Bridging the divide between neuroprosthetic design, tissue engineering and neurobiology

Frontiers in Neuroengineering

Volumn 2, Issue FEB, 2010, Pages

  Leach, Jennie B ^a   Achyuta, Anil Kumar H ^b   Murthy, Shashi K ^b  

^a University of Marylandw Baltimore County   (United States)

^b Northeastern University   (United States)

Author keywords

Drug delivery; Gliosis; Nerve regeneration; Neural probes; Neural progenitor; Neuroprosthetic; Signal degradation; Utah electrode

Indexed keywords

EID: 84890891400     PISSN: 16626443     EISSN: None     Source Type: Journal    
DOI: 10.3389/neuro.16.018.2009     Document Type: Review

References (211)

1. Abidian, M. R., Ludwig, K. A., Marzullo, T. C., Martin, D. C., and Kipke, D. R. (2009). Interfacing conducting polymer nanotubes with the central nervous system: chronic neural recording using poly(3,4-ethylenedioxythiophene) nanotubes. Adv. Mater. 21, 3764-3770.
2. Abidian, M. R., and Martin, D. C. (2009). Multifunctional nanobiomaterials for neural interfaces. Adv. Funct. Mater. 19, 573-585.
3. Achyuta, A. K. H., Cieri, R., Unger, K., and Murthy, S. K. (2009). Synergistic effect of immobilized laminin and nerve growth factor on PC12 neurite outgrowth. Biotechnol. Prog. 25, 227-234.
4. Ahmed, I., Liu, H. Y., Mamiya, P. C., Ponery, A. S., Babu, A. N., Weik, T., Schindler, M., and Meiners, S. (2006). Three-dimensional nanofibrillar surfaces covalently modified with tenascin-C-derived peptides enhance neuronal growth in vitro. J. Biomed. Mater. Res. A 76, 851-860.
5. Alberts, B., Johnson, A., Lewis, A., Raff, M., Roberts, K., and Walter, P. (2001). Molecular Biology of the Cell. New York, NY, Garland.
6. Alonso, G., and Privat, A. (1993). Neuropeptide Y-producing neurons of the arcuate nucleus regenerate axons after surgical deafferentation of the mediobasal hypothalamus. J. Neurosci. Res. 34, 510-522.
7. Arcaute, K., Mann, B. K., and Wicker, R. B. (2006). Stereolithography of threedimensional bioactive poly(ethylene glycol) constructs with encapsulated cells. Ann. Biomed. Eng. 34, 1429-1441.
8. Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., and Lindvall, O. (2002). Neuronal replacement from endogenous precursors in the adult brain after stroke. Nat. Med. 8, 963-970.
9. Balasingam, V., Tejadaberges, T., Wright, E., Bouckova, R., and Yong, V. W. (1994). Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J. Neurosci. 14, 846-856.
10. Bellamkonda, R. V. (2008). Biomimetic materials - marine inspiration. Nat. Mater. 7, 347-348.
11. Bernardos, R. L., Barthel, L. K., Meyers, J. R., and Raymond, P. A. (2007). Latestage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells. J. Neurosci. 27, 7028-7040.
12. Berry, M., Maxwell, W. L., Logan, A., Mathewson, A., McConnell, P., Ashhurst, D. E., and Thomas, G. H. (1983). Deposition of scar tissue in the central nervous system. Acta Neurochir. Suppl. (Wien) 32, 31-53.
13. Bertschinger, D. R., Beknazar, E., Simonutti, M., Safran, A. B., Sahel, J. A., Rosolen, S. G., Picaud, S., and Salzmann, J. (2008). A review of in vivo animal studies in retinal prosthesis research. Graefes Arch. Clin. Exp. Ophthalmol. 246, 1505-1517.
14. Biran, R., Martin, D. C., and Tresco, P. A. (2005). Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays. Exp. Neurol. 195, 115-126.
15. Biran, R., Martin, D. C., and Tresco, P. A. (2007). The brain tissue response to implanted silicon microelectrode arrays is increased when the device is tethered to the skull. J. Biomed. Mater. Res. A 82A, 169-178.
16. Biran, R., Noble, M. D., and Tresco, P. A. (2003). Directed nerve outgrowth is enhanced by engineered glial substrates. Exp. Neurol. 184, 141-152.
17. Bjornsson, C. S., Oh, S. J., Al-Kofahi, Y. A., Lim, Y. J., Smith, K. L., Turner, J. N., De, S., Roysam, B., Shain, W., and Kim, S. J. (2006). Effects of insertion conditions on tissue strain and vascular damage during neuroprosthetic device insertion. J. Neural Eng. 3, 196-207.
18. Black, J. (1999). Biological Performance of Materials: Fundamentals of Biocompatibility. New York, Dekker.
19. Blight, A. R. (1994). Effects of silica on the outcome from experimental spinal cord injury: implication of macrophages in secondary tissue damage. Neuroscience 60, 263-273.
20. Brazda, N., and Muller, H. W. (2009). Pharmacological modification of the extracellular matrix to promote regeneration of the injured brain and spinal cord. Prog. Brain Res. 175, 269-281.
21. Bruder, J. M., Lee, A. P., and Hoffman- Kim, D. (2007). Biomimetic materials replicating Schwann cell topography enhance neuronal adhesion and neurite alignment in vitro. J. Biomater. Sci. Polym. Ed. 18, 967-982.
22. Bush, T. G., Puvanachandra, N., Horner, C. H., Polito, A., Ostenfeld, T., Svendsen, C. N., Mucke, L., Johnson, M. H., and Sofroniew, M. V. (1999). Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 23, 297-308.
23. Butovsky, O., Ziv, Y., Schwartz, A., Landa, G., Talpalar, A. E., Pluchino, S., Martino, G., and Schwartz, M. (2006). Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol. Cell. Neurosci. 31, 149-160.
24. Byrnes, K. R., and Faden, A. I. (2007). Role of cell cycle proteins in CNS injury. Neurochem. Res. 32, 1799-1807.
25. Cao, Q. L., Howard, R. M., Dennison, J. B., and Whittemore, S. R. (2002). Differentiation of engrafted neuronalrestricted precursor cells is inhibited in the traumatically injured spinal cord. Exp. Neurol. 177, 349-359.
26. Cao, Q. L., Zhang, Y. P., Howard, R. M., Walters, W. M., Tsoulfas, P., and Whittemore, S. R. (2001). Pluripotent stem cells engrafted into the normal or lesioned adult rat spinal cord are restricted to a glial lineage. Exp. Neurol. 167, 48-58.
27. Capadona, J. R., Shanmuganathan, K., Tyler, D. J., Rowan, S. J., and Weder, C. (2008). Stimuli-responsive polymer nanocomposites inspired by the sea cucumber dermis. Science 319, 1370-1374.
28. Carbonell, A. L., and Boya, J. (1988). Ultrastructural study on meningeal regeneration and meningo-glial relationships after cerebral stab wound in the adult rat. Brain Res. 439, 337-344.
29. Catapano, L. A., Arnold, M. W., Perez, F. A., and Macklis, J. D. (2001). Specific neurotrophic factors support the survival of cortical projection neurons at distinct stages of development. J. Neurosci. 21, 8863-8872.
30. Chamak, B., Morandi, V., and Mallat, M. (1994). Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin. J. Neurosci. Res. 38, 221-233.
31. Chen, C. S. (2008). Mechanotransduction - a field pulling together? J. Cell. Sci. 121, 3285-3292.
32. Chen, D., Du, W. B., Liu, Y., Liu, W. S., Kuznetsov, A., Mendez, F. E., Philipson, L. H., and Ismagilov, R. F. (2008). The chemistrode: a droplet-based microfluidic device for stimulation and recording with high temporal, spatial, and chemical resolution. Proc. Natl. Acad. Sci. U.S.A. 105, 16843-16848.
33. Chen, J., Wise, K. D., Hetke, J. F., and Bledsoe, S. C. Jr. (1997). A multichannel neural probe for selective chemical delivery at the cellular level. IEEE Trans. Biomed. Eng. 44, 760-769.
34. Clark, G. (2003). Cochlear Implants: Fundamentals and Applications. New York, Springer.
35. Coumans, J. V., Lin, T. T., Dai, H. N., MacArthur, L., McAtee, M., Nash, C., and Bregman, B. S. (2001). Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J. Neurosci. 21, 9334-9344.
36. Csicsvari, J., Henze, D. A., Jamieson, B., Harris, K. D., Sirota, A., Bartho, P., Wise, K. D., and Buzsaki, G. (2003). Massively parallel recording of unit and local field potentials with silicon-based electrodes. J. Neurophysiol. 90, 1314-1323.
37. Cui, X. Y., Lee, V. A., Raphael, Y., Wiler, J. A., Hetke, J. F., Anderson, D. J., and Martin, D. C. (2001). Surface modification of neural recording electrodes with conducting polymer/ biomolecule blends. J. Biomed. Mater. Res. 56, 261-272.
38. Cui, X. Y., Wiler, J., Dzaman, M., Altschuler, R. A., and Martin, D. C. (2003). In vivo studies of polypyrrole/ peptide coated neural probes. Biomaterials 24, 777-787.
39. Cukierman, E., Pankov, R., Stevens, D. R., and Yamada, K. M. (2001). Taking cellmatrix adhesions to the third dimension. Science 294, 1708-1712.
40. Cullen, D. K., Stabenfeldt, S. E., Simon, C. M., Tate, C. C., and LaPlaca, M. C. (2007). In vitro neural injury model for optimization of tissue-engineered constructs. J. Neurosci. Res. 85, 3642-3651.
41. Das, S., and Basu, A. (2008). Inflammation: a new candidate in modulating adult neurogenesis. J. Neurosci. Res. 86, 1199-1208.
42. Davies, S. J., Field, P. M., and Raisman, G. (1996). Regeneration of cut adult axons fails even in the presence of continuous aligned glial pathways. Exp. Neurol. 142, 203-216.
43. De Winter, F., Oudega, M., Lankhorst, A. J., Hamers, F. P., Blits, B., Ruitenberg, M. J., Pasterkamp, R. J., Gispen, W. H., and Verhaagen, J. (2002). Injuryinduced class 3 semaphorin expression in the rat spinal cord. Exp. Neurol. 175, 61-75.
44. Di Giovanni, S., Movsesyan, V., Ahmed, F., Cernak, I., Schinelli, S., Stoica, B., and Faden, A. I. (2005). Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc. Natl. Acad. Sci. U.S.A. 102, 8333-8338.
45. Dityatev, A., Bukalo, O., and Schachner, M. (2008). Modulation of synaptic transmission and plasticity by cell adhesion and repulsion molecules. Neuron Glia Biol. 4, 197-209.
46. Edell, D. J., Toi, V. V., McNeil, V. M., and Clark, L. D. (1992). Factors influencing the biocompatibility of insertable silicon microshafts in cerebral- cortex. IEEE Trans. Biomed. Eng. 39, 635-643.
47. Ekdahl, C. T., Claasen, J. H., Bonde, S., Kokaia, Z., and Lindvall, O. (2003). Inflammation is detrimental for neurogenesis in adult brain. Proc. Natl. Acad. Sci. U.S.A. 100, 13632-13637.
48. Englund, U., Bjorklund, A., Wictorin, K., Lindvall, O., and Kokaia, M. (2002). Grafted neural stem cells develop into functional pyramidal neurons and integrate into host cortical circuitry. Proc. Natl. Acad. Sci. U.S.A. 99, 17089-17094.
49. Faijerson, J., Tinsley, R. B., Aprico, K., Thorsell, A., Nodin, C., Nilsson, M., Blomstrand, F., and Eriksson, P. S. (2006). Reactive astrogliosis induces astrocytic differentiation of adult neural stem/progenitor cells in vitro. J. Neurosci. Res. 84, 1415-1424.
50. Faulkner, J. R., Herrmann, J. E., Woo, M. J., Tansey, K. E., Doan, N. B., and Sofroniew, M. V. (2004). Reactive astrocytes protect tissue and preserve function after spinal cord injury. J. Neurosci. 24, 2143-2155.
51. Fawcett, J. W., and Asher, R. A. (1999). The glial scar and central nervous system repair. Brain Res. Bull. 49, 377-391.
52. Fernaud-Espinosa, I., Nieto-Sampedro, M., and Bovolenta, P. (1993). Differential activation of microglia and astrocytes in aniso- and isomorphic gliotic tissue. Glia 8, 277-291.
53. Fitch, M. T., and Silver, J. (1997). Activated macrophages and the blood-brain barrier: inflammation after CNS injury leads to increases in putative inhibitory molecules. Exp. Neurol. 148, 587-603.
54. Fitch, M. T., and Silver, J. (2008). CNS injury, glial scars, and inflammation: inhibitory extracellular matrices and regeneration failure. Exp. Neurol. 209, 294-301.
55. Fricker, R. A., Carpenter, M. K., Winkler, C., Greco, C., Gates, M. A., and Bjorklund, A. (1999). Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J. Neurosci. 19, 5990-6005.
56. Frontczak-Baniewicz, M., and Walski, M. (2006). Glial scar instability after brain injury. J. Physiol. Pharmacol. 57(Suppl. 4), 97-102.
57. Fujita, T., Yoshimine, T., Maruno, M., and Hayakawa, T. (1998). Cellular dynamics of macrophages and microglial cells in reaction to stab wounds in rat cerebral cortex. Acta Neurochir. 140, 275-279.
58. Gao, J., Prough, D. S., McAdoo, D. J., Grady, J. J., Parsley, M. O., Ma, L., Tarensenko, Y. I., and Wu, P. (2006). Transplantation of primed human fetal neural stem cells improves cognitive function in rats after traumatic brain injury. Exp. Neurol. 201, 281-292.
59. Gervasi, N. M., Kwok, J. C., and Fawcett, J. W. (2008). Role of extracellular factors in axon regeneration in the CNS: implications for therapy. Regen. Med. 3, 907-923.
60. Gingras, M., Bergeron, J., Dery, J., Durham, H. D., and Berthod, F. (2003). In vitro development of a tissue- engineered model of peripheral nerve regeneration to study neurite growth. FASEB J. 17, 2124-2126.
61. Giordana, M. T., Attanasio, A., Cavalla, P., Migheli, A., Vigliani, M. C., and Schiffer, D. (1994). Reactive cell proliferation and microglia following injury to the rat brain. Neuropathol. Appl. Neurobiol. 20, 163-174.
62. Giordano, C., Causa, F., Bianco, F., Perale, G., Netti, P. A., Ambrosio, L., and Cigada, A. (2008). Gene delivery systems for gene therapy in tissue engineering and central nervous system applications. Int. J. Artif. Organs 31, 1017-1026.
63. Goh, E. L., Ma, D., Ming, G. L., and Song, H. (2003). Adult neural stem cells and repair of the adult central nervous system. J. Hematother. Stem Cell Res. 12, 671-679.
64. Goings, G. E., Sahni, V., and Szele, F. G. (2004). Migration patterns of subventricular zone cells in adult mice change after cerebral cortex injury. Brain Res. 996, 213-226.
65. Goldshmit, Y., Galea, M. P., Wise, G., Bartlett, P. F., and Turnley, A. M. (2004). Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. J. Neurosci. 24, 10064-10073.
66. Goldshmit, Y., McLenachan, S., and Turnley, A. (2006). Roles of Eph receptors and ephrins in the normal and damaged adult CNS. Brain Res. Rev. 52, 327-345.
67. Gomez, N., Lu, Y., Chen, S. C., and Schmidt, C. E. (2007). Immobilized nerve growth factor and microtopography have distinct effects on polarization versus axon elongation in hippocampal cells in culture. Biomaterials 28, 271-284.
68. Gomez, N., and Schmidt, C. E. (2007). Nerve growth factor-immobilized polypyrrole: bioactive electrically conducting polymer for enhanced neurite extension. J. Biomed. Mater. Res. A 81A, 135-149.
69. Groenendaal, B. L., Jonas, F., Freitag, D., Pielartzik, H., and Reynolds, J. R. (2000). Poly(3,4-ethylenedioxythiophene) and its derivatives: past, present, and future. Adv. Mater. 12, 481-494.
70. Han, S. S., Kang, D.Y., Mujtaba, T., Rao, M. S., and Fischer, I. (2002). Grafted lineage-restricted precursors differentiate exclusively into neurons in the adult spinal cord. Exp. Neurol. 177, 360-375.
71. Harris, N. G., Carmichael, S. T., Hovda, D. A., and Sutton, R. L. (2009). Traumatic brain injury results in disparate regions of chondroitin sulfate proteoglycan expression that are temporally limited. J. Neurosci. Res. 87, 2937-2950.
72. Hashimoto, M., Ino, H., Koda, M., Murakami, M., Yoshinaga, K., Yamazaki, M., and Moriya, H. (2004). Regulation of semaphorin 3A expression in neurons of the rat spinal cord and cerebral cortex after transection injury. Acta Neuropathol. 107, 250-256.
73. He, W., McConnell, G. C., Schneider, T. M., and Bellamkonda, R. V. (2007). A novel anti-inflammatory surface for neural electrodes. Adv. Mater. 19, 3529-3533.
74. Hertz, L., and Zielke, H. R. (2004). Astrocytic control of glutamatergic activity: astrocytes as stars of the show. Trends Neurosci. 27, 735-743.
75. Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., and Donoghue, J. P. (2006). Neuronal ensemble control of prosthetic devices by a human with tetraplegia. Nature 442, 164-171.
76. Holland, T. A., Tabata, Y., and Mikos, A. G. (2005). Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering. J. Control Release 101, 111-125.
77. Hubert, T., Grimal, S., Carroll, P., and Fichard-Carroll, A. (2009). Collagens in the developing and diseased nervous system. Cell. Mol. Life Sci. 66, 1223-1238.
78. Iarikov, D. E., Kim, B. G., Dai, H. N., McAtee, M., Kuhn, P. L., and Bregman, B. S. (2007). Delayed transplantation with exogenous neurotrophin administration enhances plasticity of corticofugal projections after spinal cord injury. J. Neurotrauma 24, 690-702.
79. Ignatius, M. J., Sawhney, N., Gupta, A., Thibadeau, B. M., Monteiro, O. R., and Brown, I. G. (1998). Bioactive surface coatings for nanoscale instruments: Effects on CNS neurons. J. Biomed. Mater. Res. 40, 264-274.
80. Irons, H. R., Cullen, D. K., Shapiro, N. P., Lambert, N. A., Lee, R. H., and Laplaca, M. C. (2008). Three-dimensional neural constructs: a novel platform for neurophysiological investigation. J. Neural Eng. 5, 333-341.
81. Jessell, T. M., and Sanes, J. R. (2000). Development. The decade of the developing brain. Curr. Opin. Neurobiol. 10, 599-611.
82. Jhaveri, S. J., Hynd, M. R., Dowell-Mesfin, N., Turner, J. N., Shain, W., and Ober, C. K. (2009). Release of nerve growth factor from HEMA hydrogel- coated substrates and its effect on the differentiation of neural cells. Biomacromolecules 10, 174-183.
83. Jin, K., Sun, Y., Xie, L., Peel, A., Mao, X. O., Batteur, S., and Greenberg, D. A. (2003). Directed migration of neuronal precursors into the ischemic cerebral cortex and striatum. Mol. Cell. Neurosci. 24, 171-189.
84. John, G. R., Lee, S. C., Song, X. Y., Rivieccio, M., and Brosnan, C. F. (2005). IL- 1-regulated responses in astrocytes: relevance to injury and recovery. Glia 49, 161-176.
85. Jun, S. B., Hynd, M. R., Dowell-Mesfin, N. M., Al-Kofahi, Y., Roysam, B., Shain, W., and Kim, S. J. (2008). Modulation of cultured neural networks using neurotrophin release from hydrogelcoated microelectrode arrays. J. Neural Eng. 5, 203-213.
86. Kaneko, M., Kubo, T., Hata, K., Yamaguchi, A., and Yamashita, T. (2007). Repulsion of cerebellar granule neurons by chondroitin sulfate proteoglycans is mediated by MAPK pathway. Neurosci. Lett. 423, 62-67.
87. Kao, W. J., Hubbell, J. A., and Anderson, J. M. (1999). Protein-mediated macrophage adhesion and activation on biomaterials: a model for modulating cell behavior. J. Mater. Sci. Mater. Med. 10, 601-605.
88. Kao, W. J., Lee, D., Schense, J. C., and Hubbell, J. A. (2001). Fibronectin modulates macrophage adhesion and FBGC formation: the role of RGD, PHSRN, and PRRARV domains. J. Biomed. Mater. Res. 55, 79-88.
89. Kapur, T. A., and Shoichet, M. S. (2003). Chemically-bound nerve growth factor for neural tissue engineering applications. J. Biomater. Sci. Polym. Ed. 14, 383-394.
90. Kawaja, M. D., and Gage, F. H. (1991). Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor. Neuron 7, 1019-1030.
91. Kawasaki, Y., Zhang, L., Cheng, J. K., and Ji, R. R. (2008). Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor- alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J. Neurosci. 28, 5189-5194.
92. Khademhosseini, A., Eng, G., Yeh, J., Kucharczyk, P. A., Langer, R., Vunjak- Novakovic, G., and Radisic, M. (2007). Microfluidic patterning for fabrication of contractile cardiac organoids. Biomed. Microdevices 9, 149-157.
93. Khetani, S. R., and Bhatia, S. N. (2006). Engineering tissues for in vitro applications. Curr. Opin. Biotechnol. 17, 524-531.
94. Kim, Y. T., Hitchcock, R. W., Bridge, M. J., and Tresco, P. A. (2004). Chronic response of adult rat brain tissue to implants anchored to the skull. Biomaterials 25, 2229-2237.
95. Klaver, C. L., and Caplan, M. R. (2007). Bioactive surface for neural electrodes: decreasing astrocyte proliferation via transforming growth factor-beta1. J. Biomed. Mater. Res. A 81, 1011-1016.
96. Koprivica, V., Cho, K. S., Park, J. B., Yiu, G., Atwal, J., Gore, B., Kim, J. A., Lin, E., Tessier-Lavigne, M., Chen, D. F., and He, Z. (2005). EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans. Science 310, 106-110.
97. Kyrkanides, S., O'Banion, M. K., Whiteley, P. E., Daeschner, J. C., and Olschowka, J. A. (2001). Enhanced glial activation and expression of specific CNS inflammation- related molecules in aged versus young rats following cortical stab injury. J. Neuroimmunol. 119, 269-277.
98. Lagord, C., Berry, M., and Logan, A. (2002). Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord. Mol. Cell. Neurosci. 20, 69-92.
99. Landis, D. M. D. (1994). The early reactions of nonneuronal cells to brain injury. Annu. Rev. Neurosci. 17, 133-151.
100. LaPlaca, M. C., Cullen, D. K., McLoughlin, J. J., and Cargill, R. S. II (2005). High rate shear strain of three-dimensional neural cell cultures: a new in vitro traumatic brain injury model. J. Biomech. 38, 1093-1105.
101. Lee, K., He, J., Clement, R., Massia, S., and Kim, B. (2004). Biocompatible benzocyclobutene (BCB)-based neural implants with micro-fluidic channel. Biosens. Bioelectron. 20, 404-407.
102. Lee, W., Pinckney, J., Lee, V., Lee, J. H., Fischer, K., Polio, S., Park, J. K., and Yoo, S. S. (2009). Three-dimensional bioprinting of rat embryonic neural cells. Neuroreport 20, 798-803.
103. Lepore, A. C., Neuhuber, B., Connors, T. M., Han, S. S., Liu, Y., Daniels, M. P., Rao, M. S., and Fischer, I. (2006). Long-term fate of neural precursor cells following transplantation into developing and adult CNS. Neuroscience 142, 287-304.
104. Li, N., and Folch, A. (2005). Integration of topographical and biochemical cues by axons during growth on microfabricated 3-D substrates. Exp. Cell Res. 311, 307-316.
105. Li, Y., and Raisman, G. (1995). Sprouts from cut corticospinal axons persist in the presence of astrocytic scarring in long-term lesions of the adult rat spinal cord. Exp. Neurol. 134, 102-111.
106. Liberto, C. M., Albrecht, P. J., Herx, L. M., Yong, V. W., and Levison, S. W. (2004). Pro-regenerative properties of cytokine-activated astrocytes. J. Neurochem. 89, 1092-1100.
107. Lim, J. H., Gibbons, H. M., O'Carroll, S. J., Narayan, P. J., Faull, R. L., and Dragunow, M. (2007). Extracellular signal-regulated kinase involvement in human astrocyte migration. Brain Res. 1164, 1-13.
108. Lin, C. C., and Anseth, K. S. (2009). PEG hydrogels for the controlled release of biomolecules in regenerative medicine. Pharm. Res. 26, 631-643.
109. Lin, P. W., Wu, C. C., Chen, C. H., Ho, H. O., Chen, Y. C., and Sheu, M. T. (2005). Characterization of cortical neuron outgrowth in two- and three-dimensional culture systems. J. Biomed. Mater. Res. B Appl. Biomater. 75, 146-157.
110. Liu, X., McCreery, D. B., Carter, R. R., Bullara, L. A., Yuen, T. G., and Agnew, W. F. (1999). Stability of the interface between neural tissue and chronically implanted intracortical microelectrodes. IEEE Trans. Rehabil. Eng. 7, 315-326.
111. Liu, X. D., McCreery, D. B., Bullara, L. A., and Agnew, W. F. (2006). Evaluation of the stability of intracortical microelectrode arrays. IEEE Trans. Neural Syst. Rehabil. Eng. 14, 91-100.
112. Logan, A., and Berry, M. (2002). Cellular and molecular determinants of glial scar formation. In: Molecular and Cellular Biology of Neuroprotection in the CNS, C. Alzheimer, ed. (New York, NY, Kluwer Academic), pp. 115-137.
113. Lotan, M., and Schwartz, M. (1994). Cross talk between the immune system and the nervous system in response to injury: implications for regeneration. FASEB J. 8, 1026-1033.
114. Ludwig, K. A., Uram, J. D., Yang, J. Y., Martin, D. C., and Kipke, D. R. (2006). Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4- ethylenedioxythiophene) (PEDOT) film. J. Neural Eng. 3, 59-70.
115. Lundberg, C., Englund, U., Trono, D., Bjorklund, A., and Wictorin, K. (2002). Differentiation of the RN33B cell line into forebrain projection neurons after transplantation into the neonatal rat brain. Exp. Neurol. 175, 370-387.
116. Lutolf, M. P., Lauer-Fields, J. L., Schmoekel, H. G., Metters, A. T., Weber, F. E., Fields, G. B., and Hubbell, J. A. (2003). Synthetic matrix metalloproteinasesensitive hydrogels for the conduction of tissue regeneration: engineering cell-invasion characteristics. Proc. Natl. Acad. Sci. U.S.A. 100, 5413-5418.
117. Malhotra, S. K., and Shnitka, T. K. (2002). Diversity in reactive astrocytes. In: Neuroglia in the Aging Brain, J. de Vellis, ed. (Totowa, NJ, Humana Press), pp. 17-33.
118. Manwaring, M. E., Biran, R., and Tresco, P. A. (2001). Characterization of rat meningeal cultures on materials of differing surface chemistry. Biomaterials 22, 3155-3168.
119. Mapili, G., Lu, Y., Chen, S., and Roy, K. (2005). Laser-layered microfabrication of spatially patterned functionalized tissue-engineering scaffolds. J. Biomed. Mater. Res. B Appl. Biomater. 75, 414-424.
120. Massia, S. P., and Hubbell, J. A. (1990). Covalent surface immobilization of Arg-Gly-Asp and Tyl-Ile-Gly-Argcontaining peptides to obtain welldefined cell-adhesive substrates. Anal. Chem. 187, 292-301.
121. Maynard, E. M., Fernandez, E., and Normann, R. A. (2000). A technique to prevent dural adhesions to chronically implanted microelectrode arrays. J. Neurosci. Methods 97, 93-101.
122. McConnell, G. C., Rees, H. D., Levey, A. I., Gutekunst, C. A., Gross, R. E., and Bellamkonda, R. V. (2009). Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration. J. Neural Eng. 6. doi: 10.1088/1741-2560/6/5/056003.
123. McGraw, J., Hiebert, G. W., and Steeves, J. D. (2001). Modulating astrogliosis after neurotrauma. J. Neurosci. Res. 63, 109-115.
124. McMillian, M. K., Thai, L., Hong, J. S., Ocallaghan, J. P., and Pennypacker, K. R. (1994). Brain injury in a dish - a model for reactive gliosis. Trends Neurosci. 17, 138-142.
125. Mercanzini, A., Cheung, K., Buhl, D. L., Boers, M., Maillard, A., Colin, P., Bensadoun, J. C., Bertsch, A., and Renaud, P. (2008). Demonstration of cortical recording using novel flexible polymer neural probes. Sens. Actuators A Phys. 143, 90-96.
126. Merrill, J. E., and Benveniste, E. N. (1996). Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 19, 331-338.
127. Milenkovic, I., Nedeljkovic, N., Filipovic, R., Pekovic, S., Culic, M., Rakic, L., and Stojiljkovic, M. (2005). Pattern of glial fibrillary acidic protein expression following kainate-induced cerebellar lesion in rats. Neurochem. Res. 30, 207-213.
128. Miller, G. (2005). Neuroscience. Cancer drugs may help injured nerve cells regrow their axons. Science 310, 31.
129. Miller, K., and Chinzei, K. (2002). Mechanical properties of brain tissue in tension. J. Biomech. 35, 483-490.
130. Mofid, M. M., Thompson, R. C., Pardo, C. A., Manson, P. N., and Vander Kolk, C. A. (1997). Biocompatibility of fixation materials in the brain. Plast. Reconstr. Surg. 100, 14-20.
131. Montezuma, S. R., Loewenstein, J., Scholz, C., and Rizzo, J. F. (2006). Biocompatibility of materials implanted into the subretinal space of Yucatan pigs. Invest. Ophthalmol. Vis. Sci. 47, 3514-3522.
132. Moore, K., Macsween, M., and Shoichet, M. (2006). Immobilized concentration gradients of neurotrophic factors guide neurite outgrowth of primary neurons in macroporous scaffolds. Tissue Eng. 12, 267-278.
133. Murua, A., Portero, A., Orive, G., Hernandez, R. M., de Castro, M., and Pedraz, J. L. (2008). Cell microencapsulation technology: towards clinical application. J. Control Release. 132, 76-83.
134. Nadal, A., Fuentes, E., Pastor, J., and McNaughton, P. A. (1995). Plasma albumin is a potent trigger of calcium signals and DNA-synthesis in astrocytes. Proc. Natl. Acad. Sci. U.S.A. 92, 1426-1430.
135. Nadal, A., Fuentes, E., Pastor, J., and McNaughton, P. A. (1997). Plasma albumin induces calcium waves in rat cortical astrocytes. Glia 19, 343-351.
136. Nait-Oumesmar, B., Decker, L., Lachapelle, F., Avellana-Adalid, V., Bachelin, C., and Van Evercooren, A. B. (1999). Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination. Eur. J. Neurosci. 11, 4357-4366.
137. Nakatomi, H., Kuriu, T., Okabe, S., Yamamoto, S., Hatano, O., Kawahara, N., Tamura, A., Kirino, T., and Nakafuku, M. (2002). Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110, 429-441.
138. Neary, J. T., and Kang, Y. (2005). Signaling from P2 nucleotide receptors to protein kinase cascades induced by CNS injury: implications for reactive gliosis and neurodegeneration. Mol. Neurobiol. 31, 95-103.
139. Nguyen, M. D., Mushynski, W. E., and Julien, J. P. (2002). Cycling at the interface between neurodevelopment and neurodegeneration. Cell Death Differ. 9, 1294-1306.
140. Nicole, O., Goldshmidt, A., Hamill, C. E., Sorensen, S. D., Sastre, A., Lyuboslavsky, P., Hepler, J. R., McKeon, R. J., and Traynelis, S. F. (2005). Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J. Neurosci. 25, 4319-4329.
141. Nicolelis, M. A. L., Dimitrov, D., Carmena, J. M., Crist, R., Lehew, G., Kralik, J. D., and Wise, S. P. (2003). Chronic, multisite, multielectrode recordings in macaque monkeys. Proc. Natl. Acad. Sci. U.S.A. 100, 11041-11046.
142. Nicolelis, M. A. L., and Ribeiro, S. (2002). Multielectrode recordings: the next steps. Curr. Opin. Neurobiol. 12, 602-606.
143. O'Connor, S. M., Stenger, D. A., Shaffer, K. M., and Ma, W. (2001). Survival and neurite outgrowth of rat cortical neurons in three-dimensional agarose and collagen gel matrices. Neurosci. Lett. 304, 189-193.
144. Oda, K., Matsuoka, Y., Funahashi, A., and Kitano, H. (2005). A comprehensive pathway map of epidermal growth factor receptor signaling. Mol. Syst. Biol. 1, 2005.0010.
145. Ohta, M., Suzuki, Y., Chou, H., Ishikawa, N., Suzuki, S., Tanihara, M., Mizushima, Y., Dezawa, M., and Ide, C. (2004). Novel heparin/alginate gel combined with basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. J. Biomed. Mater. Res. A. 71, 661-668.
146. Okada, S., Nakamura, M., Katoh, H., Miyao, T., Shimazaki, T., Ishii, K., Yamane, J., Yoshimura, A., Iwamoto, Y., Toyama, Y., and Okano, H. (2006). Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat. Med. 12, 829-834.
147. Onifer, S. M., Whittemore, S. R., and Holets, V. R. (1993). Variable morphological- differentiation of a raphederived neuronal cell-line following transplantation into the adult-rat CNS. Exp. Neurol. 122, 130-142.
148. Pampaloni, F., Reynaud, E. G., and Stelzer, E. H. (2007). The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 8, 839-845.
149. Papageorgiou, D. P., Shore, S. E., Bledsoe, S. C., and Wise, K. D. (2006). A shuttered neural probe with on-chip flowmeters for chronic in vivo drug delivery. J. Microelectromech. Syst. 15, 1025-1033.
150. Papavasiliou, G., Songprawat, P., Perez- Luna, V., Hammes, E., Morris, M., Chiu, Y. C., and Brey, E. (2008). Threedimensional pattering of poly(ethylene glycol) hydrogels through surface-initiated photopolymerization. Tissue Eng. C Methods 14, 129-140.
151. Park, H., Temenoff, J. S., Tabata, Y., Caplan, A. I., and Mikos, A. G. (2007). Injectable biodegradable hydrogel composites for rabbit marrow mesenchymal stem cell and growth factor delivery for cartilage tissue engineering. Biomaterials 28, 3217-3227.
152. Polikov, V. S. (2009). An In Vitro Model of the Brain Tissue Reaction to Chronically Implanted Recording Electrodes Reveals Essential Roles for Serum and bfgf in Glial Scarring. Doctor of Philosophy Thesis, Department of Biomedical Engineering, Duke University, Durham, NC.
153. Polikov, V. S., Block, M. L., Fellous, J. M., Hong, J. S., and Reichert, W. M. (2006). In vitro model of glial scarring around neuroelectrodes chronically implanted in the CNS. Biomaterials 27, 5368-5376.
154. Polikov, V. S., Su, E. C., Bail, M. A., Hong, J. S., and Reichert, W. M. (2009). Control protocol for robust in vitro glial scar formation around microwires: Essential roles of bFGF and serum in gliosis. J. Neurosci. Methods 181, 170-177.
155. Polikov, V. S., Tresco, P. A., and Reichert, W. M. (2005). Response of brain tissue to chronically implanted neural electrodes. J. Neurosci. Methods 148, 1-18.
156. Popovich, P. G., Guan, Z., Wei, P., Huitinga, I., van Rooijen, N., and Stokes, B. T. (1999). Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp. Neurol. 158, 351-365.
157. Quaglia, F. (2008). Bioinspired tissue engineering: the great promise of protein delivery technologies. Int. J. Pharm. 364, 281-297.
158. Raivich, G., Bohatschek, M., Kloss, C. U. A., Werner, A., Jones, L. L., and Kreutzberg, G. W. (1999). Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function. Brain Res. Rev. 30, 77-105.
159. Rapalino, O., Lazarov-Spiegler, O., Agranov, E., Velan, G. J., Yoles, E., Fraidakis, M., Solomon, A., Gepstein, R., Katz, A., Belkin, M., Hadani, M., and Schwartz, M. (1998). Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat. Med. 4, 814-821.
160. Renault-Mihara, F., Okada, S., Shibata, S., Nakamura, M., Toyama, Y., and Okano, H. (2008). Spinal cord injury: emerging beneficial role of reactive astrocytes' migration. Int. J. Biochem. Cell Biol. 40, 1649-1653.
161. Retterer, S. T., Smith, K. L., Bjornsson, C. S., Neeves, K. B., Spence, A. J., Turner, J. N., Shain, W., and Isaacson, M. S. (2004). Model neural prostheses with integrated microfluidics: a potential intervention strategy for controlling reactive cell and tissue responses. IEEE Trans. Biomed. Eng. 51, 2063-2073.
162. Rhodes, K. E., Raivich, G., and Fawcett, J. W. (2006). The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines. Neuroscience 140, 87-100.
163. Richardson, R. T., Wise, A. K., Thompson, B. C., Flynn, B. O., Atkinson, P. J., Fretwell, N. J., Fallon, J. B., Wallace, G. G., Shepherd, R. K., Clark, G. M., and O'Leary, S. J. (2009). Polypyrrolecoated electrodes for the delivery of charge and neurotrophins to cochlear neurons. Biomaterials 30, 2614-2624.
164. Richardson, T. P., Peters, M. C., Ennett, A. B., and Mooney, D. J. (2001). Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19, 1029-1034.
165. Ridet, J. L., Malhotra, S. K., Privat, A., and Gage, F. H. (1997). Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20, 570-577.
166. Roitbak, T., and Sykova, E. (1999). Diffusion barriers evoked in the rat cortex by reactive astrogliosis. Glia 28, 40-48.
167. Rolls, A., Shechter, R., London, A., Segev, Y., Jacob-Hirsch, J., Amariglio, N., Rechavi, G., and Schwartz, M. (2008). Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation. PLoS Med. 5, e171. doi: 10.1371/journal. pmed.0050171.
168. Rolls, A., Shechter, R., and Schwartz, M. (2009). The bright side of the glial scar in CNS repair. Nat. Rev. Neurosci. 10, 235-241.
169. Rousche, P. J., and Normann, R. A. (1998). Chronic recording capability of the Utah Intracortical Electrode Array in cat sensory cortex. J. Neurosci. Methods 82, 1-15.
170. Saadoun, S., Papadopoulos, M. C., Watanabe, H., Yan, D. H., Manley, G. T., and Verkman, A. S. (2005). Involvement of aquaporin-4 in astroglial cell migration and glial scar formation. J. Cell Sci. 118, 5691-5698.
171. Saneinejad, S., and Shoichet, M. S. (1998). Patterned glass surfaces direct cell adhesion and process outgrowth of primary neurons of the central nervous system. J. Biomed. Mater. Res. 42, 13-19.
172. Schlosshauer, B., Brinker, T., Muller, H. W., and Meyer, J. U. (2001). Towards micro electrode implants: in vitro guidance of rat spinal cord neurites through polyimide sieves by Schwann cells. Brain Res. 903, 237-241.
173. Schmidt, J. J., Rowley, J., and Kong, H. J. (2008). Hydrogels used for cell-based drug delivery. J. Biomed. Mater. Res. A. 87, 1113-1122.
174. Schmidt, S., Horch, K., and Normann, R. (1993). Biocompatibility of siliconbased electrode arrays implanted in feline cortical tissue. J. Biomed. Mater. Res. 27, 1393-1399.
175. Schwartz, A. B. (2004). Cortical neural prosthetics. Annu. Rev. Neurosci. 27, 487-507.
176. Sheen, V. L., Arnold, M. W., Wang, Y., and Macklis, J. D. (1999). Neural precursor differentiation following transplantation into neocortex is dependent on intrinsic developmental state and receptor competence. Exp. Neurol. 158, 47-62.
177. Shihabuddin, L. S., Brunschwig, J. P., Holets, V. R., Bunge, M. B., and Whittemore, S. R. (1996). Induction of mature neuronal properties in immortalized neuronal precursor cells following grafting into the neonatal CNS. J. Neurocytol. 25, 101-111.
178. Silva, A. K., Richard, C., Bessodes, M., Scherman, D., and Merten, O. W. (2009). Growth factor delivery approaches in hydrogels. Biomacromolecules 10, 9-18.
179. Sivron, T., and Schwartz, M. (1995). Glial cell types, lineages, and response to injury in rat and fish: implications for regeneration. Glia 13, 157-165.
180. Stensaas, S. S., and Stensaas, L. J. (1976). Reaction of cerebral cortex to chronically implanted plastic needles. Acta Neuropathol. 35, 187-203.
181. Suuronen, E. J., McLaughlin, C. R., Stys, P. K., Nakamura, M., Munger, R., and Griffith, M. (2004). Functional innervation in tissue engineered models for in vitro study and testing purposes. Toxicol. Sci. 82, 525-533.
182. Swan, E. E. L., Mescher, M. J., Sewell, W. F., Tao, S. L., and Borenstein, J. I. (2008). Inner ear drug delivery for auditory applications. Adv. Drug Deliv. Rev. 60, 1583-1599.
183. Szarowski, D. H., Andersen, M. D., Retterer, S., Spence, A. J., Isaacson, M., Craighead, H. G., Turner, J. N., and Shain, W. (2003). Brain responses to micro-machined silicon devices. Brain Res. 983, 23-35.
184. Takeuchi, A., Miyaishi, O., Kiuchi, K., and Isobe, K. (2001). Macrophage colony-stimulating factor is expressed in neuron and microglia after focal brain injury. J. Neurosci. Res. 65, 38-44.
185. Takeuchi, S., Ziegler, D., Yoshida, Y., Mabuchi, K., and Suzuki, T. (2005). Parylene flexible neural probes integrated with microfluidic channels. Lab. Chip 5, 519-523.
186. Tanihara, M., Suzuki, Y., Yamamoto, E., Noguchi, A., and Mizushima, Y. (2001). Sustained release of basic fibroblast growth factor and angiogenesis in a novel covalently crosslinked gel of heparin and alginate. J. Biomed. Mater. Res. 56, 216-221.
187. Tibbitt, M. W., and Anseth, K. S. (2009). Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol. Bioeng. 103, 655-663.
188. Tong, Y. W., and Shoichet, M. S. (1998). Peptide surface modification of poly(tetrafluoroethylene-co-hexafluoropropylene) enhances its interaction with central nervous system neurons. J. Biomed. Mater. Res. 42, 85-95.
189. Tong, Y. W., and Shoichet, M. S. (2001). Enhancing the neuronal interaction on fluoropolymer surfaces with mixed peptides or spacer group linkers. Biomaterials 22, 1029-1034.
190. Turner, J. N., Shain, W., Szarowski, D. H., Andersen, M., Martins, S., Isaacson, M., and Craighead, H. (1999). Cerebral astrocyte response to micromachined silicon implants. Exp. Neurol. 156, 33-49.
191. Venstrom, K. A., and Reichardt, L. F. (1993). Extracellular matrix. 2: role of extracellular matrix molecules and their receptors in the nervous system. FASEB J. 7, 996-1003.
192. Vetter, R. J., Williams, J. C., Hetke, J. F., Nunamaker, E. A., and Kipke, D. R. (2004). Chronic neural recording using silicon-substrate microelectrode arrays implanted in cerebral cortex. IEEE Trans. Biomed. Eng. 51, 896-904.
193. Wang, N., Tytell, J. D., and Ingber, D. E. (2009a). Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat. Rev. Mol. Cell Biol. 10, 75-82.
194. Wang, W., Bu, B., Xie, M., Zhang, M., Yu, Z., and Tao, D. (2009b). Neural cell cycle dysregulation and central nervous system diseases. Prog. Neurobiol. 89, 1-17.
195. Wang, Y., Moges, H., Bharucha, Y., and Symes, A. (2007). Smad3 null mice display more rapid wound closure and reduced scar formation after a stab wound to the cerebral cortex. Exp. Neurol. 203, 168-184.
196. Wanner, I. B., Deik, A., Torres, M., Rosendahl, A., Neary, J. T., Lemmon, V. P., and Bixby, J. L. (2008). A new in vitro model of the glial scar inhibits axon growth. Glia 56, 1691-1709.
197. Wartiovaara, K., Barnabe-Heider, F., Miller, F. D., and Kaplan, D. R. (2002). N-myc promotes survival and induces S-phase entry of postmitotic sympathetic neurons. J. Neurosci. 22, 815-824.
198. Webb, K., Budko, E., Neuberger, T. J., Chen, S. Z., Schachner, M., and Tresco, P. A. (2001). Substrate-bound human recombinant L1 selectively promotes neuronal attachment and outgrowth in the presence of astrocytes and fibroblasts. Biomaterials 22, 1017-1028.
199. Weiland, J. D., Liu, W. T., and Humayun, M. S. (2005). Retinal prosthesis. Annu. Rev. Biomed. Eng. 7, 361-401.
200. Whitney, N. P., Eidem, T. M., Peng, H., Huang, Y., and Zheng, J. C. (2009). Inflammation mediates varying effects in neurogenesis: relevance to the pathogenesis of brain injury and neurodegenerative disorders. J. Neurochem. 108, 1343-1359.
201. Whittemore, S. R., and White, L. A. (1993). Target regulation of neuronal differentiation in a temperature-sensitive cellline derived from medullary raphe. Brain Res. 615, 27-40.
202. Wilkins, A., Majed, H., Layfield, R., Compston, A., and Chandran, S. (2003). Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocytederived glial cell line-derived neurotrophic factor. J. Neurosci. 23, 4967-4974.
203. Williams, J. C., Hippensteel, J. A., Dilgen, J., Shain, W., and Kipke, D. R. (2007). Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants. J. Neural Eng. 4, 410-423.
204. Williams, J. C., Rennaker, R. L., and Kipke, D. R. (1999). Long-term neural recording characteristics of wire microelectrode arrays implanted in cerebral cortex. Brain Res. Protoc. 4, 303-313.
205. Winn, S. R., Aebischer, P., and Galletti, P. M. (1989). Brain tissue reaction to permselective polymer capsules. J. Biomed. Mater. Res. 23, 31-44.
206. Winter, J. O., Cogan, S. F., and Rizzo, J. F. III (2007a). Retinal prostheses: current challenges and future outlook. J. Biomater. Sci. Polym. Ed. 18, 1031-1055.
207. Winter, J. O., Cogan, S. F., and Rizzo, J. F. III (2007b). Neurotrophin-eluting hydrogel coatings for neural stimulating electrodes. J. Biomed. Mater. Res. B Appl. Biomater. 81, 551-563.
208. Wise, K. D., Anderson, D. J., Hetke, J. F., Kipke, D. R., and Najafi, K. (2004). Wireless implantable microsystems: high-density electronic interfaces to the nervous system. Proc. IEEE 92, 76-97.
209. Wu, V. W., and Schwartz, J. P. (1998). Cell culture models for reactive gliosis: new perspectives. J. Neurosci. Res. 51, 675-681.
210. Zhao, C., Deng, W., and Gage, F. H. (2008). Mechanisms and functional implications of adult neurogenesis. Cell 132, 645-660.
211. Zhong, Y. H., and Bellamkonda, R. V. (2008). Biomaterials for the central nervous system. J. R. Soc. Interface 5, 957-975.