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Volumn 17, Issue 2, 2010, Pages 116-125

Evidences for antiosteoporotic and selective estrogen receptor modulator activity of silymarin compared with ethinylestradiol in ovariectomized rats

Author keywords

Ethinylestradiol; Hormone; Osteoporosis; Silymarin; Uterus

Indexed keywords

ALKALINE PHOSPHATASE; BIOLOGICAL MARKER; CALCIUM; CHOLESTEROL; ESTRADIOL; ESTROGEN RECEPTOR; ETHINYLESTRADIOL; FOLLITROPIN; LIPID; LUTEINIZING HORMONE; OSTEOCALCIN; PARATHYROID HORMONE; PHOSPHORUS; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SILYMARIN;

EID: 73449128972     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2009.05.012     Document Type: Article
Times cited : (46)

References (49)
  • 1
    • 3142590602 scopus 로고    scopus 로고
    • In vitro anti-resorptive activity and prevention of ovariectomy-induced osteoporosis in female Sprague-Dawley rats by ormeloxifene, a selective estrogen receptor modulator
    • Arshad M., Sengupta S., Sharma S., Ghosh R., Sawlani V., and Singh M.M. In vitro anti-resorptive activity and prevention of ovariectomy-induced osteoporosis in female Sprague-Dawley rats by ormeloxifene, a selective estrogen receptor modulator. J. Steroid Biochem. Mol. Biol. 91 (2004) 67-78
    • (2004) J. Steroid Biochem. Mol. Biol. , vol.91 , pp. 67-78
    • Arshad, M.1    Sengupta, S.2    Sharma, S.3    Ghosh, R.4    Sawlani, V.5    Singh, M.M.6
  • 2
    • 0015847281 scopus 로고
    • Performance of kits used for clinical chemical analysis of calcium in serum
    • Barnett R.N., Skodon S.B., and Goldberg M.H. Performance of kits used for clinical chemical analysis of calcium in serum. Am. J. Clin. Path. 59 (1973) 836-843
    • (1973) Am. J. Clin. Path. , vol.59 , pp. 836-843
    • Barnett, R.N.1    Skodon, S.B.2    Goldberg, M.H.3
  • 3
    • 0034773822 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators and coronary heart disease
    • Bian Z., Nilsson S., and Gustafsson J.A. Selective estrogen receptor modulators and coronary heart disease. Trends Cardiovasc. Med 11 (2001) 196-202
    • (2001) Trends Cardiovasc. Med , vol.11 , pp. 196-202
    • Bian, Z.1    Nilsson, S.2    Gustafsson, J.A.3
  • 5
    • 0034946756 scopus 로고    scopus 로고
    • Insulin-like growth factor-I deficiency
    • Camacho-Hubner C., and Savage M. Insulin-like growth factor-I deficiency. Horm. Res. 55 (2001) 17-20
    • (2001) Horm. Res. , vol.55 , pp. 17-20
    • Camacho-Hubner, C.1    Savage, M.2
  • 6
    • 0033828271 scopus 로고    scopus 로고
    • Regulation of the differentiation and function of osteoclasts
    • Chambers T.J. Regulation of the differentiation and function of osteoclasts. J. Pathol. 192 (2000) 4-13
    • (2000) J. Pathol. , vol.192 , pp. 4-13
    • Chambers, T.J.1
  • 7
    • 0033305438 scopus 로고    scopus 로고
    • Estrogen receptor null mice: what have we learned and where will they lead us?
    • Couse J.F., and Korach K.S. Estrogen receptor null mice: what have we learned and where will they lead us?. Endocr. Rev 20 (1999) 358-417
    • (1999) Endocr. Rev , vol.20 , pp. 358-417
    • Couse, J.F.1    Korach, K.S.2
  • 8
    • 33645993295 scopus 로고    scopus 로고
    • Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication
    • Crocenzi F.A., and Roma M.G. Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication. Curr. Med. Chem. 13 9 (2006) 1055-1074
    • (2006) Curr. Med. Chem. , vol.13 , Issue.9 , pp. 1055-1074
    • Crocenzi, F.A.1    Roma, M.G.2
  • 9
    • 0034095502 scopus 로고    scopus 로고
    • Bone mineral density and biochemical markers of bone turnover in peri- and postmenopausal women
    • Leo V., Ditto A., Marca A., Lanzetta D., Massafra C., and Morgante G. Bone mineral density and biochemical markers of bone turnover in peri- and postmenopausal women. Calcif. Tissue Int. 66 (2000) 263-267
    • (2000) Calcif. Tissue Int. , vol.66 , pp. 263-267
    • Leo, V.1    Ditto, A.2    Marca, A.3    Lanzetta, D.4    Massafra, C.5    Morgante, G.6
  • 10
    • 0023857454 scopus 로고
    • Effects of estradiol and progesterone on parathyroid hormone secretion from human parathyroid tissue
    • Duarte B., Hargis G.K., and Kukreja S.C. Effects of estradiol and progesterone on parathyroid hormone secretion from human parathyroid tissue. J. Clin. Endocrinol. Metab. 66 (1988) 584-587
    • (1988) J. Clin. Endocrinol. Metab. , vol.66 , pp. 584-587
    • Duarte, B.1    Hargis, G.K.2    Kukreja, S.C.3
  • 12
    • 0019306826 scopus 로고
    • Determination of serum-phosphate without deproteinization by ultraviolet spectrophotometry of the phosphomolybdic acid complex
    • Gamst O., and Try K. Determination of serum-phosphate without deproteinization by ultraviolet spectrophotometry of the phosphomolybdic acid complex. Scand. J. Clin. Lab. Invest. 40 (1980) 483-486
    • (1980) Scand. J. Clin. Lab. Invest. , vol.40 , pp. 483-486
    • Gamst, O.1    Try, K.2
  • 13
    • 0025910730 scopus 로고    scopus 로고
    • Interrelationship of thyroid and sex functions in males
    • Gladkova A.I., and Karpenova N.A. Interrelationship of thyroid and sex functions in males. Probl. Endokrinol. (Mosk). 37 (1999) 56-59
    • (1999) Probl. Endokrinol. (Mosk). , vol.37 , pp. 56-59
    • Gladkova, A.I.1    Karpenova, N.A.2
  • 14
    • 47949119216 scopus 로고    scopus 로고
    • Estrogen receptor alpha signaling pathways differentially regulate gonadotropin subunit gene expression and serum FSH in the female mouse
    • [Epub ahead of print]
    • Glidewell-Kenney C., Weiss J., Hurley L.A., Levine J.E., and Jameson J.L. Estrogen receptor alpha signaling pathways differentially regulate gonadotropin subunit gene expression and serum FSH in the female mouse. Endocrinology (2008) [Epub ahead of print]
    • (2008) Endocrinology
    • Glidewell-Kenney, C.1    Weiss, J.2    Hurley, L.A.3    Levine, J.E.4    Jameson, J.L.5
  • 16
    • 0033749264 scopus 로고    scopus 로고
    • Increased adipose tissue in male and female estrogen receptor-alpha knockout mice
    • Heine P.A., Taylor J.A., Iwamoto G.A., Lubahn D.B., and Cooke P.S. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc. Natl. Acad. Sci. USA 97 23 (2000) 12729-12734
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , Issue.23 , pp. 12729-12734
    • Heine, P.A.1    Taylor, J.A.2    Iwamoto, G.A.3    Lubahn, D.B.4    Cooke, P.S.5
  • 17
    • 34249072897 scopus 로고    scopus 로고
    • The bone-protective effect of the phytoestrogen genistein is mediated via ERα- dependent mechanisms and strongly enhanced by physical activity
    • Hertrampf T., Gruca M.J., Seibel J., Laudenbach U., Fritzemeier K.H., and Diel P. The bone-protective effect of the phytoestrogen genistein is mediated via ERα- dependent mechanisms and strongly enhanced by physical activity. Bone 40 6 (2007) 1529-1535
    • (2007) Bone , vol.40 , Issue.6 , pp. 1529-1535
    • Hertrampf, T.1    Gruca, M.J.2    Seibel, J.3    Laudenbach, U.4    Fritzemeier, K.H.5    Diel, P.6
  • 19
    • 33748136432 scopus 로고    scopus 로고
    • Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model
    • Hidaka S., Okamoto Y., Uchiyama S., Nakatsuma A., Hashimoto K., Tsuyoshi Ohnishi S., and Yamaguchi M. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. eCAM 3 3 (2006) 339-348
    • (2006) eCAM , vol.3 , Issue.3 , pp. 339-348
    • Hidaka, S.1    Okamoto, Y.2    Uchiyama, S.3    Nakatsuma, A.4    Hashimoto, K.5    Tsuyoshi Ohnishi, S.6    Yamaguchi, M.7
  • 20
    • 35349000057 scopus 로고    scopus 로고
    • Contraceptive and hormonal properties of the stem bark of Dysoxylum binectariferum in rat and docking analysis of rohitukine, the alkaloid isolated from active chloroform soluble fraction
    • Keshri G., Oberoi R.M., Lakshmi V., Pandey K., and Singh M.M. Contraceptive and hormonal properties of the stem bark of Dysoxylum binectariferum in rat and docking analysis of rohitukine, the alkaloid isolated from active chloroform soluble fraction. Contraception 76 (2007) 400-407
    • (2007) Contraception , vol.76 , pp. 400-407
    • Keshri, G.1    Oberoi, R.M.2    Lakshmi, V.3    Pandey, K.4    Singh, M.M.5
  • 21
    • 77049203740 scopus 로고
    • Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine
    • Kind P.R.N., and King E.J. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J. Clin. Path. 7 (1954) 322-326
    • (1954) J. Clin. Path. , vol.7 , pp. 322-326
    • Kind, P.R.N.1    King, E.J.2
  • 22
    • 0015307920 scopus 로고
    • Estimation of total lipids in serum and tissues
    • Knight J.A., Anderson S., and Rawlem J.M. Estimation of total lipids in serum and tissues. Clin. Chem. 18 (1972) 199-201
    • (1972) Clin. Chem. , vol.18 , pp. 199-201
    • Knight, J.A.1    Anderson, S.2    Rawlem, J.M.3
  • 28
    • 0034529292 scopus 로고    scopus 로고
    • Links among growth factors, hormones, and nuclear factors with essential roles in bone formation
    • McCarthy T.L., Ji C., and Centrella M. Links among growth factors, hormones, and nuclear factors with essential roles in bone formation. Crit. Rev. Oral Biol. Med. 11 (2000) 409-422
    • (2000) Crit. Rev. Oral Biol. Med. , vol.11 , pp. 409-422
    • McCarthy, T.L.1    Ji, C.2    Centrella, M.3
  • 29
    • 0029044661 scopus 로고
    • Oestrogens and calcium regulatory hormones: potential implications for bone
    • Naveh-Many T., Epstein E., and Silver J. Oestrogens and calcium regulatory hormones: potential implications for bone. Curr. Opin. Nephrol. Hypertens 4 4 (1995) 319-323
    • (1995) Curr. Opin. Nephrol. Hypertens , vol.4 , Issue.4 , pp. 319-323
    • Naveh-Many, T.1    Epstein, E.2    Silver, J.3
  • 32
    • 0028783576 scopus 로고
    • The effect of ovariectomy on bone metabolism in rats
    • Omi N., and Ezawa I. The effect of ovariectomy on bone metabolism in rats. Bone 17 (1995) 163S-168S
    • (1995) Bone , vol.17
    • Omi, N.1    Ezawa, I.2
  • 33
  • 34
    • 0015719916 scopus 로고
    • Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum
    • Richmond W. Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin. Chem. 19 12 (1973) 1350-1356
    • (1973) Clin. Chem. , vol.19 , Issue.12 , pp. 1350-1356
    • Richmond, W.1
  • 35
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial
    • Rossouw J.E., Anderson G.L., Prentice R.L., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health initiative randomized controlled trial. J.A.M.A 288 (2002) 321-333
    • (2002) J.A.M.A , vol.288 , pp. 321-333
    • Rossouw, J.E.1    Anderson, G.L.2    Prentice, R.L.3
  • 36
    • 0027207230 scopus 로고
    • Effect of weight manipulation on bone loss due to ovariectomy and the protective effects of estrogen in the rat
    • Roudebush R.E., Magee D.E., Benslay D.N., Bendele A.M., and Bryant H.U. Effect of weight manipulation on bone loss due to ovariectomy and the protective effects of estrogen in the rat. Calcif. Tissue Int. 53 1 (1993) 61-64
    • (1993) Calcif. Tissue Int. , vol.53 , Issue.1 , pp. 61-64
    • Roudebush, R.E.1    Magee, D.E.2    Benslay, D.N.3    Bendele, A.M.4    Bryant, H.U.5
  • 37
    • 0030824020 scopus 로고    scopus 로고
    • Expression of oestrogen receptor beta (ERβ) in multiple rat tissues visualized by immunohistochemistry
    • Saunders P.T.K., Maguire S.M., Gaughan J., and Millar M.R. Expression of oestrogen receptor beta (ERβ) in multiple rat tissues visualized by immunohistochemistry. J. Endocrinol. 154 (1997) R13-R16
    • (1997) J. Endocrinol. , vol.154
    • Saunders, P.T.K.1    Maguire, S.M.2    Gaughan, J.3    Millar, M.R.4
  • 38
    • 0141953283 scopus 로고    scopus 로고
    • Silymarin is a selective estrogen receptor β (ERβ) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in uterus of ovariectomized (ovx) rats
    • Seidlová-Wuttke D., Becker T., Christoffel V., Jarry H., and Wuttke W. Silymarin is a selective estrogen receptor β (ERβ) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in uterus of ovariectomized (ovx) rats. J. Steroid Biochem. Mol. Biol. 86 (2003) 179-188
    • (2003) J. Steroid Biochem. Mol. Biol. , vol.86 , pp. 179-188
    • Seidlová-Wuttke, D.1    Becker, T.2    Christoffel, V.3    Jarry, H.4    Wuttke, W.5
  • 39
    • 0142216493 scopus 로고    scopus 로고
    • Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta
    • Seidlová-Wuttke D., Hesse O., Jarry H., Christoffel V., Spengler B., Becker T., and Wuttke W. Evidence for selective estrogen receptor modulator activity in a black cohosh (Cimicifuga racemosa) extract: comparison with estradiol-17beta. Eur. J. Endocrinol. 149 4 (2003) 351-362
    • (2003) Eur. J. Endocrinol. , vol.149 , Issue.4 , pp. 351-362
    • Seidlová-Wuttke, D.1    Hesse, O.2    Jarry, H.3    Christoffel, V.4    Spengler, B.5    Becker, T.6    Wuttke, W.7
  • 41
    • 0032797573 scopus 로고    scopus 로고
    • Stimulatory effect of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells
    • Sonnenbichler J., Scalera F., Sonnenbichler I., and Weyhenmeyer R. Stimulatory effect of silibinin and silicristin from the milk thistle Silybum marianum on kidney cells. J. Pharm. Exp. Ther 290 (1999) 1375-1383
    • (1999) J. Pharm. Exp. Ther , vol.290 , pp. 1375-1383
    • Sonnenbichler, J.1    Scalera, F.2    Sonnenbichler, I.3    Weyhenmeyer, R.4
  • 42
    • 0023714602 scopus 로고
    • Specific binding of a flavonolignane derivative to an estradiol receptor
    • Cody V., Middleton E., Karbone J.B., and Berck A. (Eds), Alan R. Liss Inc., New York
    • Sonnenbichler J., and Zetl I. Specific binding of a flavonolignane derivative to an estradiol receptor. In: Cody V., Middleton E., Karbone J.B., and Berck A. (Eds). Progress in Clinical and Biological Research vol. 280 (1988), Alan R. Liss Inc., New York 369-374
    • (1988) Progress in Clinical and Biological Research , vol.280 , pp. 369-374
    • Sonnenbichler, J.1    Zetl, I.2
  • 43
    • 0035937747 scopus 로고    scopus 로고
    • Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation
    • Srivastava S., Toraldo G., Weitzmann M.N., Cenci S., Ross F.P., and Pacifici R. Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-kappa B ligand (RANKL)-induced JNK activation. J. Biol. Chem. 276 12 (2000) 8836-8840
    • (2000) J. Biol. Chem. , vol.276 , Issue.12 , pp. 8836-8840
    • Srivastava, S.1    Toraldo, G.2    Weitzmann, M.N.3    Cenci, S.4    Ross, F.P.5    Pacifici, R.6
  • 44
    • 0034748181 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover
    • Swaminathan R. Biochemical markers of bone turnover. Clin. Chim. Acta 313 (2001) 95-105
    • (2001) Clin. Chim. Acta , vol.313 , pp. 95-105
    • Swaminathan, R.1
  • 45
    • 0033838036 scopus 로고    scopus 로고
    • Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays
    • Tinwell H., Soames A.R., Foster J.R., and Ashby J. Estradiol-type activity of coumestrol in mature and immature ovariectomized rat uterotrophic assays. Environ. Health Prespect. 108 (2000) 631-634
    • (2000) Environ. Health Prespect. , vol.108 , pp. 631-634
    • Tinwell, H.1    Soames, A.R.2    Foster, J.R.3    Ashby, J.4
  • 46
    • 0033532876 scopus 로고    scopus 로고
    • Risk of endometrial cancer following estrogen replacement with and without progestins
    • Weiderpass E., Adami H.O., Baron J.A., et al. Risk of endometrial cancer following estrogen replacement with and without progestins. J. Natl. Cancer Inst. 91 (1999) 1131-1137
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1131-1137
    • Weiderpass, E.1    Adami, H.O.2    Baron, J.A.3
  • 47
    • 0032748023 scopus 로고    scopus 로고
    • Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ER-β-/- mice
    • Windahl S.H., Vidal O., Andersson G., Gustafsson J.A., and Ohlsson C. Increased cortical bone mineral content but unchanged trabecular bone mineral density in female ER-β-/- mice. J. Clin. Invest. 104 (1999) 895-901
    • (1999) J. Clin. Invest. , vol.104 , pp. 895-901
    • Windahl, S.H.1    Vidal, O.2    Andersson, G.3    Gustafsson, J.A.4    Ohlsson, C.5
  • 48
    • 0023690523 scopus 로고
    • Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats
    • Wronski T.J., Cintron M., Doherty A.L., and Dann L.M. Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123 (1988) 681-686
    • (1988) Endocrinology , vol.123 , pp. 681-686
    • Wronski, T.J.1    Cintron, M.2    Doherty, A.L.3    Dann, L.M.4
  • 49
    • 33748803008 scopus 로고    scopus 로고
    • Modulatory effects of Aroclors 1221 and 1254 on bone turnover and vertebral histology in intact and ovariectomized rats
    • Yilmaz B., Seyran A.D., Sandal S., Aydin M., Colakoglu N., Kocer M., and Carpenter D.O. Modulatory effects of Aroclors 1221 and 1254 on bone turnover and vertebral histology in intact and ovariectomized rats. Toxicol. Lett. 166 (2006) 276-284
    • (2006) Toxicol. Lett. , vol.166 , pp. 276-284
    • Yilmaz, B.1    Seyran, A.D.2    Sandal, S.3    Aydin, M.4    Colakoglu, N.5    Kocer, M.6    Carpenter, D.O.7


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