JNKs in liver diseases

Signaling Pathways in Liver Diseases

Volumn , Issue , 2010, Pages 215-227

  Schwabe, R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84891480064     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-00150-5_14     Document Type: Chapter

References (90)

1. Gupta S, Barrett T, Whitmarsh AJ et al (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 15:2760-2770
2. Hibi M, Lin A, Smeal T et al (1993) Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun. activation domain. Genes Dev 7:2135-2148
3. Mohit AA, Martin JH, Miller CA (1995) p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron 14:67-78
4. Kuan CY, Yang DD, Samanta Roy DR et al (1999) The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22:667-676
5. Sabapathy K, Jochum W, Hochedlinger K et al (1999) Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 89:115-124
6. Sato S, Sanjo H, Tsujimura T et al (2006) TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells. Int Immunol 18:1405-1411
7. Shim JH, Xiao C, Paschal AE et al (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev 19:2668-2681
8. Wan YY, Chi H, Xie M et al (2006) The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol 7:851-858
9. Tobiume K, Matsuzawa A, Takahashi T et al (2001) ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2:222-228
10. Nishitoh H, Matsuzawa A, Tobiume K et al (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16:1345-1355
11. Saitoh M, Nishitoh H, Fujii M et al (1998) Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17:2596-2606
12. Tournier C, Dong C, Turner TK et al (2001) MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 15:1419-1426
13. Liu Y, Shepherd EG, Nelin LD (2007) MAPK phosphatases-regulating the immune response. Nat Rev Immunol 7:202-212
14. Kamata H, Honda S, Maeda S et al (2005) Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120:649-661
15. Hamdi M, Kool J, Cornelissen-Steijger P et al (2005) DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1. Oncogene 24:7135-7144
16. Heinrichsdorff J, Luedde T, Perdiguero E, Nebreda AR, Pasparakis M. (2008) p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxininduced liver failure. EMBO Rep 9:1048-54
17. Hui L, Bakiri L, Mairhorfer A et al (2007) p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun. pathway. Nat Genet 39:741-749
18. Sakurai T, He G, Matsuzawa A et al (2008) Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14:156-165
19. Mechta-Grigoriou F, Gerald D, Yaniv M (2001) The mammalian Jun. proteins: redundancy and specificity. Oncogene 20:2378-2389
20. Smeal T, Binetruy B, Mercola DA et al (1991) Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun. on serines 63 and 73. Nature 354:494-496
21. Angel P, Hattori K, Smeal T et al (1988) The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55:875-885
22. Minden A, Karin M (1997) Regulation and function of the JNK subgroup of MAP kinases. Biochim Biophys Acta 1333:F85-F104
23. Bogoyevitch MA, Kobe B (2006) Uses for JNK: the many and varied substrates of the c-Jun. N-terminal kinases. Microbiol Mol Biol Rev 70:1061-1095
24. Sabapathy K, Hochedlinger K, Nam SY et al (2004) Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 15:713-725
25. Jaeschke A, Karasarides M, Ventura JJ et al (2006) JNK2 is a positive regulator of the cJun. transcription factor. Mol Cell 23:899-911
26. Gao M, Labuda T, Xia Y et al (2004) Jun. turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science 306:271-275
27. Chang L, Kamata H, Solinas G et al (2006) The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP (L) turnover. Cell 124:601-613
28. Chen N, She QB, Bode AM et al (2002) Differential gene expression profiles of Jnk1-and Jnk2-deficient murine fibroblast cells. Cancer Res 62:1300-1304
29. Varfolomeev EE, Ashkenazi A (2004) Tumor necrosis factor: an apoptosis JuNKie? Cell 116:491-497
30. Ventura JJ, Hubner A, Zhang C et al (2006) Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell 21:701-710
31. Lamb JA, Ventura JJ, Hess P et al (2003) JunD mediates survival signaling by the JNK signal transduction pathway. Mol Cell 11:1479-1489
32. Hasselblatt P, Rath M, Komnenovic V et al (2007) Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. Proc Natl Acad Sci U S A 104:17105-17110
33. Deng X, Xiao L, Lang W et al (2001) Novel role for JNK as a stress-activated Bcl2 kinase. J Biol Chem 276:23681-23688
34. Tang F, Tang G, Xiang J et al (2002) The absence of NF-kappaB-mediated inhibition of c-Jun. N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis. Mol Cell Biol 22:8571-8579
35. Tang G, Minemoto Y, Dibling B et al (2001) Inhibition of JNK activation through NF-kappaB target genes. Nature 414:313-317
36. Inoshita S, Takeda K, Hatai T et al (2002) Phosphorylation and inactivation of myeloid cell leukemia 1 by JNK in response to oxidative stress. J Biol Chem 277:43730-43734
37. Kharbanda S, Saxena S, Yoshida K et al (2000) Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x (L) in response to DNA damage. J Biol Chem 275:322-327
38. Tsuruta F, Sunayama J, Mori Y et al (2004) JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J 23:1889-1899
39. Deng Y, Ren X, Yang L et al (2003) A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 115:61-70
40. Lu C, Zhu F, Cho YY et al (2006) Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol Cell 23:121-132
41. Noguchi K, Kitanaka C, Yamana H et al (1999) Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun. N-terminal kinase. J Biol Chem 274:32580-32587
42. Schreiber M, Kolbus A, Piu F et al (1999) Control of cell cycle progression by c-Jun. is p53 dependent. Genes Dev 13:607-619
43. Behrens A, Sibilia M, Wagner EF (1999) Amino-terminal phosphorylation of c-Jun. regulates stress-induced apoptosis and cellular proliferation. Nat Genet 21:326-329
44. Wagner EF, Eferl R (2005) Fos/AP-1 proteins in bone and the immune system. Immunol Rev 208:126-140
45. Ishizuka T, Terada N, Gerwins P et al (1997) Mast cell tumor necrosis factor alpha production is regulated by MEK kinases. Proc Natl Acad Sci U S A 94:6358-6363
46. Bennett BL, Sasaki DT, Murray BW et al (2001) SP600125, an anthrapyrazolone inhibitor of Jun. N-terminal kinase. Proc Natl Acad Sci U S A 98:13681-13686
47. Han Z, Boyle DL, Chang L et al (2001) c-Jun. N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. J Clin Invest 108:73-81
48. Schwabe RF, Bataller R, Brenner DA (2003) Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol 285:G949-G958
49. Marra F, Delogu W, Petrai I et al (2004) Differential requirement of members of the MAPK family for CCL2 expression by hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 287:G18-G26
50. Dong C, Yang DD, Tournier C et al (2000) JNK is required for effector T-cell function but not for T-cell activation. Nature 405:91-94
51. Liu H, Lo CR, Czaja MJ (2002) NF-kappaB inhibition sensitizes hepatocytes to TNF-induced apoptosis through a sustained activation of JNK and c-Jun. Hepatology 35:772-778
52. Schwabe RF, Uchinami H, Qian T et al (2004) Differential requirement for c-Jun. NH2-terminal kinase in TNFalphaand Fas-mediated apoptosis in hepatocytes. FASEB J 18:720-722
53. Henderson NC, Pollock KJ, Frew J et al (2007) Critical role of c-jun (NH2) terminal kinase in paracetamol-induced acute liver failure. Gut 56:982-990
54. Maeda S, Chang L, Li ZW et al (2003) IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity 19:725-737
55. Wang Y, Singh R, Lefkowitch JH et al (2006) Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 281:15258-15267
56. Ni HM, Chen X, Ding WX et al (2008) Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am J Pathol 173:962-972
57. Das M, Sabio G, Jiang F et al (2009) Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136:249-260
58. Lee WM (2003) Acute liver failure in the United States. Semin Liver Dis 23:217-226
59. Jaeschke H, Bajt ML (2006) Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 89:31-41
60. Gunawan BK, Liu ZX, Han D et al (2006) c-Jun. N-terminal kinase plays a major role in murine acetaminophen hepatotoxicity. Gastroenterology 131:165-178
61. Nakagawa H, Maeda S, Hikiba Y et al (2008) Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminopheninduced liver injury by inhibiting c-Jun. N-terminal kinase activation. Gastroenterology 135:1311-1321
62. Hanawa N, Shinohara M, Saberi B et al (2008) Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury. J Biol Chem 283:13565-13577
63. Kon K, Kim JS, Jaeschke H et al (2004) Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes. Hepatology 40:1170-1179
64. Beales D, McLean AE (1996) Protection in the late stages of paracetamol-induced liver cell injury with fructose, cyslosporin A and trifluoperazine. Toxicology 107:201-208
65. Rudiger HA, Clavien PA (2002) Tumor necrosis factor alpha, but not Fas, mediates hepatocellular apoptosis in the murine ischemic liver. Gastroenterology 122:202-210
66. Colletti LM, Remick DG, Burtch GD et al (1990) Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J Clin Invest 85:1936-1943
67. Bradham CA, Stachlewitz RF, Gao W et al (1997) Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases. Hepatology 25:1128-1135
68. Zwacka RM, Zhang Y, Zhou W et al (1998) Ischemia/reperfusion injury in the liver of BALB/c mice activates AP-1 and nuclear factor kappaB independently of IkappaB degradation. Hepatology 28:1022-1030
69. Lehmann TG, Wheeler MD, Schwabe RF et al (2000) Gene delivery of Cu/Zn-superoxide dismutase improves graft function after transplantation of fatty livers in the rat. Hepatology 32:1255-1264
70. Uehara T, Bennett B, Sakata ST et al (2005) JNK mediates hepatic ischemia reperfusion injury. J Hepatol 42:850-859
71. Uehara T, Xi Peng X, Bennett B et al (2004) c-Jun. N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation 78:324-332
72. Theruvath TP, Snoddy MC, Zhong Z et al (2008) Mitochondrial permeability transition in liver ischemia and reperfusion: role of c-Jun. N-terminal kinase 2. Transplantation 85:1500-1504
73. Yoshida K, Matsuzaki K, Mori S et al (2005) Transforming growth factor-beta and platelet-derived growth factor signal via c-Jun. N-terminal kinase-dependent Smad2/3 phosphorylation in rat hepatic stellate cells after acute liver injury. Am J Pathol 166:1029-1039
74. Bataller R, Schwabe RF, Choi YH et al (2003) NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest 112:1383-1394
75. Schnabl B, Bradham CA, Bennett BL et al (2001) TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Hepatology 34:953-963
76. Taub R (2004) Liver regeneration: from myth to mechanism. Nat Rev Mol Cell Biol 5:836-847
77. Westwick JK, Weitzel C, Leffert HL et al (1995) Activation of Jun. kinase is an early event in hepatic regeneration. J Clin Invest 95:803-810
78. Schwabe RF, Bradham CA, Uehara T et al (2003) c-Jun-Nterminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology 37:824-832
79. Behrens A, Sibilia M, David JP et al (2002) Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J 21:1782-1790
80. Hui L, Zatloukal K, Scheuch H et al (2008) Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 118:3943-3953
81. Sabapathy K, Wagner EF (2004) JNK2: a negative regulator of cellular proliferation. Cell Cycle 3:1520-1523
82. Papa S, Zazzeroni F, Fu YX et al (2008) Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J Clin Invest 118:1911-1923
83. Bohmann D, Bos TJ, Admon A et al (1987) Human protooncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238:1386-1392
84. Eferl R, Ricci R, Kenner L et al (2003) Liver tumor development. c-Jun. antagonizes the proapoptotic activity of p53. Cell 112:181-192
85. Sakurai T, Maeda S, Chang L et al (2006) Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun. N-terminal kinase 1 activation. Proc Natl Acad Sci U S A 103:10544-10551
86. Maeda S, Kamata H, Luo JL et al (2005) IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121:977-990
87. Li Z, Yang S, Lin H et al (2003) Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease. Hepatology 37:343-350
88. Schattenberg JM, Singh R, Wang Y et al (2006) JNK1 but not JNK2 promotes the development of steatohepatitis in mice. Hepatology 43:163-172
89. Singh R, Wang Y, Xiang Y et al (2009) Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology 49:87-96
90. Kodama Y, Kisseleva T, Miura K et al (2008) JNK1 in hematopoietic cells mediates progression from diet-induced hepatic steatosis to steatohepatits and liver fibrosis. Hepatology 48:366A