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Volumn 7, Issue , 2013, Pages 1209-1222

Current and future G protein-coupled receptor signaling targets for heart failure therapy

Author keywords

Cardiac; G protein coupled receptor; Heart failure; Signaling; Therapeutic target

Indexed keywords

ADENOSINE RECEPTOR; ADRENOMEDULLIN; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; AMBRISENTAN; ANGIOTENSIN 1 RECEPTOR; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA 3 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BUCINDOLOL; CAPADENOSON; CLENBUTEROL; CLONIDINE; CORTICOTROPIN RELEASING FACTOR; ENDOTHELIN RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLUCAGON; GLUCAGON LIKE PEPTIDE; LOSARTAN; LY 379196; METOPROLOL; MOXONIDINE; RELAXIN; RUBOXISTAURIN; SERELAXIN; TOLVAPTAN; UNINDEXED DRUG; VASOPRESSIN RECEPTOR;

EID: 84885929140     PISSN: 11778881     EISSN: None     Source Type: Journal    
DOI: 10.2147/DDDT.S35905     Document Type: Review
Times cited : (38)

References (105)
  • 1
    • 33947606366 scopus 로고    scopus 로고
    • Drug discovery for heart failure: A new era or the end of the pipeline?
    • Kaye DM, Krum H. Drug discovery for heart failure: a new era or the end of the pipeline? Nat Rev Drug Disc. 2007;6(2):127-139.
    • (2007) Nat Rev Drug Disc , vol.6 , Issue.2 , pp. 127-139
    • Kaye, D.M.1    Krum, H.2
  • 2
    • 20544453277 scopus 로고    scopus 로고
    • Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: Executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology
    • Swedberg K, Cleland J, Dargie H, et al; Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): the Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J. 2005;26(11):1115-1140.
    • (2005) Eur Heart J , vol.26 , Issue.11 , pp. 1115-1140
    • Swedberg, K.1    Cleland, J.2    Dargie, H.3
  • 3
    • 33644624046 scopus 로고    scopus 로고
    • Prevalence of heart failure and systolic ventricular dysfunction in older Australians: The Canberra Heart Study
    • Abhayaratna W, Smith WT, Becker NG, Marwick TH, Jeffery IM, McGill DA. Prevalence of heart failure and systolic ventricular dysfunction in older Australians: the Canberra Heart Study. Med J Aust. 2006;184(4):151-154.
    • (2006) Med J Aust , vol.184 , Issue.4 , pp. 151-154
    • Abhayaratna, W.1    Smith, W.T.2    Becker, N.G.3    Marwick, T.H.4    Jeffery, I.M.5    McGill, D.A.6
  • 4
    • 0037206364 scopus 로고    scopus 로고
    • Long-term trends in the incidence of and survival with heart failure
    • Levy D, Kenchaiah S, Larson MG, et al. Long-term trends in the incidence of and survival with heart failure. N Engl J Med. 2002;347(18): 1397-1402.
    • (2002) N Engl J Med , vol.347 , Issue.18 , pp. 1397-1402
    • Levy, D.1    Kenchaiah, S.2    Larson, M.G.3
  • 5
    • 3142745348 scopus 로고    scopus 로고
    • Trends in heart failure incidence and survival in a community-based population
    • Roger VL, Weston SA, Redfield MM, et al. Trends in heart failure incidence and survival in a community-based population. JAMA. 2004;292(3):344-350.
    • (2004) JAMA , vol.292 , Issue.3 , pp. 344-350
    • Roger, V.L.1    Weston, S.A.2    Redfield, M.M.3
  • 6
    • 0032972473 scopus 로고    scopus 로고
    • Prevalence of heart failure and left ventricular dysfunction in the general population; the Rotterdam Study
    • Mosterd A, Hoes AW, de Bruyne MC, et al. Prevalence of heart failure and left ventricular dysfunction in the general population; the Rotterdam Study. Eur Heart J. 1999;20(6):447-455.
    • (1999) Eur Heart J , vol.20 , Issue.6 , pp. 447-455
    • Mosterd, A.1    Hoes, A.W.2    de Bruyne, M.C.3
  • 7
    • 0034937939 scopus 로고    scopus 로고
    • The heart failure epidemic: Exactly how big is it?
    • Cleland JG, Khand A, Clark A. The heart failure epidemic: exactly how big is it? Eur Heart J. 2001;22(8):623-626.
    • (2001) Eur Heart J , vol.22 , Issue.8 , pp. 623-626
    • Cleland, J.G.1    Khand, A.2    Clark, A.3
  • 9
    • 84883565348 scopus 로고    scopus 로고
    • Adrenergic nervous system in heart failure: Pathophysiology and therapy
    • Lymperopoulos A, Rengo G, Koch WJ. Adrenergic nervous system in heart failure: pathophysiology and therapy. Circ Res. 2013;113: 739-753.
    • (2013) Circ Res , vol.113 , pp. 739-753
    • Lymperopoulos, A.1    Rengo, G.2    Koch, W.J.3
  • 10
    • 84881232356 scopus 로고    scopus 로고
    • G-protein-coupled receptors and their (Bio) chemical significance win 2012 Nobel Prize in chemistry
    • Lin HH. G-protein-coupled receptors and their (Bio) chemical significance win 2012 Nobel Prize in chemistry. Biomed J. 2013;36(3): 118-124.
    • (2013) Biomed J , vol.36 , Issue.3 , pp. 118-124
    • Lin, H.H.1
  • 11
    • 84856504934 scopus 로고    scopus 로고
    • GRK2 inhibition in heart failure: Something old, something new
    • Lymperopoulos A, Rengo G, Koch WJ. GRK2 inhibition in heart failure: something old, something new. Curr Pharm Des. 2012;18(2): 186-191.
    • (2012) Curr Pharm Des , vol.18 , Issue.2 , pp. 186-191
    • Lymperopoulos, A.1    Rengo, G.2    Koch, W.J.3
  • 12
    • 51349085441 scopus 로고    scopus 로고
    • Beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current
    • Skeberdis VA, Gendviliene V, Zablockaite D, et al. Beta3-adrenergic receptor activation increases human atrial tissue contractility and stimulates the L-type Ca2+ current. J Clin Invest. 2008;118(9): 3219-3227.
    • (2008) J Clin Invest , vol.118 , Issue.9 , pp. 3219-3227
    • Skeberdis, V.A.1    Gendviliene, V.2    Zablockaite, D.3
  • 13
    • 0032189129 scopus 로고    scopus 로고
    • The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle
    • Gauthier C, Leblais V, Kobzik L, et al. The negative inotropic effect of beta3-adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle. J Clin Invest. 1998;102(7): 1377-1384.
    • (1998) J Clin Invest , vol.102 , Issue.7 , pp. 1377-1384
    • Gauthier, C.1    Leblais, V.2    Kobzik, L.3
  • 14
    • 64749105265 scopus 로고    scopus 로고
    • Nebivolol, a vasodilating selective beta(1)-blocker, is a beta(3)-adrenoceptor agonist in the nonfailing transplanted human heart
    • Rozec B, Erfanian M, Laurent K, Trochu JN, Gauthier C. Nebivolol, a vasodilating selective beta(1)-blocker, is a beta(3)-adrenoceptor agonist in the nonfailing transplanted human heart. J Am Coll Cardiol. 2009;53(17):1532-1538.
    • (2009) J Am Coll Cardiol , vol.53 , Issue.17 , pp. 1532-1538
    • Rozec, B.1    Erfanian, M.2    Laurent, K.3    Trochu, J.N.4    Gauthier, C.5
  • 15
    • 43549098268 scopus 로고    scopus 로고
    • Calcium cycling and signaling in cardiac myocytes
    • Bers DM. Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol. 2008;70:23-49.
    • (2008) Annu Rev Physiol , vol.70 , pp. 23-49
    • Bers, D.M.1
  • 16
    • 0030613761 scopus 로고    scopus 로고
    • Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A
    • Daaka Y, Luttrell LM, Lefkowitz RJ. Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A. Nature. 1997;390(6655):88-91.
    • (1997) Nature , vol.390 , Issue.6655 , pp. 88-91
    • Daaka, Y.1    Luttrell, L.M.2    Lefkowitz, R.J.3
  • 17
    • 79960895578 scopus 로고    scopus 로고
    • Phosphodiesterase inhibition in heart failure
    • Movsesian MA, Kukreja RC. Phosphodiesterase inhibition in heart failure. Handb Exp Pharmacol. 2011;(204):237-249.
    • (2011) Handb Exp Pharmacol , Issue.204 , pp. 237-249
    • Movsesian, M.A.1    Kukreja, R.C.2
  • 18
    • 0032729995 scopus 로고    scopus 로고
    • Opposing effects of beta(1)- and beta(2)-aadrenergic receptors on cardiac myocyte apoptosis: Role of a pertussis toxin-sensitive G protein
    • Communal C, Singh K, Sawyer DB, Colucci WS. Opposing effects of beta(1)- and beta(2)-aadrenergic receptors on cardiac myocyte apoptosis: role of a pertussis toxin-sensitive G protein. Circulation. 1999;100(22):2210-2212.
    • (1999) Circulation , vol.100 , Issue.22 , pp. 2210-2212
    • Communal, C.1    Singh, K.2    Sawyer, D.B.3    Colucci, W.S.4
  • 19
    • 0034623819 scopus 로고    scopus 로고
    • The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3′-kinase
    • Chesley A, Lundberg MS, Asai T, et al. The beta(2)-adrenergic receptor delivers an antiapoptotic signal to cardiac myocytes through G(i)-dependent coupling to phosphatidylinositol 3′-kinase. Circ Res. 2000;87(12):1172-1179.
    • (2000) Circ Res , vol.87 , Issue.12 , pp. 1172-1179
    • Chesley, A.1    Lundberg, M.S.2    Asai, T.3
  • 20
    • 0035852634 scopus 로고    scopus 로고
    • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
    • Zhu WZ, Zheng M, Koch WJ, Lefkowitz RJ, Kobilka BK, Xiao RP. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci U S A. 2001;98(4):1607-1612.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , Issue.4 , pp. 1607-1612
    • Zhu, W.Z.1    Zheng, M.2    Koch, W.J.3    Lefkowitz, R.J.4    Kobilka, B.K.5    Xiao, R.P.6
  • 21
    • 0033033440 scopus 로고    scopus 로고
    • Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice
    • Dorn GW 2nd, Tepe NM, Lorenz JN, Koch WJ, Liggett SB. Low- and high-level transgenic expression of beta2-adrenergic receptors differentially affect cardiac hypertrophy and function in Galphaq-overexpressing mice. Proc Natl Acad Sci U S A. 1999;96(11): 6400-6405.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.11 , pp. 6400-6405
    • Dorn II, G.W.1    Tepe, N.M.2    Lorenz, J.N.3    Koch, W.J.4    Liggett, S.B.5
  • 22
    • 0034636061 scopus 로고    scopus 로고
    • Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: Critical role for expression level
    • Liggett SB, Tepe NM, Lorenz JN, et al. Early and delayed consequences of beta(2)-adrenergic receptor overexpression in mouse hearts: critical role for expression level. Circulation. 2000;101(14): 1707-1714.
    • (2000) Circulation , vol.101 , Issue.14 , pp. 1707-1714
    • Liggett, S.B.1    Tepe, N.M.2    Lorenz, J.N.3
  • 23
    • 0022980843 scopus 로고
    • Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: Coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure
    • Bristow MR, Ginsburg R, Umans V, et al. Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res. 1986;59(3):297-309.
    • (1986) Circ Res , vol.59 , Issue.3 , pp. 297-309
    • Bristow, M.R.1    Ginsburg, R.2    Umans, V.3
  • 24
    • 0019982539 scopus 로고
    • Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts
    • Bristow MR, Ginsburg R, Minobe W, et al. Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts. N Engl J Med. 1982;307(4):205-211.
    • (1982) N Engl J Med , vol.307 , Issue.4 , pp. 205-211
    • Bristow, M.R.1    Ginsburg, R.2    Minobe, W.3
  • 25
    • 77950286813 scopus 로고    scopus 로고
    • Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation
    • Nikolaev VO, Moshkov A, Lyon AR, et al. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 2010;327(5973):1653-1657.
    • (2010) Science , vol.327 , Issue.5973 , pp. 1653-1657
    • Nikolaev, V.O.1    Moshkov, A.2    Lyon, A.R.3
  • 26
    • 0032573192 scopus 로고    scopus 로고
    • Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade
    • Iaccarino G, Tomhave ED, Lefkowitz RJ, Koch WJ. Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade. Circulation. 1998;98(17):1783-1789.
    • (1998) Circulation , vol.98 , Issue.17 , pp. 1783-1789
    • Iaccarino, G.1    Tomhave, E.D.2    Lefkowitz, R.J.3    Koch, W.J.4
  • 27
    • 33845428435 scopus 로고    scopus 로고
    • Reducing the risk of sudden death in heart failure with beta-blockers
    • Adamson PB, Gilbert EM. Reducing the risk of sudden death in heart failure with beta-blockers. J Card Fail. 2006;12(9):734-746.
    • (2006) J Card Fail , vol.12 , Issue.9 , pp. 734-746
    • Adamson, P.B.1    Gilbert, E.M.2
  • 28
    • 33750500333 scopus 로고    scopus 로고
    • Left ventricular assist device and drug therapy for the reversal of heart failure
    • Birks EJ, Tansley PD, Hardy J, et al. Left ventricular assist device and drug therapy for the reversal of heart failure. N Engl J Med. 2006;355(18):1873-1884.
    • (2006) N Engl J Med , vol.355 , Issue.18 , pp. 1873-1884
    • Birks, E.J.1    Tansley, P.D.2    Hardy, J.3
  • 29
    • 84873734025 scopus 로고    scopus 로고
    • Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol)
    • DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O'Keefe JH. Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol). Am J Cardiol. 2013; 111(5):765-769.
    • (2013) Am J Cardiol , vol.111 , Issue.5 , pp. 765-769
    • Dinicolantonio, J.J.1    Lavie, C.J.2    Fares, H.3    Menezes, A.R.4    O'Keefe, J.H.5
  • 30
    • 38849129420 scopus 로고    scopus 로고
    • Cardiac alpha 1-adrenergic drive in pathological remodelling
    • Woodcock EA, Du XJ, Reichelt ME, Graham RM. Cardiac alpha 1-adrenergic drive in pathological remodelling. Cardiovasc Res. 2008;77(3):452-462.
    • (2008) Cardiovasc Res , vol.77 , Issue.3 , pp. 452-462
    • Woodcock, E.A.1    Du, X.J.2    Reichelt, M.E.3    Graham, R.M.4
  • 31
    • 33750363223 scopus 로고    scopus 로고
    • Effect of alpha1-adrenergic receptors in cardiac pathophysiology
    • Shannon R, Chaudhry M. Effect of alpha1-adrenergic receptors in cardiac pathophysiology. Am Heart J. 2006;152(5):842-850.
    • (2006) Am Heart J , vol.152 , Issue.5 , pp. 842-850
    • Shannon, R.1    Chaudhry, M.2
  • 32
    • 0027176441 scopus 로고
    • The alpha 1 A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy
    • Knowlton KU, Michel MC, Itani M, et al. The alpha 1 A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy. J Biol Chem. 1993; 268(21):15374-15380.
    • (1993) J Biol Chem , vol.268 , Issue.21 , pp. 15374-15380
    • Knowlton, K.U.1    Michel, M.C.2    Itani, M.3
  • 33
    • 33845186121 scopus 로고    scopus 로고
    • Transgenic alpha1 A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival
    • Du XJ, Gao XM, Kiriazis H, et al. Transgenic alpha1 A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival. Cardiovasc Res. 2006;71(4):735-743.
    • (2006) Cardiovasc Res , vol.71 , Issue.4 , pp. 735-743
    • Du, X.J.1    Gao, X.M.2    Kiriazis, H.3
  • 34
    • 33847105534 scopus 로고    scopus 로고
    • An alpha1A-adrenergic extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes
    • Huang Y, Wright CD, Merkwan CL, et al. An alpha1A-adrenergic extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes. Circulation. 2007;115(6):763-772.
    • (2007) Circulation , vol.115 , Issue.6 , pp. 763-772
    • Huang, Y.1    Wright, C.D.2    Merkwan, C.L.3
  • 35
    • 0035853147 scopus 로고    scopus 로고
    • Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload
    • Esposito G, Prasad SV, Rapacciuolo A, Mao L, Koch WJ, Rockman HA. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation. 2001;103(10):1453-1458.
    • (2001) Circulation , vol.103 , Issue.10 , pp. 1453-1458
    • Esposito, G.1    Prasad, S.V.2    Rapacciuolo, A.3    Mao, L.4    Koch, W.J.5    Rockman, H.A.6
  • 36
    • 84862854051 scopus 로고    scopus 로고
    • PKCβII modulation of myocyte contractile performance
    • Hwang H, Robinson DA, Stevenson TK, et al. PKCβII modulation of myocyte contractile performance. J Mol Cell Cardiol. 2012; 53(2):176-186.
    • (2012) J Mol Cell Cardiol , vol.53 , Issue.2 , pp. 176-186
    • Hwang, H.1    Robinson, D.A.2    Stevenson, T.K.3
  • 37
    • 0346687568 scopus 로고    scopus 로고
    • Adrenergic receptor knockout mice: Distinct functions of 9 receptor subtypes
    • Philipp M, Hein L. Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes. Pharmacol Ther. 2004;101(1):65-74.
    • (2004) Pharmacol Ther , vol.101 , Issue.1 , pp. 65-74
    • Philipp, M.1    Hein, L.2
  • 38
    • 0036337129 scopus 로고    scopus 로고
    • Physiological significance of alpha(2)-adrenergic receptor subtype diversity: One receptor is not enough
    • Philipp M, Brede M, Hein L. Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough. Am J Physiol Regul Integr Comp Physiol. 2002;283(2):R287-R295.
    • (2002) Am J Physiol Regul Integr Comp Physiol , vol.283 , Issue.2
    • Philipp, M.1    Brede, M.2    Hein, L.3
  • 39
    • 0033547241 scopus 로고    scopus 로고
    • Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission
    • Hein L, Altman JD, Kobilka BK. Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission. Nature. 1999;402(6758):181-184.
    • (1999) Nature , vol.402 , Issue.6758 , pp. 181-184
    • Hein, L.1    Altman, J.D.2    Kobilka, B.K.3
  • 40
    • 0037027480 scopus 로고    scopus 로고
    • Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure
    • Brede M, Wiesmann F, Jahns R, et al. Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation. 2002;106(19):2491-2496.
    • (2002) Circulation , vol.106 , Issue.19 , pp. 2491-2496
    • Brede, M.1    Wiesmann, F.2    Jahns, R.3
  • 41
    • 0041765759 scopus 로고    scopus 로고
    • Differential control of adrenal and sympathetic catecholamine release by alpha2-adrenoceptor subtypes
    • Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L. Differential control of adrenal and sympathetic catecholamine release by alpha2-adrenoceptor subtypes. Mol Endocrinol. 2003;17(8):1640-1646.
    • (2003) Mol Endocrinol , vol.17 , Issue.8 , pp. 1640-1646
    • Brede, M.1    Nagy, G.2    Philipp, M.3    Sorensen, J.B.4    Lohse, M.J.5    Hein, L.6
  • 42
    • 36249021393 scopus 로고    scopus 로고
    • Adrenal adrenoceptors in heart failure: Fine-tuning cardiac stimulation
    • Lymperopoulos A, Rengo G, Koch WJ. Adrenal adrenoceptors in heart failure: fine-tuning cardiac stimulation. Trends Mol Med. 2007;13(12):503-511.
    • (2007) Trends Mol Med , vol.13 , Issue.12 , pp. 503-511
    • Lymperopoulos, A.1    Rengo, G.2    Koch, W.J.3
  • 43
    • 0037057235 scopus 로고    scopus 로고
    • Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure
    • Small KM, Wagoner LE, Levin AM, Kardia SL, Liggett SB. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. N Engl J Med. 2002;347(15):1135-1142.
    • (2002) N Engl J Med , vol.347 , Issue.15 , pp. 1135-1142
    • Small, K.M.1    Wagoner, L.E.2    Levin, A.M.3    Kardia, S.L.4    Liggett, S.B.5
  • 44
    • 20244371169 scopus 로고    scopus 로고
    • Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoceptor gene polymorphism in healthy humans
    • Neumeister A, Charney DS, Belfer I, et al. Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoceptor gene polymorphism in healthy humans. Pharmacogenet Genomics. 2005;15(3): 143-149.
    • (2005) Pharmacogenet Genomics , vol.15 , Issue.3 , pp. 143-149
    • Neumeister, A.1    Charney, D.S.2    Belfer, I.3
  • 45
    • 0021194420 scopus 로고
    • Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
    • Cohn JN, Levine TB, Olivari M T, et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med. 1984;311(13):819-823.
    • (1984) N Engl J Med , vol.311 , Issue.13 , pp. 819-823
    • Cohn, J.N.1    Levine, T.B.2    Olivari, M.T.3
  • 46
    • 0037117653 scopus 로고    scopus 로고
    • The "unsympathetic" nervous system of heart failure
    • Floras JS. The "unsympathetic" nervous system of heart failure. Circulation. 2002;105(15):1753-1755.
    • (2002) Circulation , vol.105 , Issue.15 , pp. 1753-1755
    • Floras, J.S.1
  • 47
    • 59049097977 scopus 로고    scopus 로고
    • Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure
    • Rengo G, Lymperopoulos A, Zincarelli C, et al. Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure. Circulation. 2009;119(1):89-98.
    • (2009) Circulation , vol.119 , Issue.1 , pp. 89-98
    • Rengo, G.1    Lymperopoulos, A.2    Zincarelli, C.3
  • 48
    • 0034976707 scopus 로고    scopus 로고
    • Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure
    • Port JD, Bristow MR. Altered beta-adrenergic receptor gene regulation and signaling in chronic heart failure. J Mol Cell Cardiol. 2001;33(5): 887-905.
    • (2001) J Mol Cell Cardiol , vol.33 , Issue.5 , pp. 887-905
    • Port, J.D.1    Bristow, M.R.2
  • 49
    • 0034620523 scopus 로고    scopus 로고
    • Beta-adrenergic receptor blockade in chronic heart failure
    • Bristow MR. Beta-adrenergic receptor blockade in chronic heart failure. Circulation. 2000;101(5):558-569.
    • (2000) Circulation , vol.101 , Issue.5 , pp. 558-569
    • Bristow, M.R.1
  • 50
    • 0346730904 scopus 로고    scopus 로고
    • The MOXCON Investigators. Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON)
    • Cohn JN, Pfeffer MA, Rouleau J, et al; the MOXCON Investigators. Adverse mortality effect of central sympathetic inhibition with sustained-release moxonidine in patients with heart failure (MOXCON). Eur J Heart Fail. 2003;5(5):659-667.
    • (2003) Eur J Heart Fail , vol.5 , Issue.5 , pp. 659-667
    • Cohn, J.N.1    Pfeffer, M.A.2    Rouleau, J.3
  • 51
    • 84868697486 scopus 로고    scopus 로고
    • A personalized BEST: Characterization of latent clinical classes of nonischemic heart failure that predict outcomes and response to bucindolol
    • Kao DP, Wagner BD, Robertson AD, Bristow MR, Lowes BD. A personalized BEST: characterization of latent clinical classes of nonischemic heart failure that predict outcomes and response to bucindolol. PLoS One. 2012;7(11):e48184.
    • (2012) PLoS One , vol.7 , Issue.11
    • Kao, D.P.1    Wagner, B.D.2    Robertson, A.D.3    Bristow, M.R.4    Lowes, B.D.5
  • 52
    • 0035312887 scopus 로고    scopus 로고
    • Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure
    • Aggarwal A, Esler MD, Socratous F, Kaye DM. Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure. J Am Coll Cardiol. 2001;37(5):1246-1251.
    • (2001) J Am Coll Cardiol , vol.37 , Issue.5 , pp. 1246-1251
    • Aggarwal, A.1    Esler, M.D.2    Socratous, F.3    Kaye, D.M.4
  • 53
    • 0023266532 scopus 로고
    • Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)
    • CONSENSUS Trial Study Group, The CONSENSUS Trial Study Group
    • CONSENSUS Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). The CONSENSUS Trial Study Group. N Engl J Med. 1987;316(23):1429-1435.
    • (1987) N Engl J Med , vol.316 , Issue.23 , pp. 1429-1435
  • 54
    • 0025770138 scopus 로고
    • A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure
    • Cohn JN, Johnson G, Ziesche S, et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med. 1991;325(5):303-310.
    • (1991) N Engl J Med , vol.325 , Issue.5 , pp. 303-310
    • Cohn, J.N.1    Johnson, G.2    Ziesche, S.3
  • 55
    • 0025153828 scopus 로고
    • Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD)
    • Francis GS, Benedict C, Johnstone DE, et al. Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD). Circulation. 1990;82(5): 1724-1729.
    • (1990) Circulation , vol.82 , Issue.5 , pp. 1724-1729
    • Francis, G.S.1    Benedict, C.2    Johnstone, D.E.3
  • 56
    • 0030657676 scopus 로고    scopus 로고
    • Extracellular matrix remodeling in heart failure: A role for de novo angiotensin II generation
    • Weber K. Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation. Circuation. 1997;96(11): 4065-4082.
    • (1997) Circuation , vol.96 , Issue.11 , pp. 4065-4082
    • Weber, K.1
  • 57
    • 0028261960 scopus 로고
    • Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat
    • Schieffer B, Wirger A, Meybrunn M, et al. Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation. 1994;89(5):2273-2282.
    • (1994) Circulation , vol.89 , Issue.5 , pp. 2273-2282
    • Schieffer, B.1    Wirger, A.2    Meybrunn, M.3
  • 58
    • 84880159174 scopus 로고    scopus 로고
    • Targeting the renin-angiotensin-aldosterone system in heart failure
    • Lang CC, Struthers AD. Targeting the renin-angiotensin-aldosterone system in heart failure. Nat Rev Cardiol. 2013;10(3):125-134.
    • (2013) Nat Rev Cardiol , vol.10 , Issue.3 , pp. 125-134
    • Lang, C.C.1    Struthers, A.D.2
  • 59
    • 84877814873 scopus 로고    scopus 로고
    • The role of endothelin system in cardiovascular disease and the potential therapeutic perspectives of its inhibition
    • Kaoukis A, Deftereos S, Raisakis K, et al. The role of endothelin system in cardiovascular disease and the potential therapeutic perspectives of its inhibition. Curr Top Med Chem. 2013;13(2):95-114.
    • (2013) Curr Top Med Chem , vol.13 , Issue.2 , pp. 95-114
    • Kaoukis, A.1    Deftereos, S.2    Raisakis, K.3
  • 60
    • 0037438919 scopus 로고    scopus 로고
    • RITZ-5: Randomized intravenous TeZosentan (an endothelin-A/B antagonist) for the treatment of pulmonary edema: A prospective, multicenter, double-blind, placebo-controlled study
    • Kaluski E, Kobrin I, Zimlichman R, et al. RITZ-5: randomized intravenous TeZosentan (an endothelin-A/B antagonist) for the treatment of pulmonary edema: a prospective, multicenter, double-blind, placebo-controlled study. J Am Coll Cardiol. 2003;41(2):204-210.
    • (2003) J Am Coll Cardiol , vol.41 , Issue.2 , pp. 204-210
    • Kaluski, E.1    Kobrin, I.2    Zimlichman, R.3
  • 61
    • 70349312964 scopus 로고    scopus 로고
    • Adenosine receptors and the heart: Role in regulation of coronary blood flow and cardiac electrophysiology
    • Mustafa SJ, Morrison RR, Teng B, Pelleg A. Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology. Handb Exp Pharmacol. 2009;(193):161-188.
    • (2009) Handb Exp Pharmacol , Issue.193 , pp. 61-188
    • Mustafa, S.J.1    Morrison, R.R.2    Teng, B.3    Pelleg, A.4
  • 62
    • 62849103373 scopus 로고    scopus 로고
    • The adenosine A1 receptor and its ligands
    • Nell PG, Albrecht-Küpper B. The adenosine A1 receptor and its ligands. Prog Med Chem. 2009;47:163-201.
    • (2009) Prog Med Chem , vol.47 , pp. 163-201
    • Nell, P.G.1    Albrecht-Küpper, B.2
  • 63
    • 84879205967 scopus 로고    scopus 로고
    • Chronic therapy with a partial adenosine A1-receptor agonist improves left ventricular function and remodeling in dogs with advanced heart failure
    • Sabbah HN, Gupta RC, Kohli S, et al. Chronic therapy with a partial adenosine A1-receptor agonist improves left ventricular function and remodeling in dogs with advanced heart failure. Circ Heart Fail. 2013;6(3):563-571.
    • (2013) Circ Heart Fail , vol.6 , Issue.3 , pp. 563-571
    • Sabbah, H.N.1    Gupta, R.C.2    Kohli, S.3
  • 64
    • 84885919203 scopus 로고    scopus 로고
    • Adrenomedullin in cardiovascular disease: A useful biomarker, its pathological roles and therapeutic application
    • Nishikimi T, Kuwahara K, Nakagawa Y, Kangawa K, Nakao K. Adrenomedullin in cardiovascular disease: a useful biomarker, its pathological roles and therapeutic application. Curr Protein Pept Sci. 2013;14(4):256-267.
    • (2013) Curr Protein Pept Sci , vol.14 , Issue.4 , pp. 256-267
    • Nishikimi, T.1    Kuwahara, K.2    Nakagawa, Y.3    Kangawa, K.4    Nakao, K.5
  • 65
    • 84856528059 scopus 로고    scopus 로고
    • The pharmacology of adrenomedullin 2/intermedin
    • Hong Y, Hay DL, Quirion R, Poyner DR. The pharmacology of adrenomedullin 2/intermedin. Br J Pharmacol. 2012;166(1):110-120.
    • (2012) Br J Pharmacol , vol.166 , Issue.1 , pp. 110-120
    • Hong, Y.1    Hay, D.L.2    Quirion, R.3    Poyner, D.R.4
  • 66
    • 84873059692 scopus 로고    scopus 로고
    • Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system
    • Yoshizawa T, Sakurai T, Kamiyoshi A, et al. Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin-receptor activity-modifying protein 2 system. Hypertension. 2013;61(2):341-351.
    • (2013) Hypertension , vol.61 , Issue.2 , pp. 341-351
    • Yoshizawa, T.1    Sakurai, T.2    Kamiyoshi, A.3
  • 68
    • 84871927704 scopus 로고    scopus 로고
    • Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: Correlation with outcomes
    • Metra M, Cotter G, Davison BA, et al. Effect of serelaxin on cardiac, renal, and hepatic biomarkers in the Relaxin in Acute Heart Failure (RELAX-AHF) development program: correlation with outcomes. J Am Coll Cardiol. 2013;61(2):196-206.
    • (2013) J Am Coll Cardiol , vol.61 , Issue.2 , pp. 196-206
    • Metra, M.1    Cotter, G.2    Davison, B.A.3
  • 69
    • 34548546936 scopus 로고    scopus 로고
    • Corticotropin-releasing factor family and its receptors: Tumor therapeutic targets?
    • Wang J, Li S. Corticotropin-releasing factor family and its receptors: tumor therapeutic targets? Biochem Biophys Res Commun. 2007;362(4): 785-788.
    • (2007) Biochem Biophys Res Commun , vol.362 , Issue.4 , pp. 785-788
    • Wang, J.1    Li, S.2
  • 71
    • 35948950184 scopus 로고    scopus 로고
    • Urocortin 2 infusion in human heart failure
    • Davis ME, Pemberton CJ, Yandle TG, et al. Urocortin 2 infusion in human heart failure. Eur Heart J. 2007;28(21):2589-2597.
    • (2007) Eur Heart J , vol.28 , Issue.21 , pp. 2589-2597
    • Davis, M.E.1    Pemberton, C.J.2    Yandle, T.G.3
  • 72
    • 84878278478 scopus 로고    scopus 로고
    • Haemodynamic effects, safety, and pharmacokinetics of human stresscopin in heart failure with reduced ejection fraction
    • Gheorghiade M, Greene SJ, Ponikowski P, et al. Haemodynamic effects, safety, and pharmacokinetics of human stresscopin in heart failure with reduced ejection fraction. Eur J Heart Fail. 2013;15(6):679-689.
    • (2013) Eur J Heart Fail , vol.15 , Issue.6 , pp. 679-689
    • Gheorghiade, M.1    Greene, S.J.2    Ponikowski, P.3
  • 73
    • 0347531545 scopus 로고    scopus 로고
    • Science review: Vasopressin and the cardiovascular system part 1. Receptor physiology
    • Holmes CL, Landry DW, Granton JT. Science review: Vasopressin and the cardiovascular system part 1. Receptor physiology. Crit Care. 2003;7(6):427-434.
    • (2003) Crit Care , vol.7 , Issue.6 , pp. 427-434
    • Holmes, C.L.1    Landry, D.W.2    Granton, J.T.3
  • 74
    • 79954619871 scopus 로고    scopus 로고
    • Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH)
    • Gassanov N, Semmo N, Semmo M, Nia AM, Fuhr U, Er F. Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH). Eur J Clin Pharmacol. 2011;67(4):333-346.
    • (2011) Eur J Clin Pharmacol , vol.67 , Issue.4 , pp. 333-346
    • Gassanov, N.1    Semmo, N.2    Semmo, M.3    Nia, A.M.4    Fuhr, U.5    Er, F.6
  • 75
    • 84872834070 scopus 로고    scopus 로고
    • Clinical profile and prognostic value of low systolic blood pressure in patients hospitalized for heart failure with reduced ejection fraction: Insights from the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial
    • Ambrosy AP, Vaduganathan M, Mentz RJ, et al. Clinical profile and prognostic value of low systolic blood pressure in patients hospitalized for heart failure with reduced ejection fraction: insights from the Efficacy of Vasopressin Antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST) trial. Am Heart J. 2013;165(2):216-225.
    • (2013) Am Heart J , vol.165 , Issue.2 , pp. 216-225
    • Ambrosy, A.P.1    Vaduganathan, M.2    Mentz, R.J.3
  • 76
    • 84884501178 scopus 로고    scopus 로고
    • Experience of a vasopressin receptor antagonist, tolvaptan under the unique indication in Japanese heart failure patients
    • Epub July 19
    • Kinugawa K, Imamura T, Komuro I. Experience of a vasopressin receptor antagonist, tolvaptan under the unique indication in Japanese heart failure patients. Clin Pharmacol Ther. Epub July 19, 2013.
    • (2013) Clin Pharmacol Ther
    • Kinugawa, K.1    Imamura, T.2    Komuro, I.3
  • 77
    • 84860204551 scopus 로고    scopus 로고
    • Cardiovascular biology of the incretin system
    • Ussher JR, Drucker DJ. Cardiovascular biology of the incretin system. Endocr Rev. 2012;33(2):187-215.
    • (2012) Endocr Rev , vol.33 , Issue.2 , pp. 187-215
    • Ussher, J.R.1    Drucker, D.J.2
  • 78
    • 84880688845 scopus 로고    scopus 로고
    • GLP-1 receptor agonists: Effects on cardiovascular risk reduction
    • Lorber D. GLP-1 receptor agonists: effects on cardiovascular risk reduction. Cardiovasc Ther. 2013;31(4):238-249.
    • (2013) Cardiovasc Ther , vol.31 , Issue.4 , pp. 238-249
    • Lorber, D.1
  • 79
    • 77953160144 scopus 로고    scopus 로고
    • Minireview: Update on incretin biology: Focus on glucagon-like peptide-1
    • Brubaker PL. Minireview: update on incretin biology: focus on glucagon-like peptide-1. Endocrinology. 2010;151(5):1984-1989.
    • (2010) Endocrinology , vol.151 , Issue.5 , pp. 1984-1989
    • Brubaker, P.L.1
  • 80
    • 80053101752 scopus 로고    scopus 로고
    • Rho kinase as a therapeutic target in cardiovascular disease
    • Surma M, Wei L, Shi J. Rho kinase as a therapeutic target in cardiovascular disease. Future Cardiol. 2011;7(5):657-671.
    • (2011) Future Cardiol , vol.7 , Issue.5 , pp. 657-671
    • Surma, M.1    Wei, L.2    Shi, J.3
  • 81
    • 2442509844 scopus 로고    scopus 로고
    • Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice
    • Hattori T, Shimokawa H, Higashi M, et al. Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation. 2004;109(18):2234-2239.
    • (2004) Circulation , vol.109 , Issue.18 , pp. 2234-2239
    • Hattori, T.1    Shimokawa, H.2    Higashi, M.3
  • 82
    • 34547665415 scopus 로고    scopus 로고
    • Small-molecule therapies for cardiac hypertrophy: Moving beneath the cell surface
    • McKinsey TA, Kass DA. Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface. Nat Rev Drug Discov. 2007;6(8):617-635.
    • (2007) Nat Rev Drug Discov , vol.6 , Issue.8 , pp. 617-635
    • McKinsey, T.A.1    Kass, D.A.2
  • 83
    • 84880939628 scopus 로고    scopus 로고
    • Exchange protein directly activated by cAMP (epac): A multidomain cAMP mediator in the regulation of diverse biological functions
    • Schmidt M, Dekker FJ, Maarsingh H. Exchange protein directly activated by cAMP (epac): a multidomain cAMP mediator in the regulation of diverse biological functions. Pharmacol Rev. 2013;65(2):670-709.
    • (2013) Pharmacol Rev , vol.65 , Issue.2 , pp. 670-709
    • Schmidt, M.1    Dekker, F.J.2    Maarsingh, H.3
  • 84
    • 84874472807 scopus 로고    scopus 로고
    • Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia
    • Pereira L, Cheng H, Lao DH, et al. Epac2 mediates cardiac β1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013;127(8):913-922.
    • (2013) Circulation , vol.127 , Issue.8 , pp. 913-922
    • Pereira, L.1    Cheng, H.2    Lao, D.H.3
  • 85
    • 33646162635 scopus 로고    scopus 로고
    • GRKs and beta-arrestins: Roles in receptor silencing, trafficking and signaling
    • Reiter E, Lefkowitz RJ. GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab. 2006;17(4):159-165.
    • (2006) Trends Endocrinol Metab , vol.17 , Issue.4 , pp. 159-165
    • Reiter, E.1    Lefkowitz, R.J.2
  • 86
    • 0035101820 scopus 로고    scopus 로고
    • Evolving concepts in G protein-coupled receptor endocytosis: The role in receptor desensitization and signaling
    • Ferguson SS. Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling. Pharmacol Rev. 2001;53(1):1-24.
    • (2001) Pharmacol Rev , vol.53 , Issue.1 , pp. 1-24
    • Ferguson, S.S.1
  • 87
    • 0026658663 scopus 로고
    • The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain
    • Arriza JL, Dawson TM, Simerly RB, et al. The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain. J Neurosci. 1992;12(10):4045-4055.
    • (1992) J Neurosci , vol.12 , Issue.10 , pp. 4045-4055
    • Arriza, J.L.1    Dawson, T.M.2    Simerly, R.B.3
  • 88
    • 0037050009 scopus 로고    scopus 로고
    • Seven-transmembrane-spanning receptors and heart function
    • Rockman HA, Koch WJ, Lefkowitz RJ. Seven-transmembrane-spanning receptors and heart function. Nature. 2002;415(6868):206-212.
    • (2002) Nature , vol.415 , Issue.6868 , pp. 206-212
    • Rockman, H.A.1    Koch, W.J.2    Lefkowitz, R.J.3
  • 89
    • 79961074094 scopus 로고    scopus 로고
    • G protein coupled receptor kinases as therapeutic targets in cardiovascular disease
    • Belmonte SL, Blaxall BC. G protein coupled receptor kinases as therapeutic targets in cardiovascular disease. Circ Res. 2011;109(3):309-319.
    • (2011) Circ Res , vol.109 , Issue.3 , pp. 309-319
    • Belmonte, S.L.1    Blaxall, B.C.2
  • 91
    • 0027497584 scopus 로고
    • Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart
    • Ungerer M, Böhm M, Elce JS, Erdmann E, Lohse MJ. Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart. Circulation. 1993;87(2):454-463.
    • (1993) Circulation , vol.87 , Issue.2 , pp. 454-463
    • Ungerer, M.1    Böhm, M.2    Elce, J.S.3    Erdmann, E.4    Lohse, M.J.5
  • 92
    • 0029061324 scopus 로고
    • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor
    • Koch WJ, Rockman HA, Samama P, et al. Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. Science. 1995;268(5215):1350-1353.
    • (1995) Science , vol.268 , Issue.5215 , pp. 1350-1353
    • Koch, W.J.1    Rockman, H.A.2    Samama, P.3
  • 93
    • 84869435029 scopus 로고    scopus 로고
    • Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility
    • Thal DM, Homan KT, Chen J, et al. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol. 2012;7(11):1830-1839.
    • (2012) ACS Chem Biol , vol.7 , Issue.11 , pp. 1830-1839
    • Thal, D.M.1    Homan, K.T.2    Chen, J.3
  • 94
    • 43249084545 scopus 로고    scopus 로고
    • Beta-adrenergic signaling in heart failure: Adapt or die
    • Eschenhagen T. Beta-adrenergic signaling in heart failure: adapt or die. Nat Med. 2008;14(5):485-487.
    • (2008) Nat Med , vol.14 , Issue.5 , pp. 485-487
    • Eschenhagen, T.1
  • 95
    • 33847728682 scopus 로고    scopus 로고
    • Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure
    • Lymperopoulos A, Rengo G, Funakoshi H, Eckhart AD, Koch WJ. Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med. 2007;13(3):315-323.
    • (2007) Nat Med , vol.13 , Issue.3 , pp. 315-323
    • Lymperopoulos, A.1    Rengo, G.2    Funakoshi, H.3    Eckhart, A.D.4    Koch, W.J.5
  • 96
    • 84856739717 scopus 로고    scopus 로고
    • Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: The known and the unknown
    • Lymperopoulos A, Bathgate A. Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown. Pharmacogenomics. 2012;13(3):323-341.
    • (2012) Pharmacogenomics , vol.13 , Issue.3 , pp. 323-341
    • Lymperopoulos, A.1    Bathgate, A.2
  • 97
    • 77952368252 scopus 로고    scopus 로고
    • Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction
    • Lymperopoulos A, Rengo G, Gao E, Ebert SN, Dorn GW 2nd, Koch WJ. Reduction of sympathetic activity via adrenal-targeted GRK2 gene deletion attenuates heart failure progression and improves cardiac function after myocardial infarction. J Biol Chem. 2010; 285(21):16378-16386.
    • (2010) J Biol Chem , vol.285 , Issue.21 , pp. 16378-16386
    • Lymperopoulos, A.1    Rengo, G.2    Gao, E.3    Ebert, S.N.4    Dorn II, G.W.5    Koch, W.J.6
  • 98
    • 84856475827 scopus 로고    scopus 로고
    • Beta-arrestin biased agonism/antagonism at cardiovascular seven transmembrane-spanning receptors
    • Lymperopoulos A. Beta-arrestin biased agonism/antagonism at cardiovascular seven transmembrane-spanning receptors. Curr Pharm Des. 2012;18(2):192-198.
    • (2012) Curr Pharm Des , vol.18 , Issue.2 , pp. 192-198
    • Lymperopoulos, A.1
  • 99
    • 80052795644 scopus 로고    scopus 로고
    • B-arrestin: A signaling molecule and potential therapeutic target for heart failure
    • Noor N, Patel CB, Rockman HA. B-arrestin: a signaling molecule and potential therapeutic target for heart failure. J Mol Cell Cardiol. 2011;51(4):534-541.
    • (2011) J Mol Cell Cardiol , vol.51 , Issue.4 , pp. 534-541
    • Noor, N.1    Patel, C.B.2    Rockman, H.A.3
  • 100
    • 79960355012 scopus 로고    scopus 로고
    • G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function
    • Tilley DG. G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function. Circ Res. 2011;109(2): 217-230.
    • (2011) Circ Res , vol.109 , Issue.2 , pp. 217-230
    • Tilley, D.G.1
  • 101
    • 27644468385 scopus 로고    scopus 로고
    • Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice
    • Zhai P, Yamamoto M, Galeotti J, et al. Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice. J Clin Invest. 2005;115(11):3045-3056.
    • (2005) J Clin Invest , vol.115 , Issue.11 , pp. 3045-3056
    • Zhai, P.1    Yamamoto, M.2    Galeotti, J.3
  • 102
    • 33750802401 scopus 로고    scopus 로고
    • Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
    • Rajagopal K, Whalen EJ, Violin JD, et al. Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Natl Acad Sci U S A. 2006;103(44): 16284-16289.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.44 , pp. 16284-16289
    • Rajagopal, K.1    Whalen, E.J.2    Violin, J.D.3
  • 103
    • 34247341288 scopus 로고    scopus 로고
    • Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes
    • Aplin M, Christensen GL, Schneider M, et al. Differential extracellular signal-regulated kinases 1 and 2 activation by the angiotensin type 1 receptor supports distinct phenotypes of cardiac myocytes. Basic Clin Pharmacol Toxicol. 2007;100(5):296-301.
    • (2007) Basic Clin Pharmacol Toxicol , vol.100 , Issue.5 , pp. 296-301
    • Aplin, M.1    Christensen, G.L.2    Schneider, M.3
  • 104
    • 65249162262 scopus 로고    scopus 로고
    • An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo
    • Lymperopoulos A, Rengo G, Zincarelli C, Kim J, Soltys S, Koch WJ. An adrenal beta-arrestin 1-mediated signaling pathway underlies angiotensin II-induced aldosterone production in vitro and in vivo. Proc Natl Acad Sci U S A. 2009;106(14):5825-5830.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.14 , pp. 5825-5830
    • Lymperopoulos, A.1    Rengo, G.2    Zincarelli, C.3    Kim, J.4    Soltys, S.5    Koch, W.J.6
  • 105
    • 78651326867 scopus 로고    scopus 로고
    • Adrenal Beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels
    • Lymperopoulos A, Rengo G, Zincarelli C, Kim J, Koch WJ. Adrenal Beta-arrestin 1 inhibition in vivo attenuates post-myocardial infarction progression to heart failure and adverse remodeling via reduction of circulating aldosterone levels. J Am Coll Cardiol. 2011;57(3): 356-365.
    • (2011) J Am Coll Cardiol , vol.57 , Issue.3 , pp. 356-365
    • Lymperopoulos, A.1    Rengo, G.2    Zincarelli, C.3    Kim, J.4    Koch, W.J.5


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