Neuroscience: EGFR activation mediates inhibition of axon regeneration by myelin and chondroitin sulfate proteoglycans

Science

Volumn 310, Issue 5745, 2005, Pages 106-110

  Koprivica, Vuk ^a   Cho, Kin Sang ^b   Park, Jong Bae ^a   Yiu, Glenn ^a   Atwal, Jasvinder ^c   Gore, Bryan ^c   Kim, Jieun A ^a   Lin, Estelle ^a   Tessier Lavigne, Marc ^c   Chen, Dong Feng ^b   He, Zhigang ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ENZYMES; NEURAL NETWORKS; SIGNALING;

CENTRAL NERVOUS SYSTEM (CNS); KINASE FUNCTION; OPTIC NERVE FIBERS;

NEUROLOGY;

CHONDROITIN SULFATE; EPIDERMAL GROWTH FACTOR RECEPTOR; MYELIN; PHOSPHOTRANSFERASE; PROTEOGLYCAN; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CALCIUM; CELL SURFACE RECEPTOR; ENZYME INHIBITOR; ERLOTINIB; MYELIN PROTEIN; PROTEIN NOGO; PROTEOCHONDROITIN SULFATE; QUINAZOLINE DERIVATIVE; RTN4R PROTEIN, MOUSE; TYRPHOSTIN;

NEUROLOGY;

ADULT; ARTICLE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; NERVE FIBER GROWTH; NERVE FIBER REGENERATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; ANIMAL; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MOUSE; NERVE CRUSH; NERVE FIBER; NERVE REGENERATION; NEURITE; OPTIC NERVE; OPTIC NERVE INJURY; PHOSPHORYLATION; PHYSIOLOGY; RETINA GANGLION CELL; SIGNAL TRANSDUCTION;

ANIMALS; AXONS; CALCIUM; CELLS, CULTURED; ENZYME INHIBITORS; HUMANS; MICE; MYELIN PROTEINS; NERVE CRUSH; NERVE REGENERATION; NEURITES; OPTIC NERVE; OPTIC NERVE INJURIES; PHOSPHORYLATION; PROTEOCHONDROITIN SULFATES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CELL SURFACE; RETINAL GANGLION CELLS; SIGNAL TRANSDUCTION; TYRPHOSTINS;

EID: 26444459836     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1115462     Document Type: Article

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31. We thank G. Yiu, J. Flanagan, M. Greenberg, R, Meyer RL, J. Miotke, C. Stiles, and T. Schwarz for critically reading the manuscript and for discussions and Z. Wang for providing EGFR constructs. Supported by research grants from the National Institute of Neurological Diseases and Stroke, EJLB Foundation, and Patterson Fund (Z.H.) and the NIH (D.F.C.). Z.H. is a McKnight Scholar. V.K. is a recipient of NSF predoctoral fellowship. G.Y. is supported by an NIH training grant.