-
2
-
-
84871791493
-
Making receptors a reality: The 2012 Nobel Prize in Chemistry
-
Kenakin, T. Making receptors a reality: The 2012 Nobel Prize in Chemistry. Trends Pharmacol. Sci. 2013, 34, 2-5
-
(2013)
Trends Pharmacol. Sci
, vol.34
, pp. 2-5
-
-
Kenakin, T.1
-
3
-
-
84883565348
-
Adrenergic nervous system in heart failure: Pathophysiology and therapy
-
Lymperopoulos, A.; Rengo, G.; Koch, W.J. Adrenergic nervous system in heart failure: Pathophysiology and therapy. Circ. Res. 2013, 113, 739-753
-
(2013)
Circ. Res
, vol.113
, pp. 739-753
-
-
Lymperopoulos, A.1
Rengo, G.2
Koch, W.J.3
-
4
-
-
84885929140
-
Current and future G protein-coupled receptor signaling targets for heart failure therapy
-
Siryk-Bathgate, A.; Dabul, S.; Lymperopoulos, A. Current and future G protein-coupled receptor signaling targets for heart failure therapy. Drug Des. Dev. Ther. 2013, 7, 1209-1222
-
(2013)
Drug Des. Dev. Ther
, vol.7
, pp. 1209-1222
-
-
Siryk-Bathgate, A.1
Dabul, S.2
Lymperopoulos, A.3
-
5
-
-
84884585457
-
Physiology and pharmacology of the cardiovascular adrenergic system
-
Lymperopoulos, A. Physiology and pharmacology of the cardiovascular adrenergic system. Front. Physiol. 2013, 4, 240
-
(2013)
Front. Physiol
, vol.4
, pp. 240
-
-
Lymperopoulos, A.1
-
6
-
-
84856475827
-
β-arrestin biased agonism/antagonism at cardiovascular seven transmembrane-spanning receptors
-
Lymperopoulos, A. β-arrestin biased agonism/antagonism at cardiovascular seven transmembrane-spanning receptors. Curr. Pharm. Des. 2012, 18, 192-198
-
(2012)
Curr. Pharm. Des
, vol.18
, pp. 192-198
-
-
Lymperopoulos, A.1
-
7
-
-
84856504934
-
GRK2 inhibition in heart failure: Something old, something new
-
Lymperopoulos, A.; Rengo, G.; Koch, W.J. GRK2 inhibition in heart failure: Something old, something new. Curr. Pharm. Des. 2012, 18, 186-191
-
(2012)
Curr. Pharm. Des
, vol.18
, pp. 186-191
-
-
Lymperopoulos, A.1
Rengo, G.2
Koch, W.J.3
-
8
-
-
33646414189
-
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
-
Gurevich, V.V.; Gurevich, E.V. The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol. Ther. 2006, 110, 465-502
-
(2006)
Pharmacol. Ther
, vol.110
, pp. 465-502
-
-
Gurevich, V.V.1
Gurevich, E.V.2
-
9
-
-
48249126790
-
Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors
-
Shukla, A.K.; Violin, J.D.; Whalen, E.J.; Gesty-Palmer, D.; Shenoy, S.K.; Lefkowitz, R.J. Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors. Proc. Natl. Acad. Sci. USA 2008, 105, 9988-9993
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 9988-9993
-
-
Shukla, A.K.1
Violin, J.D.2
Whalen, E.J.3
Gesty-Palmer, D.4
Shenoy, S.K.5
Lefkowitz, R.J.6
-
10
-
-
0030664060
-
Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity
-
Gurevich, V.V.; Pals-Rylaarsdam, R.; Benovic, J.L.; Hosey, M.M.; Onorato, J.J. Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity. J. Biol. Chem. 1997, 272, 28849-28852
-
(1997)
J. Biol. Chem
, vol.272
, pp. 28849-28852
-
-
Gurevich, V.V.1
Pals-Rylaarsdam, R.2
Benovic, J.L.3
Hosey, M.M.4
Onorato, J.J.5
-
11
-
-
77952415656
-
Beyond desensitization: Physiological relevance of arrestin dependent signaling
-
Luttrell, L.M.; Gesty-Palmer, D. Beyond desensitization: Physiological relevance of arrestin dependent signaling. Pharmacol. Rev. 2010, 62, 305-330
-
(2010)
Pharmacol. Rev
, vol.62
, pp. 305-330
-
-
Luttrell, L.M.1
Gesty-Palmer, D.2
-
12
-
-
0035101820
-
Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
-
Ferguson, S.S. Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling. Pharmacol. Rev. 2001, 53, 1-24
-
(2001)
Pharmacol. Rev
, vol.53
, pp. 1-24
-
-
Ferguson, S.S.1
-
13
-
-
0034595860
-
Differential affinities of visual arrestin, βarrestin1, and βarrestin2 for G protein-coupled receptors delineate two major classes of receptors
-
Oakley, R.H.; Laporte, S.A.; Holt, J.A.; Caron, M.G.; Barak, L.S. Differential affinities of visual arrestin, βarrestin1, and βarrestin2 for G protein-coupled receptors delineate two major classes of receptors. J. Biol. Chem. 2000, 275, 17201-17210
-
(2000)
J. Biol. Chem
, vol.275
, pp. 17201-17210
-
-
Oakley, R.H.1
Laporte, S.A.2
Holt, J.A.3
Caron, M.G.4
Barak, L.S.5
-
14
-
-
17644391412
-
Monitoring agonist-promoted conformational changes of β-arrestin in living cells by intramolecular BRET
-
Charest, P.G.; Terrillon, S.; Bouvier, M. Monitoring agonist-promoted conformational changes of β-arrestin in living cells by intramolecular BRET. EMBO Rep. 2005, 6, 334-340
-
(2005)
EMBO Rep
, vol.6
, pp. 334-340
-
-
Charest, P.G.1
Terrillon, S.2
Bouvier, M.3
-
15
-
-
0030613761
-
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
-
Daaka, Y.; Luttrell, L.M.; Lefkowitz, R.J. Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A. Nature 1997, 390, 88-91
-
(1997)
Nature
, vol.390
, pp. 88-91
-
-
Daaka, Y.1
Luttrell, L.M.2
Lefkowitz, R.J.3
-
16
-
-
0032729995
-
Opposing effects of β1- and β2-aadrenergic receptors on cardiac myocyte apoptosis: Role of a pertussis toxin-sensitive G protein
-
Communal, C.; Singh, K.; Sawyer, D.B.; Colucci, W.S. Opposing effects of β1- and β2-aadrenergic receptors on cardiac myocyte apoptosis: Role of a pertussis toxin-sensitive G protein. Circulation 1999, 100, 2210-2212
-
(1999)
Circulation
, vol.100
, pp. 2210-2212
-
-
Communal, C.1
Singh, K.2
Sawyer, D.B.3
Colucci, W.S.4
-
17
-
-
0034623819
-
The β2-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through Gidependent coupling to phosphatidylinositol 3-kinase
-
Chesley, A.; Lundberg, M.S.; Asai, T.; Xiao, R.P.; Ohtani, S.; Lakatta, E.G.; Crow, M.T. The β2-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through Gidependent coupling to phosphatidylinositol 3-kinase. Circ. Res. 2000, 87, 1172-1179
-
(2000)
Circ. Res
, vol.87
, pp. 1172-1179
-
-
Chesley, A.1
Lundberg, M.S.2
Asai, T.3
Xiao, R.P.4
Ohtani, S.5
Lakatta, E.G.6
Crow, M.T.7
-
18
-
-
0035852634
-
Dual modulation of cell survival and cell death by β2-adrenergic signalling in adult mouse cardiomyocytes
-
Zhu, W.Z.; Zheng, M.; Koch, W.J.; Lefkowitz, R.J.; Kobilka, B.K.; Xiao, R.P. Dual modulation of cell survival and cell death by β2-adrenergic signalling in adult mouse cardiomyocytes. Proc. Natl. Acad. Sci. USA 2001, 98, 1607-1612
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 1607-1612
-
-
Zhu, W.Z.1
Zheng, M.2
Koch, W.J.3
Lefkowitz, R.J.4
Kobilka, B.K.5
Xiao, R.P.6
-
19
-
-
0033033440
-
Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice
-
Dorn, G.W.; Tepe, N.M.; Lorenz, J.N.; Koch, W.J.; Liggett, S.B. Low- and high-level transgenic expression of β2-adrenergic receptors differentially affect cardiac hypertrophy and function in Gαq-overexpressing mice. Proc. Natl. Acad. Sci. USA 1999, 96, 6400-6405
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6400-6405
-
-
Dorn, G.W.1
Tepe, N.M.2
Lorenz, J.N.3
Koch, W.J.4
Liggett, S.B.5
-
20
-
-
0030732503
-
β-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to β-adrenergic stimulation
-
Conner, D.A.; Mathier, M.A.; Mortensen, R.M.; Christe, M.; Vatner, S.F.; Seidman, C.E.; Seidman, J.G. β-Arrestin1 knockout mice appear normal but demonstrate altered cardiac responses to β-adrenergic stimulation. Circ. Res. 1997, 81, 1021-1026
-
(1997)
Circ. Res
, vol.81
, pp. 1021-1026
-
-
Conner, D.A.1
Mathier, M.A.2
Mortensen, R.M.3
Christe, M.4
Vatner, S.F.5
Seidman, C.E.6
Seidman, J.G.7
-
21
-
-
0038581576
-
Myocyte adrenoceptor signaling pathways
-
Xiang, Y.; Kobilka, B.K. Myocyte adrenoceptor signaling pathways. Science 2003, 300, 1530-1532
-
(2003)
Science
, vol.300
, pp. 1530-1532
-
-
Xiang, Y.1
Kobilka, B.K.2
-
22
-
-
0034620523
-
β-adrenergic receptor blockade in chronic heart failure
-
Bristow, M.R. β-adrenergic receptor blockade in chronic heart failure. Circulation 2000, 101, 558-569
-
(2000)
Circulation
, vol.101
, pp. 558-569
-
-
Bristow, M.R.1
-
23
-
-
0029937949
-
The effect of carvedilol on morbidity and mortality in patients with chronic heart failure
-
Packer, M.; Bristow, M.R.; Cohn, J.N.; Colucci, W.S.; Fowler, M.B.; Gilbert, E.M.; Shusterman, N.H. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N. Engl. J. Med. 1996, 334, 1349-1355
-
(1996)
N. Engl. J. Med
, vol.334
, pp. 1349-1355
-
-
Packer, M.1
Bristow, M.R.2
Cohn, J.N.3
Colucci, W.S.4
Fowler, M.B.5
Gilbert, E.M.6
Shusterman, N.H.7
-
24
-
-
34848820302
-
β-arrestin-mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection
-
Noma, T.; Lemaire, A.; Naga Prasad, S.V.; Barki-Harrington, L.; Tilley, D.G.; Chen, J.; le Corvoisier, P.; Violin, J.D.; Wei, H.; Lefkowitz, R.J.; et al. β-arrestin-mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J. Clin. Invest. 2007, 117, 2445-2458
-
(2007)
J. Clin. Invest
, vol.117
, pp. 2445-2458
-
-
Noma, T.1
Lemaire, A.2
Naga, P.S.V.3
Barki-Harrington, L.4
Tilley, D.G.5
Chen, J.6
le Corvoisier, P.7
Violin, J.D.8
Wei, H.9
Lefkowitz, R.J.10
-
25
-
-
79960355012
-
G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function
-
Tilley, D.G. G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function. Circ. Res. 2011, 109, 217-230
-
(2011)
Circ. Res
, vol.109
, pp. 217-230
-
-
Tilley, D.G.1
-
26
-
-
80052795644
-
β-arrestin: A signaling molecule and potential therapeutic target for heart failure
-
Noor, N.; Patel, C.B.; Rockman, H.A. β-arrestin: A signaling molecule and potential therapeutic target for heart failure. J. Mol. Cell. Cardiol. 2011, 51, 534-41
-
(2011)
J. Mol. Cell. Cardiol
, vol.51
, pp. 534-541
-
-
Noor, N.1
Patel, C.B.2
Rockman, H.A.3
-
27
-
-
84892921129
-
Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms
-
doi:10.1161/HYPERTENSIONAHA.113.02043
-
Bathgate-Siryk, A.; Dabul, S.; Pandya, K.; Walklett, K.; Rengo, G.; Cannavo, A.; de Lucia, C.; Liccardo, D.; Gao, E.; Leosco, D.; et al. Negative impact of β-arrestin-1 on post-myocardial infarction heart failure via cardiac and adrenal-dependent neurohormonal mechanisms. Hypertension 2013, doi:10.1161/HYPERTENSIONAHA.113.02043
-
(2013)
Hypertension
-
-
Bathgate-Siryk, A.1
Dabul, S.2
Pandya, K.3
Walklett, K.4
Rengo, G.5
Cannavo, A.6
de Lucia, C.7
Liccardo, D.8
Gao, E.9
Leosco, D.10
-
28
-
-
43549098268
-
Calcium cycling and signaling in cardiac myocytes
-
Bers, D.M. Calcium cycling and signaling in cardiac myocytes. Annu. Rev. Physiol. 2008, 70, 23-49
-
(2008)
Annu. Rev. Physiol
, vol.70
, pp. 23-49
-
-
Bers, D.M.1
-
29
-
-
80053349683
-
SUMO1-dependent modulation of SERCA2a in heart failure
-
Kho, C.; Lee, A.; Jeong, D.; Oh, J.G.; Chaanine, A.H.; Kizana, E.; Park, W.J.; Hajjar, R.J. SUMO1-dependent modulation of SERCA2a in heart failure. Nature 2011, 477, 601-605
-
(2011)
Nature
, vol.477
, pp. 601-605
-
-
Kho, C.1
Lee, A.2
Jeong, D.3
Oh, J.G.4
Chaanine, A.H.5
Kizana, E.6
Park, W.J.7
Hajjar, R.J.8
-
31
-
-
77951872871
-
β-Arrestin-dependent activation of Ca2+/calmodulin kinase II after β1-adrenergic receptor stimulation
-
Mangmool, S.; Shukla, A.K.; Rockman, H.A. β-Arrestin-dependent activation of Ca2+/calmodulin kinase II after β1-adrenergic receptor stimulation. J. Cell Biol. 2010, 189, 573-587
-
(2010)
J. Cell Biol
, vol.189
, pp. 573-587
-
-
Mangmool, S.1
Shukla, A.K.2
Rockman, H.A.3
-
32
-
-
66449085988
-
CaMKII and a failing strategy for growth in heart
-
Anderson, M.E. CaMKII and a failing strategy for growth in heart. J. Clin. Invest. 2009, 119, 1082-1085
-
(2009)
J. Clin. Invest
, vol.119
, pp. 1082-1085
-
-
Anderson, M.E.1
-
33
-
-
3042659100
-
Subtype-specific β-adrenoceptor signaling pathways in the heart and their potential clinical implications
-
Xiao, R.P.; Zhu, W.; Zheng, M.; Chakir, K.; Bond, R.; Lakatta, E.G.; Cheng, H. Subtype-specific β-adrenoceptor signaling pathways in the heart and their potential clinical implications. Trends Pharmacol. Sci. 2004, 25, 358-365
-
(2004)
Trends Pharmacol. Sci
, vol.25
, pp. 358-365
-
-
Xiao, R.P.1
Zhu, W.2
Zheng, M.3
Chakir, K.4
Bond, R.5
Lakatta, E.G.6
Cheng, H.7
-
34
-
-
0035956983
-
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
-
Luttrell, L.M.; Roudabush, F.L.; Choy, E.W.; Miller, W.E.; Field, M.E.; Pierce, K.L.; Lefkowitz, R.J. Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds. Proc. Natl. Acad. Sci. USA 2001, 98, 2449-2454
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 2449-2454
-
-
Luttrell, L.M.1
Roudabush, F.L.2
Choy, E.W.3
Miller, W.E.4
Field, M.E.5
Pierce, K.L.6
Lefkowitz, R.J.7
-
35
-
-
2942554958
-
β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IkappaBalpha
-
Witherow, D.S.; Garrison, T.R.; Miller, W.E.; Lefkowitz, R.J. β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IkappaBalpha. Proc. Natl. Acad. Sci. USA 2004, 101, 8603-8607
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 8603-8607
-
-
Witherow, D.S.1
Garrison, T.R.2
Miller, W.E.3
Lefkowitz, R.J.4
-
36
-
-
2342510314
-
Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-κB pathways
-
Gao, H.; Sun, Y.; Wu, Y.; Luan, B.; Wang, Y.; Qu, B.; Pei, G. Identification of β-arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-κB pathways. Mol. Cell. 2004, 14, 303-317
-
(2004)
Mol. Cell
, vol.14
, pp. 303-317
-
-
Gao, H.1
Sun, Y.2
Wu, Y.3
Luan, B.4
Wang, Y.5
Qu, B.6
Pei, G.7
-
37
-
-
38549107922
-
Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4
-
Richter, W.; Day, P.; Agrawal, R.; Bruss, M.D.; Granier, S.; Wang, Y.L.; Rasmussen, S.G.; Horner, K.; Wang, P.; Lei, T.; et al. Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J. 2008, 27, 384-393
-
(2008)
EMBO J
, vol.27
, pp. 384-393
-
-
Richter, W.1
Day, P.2
Agrawal, R.3
Bruss, M.D.4
Granier, S.5
Wang, Y.L.6
Rasmussen, S.G.7
Horner, K.8
Wang, P.9
Lei, T.10
-
38
-
-
14144251238
-
Phosphodiesterase 4D is required for β2-adrenoceptor subtype-specific signaling in cardiac myocytes
-
Xiang, Y.; Naro, F.; Zoudilova, M.; Jin, S.L.; Conti, M.; Kobilka, B. Phosphodiesterase 4D is required for β2-adrenoceptor subtype-specific signaling in cardiac myocytes. Proc. Natl. Acad. Sci. USA 2005, 102, 909-914
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 909-914
-
-
Xiang, Y.1
Naro, F.2
Zoudilova, M.3
Jin, S.L.4
Conti, M.5
Kobilka, B.6
-
39
-
-
84883539947
-
GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility
-
Salazar, N.C.; Vallejos, X.; Siryk, A.; Rengo, G.; Cannavo, A.; Liccardo, D.; de Lucia, C.; Gao, E.; Leosco, D.; Koch, W.J.; et al. GRK2 blockade with βARKct is essential for cardiac β2-adrenergic receptor signaling towards increased contractility. Cell Commun. Signal. 2013, 11, 64
-
(2013)
Cell Commun. Signal
, vol.11
, pp. 64
-
-
Salazar, N.C.1
Vallejos, X.2
Siryk, A.3
Rengo, G.4
Cannavo, A.5
Liccardo, D.6
de Lucia, C.7
Gao, E.8
Leosco, D.9
Koch, W.J.10
-
40
-
-
34247105883
-
cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: A molecular toolbox for generating compartmentalized cAMP signaling
-
Houslay, M.D.; Baillie, G.S.; Maurice, D.H. cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: A molecular toolbox for generating compartmentalized cAMP signaling. Circ. Res. 2007, 100, 950-966
-
(2007)
Circ. Res
, vol.100
, pp. 950-966
-
-
Houslay, M.D.1
Baillie, G.S.2
Maurice, D.H.3
-
41
-
-
41949089470
-
β-arrestin-biased agonism at the β2-adrenergic receptor
-
Drake, M.T.; Violin, J.D.; Whalen, E.J.; Wisler, J.W.; Shenoy, S.K.; Lefkowitz, R.J. β-arrestin-biased agonism at the β2-adrenergic receptor. J. Biol. Chem. 2008, 283, 5669-5676
-
(2008)
J. Biol. Chem
, vol.283
, pp. 5669-5676
-
-
Drake, M.T.1
Violin, J.D.2
Whalen, E.J.3
Wisler, J.W.4
Shenoy, S.K.5
Lefkowitz, R.J.6
-
42
-
-
36749094552
-
A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling
-
Wisler, J.W.; DeWire, S.M.; Whalen, E.J.; Violin, J.D.; Drake, M.T.; Ahn, S.; Shenoy, S.K.; Lefkowitz, R.J. A unique mechanism of β-blocker action: Carvedilol stimulates β-arrestin signaling. Proc. Natl. Acad. Sci. USA 2007, 104, 16657-16662
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 16657-16662
-
-
Wisler, J.W.1
Dewire, S.M.2
Whalen, E.J.3
Violin, J.D.4
Drake, M.T.5
Ahn, S.6
Shenoy, S.K.7
Lefkowitz, R.J.8
-
43
-
-
56549117604
-
Role of angiotensin II AT1 receptor activation in cardiovascular diseases
-
Billet, S.; Aguilar, F.; Baudry, C.; Clauser, E. Role of angiotensin II AT1 receptor activation in cardiovascular diseases. Kidney Int. 2008, 74, 1379-1384
-
(2008)
Kidney Int
, vol.74
, pp. 1379-1384
-
-
Billet, S.1
Aguilar, F.2
Baudry, C.3
Clauser, E.4
-
44
-
-
0030734648
-
Evidence of an important and direct role for protein kinase C in agonist-induced phosphorylation leading to desensitization of the angiotensin AT1A receptor
-
Balmforth, A.J.; Shepherd, F.H.; Warburton, P.; Ball, S.G. Evidence of an important and direct role for protein kinase C in agonist-induced phosphorylation leading to desensitization of the angiotensin AT1A receptor. Br. J. Pharmacol. 1997, 122, 1469-1477
-
(1997)
Br. J. Pharmacol
, vol.122
, pp. 1469-1477
-
-
Balmforth, A.J.1
Shepherd, F.H.2
Warburton, P.3
Ball, S.G.4
-
45
-
-
0035851199
-
Agonist-induced signaling, desensitization, and internalization of a phosphorylation-deficient AT1A angiotensin receptor
-
Olivares-Reyes, J.A.; Smith, R.D.; Hunyady, L.; Shah, B.H.; Catt, K.J. Agonist-induced signaling, desensitization, and internalization of a phosphorylation-deficient AT1A angiotensin receptor. J. Biol. Chem. 2001, 276, 37761-37768
-
(2001)
J. Biol. Chem
, vol.276
, pp. 37761-37768
-
-
Olivares-Reyes, J.A.1
Smith, R.D.2
Hunyady, L.3
Shah, B.H.4
Catt, K.J.5
-
46
-
-
0029920043
-
Cardiac effects of AII. AT1A receptor signaling, desensitization, and internalization
-
Thomas, W.G.; Thekkumkara, T.J.; Baker, K.M. Cardiac effects of AII. AT1A receptor signaling, desensitization, and internalization. Adv. Exp. Med. Biol. 1996, 396, 59-69
-
(1996)
Adv. Exp. Med. Biol
, vol.396
, pp. 59-69
-
-
Thomas, W.G.1
Thekkumkara, T.J.2
Baker, K.M.3
-
47
-
-
27644468385
-
Cardiac-specific overexpression of AT1 receptor mutant lacking G αq/G α i coupling causes hypertrophy and bradycardia in transgenic mice
-
Zhai, P.; Yamamoto, M.; Galeotti, J.; Liu, J.; Masurekar, M.; Thaisz, J.; Irie, K.; Holle, E.; Yu, X.; Kupershmidt, S.; et al. Cardiac-specific overexpression of AT1 receptor mutant lacking G αq/G α i coupling causes hypertrophy and bradycardia in transgenic mice. J. Clin. Invest. 2005, 115, 3045-3056
-
(2005)
J. Clin. Invest
, vol.115
, pp. 3045-3056
-
-
Zhai, P.1
Yamamoto, M.2
Galeotti, J.3
Liu, J.4
Masurekar, M.5
Thaisz, J.6
Irie, K.7
Holle, E.8
Yu, X.9
Kupershmidt, S.10
-
48
-
-
0036208442
-
Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors
-
Holloway, A.C.; Qian, H.; Pipolo, L.; Ziogas, J.; Miura, S.; Karnik, S.; Southwell, B.R.; Lew, M.J.; Thomas, W.G. Side-chain substitutions within angiotensin II reveal different requirements for signaling, internalization, and phosphorylation of type 1A angiotensin receptors. Mol. Pharmacol. 2002, 61, 768-777
-
(2002)
Mol. Pharmacol
, vol.61
, pp. 768-777
-
-
Holloway, A.C.1
Qian, H.2
Pipolo, L.3
Ziogas, J.4
Miura, S.5
Karnik, S.6
Southwell, B.R.7
Lew, M.J.8
Thomas, W.G.9
-
49
-
-
33750802401
-
β-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
-
Rajagopal, K.; Whalen, E.J.; Violin, J.D.; Stiber, J.A.; Rosenberg, P.B.; Premont, R.T.; Coffman, T.M.; Rockman, H.A.; Lefkowitz, R.J. β-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc. Natl. Acad. Sci. USA 2006, 103, 16284-16289
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 16284-16289
-
-
Rajagopal, K.1
Whalen, E.J.2
Violin, J.D.3
Stiber, J.A.4
Rosenberg, P.B.5
Premont, R.T.6
Coffman, T.M.7
Rockman, H.A.8
Lefkowitz, R.J.9
-
50
-
-
78751647632
-
Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling
-
Mishra, S.; Ling, H.; Grimm, M.; Zhang, T.; Bers, D.M.; Brown, J.H. Cardiac hypertrophy and heart failure development through Gq and CaM kinase II signaling. J. Cardiovasc. Pharmacol. 2010, 56, 598-603
-
(2010)
J. Cardiovasc. Pharmacol
, vol.56
, pp. 598-603
-
-
Mishra, S.1
Ling, H.2
Grimm, M.3
Zhang, T.4
Bers, D.M.5
Brown, J.H.6
-
51
-
-
14644414790
-
Protein kinase cascades in the regulation of cardiac hypertrophy
-
Dorn, G.W., II; Force, T. Protein kinase cascades in the regulation of cardiac hypertrophy. J. Clin. Invest. 2005, 115, 527-537
-
(2005)
J. Clin. Invest
, vol.115
, pp. 527-537
-
-
Dorn II, G.W.1
Force, T.2
-
52
-
-
20344375461
-
Regulation of receptor-coupling to (multiple) G proteins. A challenge for basic research and drug discovery
-
Kukkonen, J.P. Regulation of receptor-coupling to (multiple) G proteins. A challenge for basic research and drug discovery. Recept. Channels 2004, 10, 167-183
-
(2004)
Recept. Channels
, vol.10
, pp. 167-183
-
-
Kukkonen, J.P.1
-
53
-
-
67649856866
-
Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands
-
Zidar, D.A.; Violin, J.D.; Whalen, E.J.; Lefkowitz, R.J. Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc. Natl. Acad. Sci. USA 2009, 106, 9649-9654
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 9649-9654
-
-
Zidar, D.A.1
Violin, J.D.2
Whalen, E.J.3
Lefkowitz, R.J.4
-
54
-
-
34247341288
-
Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes
-
Aplin, M.; Christensen, G.L.; Schneider, M.; Heydorn, A.; Gammeltoft, S.; Kjølbye, A.L.; Sheikh, S.P.; Hansen, J.L. Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes. Basic Clin. Pharmacol. Toxicol. 2007, 100, 296-301
-
(2007)
Basic Clin. Pharmacol. Toxicol
, vol.100
, pp. 296-301
-
-
Aplin, M.1
Christensen, G.L.2
Schneider, M.3
Heydorn, A.4
Gammeltoft, S.5
Kjølbye, A.L.6
Sheikh, S.P.7
Hansen, J.L.8
-
55
-
-
84856343982
-
Cardiorenal actions of TRV120027, a novel β-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: A novel therapeutic strategy for acute heart failure
-
Boerrigter, G.; Lark, M.W.; Whalen, E.J.; Soergel, D.G.; Violin, J.D.; Burnett, J.C., Jr. Cardiorenal actions of TRV120027, a novel β-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: A novel therapeutic strategy for acute heart failure. Circ. Heart Fail. 2011, 4, 770-778
-
(2011)
Circ. Heart Fail
, vol.4
, pp. 770-778
-
-
Boerrigter, G.1
Lark, M.W.2
Whalen, E.J.3
Soergel, D.G.4
Violin, J.D.5
Burnett Jr., J.C.6
-
56
-
-
77953819826
-
β-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress
-
Rakesh, K.; Yoo, B.; Kim, I.M.; Salazar, N.; Kim, K.S.; Rockman, H.A. β-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress. Sci. Signal. 2010, 3, ra46
-
(2010)
Sci. Signal
, vol.3
-
-
Rakesh, K.1
Yoo, B.2
Kim, I.M.3
Salazar, N.4
Kim, K.S.5
Rockman, H.A.6
-
57
-
-
33847728682
-
Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure
-
Lymperopoulos, A.; Rengo, G.; Funakoshi, H.; Eckhart, A.D.; Koch, W.J. Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat. Med. 2007, 13, 315-323
-
(2007)
Nat. Med
, vol.13
, pp. 315-323
-
-
Lymperopoulos, A.1
Rengo, G.2
Funakoshi, H.3
Eckhart, A.D.4
Koch, W.J.5
-
58
-
-
65249162262
-
An adrenal β-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo
-
Lymperopoulos, A.; Rengo, G.; Zincarelli, C.; Kim, J.; Soltys, S.; Koch, W.J. An adrenal β-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo. Proc. Natl. Acad. Sci. USA 2009, 106, 5825-5830
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 5825-5830
-
-
Lymperopoulos, A.1
Rengo, G.2
Zincarelli, C.3
Kim, J.4
Soltys, S.5
Koch, W.J.6
-
59
-
-
78651326867
-
Adrenal β-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels
-
Lymperopoulos, A.; Rengo, G.; Zincarelli, C.; Kim, J.; Koch, W.J. Adrenal β-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels. J. Am. Coll. Cardiol. 2011, 57, 356-365
-
(2011)
J. Am. Coll. Cardiol
, vol.57
, pp. 356-365
-
-
Lymperopoulos, A.1
Rengo, G.2
Zincarelli, C.3
Kim, J.4
Koch, W.J.5
-
60
-
-
0038753915
-
Cardiac-specific overexpression of human β2 adrenoceptors in mice exposes coupling to both Gs and Gi proteins
-
Hasseldine, A.R.; Harper, E.A.; Black, J.W. Cardiac-specific overexpression of human β2 adrenoceptors in mice exposes coupling to both Gs and Gi proteins. Br. J. Pharmacol. 2003, 138, 1358-1366
-
(2003)
Br. J. Pharmacol
, vol.138
, pp. 1358-1366
-
-
Hasseldine, A.R.1
Harper, E.A.2
Black, J.W.3
-
61
-
-
33947401068
-
β-arrestins and cell signaling
-
DeWire, S.M.; Ahn, S.; Lefkowitz, R.J.; Shenoy, S.K. β-arrestins and cell signaling. Annu. Rev. Physiol. 2007, 69. 483-510
-
(2007)
Annu. Rev. Physiol
, vol.69
, pp. 483-510
-
-
Dewire, S.M.1
Ahn, S.2
Lefkowitz, R.J.3
Shenoy, S.K.4
-
62
-
-
84862776738
-
Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR
-
Liu, J.J.; Horst, R.; Katritch, V.; Stevens, R.C.; Wüthrich, K. Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR. Science 2012, 335, 1106-1110
-
(2012)
Science
, vol.335
, pp. 1106-1110
-
-
Liu, J.J.1
Horst, R.2
Katritch, V.3
Stevens, R.C.4
Wüthrich, K.5
-
63
-
-
13444291851
-
Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling
-
Kim, J.; Ahn, S.; Ren, X.R.; Whalen, E.J.; Reiter, E.; Wei, H.; Lefkowitz, R.J. Functional antagonism of different G protein-coupled receptor kinases for β-arrestin-mediated angiotensin II receptor signaling. Proc. Natl. Acad. Sci. USA 2005, 102, 1442-1447
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 1442-1447
-
-
Kim, J.1
Ahn, S.2
Ren, X.R.3
Whalen, E.J.4
Reiter, E.5
Wei, H.6
Lefkowitz, R.J.7
-
64
-
-
79960382104
-
Biased ligands for better cardiovascular drugs: Dissecting G-protein-coupled receptor pharmacology
-
DeWire, S.M.; Violin, J.D. Biased ligands for better cardiovascular drugs: Dissecting G-protein-coupled receptor pharmacology. Circ. Res. 2011, 109, 205-216
-
(2011)
Circ. Res
, vol.109
, pp. 205-216
-
-
DeWire, S.M.1
Violin, J.D.2
-
65
-
-
84883752677
-
GPCR biased ligands as novel heart failure therapeutics
-
Violin, J.D.; Soergel, D.G.; Boerrigter, G.; Burnett, J.C., Jr.; Lark, M.W. GPCR biased ligands as novel heart failure therapeutics. Trends Cardiovasc. Med. 2013, 23, 242-249.
-
(2013)
Trends Cardiovasc. Med
, vol.23
, pp. 242-249
-
-
Violin, J.D.1
Soergel, D.G.2
Boerrigter, G.3
Burnett Jr., J.C.4
Lark, M.W.5
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