Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 23, 2005, Pages 8333-8338

  Di Giovanni, Simone ^a,b   Movsesyan, Vilen ^a,b   Ahmed, Farid ^a,b   Cernak, Ibolja ^a   Schinelli, Sergio ^b   Stoica, Bogdan ^a   Faden, Alan I ^a  

^a GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

Flavopiridol; Glial scar; Neuron; Trauma

Indexed keywords

CASPASE; CELL CYCLE PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; ETOPOSIDE; FLAVOPIRIDOL; OLOMOUCINE; ROSCOVITINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; ASTROCYTOSIS; ATTENUATION; BRAIN CORTEX; BRAIN INJURY; CELL CULTURE; CELL CYCLE; CELL CYCLE INHIBITION; CELL DEATH; CELL PROLIFERATION; COGNITION; CONTROLLED STUDY; DISABILITY; DNA DAMAGE; GLIA; HIPPOCAMPUS; INFLAMMATION; MALE; MICROGLIA; MOTOR ACTIVITY; NERVE REGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCAR FORMATION; TISSUE NECROSIS; TRAUMATIC BRAIN INJURY; UPREGULATION;

ANIMALS; APOPTOSIS; ASTROCYTES; BRAIN INJURIES; CASPASE 3; CASPASES; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CICATRIX; CYCLIN D1; CYCLIN-DEPENDENT KINASES; DNA DAMAGE; ETOPOSIDE; FLAVONOIDS; GENE EXPRESSION REGULATION; MALE; NEUROGLIA; NEUROPROTECTIVE AGENTS; PIPERIDINES; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 20444427615     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500989102     Document Type: Article

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