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Volumn 31, Issue 1-3, 2005, Pages 95-103

Signaling from P2 nucleotide receptors to protein kinase cascades induced by CNS injury: Implications for reactive gliosis and neurodegeneration

Author keywords

Akt; ATP; ERK; Gliosis; Protein kinases; Purinergic receptors; Trauma

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHEMOKINE RECEPTOR CXCR4; G PROTEIN COUPLED RECEPTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMATE RECEPTOR; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE B; PURINE P2X RECEPTOR; PURINE P2Y RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

EID: 24644471872     PISSN: 08937648     EISSN: None     Source Type: Journal    
DOI: 10.1385/mn:31:1-3:095     Document Type: Conference Paper
Times cited : (45)

References (68)
  • 1
    • 0023086915 scopus 로고
    • Astrocyte activation and fibrous gliosis: Glial fibrillary acidic protein immunostaining of astroyctes following intraspinal cord grafting of fetal CNS tissue
    • Eng L.F., Reier P.J., and Houle J.D. (1987) Astrocyte activation and fibrous gliosis: glial fibrillary acidic protein immunostaining of astroyctes following intraspinal cord grafting of fetal CNS tissue. Prog. Brain. Res. 71, 439-455.
    • (1987) Prog. Brain. Res. , vol.71 , pp. 439-455
    • Eng, L.F.1    Reier, P.J.2    Houle, J.D.3
  • 2
    • 0028327286 scopus 로고
    • Astrocyte responses to CNS injury
    • Norenberg M.D. (1994) Astrocyte responses to CNS injury. J. Neuropath. Exp. Neurol. 53, 213-220.
    • (1994) J. Neuropath. Exp. Neurol. , vol.53 , pp. 213-220
    • Norenberg, M.D.1
  • 3
    • 0034305621 scopus 로고    scopus 로고
    • Glial fibrillary acidic protein: GFAP - Thirty-one years (1969-2000)
    • Eng L.F., Ghirnikar R.S., and Lee Y.L. (2000) Glial fibrillary acidic protein: GFAP - thirty-one years (1969-2000). Neurochem. Res. 25, 1439-1451.
    • (2000) Neurochem. Res. , vol.25 , pp. 1439-1451
    • Eng, L.F.1    Ghirnikar, R.S.2    Lee, Y.L.3
  • 4
    • 0030697366 scopus 로고    scopus 로고
    • Reactive astrocytes: Cellular and molecular cues to biological function
    • Ridet J.L., Malhotra S.K., Privat A., and Gage F.H. (1997) Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci. 20, 570-577.
    • (1997) Trends Neurosci. , vol.20 , pp. 570-577
    • Ridet, J.L.1    Malhotra, S.K.2    Privat, A.3    Gage, F.H.4
  • 5
    • 85047676379 scopus 로고
    • Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia
    • Bergfeld G.R. and Forrester T. (1992) Release of ATP from human erythrocytes in response to a brief period of hypoxia and hypercapnia. Cardiol. Res. 26, 40-47.
    • (1992) Cardiol. Res. , vol.26 , pp. 40-47
    • Bergfeld, G.R.1    Forrester, T.2
  • 6
    • 0026556240 scopus 로고
    • Chronic hypoxia changes the ratio of endothelin to ATP release from rat aortic endothelial cells exposed to high flow
    • Bodin P., Milner P., Winter R., and Burnstock G. (1992) Chronic hypoxia changes the ratio of endothelin to ATP release from rat aortic endothelial cells exposed to high flow. Proc. R. Soc. London (B) 247, 131-135.
    • (1992) Proc. R. Soc. London (B) , vol.247 , pp. 131-135
    • Bodin, P.1    Milner, P.2    Winter, R.3    Burnstock, G.4
  • 7
    • 33845216127 scopus 로고    scopus 로고
    • Adenosine and neuroprotection
    • Fredholm B.B. (1997) Adenosine and neuroprotection. Int. Rev. Neurobiol. 40, 259-280.
    • (1997) Int. Rev. Neurobiol. , vol.40 , pp. 259-280
    • Fredholm, B.B.1
  • 8
    • 0034093306 scopus 로고    scopus 로고
    • Stretch-induced injury alters mitochondrial membrane potential and cellular ATP in cultured astrocytes and neurons
    • Ahmed S.M., Rzigalinski B.A., Willoughby K.A., Sitterding H.A., and Ellis E.F. (2000) Stretch-induced injury alters mitochondrial membrane potential and cellular ATP in cultured astrocytes and neurons. J. Neurochem. 74, 1951-1960.
    • (2000) J. Neurochem. , vol.74 , pp. 1951-1960
    • Ahmed, S.M.1    Rzigalinski, B.A.2    Willoughby, K.A.3    Sitterding, H.A.4    Ellis, E.F.5
  • 9
  • 10
    • 0026505517 scopus 로고
    • Adenosine and its nucleotides stimulate proliferation of chick astrocytes and human astrocytoma cells
    • Rathbone M.P., Middlemiss P.J., Kim J.-L., et al. (1992) Adenosine and its nucleotides stimulate proliferation of chick astrocytes and human astrocytoma cells. Neurosci. Res. 13, 1-17.
    • (1992) Neurosci. Res. , vol.13 , pp. 1-17
    • Rathbone, M.P.1    Middlemiss, P.J.2    Kim, J.-L.3
  • 11
    • 0028123312 scopus 로고
    • Extracellular ATP induces stellation and increases GFAP content and DNA synthesis in primary astrocyte cultures
    • Neary J.T., Baker L., Jorgensen S.L., and Norenberg M.D. (1994) Extracellular ATP induces stellation and increases GFAP content and DNA synthesis in primary astrocyte cultures. Acta Neuropathol. 87, 8-13.
    • (1994) Acta Neuropathol. , vol.87 , pp. 8-13
    • Neary, J.T.1    Baker, L.2    Jorgensen, S.L.3    Norenberg, M.D.4
  • 12
    • 0028329654 scopus 로고
    • Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum
    • Abbracchio M.P., Saffrey M.J., Hopker V., and Burnstock G. (1994) Modulation of astroglial cell proliferation by analogues of adenosine and ATP in primary cultures of rat striatum. Neuroscience 59, 67-76.
    • (1994) Neuroscience , vol.59 , pp. 67-76
    • Abbracchio, M.P.1    Saffrey, M.J.2    Hopker, V.3    Burnstock, G.4
  • 13
    • 0027936235 scopus 로고
    • Synergistic activation of DNA synthesis in astrocytes by fibroblast growth factor and extracellular ATP
    • Neary J.T., Whittemore S.R., Zhu Q., and Norenberg M.D. (1994) Synergistic activation of DNA synthesis in astrocytes by fibroblast growth factor and extracellular ATP. J. Neurochem. 63, 490-494.
    • (1994) J. Neurochem. , vol.63 , pp. 490-494
    • Neary, J.T.1    Whittemore, S.R.2    Zhu, Q.3    Norenberg, M.D.4
  • 14
    • 0028130422 scopus 로고
    • Destabilization of glial fibrillary acidic protein mRNA by ammonia and protection by extracellular ATP
    • Neary J.T., Whittemore S.R., Zhu Q., and Norenberg M.D. (1994) Destabilization of glial fibrillary acidic protein mRNA by ammonia and protection by extracellular ATP. J. Neurochem. 63, 2021-2027.
    • (1994) J. Neurochem. , vol.63 , pp. 2021-2027
    • Neary, J.T.1    Whittemore, S.R.2    Zhu, Q.3    Norenberg, M.D.4
  • 15
    • 0032548768 scopus 로고    scopus 로고
    • Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocytes
    • Neary J.T., McCarthy M., Kang Y., and Zuniga S. (1998) Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocytes. Neurosci. Lett. 242, 159-162.
    • (1998) Neurosci. Lett. , vol.242 , pp. 159-162
    • Neary, J.T.1    McCarthy, M.2    Kang, Y.3    Zuniga, S.4
  • 16
    • 0344286628 scopus 로고    scopus 로고
    • P2 receptor-mediated proliferative effects on astrocytes in vivo
    • Franke H., Krügel U., and Illes P. (1999) P2 receptor-mediated proliferative effects on astrocytes in vivo. Glia 28, 190-200.
    • (1999) Glia , vol.28 , pp. 190-200
    • Franke, H.1    Krügel, U.2    Illes, P.3
  • 18
    • 0029011218 scopus 로고
    • The MAPK signaling cascade
    • Seger R. and Krebs E.G. (1995) The MAPK signaling cascade. FASEB J. 9, 726-735.
    • (1995) FASEB J. , vol.9 , pp. 726-735
    • Seger, R.1    Krebs, E.G.2
  • 19
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang L. and Karin M. (2001) Mammalian MAP kinase signalling cascades. Nature 410, 37-40.
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 20
    • 0037862006 scopus 로고    scopus 로고
    • Unraveling the activation mechanisms of protein kinase B/Akt
    • Scheid M.P. and Woodgett J.R. (2003) Unraveling the activation mechanisms of protein kinase B/Akt. FEBS Lett. 546, 108-112.
    • (2003) FEBS Lett. , vol.546 , pp. 108-112
    • Scheid, M.P.1    Woodgett, J.R.2
  • 21
    • 0037599243 scopus 로고    scopus 로고
    • Signal transduction pathways for P2Y2 and P2X7 nucleotide receptors that mediate neuroinflammatory responses in astrocytes and microglial cells
    • Gendron F.P., Newbold N.L., Vivas-Mejia P.E., et al. (2003) Signal transduction pathways for P2Y2 and P2X7 nucleotide receptors that mediate neuroinflammatory responses in astrocytes and microglial cells. Biomed. Res. 14, 47-61.
    • (2003) Biomed. Res. , vol.14 , pp. 47-61
    • Gendron, F.P.1    Newbold, N.L.2    Vivas-Mejia, P.E.3
  • 22
    • 0028106545 scopus 로고
    • Signaling by ATP receptors in astrocytes
    • Neary J.T. and Zhu Q. (1994) Signaling by ATP receptors in astrocytes. Neuroreport 5, 1617-1620.
    • (1994) Neuroreport , vol.5 , pp. 1617-1620
    • Neary, J.T.1    Zhu, Q.2
  • 23
    • 0030254252 scopus 로고    scopus 로고
    • P2 purinoceptors in rat cortical astrocytes: Expression., calcium-imaging and signalling studies
    • King B.F., Neary J.T., Zhu Q., Wang S., Norenberg M.D., and Burnstock G. (1996) P2 purinoceptors in rat cortical astrocytes: expression., calcium-imaging and signalling studies. Neuroscience 74, 1187-1196.
    • (1996) Neuroscience , vol.74 , pp. 1187-1196
    • King, B.F.1    Neary, J.T.2    Zhu, Q.3    Wang, S.4    Norenberg, M.D.5    Burnstock, G.6
  • 24
    • 0033153149 scopus 로고    scopus 로고
    • Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: Involvement of a calcium-independent protein kinase C, extracellular signal regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C, calcium pathway
    • Neary J.T., Kang Y., Bu Y., Yu E., Akong K., and Peters C.M. (1999) Mitogenic signaling by ATP/P2Y purinergic receptors in astrocytes: involvement of a calcium-independent protein kinase C, extracellular signal regulated protein kinase pathway distinct from the phosphatidylinositol-specific phospholipase C, calcium pathway. J. Neurosci. 19, 4211-4220.
    • (1999) J. Neurosci. , vol.19 , pp. 4211-4220
    • Neary, J.T.1    Kang, Y.2    Bu, Y.3    Yu, E.4    Akong, K.5    Peters, C.M.6
  • 25
    • 18744383029 scopus 로고    scopus 로고
    • Induction of COX-2 by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signaling
    • Brambilla R., Neary J.T., Cattabeni F., et al. (2002) Induction of COX-2 by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signaling. J. Neurochem. 83, 1285-1296.
    • (2002) J. Neurochem. , vol.83 , pp. 1285-1296
    • Brambilla, R.1    Neary, J.T.2    Cattabeni, F.3
  • 26
    • 0035884937 scopus 로고    scopus 로고
    • P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase
    • Panenka W., Jijon H., Herx L.M., et al. (2001) P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J. Neurosci. 21, 7135-7142.
    • (2001) J. Neurosci. , vol.21 , pp. 7135-7142
    • Panenka, W.1    Jijon, H.2    Herx, L.M.3
  • 27
    • 0025228658 scopus 로고
    • Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: Pharmacological characterization
    • Dragunow M., Goulding M., Faull R.L.M., Ralph R., Mee E., and Frith R. (1990) Induction of c-fos mRNA and protein in neurons and glia after traumatic brain injury: pharmacological characterization. Exp. Neurol. 107, 236-248.
    • (1990) Exp. Neurol. , vol.107 , pp. 236-248
    • Dragunow, M.1    Goulding, M.2    Faull, R.L.M.3    Ralph, R.4    Mee, E.5    Frith, R.6
  • 28
    • 0028172846 scopus 로고
    • Increased expression of c-fos mRNA and AP-1 transcription factors after cortical impact injury in rats
    • Yang K., Mu X.S., Xue J.J., et al. (1994) Increased expression of c-fos mRNA and AP-1 transcription factors after cortical impact injury in rats. Brain Res. 664, 140-147.
    • (1994) Brain Res. , vol.664 , pp. 140-147
    • Yang, K.1    Mu, X.S.2    Xue, J.J.3
  • 29
    • 0028922688 scopus 로고
    • Spatial memory deficits, increased phosphorylation of the transcription factor CREB, and induction of the AP-1 complex following experimental brain injury
    • Dash P.K., Moore A.N., and Dixon C.E. (1995) Spatial memory deficits, increased phosphorylation of the transcription factor CREB, and induction of the AP-1 complex following experimental brain injury. J. Neurosci. 15, 2030-2039.
    • (1995) J. Neurosci. , vol.15 , pp. 2030-2039
    • Dash, P.K.1    Moore, A.N.2    Dixon, C.E.3
  • 30
  • 31
    • 24644456196 scopus 로고    scopus 로고
    • Activation of ERK/CREB and ATF-2 signaling pathways following traumatic brain injury
    • Hu B., Bramlett H.M., Sick T.J., Perez-Pinzon M., and Dietrich W.D. (2001) Activation of ERK/CREB and ATF-2 signaling pathways following traumatic brain injury. J. Neurotrauma 18, 1161.
    • (2001) J. Neurotrauma , vol.18 , pp. 1161
    • Hu, B.1    Bramlett, H.M.2    Sick, T.J.3    Perez-Pinzon, M.4    Dietrich, W.D.5
  • 32
    • 0030841180 scopus 로고    scopus 로고
    • Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor-induced astrogliosis
    • Bolego C., Ceruti S., Brambilla R., et al. (1997) Characterization of the signalling pathways involved in ATP and basic fibroblast growth factor-induced astrogliosis. Br. J. Pharmacol. 121, 1692-1699.
    • (1997) Br. J. Pharmacol. , vol.121 , pp. 1692-1699
    • Bolego, C.1    Ceruti, S.2    Brambilla, R.3
  • 33
    • 0030477550 scopus 로고    scopus 로고
    • Extracellular ATP induces formation of AP-1 complexes in astrocytes via P2 purinoceptors
    • Neary J.T., Zhu Q., Kang Y., and Dash P.K. (1996) Extracellular ATP induces formation of AP-1 complexes in astrocytes via P2 purinoceptors. Neuroreport 7, 2893-2896.
    • (1996) Neuroreport , vol.7 , pp. 2893-2896
    • Neary, J.T.1    Zhu, Q.2    Kang, Y.3    Dash, P.K.4
  • 34
    • 0032860755 scopus 로고    scopus 로고
    • Trophic signaling pathways activated by purinergic receptors in rat and human astroglia
    • Neary J.T., McCarthy M., Cornell-Bell A.H., and Kang Y. (1999) Trophic signaling pathways activated by purinergic receptors in rat and human astroglia. Prog. Brain Res. 120, 323-332.
    • (1999) Prog. Brain Res. , vol.120 , pp. 323-332
    • Neary, J.T.1    McCarthy, M.2    Cornell-Bell, A.H.3    Kang, Y.4
  • 35
    • 0027193391 scopus 로고
    • Analysis of a segment of the human glial fibrillary acidic protein gene that directs astrocyte-specific transcription
    • Masood K., Bresnard F., Su Y., and Brenner M. (1993) Analysis of a segment of the human glial fibrillary acidic protein gene that directs astrocyte-specific transcription. J. Neurochem. 61, 160-166.
    • (1993) J. Neurochem. , vol.61 , pp. 160-166
    • Masood, K.1    Bresnard, F.2    Su, Y.3    Brenner, M.4
  • 36
    • 0035936653 scopus 로고    scopus 로고
    • PDK2: A complex tail in one Akt
    • Chan T.O. and Tsichlis P.N. (2001) PDK2: a complex tail in one Akt. Sci STKE 2001(66): PE1
    • (2001) Sci STKE , vol.2001 , Issue.66
    • Chan, T.O.1    Tsichlis, P.N.2
  • 37
    • 2342469938 scopus 로고    scopus 로고
    • P2X7 receptors stimulate Akt phosphorylation in astrocytes
    • Jacques-Silva M.C., Rodnight R., Lenz G., et al. (2004) P2X7 receptors stimulate Akt phosphorylation in astrocytes. Br. J. Pharmacol. 141, 1107-1118.
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 1107-1118
    • Jacques-Silva, M.C.1    Rodnight, R.2    Lenz, G.3
  • 38
    • 24644513134 scopus 로고    scopus 로고
    • P2 nucleotide receptors are coupled to glycogen synthase kinase-3beta in astrocytes
    • Program No. 631.7
    • Neary J.T. and Kang Y. (2004) P2 nucleotide receptors are coupled to glycogen synthase kinase-3beta in astrocytes. Soc. Neurosci. Abstr., Program No. 631.7.
    • (2004) Soc. Neurosci. Abstr.
    • Neary, J.T.1    Kang, Y.2
  • 39
    • 0036214603 scopus 로고    scopus 로고
    • Mood stabilizers., glycogen synthase kinase-3beta and cell survival
    • Jope R.S. and Bijur G.N. (2002) Mood stabilizers., glycogen synthase kinase-3beta and cell survival. Mol. Psychiatry 7 (Suppl. 1), S35-S45.
    • (2002) Mol. Psychiatry , vol.7 , Issue.1 SUPPL.
    • Jope, R.S.1    Bijur, G.N.2
  • 40
    • 0842320458 scopus 로고    scopus 로고
    • A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: Application to sepsis-apoptosis
    • Janes K.A., Albeck J.G., Peng L.X., Sorger P.K., Lauffenburger D.A., and Yaffe M.B. (2003) A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol. Cell. Proteomics 2, 463-473.
    • (2003) Mol. Cell. Proteomics , vol.2 , pp. 463-473
    • Janes, K.A.1    Albeck, J.G.2    Peng, L.X.3    Sorger, P.K.4    Lauffenburger, D.A.5    Yaffe, M.B.6
  • 41
    • 0031771017 scopus 로고    scopus 로고
    • In vitro central nervous system models of mechanically induced trauma: A review
    • Morrison B.I., Saatman K.E., Meaney D.F., and McIntosh T.K. (1998) In vitro central nervous system models of mechanically induced trauma: a review. J. Neurotrauma 15, 911-928.
    • (1998) J. Neurotrauma , vol.15 , pp. 911-928
    • Morrison, B.I.1    Saatman, K.E.2    Meaney, D.F.3    McIntosh, T.K.4
  • 42
    • 0037063692 scopus 로고    scopus 로고
    • The role of extracellular signal-regulated kinase in cognitive and motor deficits following experimental traumatic brain injury
    • Dash P.K., Mach S.A., and Moore A.N. (2002) The role of extracellular signal-regulated kinase in cognitive and motor deficits following experimental traumatic brain injury. Neuroscience 114, 755-767.
    • (2002) Neuroscience , vol.114 , pp. 755-767
    • Dash, P.K.1    Mach, S.A.2    Moore, A.N.3
  • 43
    • 0036208464 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase inhibition in traumatic brain injury: In vitro and in vivo effects
    • Mori T., Wang X., Jung J.C., et al. (2002) Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J. Cereb. Blood Flow Metab. 22, 444-452.
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 444-452
    • Mori, T.1    Wang, X.2    Jung, J.C.3
  • 44
    • 0036197012 scopus 로고    scopus 로고
    • Differential activation of mitogen-activated protein kinase pathways after traumatic brain injury in the rat hippocampus
    • Otani N., Nawashiro H., Fukui S., et al. (2002) Differential activation of mitogen-activated protein kinase pathways after traumatic brain injury in the rat hippocampus. J. Cereb. Blood Flow Metab. 22, 327-334.
    • (2002) J. Cereb. Blood Flow Metab. , vol.22 , pp. 327-334
    • Otani, N.1    Nawashiro, H.2    Fukui, S.3
  • 45
    • 0042986952 scopus 로고    scopus 로고
    • Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: Implications for posttraumatic cell death
    • Raghupathi R., Muir J.K., Fulp C.T., Pittman R.N., and McIntosh T.K. (2003) Acute activation of mitogen-activated protein kinases following traumatic brain injury in the rat: implications for posttraumatic cell death. Exp. Neurol. 183, 438-448.
    • (2003) Exp. Neurol. , vol.183 , pp. 438-448
    • Raghupathi, R.1    Muir, J.K.2    Fulp, C.T.3    Pittman, R.N.4    McIntosh, T.K.5
  • 46
    • 0037731544 scopus 로고    scopus 로고
    • Transient neuronal but persistent astroglial activation of ERK/MAP kinase after focal brain injury in mice
    • Carbonell W.S. and Mandell J.W. (2003) Transient neuronal but persistent astroglial activation of ERK/MAP kinase after focal brain injury in mice. J. Neurotrauma 20, 327-336.
    • (2003) J. Neurotrauma , vol.20 , pp. 327-336
    • Carbonell, W.S.1    Mandell, J.W.2
  • 47
    • 0036310821 scopus 로고    scopus 로고
    • Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats
    • Jenkins L.W., Peters G.W., Dixon C.E., et al. (2002) Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats. J. Neurotrauma 19, 715-740.
    • (2002) J. Neurotrauma , vol.19 , pp. 715-740
    • Jenkins, L.W.1    Peters, G.W.2    Dixon, C.E.3
  • 48
    • 0036237137 scopus 로고    scopus 로고
    • Akt phosphorylation and neuronal survival after traumatic brain injury in mice
    • Noshita N., Lewen A., Sugawara T., and Chan P.H. (2002) Akt phosphorylation and neuronal survival after traumatic brain injury in mice. Neurobiol. Dis. 9, 294-304.
    • (2002) Neurobiol. Dis. , vol.9 , pp. 294-304
    • Noshita, N.1    Lewen, A.2    Sugawara, T.3    Chan, P.H.4
  • 49
    • 0034655803 scopus 로고    scopus 로고
    • Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration
    • Namikawa K., Homma M., Abe K., et al. (2000) Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J. Neurosci. 20, 2875-2886.
    • (2000) J. Neurosci. , vol.20 , pp. 2875-2886
    • Namikawa, K.1    Homma, M.2    Abe, K.3
  • 50
    • 0028813422 scopus 로고
    • Astrogliosis in culture. IV. Effects of basic fibroblast growth factor
    • Hou Y.J., Yu A.C., Garcia J.M., et al. (1995) Astrogliosis in culture. IV. Effects of basic fibroblast growth factor. J. Neurosci. Res. 40, 359-370.
    • (1995) J. Neurosci. Res. , vol.40 , pp. 359-370
    • Hou, Y.J.1    Yu, A.C.2    Garcia, J.M.3
  • 51
    • 0034954305 scopus 로고    scopus 로고
    • Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: Evidence for a paracrine signal
    • Mandell J.W., Gocan N.C., and Vandenberg S.R. (2001) Mechanical trauma induces rapid astroglial activation of ERK/MAP kinase: evidence for a paracrine signal. Glia 34, 283-295.
    • (2001) Glia , vol.34 , pp. 283-295
    • Mandell, J.W.1    Gocan, N.C.2    Vandenberg, S.R.3
  • 52
    • 0029151874 scopus 로고
    • A new model for rapid stretch-induced injury of cells in culture: Characterization of the model using astrocytes
    • Ellis E.F., McKinney J.S., Willoughby K.A., Liang S., and Povlishock J.T. (1995) A new model for rapid stretch-induced injury of cells in culture: characterization of the model using astrocytes. J. Neurotrauma 12, 325-339.
    • (1995) J. Neurotrauma , vol.12 , pp. 325-339
    • Ellis, E.F.1    McKinney, J.S.2    Willoughby, K.A.3    Liang, S.4    Povlishock, J.T.5
  • 54
    • 0031746415 scopus 로고    scopus 로고
    • Intracellular free calcium dynamics in stretch-injured astrocytes
    • Rzigalinski B.A., Weber J.T., Willoughby K.A., and Ellis E.F. (1998) Intracellular free calcium dynamics in stretch-injured astrocytes. J. Neurochem. 70, 2377-2385.
    • (1998) J. Neurochem. , vol.70 , pp. 2377-2385
    • Rzigalinski, B.A.1    Weber, J.T.2    Willoughby, K.A.3    Ellis, E.F.4
  • 55
    • 0030992173 scopus 로고    scopus 로고
    • Alterations in phosphatidylcholine metabolism of stretch injured cultured rat astrocytes
    • Lamb R.G., Harper C.C., McKinney J.S., Rzigalinski B.A., and Ellis E.F. (1997) Alterations in phosphatidylcholine metabolism of stretch injured cultured rat astrocytes. J. Neurochem. 68, 1904-1910.
    • (1997) J. Neurochem. , vol.68 , pp. 1904-1910
    • Lamb, R.G.1    Harper, C.C.2    McKinney, J.S.3    Rzigalinski, B.A.4    Ellis, E.F.5
  • 56
    • 0035138917 scopus 로고    scopus 로고
    • Traumatic injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling
    • Floyd C.L., Rzigalinski B.A., Weber J.T., Sitterding H.A., Willoughby K.A., and Ellis E.F. (2001) Traumatic injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling. Glia 33, 12-23.
    • (2001) Glia , vol.33 , pp. 12-23
    • Floyd, C.L.1    Rzigalinski, B.A.2    Weber, J.T.3    Sitterding, H.A.4    Willoughby, K.A.5    Ellis, E.F.6
  • 57
    • 0029989457 scopus 로고    scopus 로고
    • Stretch-induced injury of cultured neuronal, glial, and endothelial cells
    • McKinney J.S., Willoughby K.A., Liang S., and Ellis E.F. (1996) Stretch-induced injury of cultured neuronal, glial, and endothelial cells. Stroke 27, 934-940.
    • (1996) Stroke , vol.27 , pp. 934-940
    • McKinney, J.S.1    Willoughby, K.A.2    Liang, S.3    Ellis, E.F.4
  • 58
    • 1242343630 scopus 로고    scopus 로고
    • Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes
    • Floyd C.L., Rzigalinski B.A., Sitterding H.A., Willoughby K.A., and Ellis E.F. (2004) Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes. J. Neurotrauma 21, 205-216.
    • (2004) J. Neurotrauma , vol.21 , pp. 205-216
    • Floyd, C.L.1    Rzigalinski, B.A.2    Sitterding, H.A.3    Willoughby, K.A.4    Ellis, E.F.5
  • 59
    • 0037444676 scopus 로고    scopus 로고
    • Activation of ERK by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors
    • Neary J.T., Kang Y., Willoughby K.A., and Ellis E.F. (2003) Activation of ERK by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors. J. Neurosci. 23, 2348-2356.
    • (2003) J. Neurosci. , vol.23 , pp. 2348-2356
    • Neary, J.T.1    Kang, Y.2    Willoughby, K.A.3    Ellis, E.F.4
  • 60
    • 10844258519 scopus 로고    scopus 로고
    • Mechanical strain activates protein kinase B/Akt in cultured astrocytes
    • Neary J.T. and Kang Y. (2003) Mechanical strain activates protein kinase B/Akt in cultured astrocytes. J. Neurotrauma 20, 1104.
    • (2003) J. Neurotrauma , vol.20 , pp. 1104
    • Neary, J.T.1    Kang, Y.2
  • 61
    • 0031754497 scopus 로고    scopus 로고
    • Receptors for purines and pyrimidines
    • Ralevic V. and Burnstock G. (1998) Receptors for purines and pyrimidines. Pharmacol. Rev. 50, 413-492.
    • (1998) Pharmacol. Rev. , vol.50 , pp. 413-492
    • Ralevic, V.1    Burnstock, G.2
  • 62
    • 24644459097 scopus 로고    scopus 로고
    • Role of ATP/P2 receptors in the activation of asrrocytic protein kinaseB/Akt by traumatic injury
    • Neary J.T. and Kang Y. (2003) Role of ATP/P2 receptors in the activation of asrrocytic protein kinaseB/Akt by traumatic injury. J. Rehab. Res. Dev. 40, 58.
    • (2003) J. Rehab. Res. Dev. , vol.40 , pp. 58
    • Neary, J.T.1    Kang, Y.2
  • 63
    • 24644438422 scopus 로고    scopus 로고
    • Mechanical strain activates glycogen synthase kinase-3beta in astrocytes
    • Neary J.T. and Kang Y. (2004) Mechanical strain activates glycogen synthase kinase-3beta in astrocytes. J. Neurotrauma, 21, 1283.
    • (2004) J. Neurotrauma , vol.21 , pp. 1283
    • Neary, J.T.1    Kang, Y.2
  • 64
    • 0034960228 scopus 로고    scopus 로고
    • CXCR4-activated astrocyte glutamate release via TNFalpha: Amplification by microglia triggers neurotoxicity
    • Bezzi P., Domercq M., Brambilla L., et al. (2001) CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat. Neurosci. 4, 702-710.
    • (2001) Nat. Neurosci. , vol.4 , pp. 702-710
    • Bezzi, P.1    Domercq, M.2    Brambilla, L.3
  • 65
    • 0032032424 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures
    • Bhat N.R., Zhang P., Lee J.C., and Hogan E.L. (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18, 1633-1641.
    • (1998) J. Neurosci. , vol.18 , pp. 1633-1641
    • Bhat, N.R.1    Zhang, P.2    Lee, J.C.3    Hogan, E.L.4
  • 66
    • 0028973275 scopus 로고
    • Metabotropic glutamate antagonist, MCPG, treatment of traumatic brain injury in rats
    • Gong Q.Z., Delahunty T.M., Hamm R.J., and Lyeth B.G. (1995) Metabotropic glutamate antagonist, MCPG, treatment of traumatic brain injury in rats. Brain Res. 700, 299-302.
    • (1995) Brain Res. , vol.700 , pp. 299-302
    • Gong, Q.Z.1    Delahunty, T.M.2    Hamm, R.J.3    Lyeth, B.G.4
  • 67
    • 24644508619 scopus 로고    scopus 로고
    • Roles of metabotropic glutamate receptors in spinal cord injury
    • Mills C.D., McAdoo D.J., and Hulsebosch C.E. (2001) Roles of metabotropic glutamate receptors in spinal cord injury. J. Neurotrauma 18, 1182.
    • (2001) J. Neurotrauma , vol.18 , pp. 1182
    • Mills, C.D.1    McAdoo, D.J.2    Hulsebosch, C.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.