-
1
-
-
27944479854
-
Rho GTPases: biochemistry and biology
-
Jaffe AB,Hall A.Rho GTPases: biochemistry and biology.Annu Rev Cell Dev Biol. 2005;21:247-69.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
2
-
-
84868656736
-
SnapShot: Rho family GTPases
-
Vega FM,Ridley AJ.SnapShot: Rho family GTPases.Cell. 2007 1430;129:.
-
(2007)
Cell
, vol.1430
, pp. 129
-
-
Vega, F.M.1
Ridley, A.J.2
-
3
-
-
34249018367
-
GEFs and GAPs: critical elements in the control of small G proteins
-
Bos JL,Rehmann H,Wittinghofer A.GEFs and GAPs: critical elements in the control of small G proteins.Cell. 2007;129:865-77.
-
(2007)
Cell
, vol.129
, pp. 865-877
-
-
Bos, J.L.1
Rehmann, H.2
Wittinghofer, A.3
-
4
-
-
13444252631
-
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
-
Rossman KL,Der CJ,Sondek J.GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.Nat Rev Mol Cell Biol. 2005;6:167-80.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 167-180
-
-
Rossman, K.L.1
Der, C.J.2
Sondek, J.3
-
5
-
-
0027984138
-
GAPs for rho-related GTPases
-
Lamarche N,Hall A.GAPs for rho-related GTPases.Trends Genet. 1994;10:436-40.
-
(1994)
Trends Genet
, vol.10
, pp. 436-440
-
-
Lamarche, N.1
Hall, A.2
-
6
-
-
78649487698
-
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
-
Vigil D,Cherfils J,Rossman KL,Der CJ.Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?.Nat Rev Cancer. 2010;10:842-57.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 842-857
-
-
Vigil, D.1
Cherfils, J.2
Rossman, K.L.3
Der, C.J.4
-
7
-
-
68249125947
-
14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response
-
Mohammad DH,Yaffe MB.14-3-3 proteins, FHA domains and BRCT domains in the DNA damage response.DNA Repair (Amst). 2009;8:1009-17.
-
(2009)
DNA Repair (Amst)
, vol.8
, pp. 1009-1017
-
-
Mohammad, D.H.1
Yaffe, M.B.2
-
9
-
-
66249092744
-
Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation
-
Wolfe BA,Takaki T,Petronczki M,Glotzer M.Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.PLoS Biol. 2009;7:e1000110.
-
(2009)
PLoS Biol
, vol.7
-
-
Wolfe, B.A.1
Takaki, T.2
Petronczki, M.3
Glotzer, M.4
-
10
-
-
14044263688
-
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis
-
Kim JE,Billadeau DD,Chen J.The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.J Biol Chem. 2005;280:5733-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 5733-5739
-
-
Kim, J.E.1
Billadeau, D.D.2
Chen, J.3
-
11
-
-
66249133671
-
Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells
-
Burkard ME,Maciejowski J,Rodriguez-Bravo V, et al.Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.PLoS Biol. 2009;7:e1000111.
-
(2009)
PLoS Biol
, vol.7
-
-
Burkard, M.E.1
Maciejowski, J.2
Rodriguez-Bravo, V.3
-
12
-
-
0037177885
-
The Rho exchange factor Net1 is regulated by nuclear sequestration
-
Schmidt A,Hall A.The Rho exchange factor Net1 is regulated by nuclear sequestration.J Biol Chem. 2002;277:14581-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 14581-14588
-
-
Schmidt, A.1
Hall, A.2
-
13
-
-
0033615978
-
Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis
-
Tatsumoto T,Xie X,Blumenthal R,Okamoto I,Miki T.Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.J Cell Biol. 1999;147:921-8.
-
(1999)
J Cell Biol
, vol.147
, pp. 921-928
-
-
Tatsumoto, T.1
Xie, X.2
Blumenthal, R.3
Okamoto, I.4
Miki, T.5
-
14
-
-
10744225152
-
Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation
-
Saito S,Liu XF,Kamijo K, et al.Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.J Biol Chem. 2004;279:7169-79.
-
(2004)
J Biol Chem
, vol.279
, pp. 7169-7179
-
-
Saito, S.1
Liu, X.F.2
Kamijo, K.3
-
15
-
-
79952084024
-
The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals
-
Dubash AD,Guilluy C,Srougi MC,Boulter E,Burridge K,Garcia-Mata R.The small GTPase RhoA localizes to the nucleus and is activated by Net1 and DNA damage signals.PLoS One. 2011;6:e17380.
-
(2011)
PLoS One
, vol.6
-
-
Dubash, A.D.1
Guilluy, C.2
Srougi, M.C.3
Boulter, E.4
Burridge, K.5
Garcia-Mata, R.6
-
16
-
-
77955299128
-
The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer
-
Fields AP,Justilien V.The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer.Adv Enzyme Regul. 2010;50:190-200.
-
(2010)
Adv Enzyme Regul
, vol.50
, pp. 190-200
-
-
Fields, A.P.1
Justilien, V.2
-
17
-
-
77949902198
-
Cytokinesis and cancer: polo loves ROCK'n' Rho(A) J Genet Genomics
-
Li J,Wang J,Jiao H,Liao J,Xu X.Cytokinesis and cancer: polo loves ROCK'n' Rho(A) J Genet Genomics. 2010;37:159-72.
-
(2010)
, vol.37
, pp. 159-172
-
-
Li, J.1
Wang, J.2
Jiao, H.3
Liao, J.4
Xu, X.5
-
18
-
-
31544476883
-
Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase
-
Hara T,Abe M,Inoue H, et al.Cytokinesis regulator ECT2 changes its conformation through phosphorylation at Thr-341 in G2/M phase.Oncogene. 2006;25:566-78.
-
(2006)
Oncogene
, vol.25
, pp. 566-578
-
-
Hara, T.1
Abe, M.2
Inoue, H.3
-
19
-
-
13844252076
-
Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
-
Oceguera-Yanez F,Kimura K,Yasuda S, et al.Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis.J Cell Biol. 2005;168:221-32.
-
(2005)
J Cell Biol
, vol.168
, pp. 221-232
-
-
Oceguera-Yanez, F.1
Kimura, K.2
Yasuda, S.3
-
20
-
-
0027502565
-
Oncogene ect2 is related to regulators of small GTP-binding proteins
-
Miki T,Smith CL,Long JE,Eva A,Fleming TP.Oncogene ect2 is related to regulators of small GTP-binding proteins.Nature. 1993;362:462-5.
-
(1993)
Nature
, vol.362
, pp. 462-465
-
-
Miki, T.1
Smith, C.L.2
Long, J.E.3
Eva, A.4
Fleming, T.P.5
-
21
-
-
33644835805
-
Identification of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines
-
Roversi G,Pfundt R,Moroni RF, et al.Identification of novel genomic markers related to progression to glioblastoma through genomic profiling of 25 primary glioma cell lines.Oncogene. 2006;25:1571-83.
-
(2006)
Oncogene
, vol.25
, pp. 1571-1583
-
-
Roversi, G.1
Pfundt, R.2
Moroni, R.F.3
-
22
-
-
57149120776
-
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma
-
Salhia B,Tran NL,Chan A, et al.The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.Am J Pathol. 2008;173:1828-38.
-
(2008)
Am J Pathol
, vol.173
, pp. 1828-1838
-
-
Salhia, B.1
Tran, N.L.2
Chan, A.3
-
23
-
-
70350074501
-
Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation
-
Justilien V,Fields AP.Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.Oncogene. 2009;28:3597-607.
-
(2009)
Oncogene
, vol.28
, pp. 3597-3607
-
-
Justilien, V.1
Fields, A.P.2
-
24
-
-
0015745929
-
Hatching, attachment, and outgrowth of mouse blastocysts in vitro: fixed nitrogen requirements
-
Spindle AI,Pedersen RA.Hatching, attachment, and outgrowth of mouse blastocysts in vitro: fixed nitrogen requirements.J Exp Zool. 1973;186:305-18.
-
(1973)
J Exp Zool
, vol.186
, pp. 305-318
-
-
Spindle, A.I.1
Pedersen, R.A.2
-
25
-
-
0031260578
-
A novel Cdc42Hs mutant induces cellular transformation
-
Lin R,Bagrodia S,Cerione R,Manor D.A novel Cdc42Hs mutant induces cellular transformation.Curr Biol. 1997;7:794-7.
-
(1997)
Curr Biol
, vol.7
, pp. 794-797
-
-
Lin, R.1
Bagrodia, S.2
Cerione, R.3
Manor, D.4
-
26
-
-
0033200353
-
A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila
-
Prokopenko SN,Brumby A,O'Keefe L, et al.A putative exchange factor for Rho1 GTPase is required for initiation of cytokinesis in Drosophila.Genes Dev. 1999;13:2301-14.
-
(1999)
Genes Dev
, vol.13
, pp. 2301-2314
-
-
Prokopenko, S.N.1
Brumby, A.2
O'Keefe, L.3
-
27
-
-
28544448876
-
The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells
-
Morita K,Hirono K,Han M.The Caenorhabditis elegans ect-2 RhoGEF gene regulates cytokinesis and migration of epidermal P cells.EMBO Rep. 2005;6:1163-8.
-
(2005)
EMBO Rep
, vol.6
, pp. 1163-1168
-
-
Morita, K.1
Hirono, K.2
Han, M.3
-
28
-
-
34247615185
-
GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases
-
Birkenfeld J,Nalbant P,Bohl BP,Pertz O,Hahn KM,Bokoch GM.GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases.Dev Cell. 2007;12:699-712.
-
(2007)
Dev Cell
, vol.12
, pp. 699-712
-
-
Birkenfeld, J.1
Nalbant, P.2
Bohl, B.P.3
Pertz, O.4
Hahn, K.M.5
Bokoch, G.M.6
-
29
-
-
38749123941
-
Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells
-
Kanada M,Nagasaki A,Uyeda TQ.Novel functions of Ect2 in polar lamellipodia formation and polarity maintenance during "contractile ring-independent" cytokinesis in adherent cells.Mol Biol Cell. 2008;19:8-16.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 8-16
-
-
Kanada, M.1
Nagasaki, A.2
Uyeda, T.Q.3
-
30
-
-
0035056402
-
Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development
-
Van de Putte T,Zwijsen A,Lonnoy O, et al.Mice with a homozygous gene trap vector insertion in mgcRacGAP die during pre-implantation development.Mech Dev. 2001;102:33-44.
-
(2001)
Mech Dev
, vol.102
, pp. 33-44
-
-
van de Putte, T.1
Zwijsen, A.2
Lonnoy, O.3
-
31
-
-
23944499922
-
An ECT2-centralspindlin complex regulates the localization and function of RhoA
-
Yuce O,Piekny A,Glotzer M.An ECT2-centralspindlin complex regulates the localization and function of RhoA.J Cell Biol. 2005;170:571-82.
-
(2005)
J Cell Biol
, vol.170
, pp. 571-582
-
-
Yuce, O.1
Piekny, A.2
Glotzer, M.3
-
32
-
-
24944480674
-
MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis
-
Zhao WM,Fang G.MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis.Proc Natl Acad Sci U S A. 2005;102:13158-63.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 13158-13163
-
-
Zhao, W.M.1
Fang, G.2
-
33
-
-
30044437466
-
Dissecting the role of Rho-mediated signaling in contractile ring formation
-
Kamijo K,Ohara N,Abe M, et al.Dissecting the role of Rho-mediated signaling in contractile ring formation.Mol Biol Cell. 2006;17:43-55.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 43-55
-
-
Kamijo, K.1
Ohara, N.2
Abe, M.3
-
34
-
-
31644438188
-
Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis
-
Nishimura Y,Yonemura S.Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis.J Cell Sci. 2006;119:104-14.
-
(2006)
J Cell Sci
, vol.119
, pp. 104-114
-
-
Nishimura, Y.1
Yonemura, S.2
-
35
-
-
74949132733
-
Epithelial cell transforming protein 2 (ECT2) depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles
-
Elbaz J,Reizel Y,Nevo N,Galiani D,Dekel N.Epithelial cell transforming protein 2 (ECT2) depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles.Endocrinology. 2010;151:755-65.
-
(2010)
Endocrinology
, vol.151
, pp. 755-765
-
-
Elbaz, J.1
Reizel, Y.2
Nevo, N.3
Galiani, D.4
Dekel, N.5
-
36
-
-
0031043507
-
Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development
-
Wang DZ,Hammond VE,Abud HE,Bertoncello I,McAvoy JW,Bowtell DD.Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.Genes Dev. 1997;11:309-20.
-
(1997)
Genes Dev
, vol.11
, pp. 309-320
-
-
Wang, D.Z.1
Hammond, V.E.2
Abud, H.E.3
Bertoncello, I.4
McAvoy, J.W.5
Bowtell, D.D.6
-
37
-
-
0034651705
-
The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties
-
Qian X,Esteban L,Vass WC, et al.The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties.EMBO J. 2000;19:642-54.
-
(2000)
EMBO J
, vol.19
, pp. 642-654
-
-
Qian, X.1
Esteban, L.2
Vass, W.C.3
-
38
-
-
0034710926
-
Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos
-
O'Brien SP,Seipel K,Medley QG,Bronson R,Segal R,Streuli M.Skeletal muscle deformity and neuronal disorder in Trio exchange factor-deficient mouse embryos.Proc Natl Acad Sci U S A. 2000;97:12074-8.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 12074-12078
-
-
O'Brien, S.P.1
Seipel, K.2
Medley, Q.G.3
Bronson, R.4
Segal, R.5
Streuli, M.6
-
39
-
-
0034625353
-
Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation
-
Kimura K,Tsuji T,Takada Y,Miki T,Narumiya S.Accumulation of GTP-bound RhoA during cytokinesis and a critical role of ECT2 in this accumulation.J Biol Chem. 2000;275:17233-6.
-
(2000)
J Biol Chem
, vol.275
, pp. 17233-17236
-
-
Kimura, K.1
Tsuji, T.2
Takada, Y.3
Miki, T.4
Narumiya, S.5
-
40
-
-
2942554939
-
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation
-
Solski PA,Wilder RS,Rossman KL, et al.Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.J Biol Chem. 2004;279:25226-33.
-
(2004)
J Biol Chem
, vol.279
, pp. 25226-25233
-
-
Solski, P.A.1
Wilder, R.S.2
Rossman, K.L.3
-
41
-
-
3042854053
-
The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless
-
Schumacher S,Gryzik T,Tannebaum S,Muller HA.The RhoGEF Pebble is required for cell shape changes during cell migration triggered by the Drosophila FGF receptor Heartless.Development. 2004;131:2631-40.
-
(2004)
Development
, vol.131
, pp. 2631-2640
-
-
Schumacher, S.1
Gryzik, T.2
Tannebaum, S.3
Muller, H.A.4
-
42
-
-
65549104391
-
Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula
-
van Impel A,Schumacher S,Draga M,Herz HM,Grosshans J,Muller HA.Regulation of the Rac GTPase pathway by the multifunctional Rho GEF Pebble is essential for mesoderm migration in the Drosophila gastrula.Development. 2009;136:813-22.
-
(2009)
Development
, vol.136
, pp. 813-822
-
-
van Impel, A.1
Schumacher, S.2
Draga, M.3
Herz, H.M.4
Grosshans, J.5
Muller, H.A.6
-
43
-
-
0036468677
-
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors
-
Lois C,Hong EJ,Pease S,Brown EJ,Baltimore D.Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors.Science. 2002;295:868-72.
-
(2002)
Science
, vol.295
, pp. 868-872
-
-
Lois, C.1
Hong, E.J.2
Pease, S.3
Brown, E.J.4
Baltimore, D.5
-
44
-
-
0025352187
-
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
-
Morgenstern JP,Land H.Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line.Nucleic Acids Res. 1990;18:3587-96.
-
(1990)
Nucleic Acids Res
, vol.18
, pp. 3587-3596
-
-
Morgenstern, J.P.1
Land, H.2
|