-
1
-
-
84859709877
-
CD4+T cells: Differentiation and functions
-
Luckheeram, R. V., R. Zhou, A. D. Verma, and B. Xia. 2012. CD4?T cells: differentiation and functions. Clin. Dev. Immunol. 2012: 925135.
-
(2012)
Clin. Dev. Immunol.
, vol.2012
, pp. 925135
-
-
Luckheeram, R.V.1
Zhou, R.2
Verma, A.D.3
Xia, B.4
-
2
-
-
52649167708
-
CD4 T cells: Fates, functions, and faults
-
Zhu, J., and W. E. Paul. 2008. CD4 T cells: fates, functions, and faults. Blood 112: 1557-1569.
-
(2008)
Blood
, vol.112
, pp. 1557-1569
-
-
Zhu, J.1
Paul, W.E.2
-
3
-
-
36849036211
-
IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner
-
Wei, L., A. Laurence, K. M. Elias, and J. J. O'Shea. 2007. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner. J. Biol. Chem. 282: 34605-34610.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 34605-34610
-
-
Wei, L.1
Laurence, A.2
Elias, K.M.3
O'Shea, J.J.4
-
4
-
-
34247593586
-
STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
-
Yang, X. O., A. D. Panopoulos, R. Nurieva, S. H. Chang, D. Wang, S. S. Watowich, and C. Dong. 2007. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282: 9358-9363.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 9358-9363
-
-
Yang, X.O.1
Panopoulos, A.D.2
Nurieva, R.3
Chang, S.H.4
Wang, D.5
Watowich, S.S.6
Dong, C.7
-
5
-
-
34547188748
-
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
-
Zhou, L., I. I. Ivanov, R. Spolski, R. Min, K. Shenderov, T. Egawa, D. E. Levy, W. J. Leonard, and D. R. Littman. 2007. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat. Immunol. 8: 967-974.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 967-974
-
-
Zhou, L.1
Ivanov, I.I.2
Spolski, R.3
Min, R.4
Shenderov, K.5
Egawa, T.6
Levy, D.E.7
Leonard, W.J.8
Littman, D.R.9
-
6
-
-
61949463911
-
IL-17 and Th17 cells
-
Korn, T., E. Bettelli, M. Oukka, and V. K. Kuchroo. 2009. IL-17 and Th17 cells. Annu. Rev. Immunol. 27: 485-517.
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 485-517
-
-
Korn, T.1
Bettelli, E.2
Oukka, M.3
Kuchroo, V.K.4
-
7
-
-
60749107176
-
The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo
-
McGeachy, M. J., Y. Chen, C. M. Tato, A. Laurence, B. Joyce-Shaikh, W. M. Blumenschein, T. K. McClanahan, J. J. O'Shea, and D. J. Cua. 2009. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat. Immunol. 10: 314-324.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 314-324
-
-
McGeachy, M.J.1
Chen, Y.2
Tato, C.M.3
Laurence, A.4
Joyce-Shaikh, B.5
Blumenschein, W.M.6
McClanahan, T.K.7
O'Shea, J.J.8
Cua, D.J.9
-
8
-
-
0035515347
-
The ETS-domain transcription factor family
-
Sharrocks, A. D. 2001. The ETS-domain transcription factor family. Nat. Rev. Mol. Cell Biol. 2: 827-837.
-
(2001)
Nat. Rev. Mol. Cell Biol.
, vol.2
, pp. 827-837
-
-
Sharrocks, A.D.1
-
9
-
-
0037448612
-
Molecular biology of the Ets family of transcription factors
-
Oikawa, T., and T. Yamada. 2003. Molecular biology of the Ets family of transcription factors. Gene 303: 11-34.
-
(2003)
Gene
, vol.303
, pp. 11-34
-
-
Oikawa, T.1
Yamada, T.2
-
10
-
-
0032540454
-
Ets transcription factors and human disease
-
Dittmer, J., and A. Nordheim. 1998. Ets transcription factors and human disease. Biochim. Biophys. Acta 1377: F1-F11.
-
(1998)
Biochim. Biophys. Acta
, vol.1377
-
-
Dittmer, J.1
Nordheim, A.2
-
11
-
-
0242551607
-
The emerging role of the myeloid Elf-1 like transcription factor in hematopoiesis
-
Lacorazza, H. D., and S. D. Nimer. 2003. The emerging role of the myeloid Elf-1 like transcription factor in hematopoiesis. Blood Cells Mol. Dis. 31: 342-350.
-
(2003)
Blood Cells Mol. Dis.
, vol.31
, pp. 342-350
-
-
Lacorazza, H.D.1
Nimer, S.D.2
-
12
-
-
14244251950
-
Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses
-
Grenningloh, R., B. Y. Kang, and I. C. Ho. 2005. Ets-1, a functional cofactor of T-bet, is essential for Th1 inflammatory responses. J. Exp. Med. 201: 615-626.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 615-626
-
-
Grenningloh, R.1
Kang, B.Y.2
Ho, I.C.3
-
13
-
-
36548999223
-
Ets-1 is a negative regulator of Th17 differentiation
-
Moisan, J., R. Grenningloh, E. Bettelli, M. Oukka, and I. C. Ho. 2007. Ets-1 is a negative regulator of Th17 differentiation. J. Exp. Med. 204: 2825-2835.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2825-2835
-
-
Moisan, J.1
Grenningloh, R.2
Bettelli, E.3
Oukka, M.4
Ho, I.C.5
-
14
-
-
77957724587
-
The Ets-1 transcription factor controls the development and function of natural regulatory T cells
-
Mouly, E., K. Chemin, H. V. Nguyen, M. Chopin, L. Mesnard, M. Leite-de-Moraes, O. Burlen-defranoux, A. Bandeira, and J. C. Bories. 2010. The Ets-1 transcription factor controls the development and function of natural regulatory T cells. J. Exp. Med. 207: 2113-2125.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2113-2125
-
-
Mouly, E.1
Chemin, K.2
Nguyen, H.V.3
Chopin, M.4
Mesnard, L.5
Leite-De-Moraes, M.6
Burlen-Defranoux, O.7
Bandeira, A.8
Bories, J.C.9
-
15
-
-
77952584843
-
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation
-
Chang, H. C., S. Sehra, R. Goswami, W. Yao, Q. Yu, G. L. Stritesky, R. Jabeen, C. McKinley, A. N. Ahyi, L. Han, et al. 2010. The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation. Nat. Immunol. 11: 527-534.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 527-534
-
-
Chang, H.C.1
Sehra, S.2
Goswami, R.3
Yao, W.4
Yu, Q.5
Stritesky, G.L.6
Jabeen, R.7
McKinley, C.8
Ahyi, A.N.9
Han, L.10
-
16
-
-
20444502955
-
PU.1 expression delineates heterogeneity in primary Th2 cells
-
Chang, H. C., S. Zhang, V. T. Thieu, R. B. Slee, H. A. Bruns, R. N. Laribee, M. J. Klemsz, and M. H. Kaplan. 2005. PU.1 expression delineates heterogeneity in primary Th2 cells. Immunity 22: 693-703.
-
(2005)
Immunity
, vol.22
, pp. 693-703
-
-
Chang, H.C.1
Zhang, S.2
Thieu, V.T.3
Slee, R.B.4
Bruns, H.A.5
Laribee, R.N.6
Klemsz, M.J.7
Kaplan, M.H.8
-
17
-
-
0029860814
-
MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties
-
Miyazaki, Y., X. Sun, H. Uchida, J. Zhang, and S. Nimer. 1996. MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties. Oncogene 13: 1721-1729.
-
(1996)
Oncogene
, vol.13
, pp. 1721-1729
-
-
Miyazaki, Y.1
Sun, X.2
Uchida, H.3
Zhang, J.4
Nimer, S.5
-
18
-
-
0037112510
-
The ETS transcription factor MEF is a candidate tumor suppressor gene on the X chromosome
-
Seki, Y., M. A. Suico, A. Uto, A. Hisatsune, T. Shuto, Y. Isohama, and H. Kai. 2002. The ETS transcription factor MEF is a candidate tumor suppressor gene on the X chromosome. Cancer Res. 62: 6579-6586.
-
(2002)
Cancer Res.
, vol.62
, pp. 6579-6586
-
-
Seki, Y.1
Suico, M.A.2
Uto, A.3
Hisatsune, A.4
Shuto, T.5
Isohama, Y.6
Kai, H.7
-
19
-
-
34250030216
-
Tumor promoting properties of the ETS protein MEF in ovarian cancer
-
Yao, J. J., Y. Liu, H. D. Lacorazza, R. A. Soslow, J. M. Scandura, S. D. Nimer, and C. V. Hedvat. 2007. Tumor promoting properties of the ETS protein MEF in ovarian cancer. Oncogene 26: 4032-4037.
-
(2007)
Oncogene
, vol.26
, pp. 4032-4037
-
-
Yao, J.J.1
Liu, Y.2
Lacorazza, H.D.3
Soslow, R.A.4
Scandura, J.M.5
Nimer, S.D.6
Hedvat, C.V.7
-
20
-
-
79955605755
-
The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow
-
Sivina, M., T. Yamada, C. S. Park, M. Puppi, S. Coskun, K. Hirschi, and H. D. Lacorazza. 2011. The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Arterioscler. Thromb. Vasc. Biol. 31: 1185-1191.
-
(2011)
Arterioscler. Thromb. Vasc. Biol.
, vol.31
, pp. 1185-1191
-
-
Sivina, M.1
Yamada, T.2
Park, C.S.3
Puppi, M.4
Coskun, S.5
Hirschi, K.6
Lacorazza, H.D.7
-
21
-
-
33644819269
-
The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells
-
Lacorazza, H. D., T. Yamada, Y. Liu, Y. Miyata, M. Sivina, J. Nunes, and S. D. Nimer. 2006. The transcription factor MEF/ELF4 regulates the quiescence of primitive hematopoietic cells. Cancer Cell 9: 175-187.
-
(2006)
Cancer Cell
, vol.9
, pp. 175-187
-
-
Lacorazza, H.D.1
Yamada, T.2
Liu, Y.3
Miyata, Y.4
Sivina, M.5
Nunes, J.6
Nimer, S.D.7
-
22
-
-
67349101678
-
Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2
-
Yamada, T., C. S. Park, M. Mamonkin, and H. D. Lacorazza. 2009. Transcription factor ELF4 controls the proliferation and homing of CD8+ T cells via the Krüppel-like factors KLF4 and KLF2. Nat. Immunol. 10: 618-626.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 618-626
-
-
Yamada, T.1
Park, C.S.2
Mamonkin, M.3
Lacorazza, H.D.4
-
23
-
-
18644379642
-
The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells
-
Lacorazza, H. D., Y. Miyazaki, A. Di Cristofano, A. Deblasio, C. Hedvat, J. Zhang, C. Cordon-Cardo, S. Mao, P. P. Pandolfi, and S. D. Nimer. 2002. The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Immunity 17: 437-449.
-
(2002)
Immunity
, vol.17
, pp. 437-449
-
-
Lacorazza, H.D.1
Miyazaki, Y.2
Di Cristofano, A.3
Deblasio, A.4
Hedvat, C.5
Zhang, J.6
Cordon-Cardo, C.7
Mao, S.8
Pandolfi, P.P.9
Nimer, S.D.10
-
24
-
-
77958140465
-
Cutting edge: Expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells
-
Yamada, T., K. Gierach, P. H. Lee, X. Wang, and H. D. Lacorazza. 2010. Cutting edge: expression of the transcription factor E74-like factor 4 is regulated by the mammalian target of rapamycin pathway in CD8+ T cells. J. Immunol. 185: 3824-3828.
-
(2010)
J. Immunol.
, vol.185
, pp. 3824-3828
-
-
Yamada, T.1
Gierach, K.2
Lee, P.H.3
Wang, X.4
Lacorazza, H.D.5
-
25
-
-
43549110961
-
Regulation of inflammatory responses by IL-17F
-
Yang, X. O., S. H. Chang, H. Park, R. Nurieva, B. Shah, L. Acero, Y. H. Wang, K. S. Schluns, R. R. Broaddus, Z. Zhu, and C. Dong. 2008. Regulation of inflammatory responses by IL-17F. J. Exp. Med. 205: 1063-1075.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1063-1075
-
-
Yang, X.O.1
Chang, S.H.2
Park, H.3
Nurieva, R.4
Shah, B.5
Acero, L.6
Wang, Y.H.7
Schluns, K.S.8
Broaddus, R.R.9
Zhu, Z.10
Dong, C.11
-
26
-
-
34248647881
-
Active induction of experimental allergic encephalomyelitis
-
Stromnes, I. M., and J. M. Goverman. 2006. Active induction of experimental allergic encephalomyelitis. Nat. Protoc. 1: 1810-1819.
-
(2006)
Nat. Protoc.
, vol.1
, pp. 1810-1819
-
-
Stromnes, I.M.1
Goverman, J.M.2
-
27
-
-
0031065209
-
Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: Parameters in small and large intestine
-
Laky, K., L. Lefrançois, and L. Puddington. 1997. Age-dependent intestinal lymphoproliferative disorder due to stem cell factor receptor deficiency: parameters in small and large intestine. J. Immunol. 158: 1417-1427.
-
(1997)
J. Immunol.
, vol.158
, pp. 1417-1427
-
-
Laky, K.1
Lefrançois, L.2
Puddington, L.3
-
28
-
-
38849097777
-
An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment
-
Liang, S. C., A. J. Long, F. Bennett, M. J. Whitters, R. Karim, M. Collins, S. J. Goldman, K. Dunussi-Joannopoulos, C. M. Williams, J. F. Wright, and L. A. Fouser. 2007. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J. Immunol. 179: 7791-7799.
-
(2007)
J. Immunol.
, vol.179
, pp. 7791-7799
-
-
Liang, S.C.1
Long, A.J.2
Bennett, F.3
Whitters, M.J.4
Karim, R.5
Collins, M.6
Goldman, S.J.7
Dunussi-Joannopoulos, K.8
Williams, C.M.9
Wright, J.F.10
Fouser, L.A.11
-
29
-
-
67650433931
-
T-bet is essential for encephalitogenicity of both Th1 and Th17 cells
-
Yang, Y., J. Weiner, Y. Liu, A. J. Smith, D. J. Huss, R. Winger, H. Peng, P. D. Cravens, M. K. Racke, and A. E. Lovett-Racke. 2009. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J. Exp. Med. 206: 1549-1564.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1549-1564
-
-
Yang, Y.1
Weiner, J.2
Liu, Y.3
Smith, A.J.4
Huss, D.J.5
Winger, R.6
Peng, H.7
Cravens, P.D.8
Racke, M.K.9
Lovett-Racke, A.E.10
-
30
-
-
77958584113
-
Generation of pathogenic T(H)17 cells in the absence of TGF-b signalling
-
Ghoreschi, K., A. Laurence, X. P. Yang, C. M. Tato, M. J. McGeachy, J. E. Konkel, H. L. Ramos, L. Wei, T. S. Davidson, N. Bouladoux, et al. 2010. Generation of pathogenic T(H)17 cells in the absence of TGF-b signalling. Nature 467: 967-971.
-
(2010)
Nature
, vol.467
, pp. 967-971
-
-
Ghoreschi, K.1
Laurence, A.2
Yang, X.P.3
Tato, C.M.4
McGeachy, M.J.5
Konkel, J.E.6
Ramos, H.L.7
Wei, L.8
Davidson, T.S.9
Bouladoux, N.10
-
31
-
-
84866532132
-
Induction and molecular signature of pathogenic TH17 cells
-
Lee, Y., A. Awasthi, N. Yosef, F. J. Quintana, S. Xiao, A. Peters, C. Wu, M. Kleinewietfeld, S. Kunder, D. A. Hafler, et al. 2012. Induction and molecular signature of pathogenic TH17 cells. Nat. Immunol. 13: 991-999.
-
(2012)
Nat. Immunol.
, vol.13
, pp. 991-999
-
-
Lee, Y.1
Awasthi, A.2
Yosef, N.3
Quintana, F.J.4
Xiao, S.5
Peters, A.6
Wu, C.7
Kleinewietfeld, M.8
Kunder, S.9
Hafler, D.A.10
-
32
-
-
36248965294
-
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology
-
McGeachy, M. J., K. S. Bak-Jensen, Y. Chen, C. M. Tato, W. Blumenschein, T. McClanahan, and D. J. Cua. 2007. TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathology. Nat. Immunol. 8: 1390-1397.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 1390-1397
-
-
McGeachy, M.J.1
Bak-Jensen, K.S.2
Chen, Y.3
Tato, C.M.4
Blumenschein, W.5
McClanahan, T.6
Cua, D.J.7
-
33
-
-
79956152607
-
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF
-
El-Behi, M., B. Ciric, H. Dai, Y. Yan, M. Cullimore, F. Safavi, G. X. Zhang, B. N. Dittel, and A. Rostami. 2011. The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF. Nat. Immunol. 12: 568-575.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 568-575
-
-
El-Behi, M.1
Ciric, B.2
Dai, H.3
Yan, Y.4
Cullimore, M.5
Safavi, F.6
Zhang, G.X.7
Dittel, B.N.8
Rostami, A.9
-
34
-
-
79956116032
-
RORgt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation
-
Codarri, L., G. Gyülvészi, V. Tosevski, L. Hesske, A. Fontana, L. Magnenat, T. Suter, and B. Becher. 2011. RORgt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nat. Immunol. 12: 560-567.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 560-567
-
-
Codarri, L.1
Gyülvészi, G.2
Tosevski, V.3
Hesske, L.4
Fontana, A.5
Magnenat, L.6
Suter, T.7
Becher, B.8
-
35
-
-
33748588423
-
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
-
Ivanov, I. I., B. S. McKenzie, L. Zhou, C. E. Tadokoro, A. Lepelley, J. J. Lafaille, D. J. Cua, and D. R. Littman. 2006. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133.
-
(2006)
Cell
, vol.126
, pp. 1121-1133
-
-
Ivanov, I.I.1
McKenzie, B.S.2
Zhou, L.3
Tadokoro, C.E.4
Lepelley, A.5
Lafaille, J.J.6
Cua, D.J.7
Littman, D.R.8
-
36
-
-
0032143821
-
Helper T cell differentiation is controlled by the cell cycle
-
Bird, J. J., D. R. Brown, A. C. Mullen, N. H. Moskowitz, M. A. Mahowald, J. R. Sider, T. F. Gajewski, C. R. Wang, and S. L. Reiner. 1998. Helper T cell differentiation is controlled by the cell cycle. Immunity 9: 229-237.
-
(1998)
Immunity
, vol.9
, pp. 229-237
-
-
Bird, J.J.1
Brown, D.R.2
Mullen, A.C.3
Moskowitz, N.H.4
Mahowald, M.A.5
Sider, J.R.6
Gajewski, T.F.7
Wang, C.R.8
Reiner, S.L.9
-
37
-
-
78650671831
-
STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms
-
Villarino, A. V., E. Gallo, and A. K. Abbas. 2010. STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms. J. Immunol. 185: 6461-6471.
-
(2010)
J. Immunol.
, vol.185
, pp. 6461-6471
-
-
Villarino, A.V.1
Gallo, E.2
Abbas, A.K.3
-
38
-
-
47749107262
-
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
-
Kimura, A., T. Naka, K. Nohara, Y. Fujii-Kuriyama, and T. Kishimoto. 2008. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc. Natl. Acad. Sci. USA 105: 9721-9726.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9721-9726
-
-
Kimura, A.1
Naka, T.2
Nohara, K.3
Fujii-Kuriyama, Y.4
Kishimoto, T.5
-
39
-
-
33947162110
-
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
-
Laurence, A., C. M. Tato, T. S. Davidson, Y. Kanno, Z. Chen, Z. Yao, R. B. Blank, F. Meylan, R. Siegel, L. Hennighausen, et al. 2007. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26: 371-381.
-
(2007)
Immunity
, vol.26
, pp. 371-381
-
-
Laurence, A.1
Tato, C.M.2
Davidson, T.S.3
Kanno, Y.4
Chen, Z.5
Yao, Z.6
Blank, R.B.7
Meylan, F.8
Siegel, R.9
Hennighausen, L.10
-
40
-
-
79951682333
-
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5
-
Yang, X. P., K. Ghoreschi, S. M. Steward-Tharp, J. Rodriguez-Canales, J. Zhu, J. R. Grainger, K. Hirahara, H. W. Sun, L. Wei, G. Vahedi, et al. 2011. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5. Nat. Immunol. 12: 247-254.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 247-254
-
-
Yang, X.P.1
Ghoreschi, K.2
Steward-Tharp, S.M.3
Rodriguez-Canales, J.4
Zhu, J.5
Grainger, J.R.6
Hirahara, K.7
Sun, H.W.8
Wei, L.9
Vahedi, G.10
-
41
-
-
79960544098
-
Notch signaling regulates mouse and human Th17 differentiation
-
Keerthivasan, S., R. Suleiman, R. Lawlor, J. Roderick, T. Bates, L. Minter, J. Anguita, I. Juncadella, B. J. Nickoloff, I. C. Le Poole, et al. 2011. Notch signaling regulates mouse and human Th17 differentiation. J. Immunol. 187: 692-701.
-
(2011)
J. Immunol.
, vol.187
, pp. 692-701
-
-
Keerthivasan, S.1
Suleiman, R.2
Lawlor, R.3
Roderick, J.4
Bates, T.5
Minter, L.6
Anguita, J.7
Juncadella, I.8
Nickoloff, B.J.9
Le Poole, I.C.10
-
42
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov, I. I., K. Atarashi, N. Manel, E. L. Brodie, T. Shima, U. Karaoz, D. Wei, K. C. Goldfarb, C. A. Santee, S. V. Lynch, et al. 2009. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 139: 485-498.
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov, I.I.1
Atarashi, K.2
Manel, N.3
Brodie, E.L.4
Shima, T.5
Karaoz, U.6
Wei, D.7
Goldfarb, K.C.8
Santee, C.A.9
Lynch, S.V.10
-
43
-
-
78650251004
-
Induction of lamina propria Th17 cells by intestinal commensal bacteria
-
Atarashi, K., T. Tanoue, and K. Honda. 2010. Induction of lamina propria Th17 cells by intestinal commensal bacteria. Vaccine 28: 8036-8038.
-
(2010)
Vaccine
, vol.28
, pp. 8036-8038
-
-
Atarashi, K.1
Tanoue, T.2
Honda, K.3
-
44
-
-
33947195292
-
IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection
-
Umemura, M., A. Yahagi, S. Hamada, M. D. Begum, H. Watanabe, K. Kawakami, T. Suda, K. Sudo, S. Nakae, Y. Iwakura, and G. Matsuzaki. 2007. IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection. J. Immunol. 178: 3786-3796.
-
(2007)
J. Immunol.
, vol.178
, pp. 3786-3796
-
-
Umemura, M.1
Yahagi, A.2
Hamada, S.3
Begum, M.D.4
Watanabe, H.5
Kawakami, K.6
Suda, T.7
Sudo, K.8
Nakae, S.9
Iwakura, Y.10
Matsuzaki, G.11
-
45
-
-
0033144639
-
Ovalbumin (OVA) and Mycobacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper (Th) cells toward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia
-
Sano, K., K. Haneda, G. Tamura, and K. Shirato. 1999. Ovalbumin (OVA) and Mycobacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper (Th) cells toward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia. Am. J. Respir. Cell Mol. Biol. 20: 1260-1267.
-
(1999)
Am. J. Respir. Cell Mol. Biol.
, vol.20
, pp. 1260-1267
-
-
Sano, K.1
Haneda, K.2
Tamura, G.3
Shirato, K.4
-
46
-
-
0021177812
-
A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody
-
Linnington, C., M. Webb, and P. L. Woodhams. 1984. A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody. J. Neuroimmunol. 6: 387-396.
-
(1984)
J. Neuroimmunol.
, vol.6
, pp. 387-396
-
-
Linnington, C.1
Webb, M.2
Woodhams, P.L.3
-
47
-
-
77949890873
-
IL-6 promotes NK cell production of IL-17 during toxoplasmosis
-
Passos, S. T., J. S. Silver, A. C. O'Hara, D. Sehy, J. S. Stumhofer, and C. A. Hunter. 2010. IL-6 promotes NK cell production of IL-17 during toxoplasmosis. J. Immunol. 184: 1776-1783.
-
(2010)
J. Immunol.
, vol.184
, pp. 1776-1783
-
-
Passos, S.T.1
Silver, J.S.2
O'Hara, A.C.3
Sehy, D.4
Stumhofer, J.S.5
Hunter, C.A.6
-
48
-
-
60549102720
-
Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22
-
Takatori, H., Y. Kanno, W. T. Watford, C. M. Tato, G. Weiss, I. I. Ivanov, II, D. R. Littman, and J. J. O'Shea. 2009. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J. Exp. Med. 206: 35-41.
-
(2009)
J. Exp. Med.
, vol.206
, pp. 35-41
-
-
Takatori, H.1
Kanno, Y.2
Watford, W.T.3
Tato, C.M.4
Weiss, G.5
Ivanov, I.I.6
Ii7
Littman, D.R.8
O'Shea, J.J.9
-
49
-
-
68649126866
-
Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals
-
Martin, B., K. Hirota, D. J. Cua, B. Stockinger, and M. Veldhoen. 2009. Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 31: 321-330.
-
(2009)
Immunity
, vol.31
, pp. 321-330
-
-
Martin, B.1
Hirota, K.2
Cua, D.J.3
Stockinger, B.4
Veldhoen, M.5
-
50
-
-
0036105484
-
Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis
-
Lock, C., G. Hermans, R. Pedotti, A. Brendolan, E. Schadt, H. Garren, A. Langer-Gould, S. Strober, B. Cannella, J. Allard, et al. 2002. Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat. Med. 8: 500-508.
-
(2002)
Nat. Med.
, vol.8
, pp. 500-508
-
-
Lock, C.1
Hermans, G.2
Pedotti, R.3
Brendolan, A.4
Schadt, E.5
Garren, H.6
Langer-Gould, A.7
Strober, S.8
Cannella, B.9
Allard, J.10
-
51
-
-
34948909646
-
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
-
Kebir, H., K. Kreymborg, I. Ifergan, A. Dodelet-Devillers, R. Cayrol, M. Bernard, F. Giuliani, N. Arbour, B. Becher, and A. Prat. 2007. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat. Med. 13: 1173-1175.
-
(2007)
Nat. Med.
, vol.13
, pp. 1173-1175
-
-
Kebir, H.1
Kreymborg, K.2
Ifergan, I.3
Dodelet-Devillers, A.4
Cayrol, R.5
Bernard, M.6
Giuliani, F.7
Arbour, N.8
Becher, B.9
Prat, A.10
-
52
-
-
21044448355
-
Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis
-
Ishizu, T., M. Osoegawa, F. J. Mei, H. Kikuchi, M. Tanaka, Y. Takakura, M. Minohara, H. Murai, F. Mihara, T. Taniwaki, and J. Kira. 2005. Intrathecal activation of the IL-17/IL-8 axis in opticospinal multiple sclerosis. Brain 128: 988-1002.
-
(2005)
Brain
, vol.128
, pp. 988-1002
-
-
Ishizu, T.1
Osoegawa, M.2
Mei, F.J.3
Kikuchi, H.4
Tanaka, M.5
Takakura, Y.6
Minohara, M.7
Murai, H.8
Mihara, F.9
Taniwaki, T.10
Kira, J.11
-
53
-
-
34249891600
-
Gene expression changes in peripheral blood mononuclear cells from multiple sclerosis patients undergoing beta-interferon therapy
-
Singh, M. K., T. F. Scott, W. A. LaFramboise, F. Z. Hu, J. C. Post, and G. D. Ehrlich. 2007. Gene expression changes in peripheral blood mononuclear cells from multiple sclerosis patients undergoing beta-interferon therapy. J. Neurol. Sci. 258: 52-59.
-
(2007)
J. Neurol. Sci.
, vol.258
, pp. 52-59
-
-
Singh, M.K.1
Scott, T.F.2
Laframboise, W.A.3
Hu, F.Z.4
Post, J.C.5
Ehrlich, G.D.6
-
54
-
-
84879768723
-
Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes
-
Satoh, J. I., and H. Tabunoki. 2013. Molecular network of chromatin immunoprecipitation followed by deep sequencing-based vitamin D receptor target genes. Mult. Scler. 19: 1035-1045.
-
(2013)
Mult. Scler.
, vol.19
, pp. 1035-1045
-
-
Satoh, J.I.1
Tabunoki, H.2
-
55
-
-
0036604306
-
A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R
-
Parham, C., M. Chirica, J. Timans, E. Vaisberg, M. Travis, J. Cheung, S. Pflanz, R. Zhang, K. P. Singh, F. Vega, et al. 2002. A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. J. Immunol. 168: 5699-5708.
-
(2002)
J. Immunol.
, vol.168
, pp. 5699-5708
-
-
Parham, C.1
Chirica, M.2
Timans, J.3
Vaisberg, E.4
Travis, M.5
Cheung, J.6
Pflanz, S.7
Zhang, R.8
Singh, K.P.9
Vega, F.10
-
56
-
-
0032960861
-
Functional and physical interactions between AML1 proteins and an ETS protein, MEF: Implications for the pathogenesis of t(8;21)-positive leukemias
-
Mao, S., R. C. Frank, J. Zhang, Y. Miyazaki, and S. D. Nimer. 1999. Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias. Mol. Cell. Biol. 19: 3635-3644.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 3635-3644
-
-
Mao, S.1
Frank, R.C.2
Zhang, J.3
Miyazaki, Y.4
Nimer, S.D.5
-
57
-
-
33847648883
-
The suppressive effect of myeloid Elf-1-like factor (MEF) in osteogenic differentiation
-
Kim, Y. J., B. G. Kim, S. J. Lee, H. K. Lee, S. H. Lee, H. M. Ryoo, and J. Y. Cho. 2007. The suppressive effect of myeloid Elf-1-like factor (MEF) in osteogenic differentiation. J. Cell. Physiol. 211: 253-260.
-
(2007)
J. Cell. Physiol.
, vol.211
, pp. 253-260
-
-
Kim, Y.J.1
Kim, B.G.2
Lee, S.J.3
Lee, H.K.4
Lee, S.H.5
Ryoo, H.M.6
Cho, J.Y.7
-
58
-
-
54549100120
-
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells
-
Zhang, F., G. Meng, and W. Strober. 2008. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat. Immunol. 9: 1297-1306.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1297-1306
-
-
Zhang, F.1
Meng, G.2
Strober, W.3
-
59
-
-
78650306567
-
T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgt
-
Lazarevic, V., X. Chen, J. H. Shim, E. S. Hwang, E. Jang, A. N. Bolm, M. Oukka, V. K. Kuchroo, and L. H. Glimcher. 2011. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORgt. Nat. Immunol. 12: 96-104.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 96-104
-
-
Lazarevic, V.1
Chen, X.2
Shim, J.H.3
Hwang, E.S.4
Jang, E.5
Bolm, A.N.6
Oukka, M.7
Kuchroo, V.K.8
Glimcher, L.H.9
-
60
-
-
45149123617
-
Development and characterization of IL-21-producing CD4+ T cells
-
Suto, A., D. Kashiwakuma, S. Kagami, K. Hirose, N. Watanabe, K. Yokote, Y. Saito, T. Nakayama, M. J. Grusby, I. Iwamoto, and H. Nakajima. 2008. Development and characterization of IL-21-producing CD4+ T cells. J. Exp. Med. 205: 1369-1379.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1369-1379
-
-
Suto, A.1
Kashiwakuma, D.2
Kagami, S.3
Hirose, K.4
Watanabe, N.5
Yokote, K.6
Saito, Y.7
Nakayama, T.8
Grusby, M.J.9
Iwamoto, I.10
Nakajima, H.11
-
61
-
-
34547204946
-
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
-
Nurieva, R., X. O. Yang, G. Martinez, Y. Zhang, A. D. Panopoulos, L. Ma, K. Schluns, Q. Tian, S. S. Watowich, A. M. Jetten, and C. Dong. 2007. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448: 480-483.
-
(2007)
Nature
, vol.448
, pp. 480-483
-
-
Nurieva, R.1
Yang, X.O.2
Martinez, G.3
Zhang, Y.4
Panopoulos, A.D.5
Ma, L.6
Schluns, K.7
Tian, Q.8
Watowich, S.S.9
Jetten, A.M.10
Dong, C.11
-
62
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
-
Korn, T., E. Bettelli, W. Gao, A. Awasthi, A. Jäger, T. B. Strom, M. Oukka, and V. K. Kuchroo. 2007. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448: 484-487.
-
(2007)
Nature
, vol.448
, pp. 484-487
-
-
Korn, T.1
Bettelli, E.2
Gao, W.3
Awasthi, A.4
Jäger, A.5
Strom, T.B.6
Oukka, M.7
Kuchroo, V.K.8
-
63
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe, G. M., T. P. Kole, Y. Zheng, P. E. Zarek, K. L. Matthews, B. Xiao, P. F. Worley, S. C. Kozma, and J. D. Powell. 2009. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 30: 832-844.
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
Worley, P.F.7
Kozma, S.C.8
Powell, J.D.9
-
64
-
-
84861134382
-
PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORg
-
Kurebayashi, Y., S. Nagai, A. Ikejiri, M. Ohtani, K. Ichiyama, Y. Baba, T. Yamada, S. Egami, T. Hoshii, A. Hirao, et al. 2012. PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORg. Cell Rep. 1: 360-373.
-
(2012)
Cell Rep.
, vol.1
, pp. 360-373
-
-
Kurebayashi, Y.1
Nagai, S.2
Ikejiri, A.3
Ohtani, M.4
Ichiyama, K.5
Baba, Y.6
Yamada, T.7
Egami, S.8
Hoshii, T.9
Hirao, A.10
-
65
-
-
77949264184
-
Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation
-
Esposito, M., F. Ruffini, M. Bellone, N. Gagliani, M. Battaglia, G. Martino, and R. Furlan. 2010. Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation. J. Neuroimmunol. 220: 52-63.
-
(2010)
J. Neuroimmunol.
, vol.220
, pp. 52-63
-
-
Esposito, M.1
Ruffini, F.2
Bellone, M.3
Gagliani, N.4
Battaglia, M.5
Martino, G.6
Furlan, R.7
-
66
-
-
68249124611
-
Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells
-
Donia, M., K. Mangano, A. Amoroso, M. C. Mazzarino, R. Imbesi, P. Castrogiovanni, M. Coco, P. Meroni, and F. Nicoletti. 2009. Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells. J. Autoimmun. 33: 135-140.
-
(2009)
J. Autoimmun.
, vol.33
, pp. 135-140
-
-
Donia, M.1
Mangano, K.2
Amoroso, A.3
Mazzarino, M.C.4
Imbesi, R.5
Castrogiovanni, P.6
Coco, M.7
Meroni, P.8
Nicoletti, F.9
-
67
-
-
84860237060
-
Regulation and function of mTOR signalling in T cell fate decisions
-
Chi, H. 2012. Regulation and function of mTOR signalling in T cell fate decisions. Nat. Rev. Immunol. 12: 325-338.
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 325-338
-
-
Chi, H.1
-
69
-
-
84873696767
-
Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets
-
Yamane, H., and W. E. Paul. 2013. Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets. Immunol. Rev. 252: 12-23.
-
(2013)
Immunol. Rev.
, vol.252
, pp. 12-23
-
-
Yamane, H.1
Paul, W.E.2
-
70
-
-
0041331708
-
TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells
-
Palaga, T., L. Miele, T. E. Golde, and B. A. Osborne. 2003. TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells. J. Immunol. 171: 3019-3024.
-
(2003)
J. Immunol.
, vol.171
, pp. 3019-3024
-
-
Palaga, T.1
Miele, L.2
Golde, T.E.3
Osborne, B.A.4
-
71
-
-
85027948869
-
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
-
Guy, C. S., K. M. Vignali, J. Temirov, M. L. Bettini, A. E. Overacre, M. Smeltzer, H. Zhang, J. B. Huppa, Y. H. Tsai, C. Lobry, et al. 2013. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat. Immunol. 14: 262-270.
-
(2013)
Nat. Immunol.
, vol.14
, pp. 262-270
-
-
Guy, C.S.1
Vignali, K.M.2
Temirov, J.3
Bettini, M.L.4
Overacre, A.E.5
Smeltzer, M.6
Zhang, H.7
Huppa, J.B.8
Tsai, Y.H.9
Lobry, C.10
-
72
-
-
0025812701
-
Convergence of Etsand notch-related structural motifs in a heteromeric DNA binding complex
-
Thompson, C. C., T. A. Brown, and S. L. McKnight. 1991. Convergence of Etsand notch-related structural motifs in a heteromeric DNA binding complex. Science 253: 762-768.
-
(1991)
Science
, vol.253
, pp. 762-768
-
-
Thompson, C.C.1
Brown, T.A.2
McKnight, S.L.3
|