메뉴 건너뛰기




Volumn 181, Issue 2, 2012, Pages 662-674

ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN CDC42; RAC1 PROTEIN; RASAL2 PROTEIN; RHO FACTOR; UNCLASSIFIED DRUG;

EID: 84864115184     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.04.011     Document Type: Article
Times cited : (42)

References (44)
  • 1
    • 78649487698 scopus 로고    scopus 로고
    • Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy
    • D. Vigil, J. Cherfils, K.L. Rossman, C.J. Der Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy Nat Rev Cancer 10 2010 842 857
    • (2010) Nat Rev Cancer , vol.10 , pp. 842-857
    • Vigil, D.1    Cherfils, J.2    Rossman, K.L.3    Der, C.J.4
  • 2
    • 25444528940 scopus 로고    scopus 로고
    • Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1
    • B. Salhia, F. Rutten, M. Nakada, C. Beaudry, M. Berens, A. Kwan, J.T. Rutka Inhibition of Rho-kinase affects astrocytoma morphology, motility, and invasion through activation of Rac1 Cancer Res 65 2005 8792 8800
    • (2005) Cancer Res , vol.65 , pp. 8792-8800
    • Salhia, B.1    Rutten, F.2    Nakada, M.3    Beaudry, C.4    Berens, M.5    Kwan, A.6    Rutka, J.T.7
  • 5
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • M. Raftopoulou, A. Hall Cell migration: rho GTPases lead the way Dev Biol 265 2004 23 32
    • (2004) Dev Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 6
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • A.B. Jaffe, A. Hall Rho GTPases: biochemistry and biology Annu Rev Cell Dev Biol 21 2005 247 269
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 7
    • 67651204899 scopus 로고    scopus 로고
    • Rac and Rho driving tumor invasion: Who's at the wheel
    • M. Symons, J.E. Segall Rac and Rho driving tumor invasion: who's at the wheel Genome Biol 10 2009 213
    • (2009) Genome Biol , vol.10 , pp. 213
    • Symons, M.1    Segall, J.E.2
  • 8
    • 9144232309 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma cell migration and invasion
    • T. Demuth, M.E. Berens Molecular mechanisms of glioma cell migration and invasion J Neurooncol 70 2004 217 228
    • (2004) J Neurooncol , vol.70 , pp. 217-228
    • Demuth, T.1    Berens, M.E.2
  • 10
    • 0042354574 scopus 로고    scopus 로고
    • Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
    • E. Sahai, C.J. Marshall Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis Nat Cell Biol 5 2003 711 719
    • (2003) Nat Cell Biol , vol.5 , pp. 711-719
    • Sahai, E.1    Marshall, C.J.2
  • 11
    • 33746658154 scopus 로고    scopus 로고
    • FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling
    • Y. Ohta, J.H. Hartwig, T.P. Stossel FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling Nat Cell Biol 8 2006 803 814
    • (2006) Nat Cell Biol , vol.8 , pp. 803-814
    • Ohta, Y.1    Hartwig, J.H.2    Stossel, T.P.3
  • 16
    • 70350074501 scopus 로고    scopus 로고
    • Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
    • V. Justilien, A.P. Fields Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation Oncogene 28 2009 3597 3607
    • (2009) Oncogene , vol.28 , pp. 3597-3607
    • Justilien, V.1    Fields, A.P.2
  • 17
    • 77953379686 scopus 로고    scopus 로고
    • The guanine nucleotide exchange factor SWAP-70 modulates the migration and invasiveness of human malignant glioma cells
    • H.J. Seol, C.A. Smith, B. Salhia, J.T. Rutka The guanine nucleotide exchange factor SWAP-70 modulates the migration and invasiveness of human malignant glioma cells Transl Oncol 2 2009 300 309
    • (2009) Transl Oncol , vol.2 , pp. 300-309
    • Seol, H.J.1    Smith, C.A.2    Salhia, B.3    Rutka, J.T.4
  • 19
    • 3343014893 scopus 로고    scopus 로고
    • The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling
    • C.A. Smith, S.E. Dho, J. Donaldson, U. Tepass, C.J. McGlade The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling Mol Biol Cell 15 2004 3698 3708
    • (2004) Mol Biol Cell , vol.15 , pp. 3698-3708
    • Smith, C.A.1    Dho, S.E.2    Donaldson, J.3    Tepass, U.4    McGlade, C.J.5
  • 20
    • 44449117048 scopus 로고    scopus 로고
    • Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor
    • J. Tong, P. Taylor, E. Jovceva, J.R. St-Germain, L.L. Jin, A. Nikolic, X. Gu, Z.H. Li, S. Trudel, M.F. Moran Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor J Proteome Res 7 2008 1067 1077
    • (2008) J Proteome Res , vol.7 , pp. 1067-1077
    • Tong, J.1    Taylor, P.2    Jovceva, E.3    St-Germain, J.R.4    Jin, L.L.5    Nikolic, A.6    Gu, X.7    Li, Z.H.8    Trudel, S.9    Moran, M.F.10
  • 22
    • 61349128532 scopus 로고    scopus 로고
    • Rembrandt: Helping personalized medicine become a reality through integrative translational research
    • S. Madhavan, J.C. Zenklusen, Y. Kotliarov, H. Sahni, H.A. Fine, K. Buetow Rembrandt: helping personalized medicine become a reality through integrative translational research Mol Cancer Res 7 2 2009 157 167
    • (2009) Mol Cancer Res , vol.7 , Issue.2 , pp. 157-167
    • Madhavan, S.1    Zenklusen, J.C.2    Kotliarov, Y.3    Sahni, H.4    Fine, H.A.5    Buetow, K.6
  • 23
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • The Cancer Genome Atlas Research Network
    • The Cancer Genome Atlas Research Network Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 2008 1061 1068
    • (2008) Nature , pp. 1061-1068
  • 24
    • 0038049137 scopus 로고    scopus 로고
    • Tumour-cell invasion and migration: Diversity and escape mechanisms
    • P. Friedl, K. Wolf Tumour-cell invasion and migration: diversity and escape mechanisms Nat Rev Cancer 3 2003 362 374
    • (2003) Nat Rev Cancer , vol.3 , pp. 362-374
    • Friedl, P.1    Wolf, K.2
  • 25
    • 45349096499 scopus 로고    scopus 로고
    • Cell motility through plasma membrane blebbing
    • O.T. Fackler, R. Grosse Cell motility through plasma membrane blebbing J Cell Biol 181 2008 879 884
    • (2008) J Cell Biol , vol.181 , pp. 879-884
    • Fackler, O.T.1    Grosse, R.2
  • 26
    • 70349314647 scopus 로고    scopus 로고
    • Mechanical modes of 'amoeboid' cell migration
    • T. Lammermann, M. Sixt Mechanical modes of 'amoeboid' cell migration Curr Opin Cell Biol 21 2009 636 644
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 636-644
    • Lammermann, T.1    Sixt, M.2
  • 27
    • 0033772834 scopus 로고    scopus 로고
    • Use and properties of ROCK-specific inhibitor Y-27632
    • S. Narumiya, T. Ishizaki, M. Uehata Use and properties of ROCK-specific inhibitor Y-27632 Methods Enzymol 325 2000 273 284
    • (2000) Methods Enzymol , vol.325 , pp. 273-284
    • Narumiya, S.1    Ishizaki, T.2    Uehata, M.3
  • 29
    • 33748751286 scopus 로고    scopus 로고
    • Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase
    • L.T. Reiter, T.N. Seagroves, M. Bowers, E. Bier Expression of the Rho-GEF Pbl/ECT2 is regulated by the UBE3A E3 ubiquitin ligase Hum Mol Genet 15 2006 2825 2835
    • (2006) Hum Mol Genet , vol.15 , pp. 2825-2835
    • Reiter, L.T.1    Seagroves, T.N.2    Bowers, M.3    Bier, E.4
  • 30
    • 80051835465 scopus 로고    scopus 로고
    • APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis
    • C. Liot, L. Seguin, A. Siret, C. Crouin, S. Schmidt, J. Bertoglio APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis PLoS One 6 2011 e23676
    • (2011) PLoS One , vol.6 , pp. 23676
    • Liot, C.1    Seguin, L.2    Siret, A.3    Crouin, C.4    Schmidt, S.5    Bertoglio, J.6
  • 31
    • 2942554939 scopus 로고    scopus 로고
    • Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation
    • P.A. Solski, R.S. Wilder, K.L. Rossman, J. Sondek, A.D. Cox, S.L. Campbell, C.J. Der Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation J Biol Chem 279 2004 25226 25233
    • (2004) J Biol Chem , vol.279 , pp. 25226-25233
    • Solski, P.A.1    Wilder, R.S.2    Rossman, K.L.3    Sondek, J.4    Cox, A.D.5    Campbell, S.L.6    Der, C.J.7
  • 32
    • 55049085965 scopus 로고    scopus 로고
    • Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer
    • M.L. Zhang, S. Lu, L. Zhou, S.S. Zheng Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer Hepatobiliary Pancreat Dis Int 7 2008 533 538
    • (2008) Hepatobiliary Pancreat Dis Int , vol.7 , pp. 533-538
    • Zhang, M.L.1    Lu, S.2    Zhou, L.3    Zheng, S.S.4
  • 33
    • 27744546286 scopus 로고    scopus 로고
    • Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner
    • F. Niiya, X. Xie, K.S. Lee, H. Inoue, T. Miki Inhibition of cyclin-dependent kinase 1 induces cytokinesis without chromosome segregation in an ECT2 and MgcRacGAP-dependent manner J Biol Chem 280 2005 36502 36509
    • (2005) J Biol Chem , vol.280 , pp. 36502-36509
    • Niiya, F.1    Xie, X.2    Lee, K.S.3    Inoue, H.4    Miki, T.5
  • 34
    • 3242702211 scopus 로고    scopus 로고
    • Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity
    • X.F. Liu, H. Ishida, R. Raziuddin, T. Miki Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity Mol Cell Biol 24 2004 6665 6675
    • (2004) Mol Cell Biol , vol.24 , pp. 6665-6675
    • Liu, X.F.1    Ishida, H.2    Raziuddin, R.3    Miki, T.4
  • 35
    • 31544476883 scopus 로고    scopus 로고
    • Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase
    • T. Hara, M. Abe, H. Inoue, L.R. Yu, T.D. Veenstra, Y.H. Kang, K.S. Lee, T. Miki Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase Oncogene 25 2006 566 578
    • (2006) Oncogene , vol.25 , pp. 566-578
    • Hara, T.1    Abe, M.2    Inoue, H.3    Yu, L.R.4    Veenstra, T.D.5    Kang, Y.H.6    Lee, K.S.7    Miki, T.8
  • 36
    • 70350228376 scopus 로고    scopus 로고
    • Modes and regulation of glial migration in vertebrates and invertebrates
    • C. Klambt Modes and regulation of glial migration in vertebrates and invertebrates Nat Rev Neurosci 10 2009 769 779
    • (2009) Nat Rev Neurosci , vol.10 , pp. 769-779
    • Klambt, C.1
  • 37
    • 73749086570 scopus 로고    scopus 로고
    • The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells
    • K. Pankova, D. Rosel, M. Novotny, J. Brabek The molecular mechanisms of transition between mesenchymal and amoeboid invasiveness in tumor cells Cell Mol Life Sci 67 2010 63 71
    • (2010) Cell Mol Life Sci , vol.67 , pp. 63-71
    • Pankova, K.1    Rosel, D.2    Novotny, M.3    Brabek, J.4
  • 38
    • 0032410106 scopus 로고    scopus 로고
    • A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25
    • S. Noto, T. Maeda, S. Hattori, J. Inazawa, M. Imamura, M. Asaka, M. Hatakeyama A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25 FEBS Lett 441 1998 127 131
    • (1998) FEBS Lett , vol.441 , pp. 127-131
    • Noto, S.1    Maeda, T.2    Hattori, S.3    Inazawa, J.4    Imamura, M.5    Asaka, M.6    Hatakeyama, M.7
  • 41
    • 53249107550 scopus 로고    scopus 로고
    • Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway
    • P. Frankel, C. Pellet-Many, P. Lehtolainen, G.M. D'Abaco, M.L. Tickner, L. Cheng, I.C. Zachary Chondroitin sulphate-modified neuropilin 1 is expressed in human tumour cells and modulates 3D invasion in the U87MG human glioblastoma cell line through a p130Cas-mediated pathway EMBO Rep 9 2008 983 989
    • (2008) EMBO Rep , vol.9 , pp. 983-989
    • Frankel, P.1    Pellet-Many, C.2    Lehtolainen, P.3    D'Abaco, G.M.4    Tickner, M.L.5    Cheng, L.6    Zachary, I.C.7
  • 42
    • 73249141139 scopus 로고    scopus 로고
    • Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices
    • T.A. Ulrich, A. Jain, K. Tanner, J.L. MacKay, S. Kumar Probing cellular mechanobiology in three-dimensional culture with collagen-agarose matrices Biomaterials 31 2010 1875 1884
    • (2010) Biomaterials , vol.31 , pp. 1875-1884
    • Ulrich, T.A.1    Jain, A.2    Tanner, K.3    MacKay, J.L.4    Kumar, S.5
  • 43
    • 80655132137 scopus 로고    scopus 로고
    • SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells
    • F. Oppel, N. Muller, G. Schackert, S. Hendruschk, D. Martin, K.D. Geiger, A. Temme SOX2-RNAi attenuates S-phase entry and induces RhoA-dependent switch to protease-independent amoeboid migration in human glioma cells Mol Cancer 10 2011 137
    • (2011) Mol Cancer , vol.10 , pp. 137
    • Oppel, F.1    Muller, N.2    Schackert, G.3    Hendruschk, S.4    Martin, D.5    Geiger, K.D.6    Temme, A.7
  • 44
    • 62449171854 scopus 로고    scopus 로고
    • Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment
    • P.P. Provenzano, K.W. Eliceiri, P.J. Keely Multiphoton microscopy and fluorescence lifetime imaging microscopy (FLIM) to monitor metastasis and the tumor microenvironment Clin Exp Metastasis 26 2009 357 370
    • (2009) Clin Exp Metastasis , vol.26 , pp. 357-370
    • Provenzano, P.P.1    Eliceiri, K.W.2    Keely, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.