., Labauge, P., Houtteville, J. P., Lescoat, C., Cecillon, M., Marechal, E., Joutel, A., Bach, J. F., and Tournier- Lasserve, E. (1999) Nat. Genet. 23, 189-193
3. Hilder, T. L., Malone, M. H., Bencharit, S., Colicelli, J., Haystead, T. A., Johnson, G. L., and Wu, C. C. (2007) J. Proteome Res. 6, 4343-4355
4. Zawistowski, J. S., Stalheim, L., Uhlik, M. T., Abell, A. N., Ancrile, B. B., Johnson, G. L., and Marchuk, D. A. (2005) Hum. Mol. Genet. 14, 2521-2531
5. Uhlik, M. T., Abell, A. N., Johnson, N. L., Sun, W., Cuevas, B. D., Lobel-Rice, K. E., Horne, E. A., Dell'Acqua, M. L., and Johnson, G. L. (2003) Nat. Cell Biol. 5, 1104-1110
6. Kleaveland, B., Zheng, X., Liu, J. J., Blum, Y., Tung, J. J., Zou, Z., Sweeney, S. M., Chen, M., Guo, L., Lu, M. M., Zhou, D., Kitajewski, J., Affolter, M., Ginsberg, M. H., and Kahn, M. L. (2009) Nat. Med. 15, 169-176
7. Whitehead, K. J., Chan, A. C., Navankasattusas, S., Koh, W., London, N. R., Ling, J., Mayo, A. H., Drakos, S. G., Jones, C. A., Zhu, W., Marchuk, D. A., Davis, G. E., and Li, D. Y. (2009) Nat. Med. 15, 177-184
8. Crose, L. E., Hilder, T. L., Sciaky, N., and Johnson, G. L. (2009) J. Biol. Chem. 284, 13301-13305
9. Jaffe, A. B., and Hall, A. (2005) Annu. Rev. Cell Dev. Biol. 21, 247-269
10. Chrissobolis, S., and Sobey, C. G. (2006) Stroke 37, 2174-2180
11. Pertz, O., Hodgson, L., Klemke, R. L., and Hahn, K. M. (2006) Nature 440, 1069-1072
12. Machacek, M., Hodgson, L., Welch, C., Elliott, H., Pertz, O., Nalbant, P., Abell, A., Johnson, G. L., Hahn, K. M., and Danuser, G. (2009) Nature 461, 99-103
13. Liao, J. K., Seto, M., and Noma, K. (2007) J. Cardiovasc. Pharmacol. 50, 17-24
14. Kaunas, R., Nguyen, P., Usami, S., and Chien, S. (2005) Proc. Natl. Acad. Sci. U.S.A. 102, 15895-15900
15. Jiang, X. S., Wassif, C. A., Backlund, P. S., Song, L., Holtzclaw, L. A., Li, Z., Yergey, A. L., and Porter, F. D. (January 12, 2010) Hum. Mol Genet. 10.1093/hmg/ddq011
16. Awad, I. A. (2005) Surg. Neurol. 63, 317-318
17. Inan, S., and Büyükafşar, K. (2008) Br. J. Pharmacol. 155, 44-51
18. Suzuki, Y., Shibuya, M., Satoh, S., Sugiyama, H., Seto, M., and Takakura, K. (2008) Neurol. Med. Chir. (Tokyo) 48, 241-247; discussion 247-248
19. Yamazaki, K., Gohda, J., Kanayama, A., Miyamoto, Y., Sakurai, H., Yamamoto, M., Akira, S., Hayashi, H., Su, B., and Inoue, J. (2009) Sci. Signal. 2, ra66