Cardiac-specific overexpression of human β 2 adrenoceptors in mice exposes coupling to both G s and G i proteins

British Journal of Pharmacology

Volumn 138, Issue 7, 2003, Pages 1358-1366

  Hasseldine, A R G ^a,b   Harper, E A ^b   Black, J W ^a,b  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b James Black Foundation   (United Kingdom)

Author keywords

Adrenoceptor; Protein kinase A; Receptor coupling; Receptor overexpression; Transgenic mice

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; 4 (3 TERT BUTYLAMINO 2 HYDROXYPROPOXY) 2 BENZIMIDAZOLONE; 5 [2 [[2 HYDROXY 3 [4 (1 METHYL 4 TRIFLUOROMETHYL 2 IMIDAZOLYL)PHENOXY]PROPYL]AMINO]ETHOXY]SALICYLAMIDE; 8 BROMO CYCLIC AMP; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; PERTUSSIS TOXIN;

ANIMAL TISSUE; ARTICLE; BINDING KINETICS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROSTIMULATION; ENZYME PHOSPHORYLATION; GENE OVEREXPRESSION; HEART LEFT ATRIUM; INOTROPISM; LIGAND BINDING; MOUSE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ATRIAL FUNCTION, LEFT; FEMALE; GENE EXPRESSION; GENOTYPE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; HUMANS; IMIDAZOLES; ISOPROTERENOL; MALE; MICE; MICE, TRANSGENIC; MODELS, THEORETICAL; PERTUSSIS TOXIN; PROPANOLAMINES; RECEPTORS, ADRENERGIC, BETA-2;

EID: 0038753915     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705191     Document Type: Article

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