메뉴 건너뛰기




Volumn 99, Issue 12, 2008, Pages 2532-2539

Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with Lovastatin may be useful for ovarian cancer

Author keywords

[No Author keywords available]

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; EXOENZYME C3; MEVINOLIN; PRAVASTATIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 57349135304     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00977.x     Document Type: Article
Times cited : (52)

References (35)
  • 1
    • 0000442221 scopus 로고    scopus 로고
    • Epithelial ovarian cancer
    • In: Hoskins WJ, Perez CA, Young RC, eds. Philadelphia: Lippincott Williams & Wilkins
    • Ozols RF, Rubin SC, Thomas GM et al. Epithelial ovarian cancer. In: Hoskins WJ, Perez CA, Young RC, eds. Principles and Practice of Gynecologic Oncology. Philadelphia: Lippincott Williams & Wilkins, 2000: 981-1057.
    • (2000) Principles and Practice of Gynecologic Oncology , pp. 981-1057
    • Ozols, R.F.1    Rubin, S.C.2    Thomas, G.M.3
  • 2
    • 0028233680 scopus 로고
    • Biology of epithelial ovarian cancer
    • Mutch DG, Williams S. Biology of epithelial ovarian cancer. Clin Obstet Gynecol 1994; 37: 406-22.
    • (1994) Clin Obstet Gynecol , vol.37 , pp. 406-422
    • Mutch, D.G.1    Williams, S.2
  • 3
    • 0141760411 scopus 로고    scopus 로고
    • Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    • Imai T, Horiuchi A, Wang C et al. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 2003; 163: 1437-47.
    • (2003) Am J Pathol , vol.163 , pp. 1437-1447
    • Imai, T.1    Horiuchi, A.2    Wang, C.3
  • 4
    • 10744223595 scopus 로고    scopus 로고
    • The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically
    • Garofalo A, Naumova E, Manenti L et al. The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically. Clin Cancer Res 2003; 9: 3476-85.
    • (2003) Clin Cancer Res , vol.9 , pp. 3476-3485
    • Garofalo, A.1    Naumova, E.2    Manenti, L.3
  • 5
    • 0028871499 scopus 로고
    • Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients
    • Xu Y, Gaudette DC, Boynton JD et al. Characterization of an ovarian cancer activating factor in ascites from ovarian cancer patients. Clin Cancer Res 1995; 1: 1223-32.
    • (1995) Clin Cancer Res , vol.1 , pp. 1223-1232
    • Xu, Y.1    Gaudette, D.C.2    Boynton, J.D.3
  • 6
    • 0031747415 scopus 로고    scopus 로고
    • Malignant effusions contain lysophosphatidic acid (LPA)-like activity
    • Westermann AM, Havik E, Postma FR et al. Malignant effusions contain lysophosphatidic acid (LPA)-like activity. Ann Oncol 1998; 9: 437-42.
    • (1998) Ann Oncol , vol.9 , pp. 437-442
    • Westermann, A.M.1    Havik, E.2    Postma, F.R.3
  • 7
    • 33748331129 scopus 로고    scopus 로고
    • Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: An important autocrine/paracrine factor in tumor progression
    • Kikuchi N, Horiuchi A, Osada R et al. Nuclear expression of S100A4 is associated with aggressive behavior of epithelial ovarian carcinoma: An important autocrine/paracrine factor in tumor progression. Cancer Sci 2006; 97: 1061-9.
    • (2006) Cancer Sci , vol.97 , pp. 1061-1069
    • Kikuchi, N.1    Horiuchi, A.2    Osada, R.3
  • 8
    • 0031729124 scopus 로고    scopus 로고
    • Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate
    • Goetzl EJ, An S. Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate. FASEB J 1998; 12: 1589-98.
    • (1998) FASEB J , vol.12 , pp. 1589-1598
    • Goetzl, E.J.1    An, S.2
  • 10
    • 57349117524 scopus 로고    scopus 로고
    • Molecular target therapy in peritoneal dissemination of ovarian cancer
    • Horiuchi A, Kikuchi N, Imai T et al. Molecular target therapy in peritoneal dissemination of ovarian cancer. Jap J Gynecol Oncol 2005; 23: 234-8.
    • (2005) Jap J Gynecol Oncol , vol.23 , pp. 234-238
    • Horiuchi, A.1    Kikuchi, N.2    Imai, T.3
  • 11
    • 0036191304 scopus 로고    scopus 로고
    • Rho GTPases in transformation and metastasis
    • Jaffe AB, Hall A. Rho GTPases in transformation and metastasis. Adv Cancer Res 2002; 84: 57-80.
    • (2002) Adv Cancer Res , vol.84 , pp. 57-80
    • Jaffe, A.B.1    Hall, A.2
  • 12
    • 0345731237 scopus 로고    scopus 로고
    • Cell migration: Rho GTPases lead the way
    • Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004; 265: 23-32.
    • (2004) Dev Biol , vol.265 , pp. 23-32
    • Raftopoulou, M.1    Hall, A.2
  • 13
    • 0031974721 scopus 로고    scopus 로고
    • Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas
    • Suwa H, Ohshio G, Imamura T et al. Overexpression of the rhoC gene correlates with progression of ductal adenocarcinoma of the pancreas. Br J Cancer 1998; 77: 147-52.
    • (1998) Br J Cancer , vol.77 , pp. 147-152
    • Suwa, H.1    Ohshio, G.2    Imamura, T.3
  • 14
    • 0032939619 scopus 로고    scopus 로고
    • Rho GTPases are over-expressed in human tumors
    • Fritz G, Just I, Kaina B. Rho GTPases are over-expressed in human tumors. Int J Cancer 1999; 81: 682-7.
    • (1999) Int J Cancer , vol.81 , pp. 682-687
    • Fritz, G.1    Just, I.2    Kaina, B.3
  • 15
    • 0034667370 scopus 로고    scopus 로고
    • RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype
    • van Golen KL, Wu ZF, Qiao XT, Bao LW, Merajver SD. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res 2000; 60: 5832-8.
    • (2000) Cancer Res , vol.60 , pp. 5832-5838
    • van Golen, K.L.1    Wu, Z.F.2    Qiao, X.T.3    Bao, L.W.4    Merajver, S.D.5
  • 16
    • 0035129473 scopus 로고    scopus 로고
    • Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour
    • Kamai T, Arai K, Tsujii T, Honda M, Yoshida K. Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour. BJU Int 2001; 87: 227-31.
    • (2001) BJU Int , vol.87 , pp. 227-231
    • Kamai, T.1    Arai, K.2    Tsujii, T.3    Honda, M.4    Yoshida, K.5
  • 17
    • 0036168355 scopus 로고    scopus 로고
    • Characterization of RhoC expression in benign and malignant breast disease: A potential new marker for small breast carcinomas with metastatic ability
    • Kleer CG, van Golen KL, Zhang Y, Wu ZF, Rubin MA, Merajver SD. Characterization of RhoC expression in benign and malignant breast disease: A potential new marker for small breast carcinomas with metastatic ability. Am J Pathol 2002; 160: 579-84.
    • (2002) Am J Pathol , vol.160 , pp. 579-584
    • Kleer, C.G.1    van Golen, K.L.2    Zhang, Y.3    Wu, Z.F.4    Rubin, M.A.5    Merajver, S.D.6
  • 18
    • 0038679226 scopus 로고    scopus 로고
    • Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma
    • Horiuchi A, Imai T, Wang C et al. Up-regulation of small GTPases, RhoA and RhoC, is associated with tumor progression in ovarian carcinoma. Lab Invest 2003; 83: 861-70.
    • (2003) Lab Invest , vol.83 , pp. 861-870
    • Horiuchi, A.1    Imai, T.2    Wang, C.3
  • 19
    • 30644478973 scopus 로고    scopus 로고
    • 2000 Fritz GHMG-CoA reductase inhibitors (statins) as anticancer drugs
    • Laufs and Liao
    • Laufs and Liao. 2000 Fritz GHMG-CoA reductase inhibitors (statins) as anticancer drugs. Int J Oncol 2005; 27: 1401-9.
    • (2005) Int J Oncol , vol.27 , pp. 1401-1409
  • 20
    • 0032570796 scopus 로고    scopus 로고
    • Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells
    • Yoshioka K, Matsumura F, Akedo H, Itoh K. Small GTP-binding protein Rho stimulates the actomyosin system, leading to invasion of tumor cells. J Biol Chem 1998; 273: 5146-54.
    • (1998) J Biol Chem , vol.273 , pp. 5146-5154
    • Yoshioka, K.1    Matsumura, F.2    Akedo, H.3    Itoh, K.4
  • 21
    • 0023187867 scopus 로고
    • A rapid in vitro assay for quantitating the invasive potential of tumor cells
    • Albini A, Iwamoto Y, Kleinman HK et al. A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res 1987; 47: 3239-45.
    • (1987) Cancer Res , vol.47 , pp. 3239-3245
    • Albini, A.1    Iwamoto, Y.2    Kleinman, H.K.3
  • 22
    • 0029947184 scopus 로고    scopus 로고
    • Fluvastatin: A review of its pharmacology and use in the management of hypercholesterolaemia
    • Plosker GL, Wagstaff AJ. Fluvastatin: A review of its pharmacology and use in the management of hypercholesterolaemia. Drugs 1996; 51: 433-59.
    • (1996) Drugs , vol.51 , pp. 433-459
    • Plosker, G.L.1    Wagstaff, A.J.2
  • 24
    • 1042267263 scopus 로고    scopus 로고
    • Cell adhesion and signalling by cadherins and Ig-CAMs in cancer
    • Cavallaro U, Christofori G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat Rev Cancer 2004; 4: 118-32.
    • (2004) Nat Rev Cancer , vol.4 , pp. 118-132
    • Cavallaro, U.1    Christofori, G.2
  • 25
    • 23944443304 scopus 로고    scopus 로고
    • Overexpression of RhoA-GTP induces activation of the epidermal growth factor receptor, dephosphorylation of focal adhesion kinase and increased motility in breast cancer cells
    • Cáceres M, Guerrero J, Martínez J. Overexpression of RhoA-GTP induces activation of the epidermal growth factor receptor, dephosphorylation of focal adhesion kinase and increased motility in breast cancer cells. Exp Cell Res 2005; 309: 229-38.
    • (2005) Exp Cell Res , vol.309 , pp. 229-238
    • Cáceres, M.1    Guerrero, J.2    Martínez, J.3
  • 26
    • 12344264745 scopus 로고    scopus 로고
    • Targeting Ras and Rho GTPases as opportunities for cancer therapeutics
    • Walker K, Olson MF. Targeting Ras and Rho GTPases as opportunities for cancer therapeutics. Curr Opin Genet Dev 2005; 15: 62-8.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 62-68
    • Walker, K.1    Olson, M.F.2
  • 27
    • 19944432271 scopus 로고    scopus 로고
    • Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo
    • Pillé JY, Denoyelle C, Varet J et al. Anti-RhoA and anti-RhoC siRNAs inhibit the proliferation and invasiveness of MDA-MB-231 breast cancer cells in vitro and in vivo. Mol Ther 2005; 11: 267-74.
    • (2005) Mol Ther , vol.11 , pp. 267-274
    • Pillé, J.Y.1    Denoyelle, C.2    Varet, J.3
  • 28
    • 19444364509 scopus 로고    scopus 로고
    • Statins and the risk of colorectal cancer
    • Poynter JN, Gruber SB, Higgins PD et al. Statins and the risk of colorectal cancer. N Engl J Med 2005; 352: 2184-92.
    • (2005) N Engl J Med , vol.352 , pp. 2184-2192
    • Poynter, J.N.1    Gruber, S.B.2    Higgins, P.D.3
  • 29
    • 2442687001 scopus 로고    scopus 로고
    • The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: A case-control study
    • Boudreau DM, Gardner JS, Malone KE, Heckbert SR, Blough DK, Daling JR. The association between 3-hydroxy-3-methylglutaryl conenzyme A inhibitor use and breast carcinoma risk among postmenopausal women: A case-control study. Cancer 2004; 100: 2308-16.
    • (2004) Cancer , vol.100 , pp. 2308-2316
    • Boudreau, D.M.1    Gardner, J.S.2    Malone, K.E.3    Heckbert, S.R.4    Blough, D.K.5    Daling, J.R.6
  • 30
    • 0031812557 scopus 로고    scopus 로고
    • Prognostic value of low density lipoprotein receptor expression in colorectal carcinoma
    • Caruso MG, Osella AR, Notarnicola M et al. Prognostic value of low density lipoprotein receptor expression in colorectal carcinoma. Oncol Rep 1998; 5: 927-30.
    • (1998) Oncol Rep , vol.5 , pp. 927-930
    • Caruso, M.G.1    Osella, A.R.2    Notarnicola, M.3
  • 31
    • 84988281451 scopus 로고    scopus 로고
    • Inhibitory effect of Lovastatin on spontaneous metastases derived from a rat lymphoma
    • Matar P, Matar P, Rozados VR, et al. Inhibitory effect of Lovastatin on spontaneous metastases derived from a rat lymphoma. Clin Exp Metastasis 1999; 17: 19-25.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 19-25
    • Matar, P.1    Matar, P.2    Rozados, V.R.3
  • 32
    • 26944457329 scopus 로고    scopus 로고
    • Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling
    • Zhong WB, Liang YC, Wang CY, Chang TC, Lee WS. Lovastatin suppresses invasiveness of anaplastic thyroid cancer cells by inhibiting Rho geranylgeranylation and RhoA/ROCK signaling. Endocr Relat Cancer 2005; 12: 615-29.
    • (2005) Endocr Relat Cancer , vol.12 , pp. 615-629
    • Zhong, W.B.1    Liang, Y.C.2    Wang, C.Y.3    Chang, T.C.4    Lee, W.S.5
  • 33
    • 0036158675 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis
    • Kusama T, Mukai M, Iwasaki T et al. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis. Gastroenterology 2002; 122: 308-17.
    • (2002) Gastroenterology , vol.122 , pp. 308-317
    • Kusama, T.1    Mukai, M.2    Iwasaki, T.3
  • 34
    • 0031784485 scopus 로고    scopus 로고
    • Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis
    • Alonso DF, Farina HG, Skilton G, Gabri MR, De Lorenzo MS, Gomez DE. Reduction of mouse mammary tumor formation and metastasis by lovastatin, an inhibitor of the mevalonate pathway of cholesterol synthesis. Breast Cancer Res Treat 1998; 50: 83-93.
    • (1998) Breast Cancer Res Treat , vol.50 , pp. 83-93
    • Alonso, D.F.1    Farina, H.G.2    Skilton, G.3    Gabri, M.R.4    De Lorenzo, M.S.5    Gomez, D.E.6
  • 35
    • 20044366735 scopus 로고    scopus 로고
    • A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix
    • Knox JJ, Siu LL, Chen E et al. A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix. Eur J Cancer 2005; 41: 523-30.
    • (2005) Eur J Cancer , vol.41 , pp. 523-530
    • Knox, J.J.1    Siu, L.L.2    Chen, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.