Colon cancer chemopreventive efficacy of silibinin through perturbation of xenobiotic metabolizing enzymes in experimental rats

European Journal of Pharmacology

Volumn 674, Issue 2-3, 2012, Pages 430-438

  Sangeetha, Nagarajan ^a   Viswanathan, Periyaswamy ^a   Balasubramanian, Thangavel ^a   Nalini, Namasivayam ^a  

^a ANNAMALAI UNIVERSITY   (India)

Author keywords

Chemoprevention; Colon cancer; Oxidative stress; Silibinin; Xenobiotic metabolizing enzyme

Indexed keywords

1,2 DIMETHYLHYDRAZINE; CATALASE; CYTOCHROME B5; CYTOCHROME B5 REDUCTASE; CYTOCHROME P450; CYTOCHROME P450 2E1; CYTOCHROME P450 REDUCTASE; DRUG METABOLIZING ENZYME; GLUCURONOSYLTRANSFERASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LIPID HYDROPEROXIDE; REACTIVE OXYGEN METABOLITE; SILIBININ; SUPEROXIDE DISMUTASE; XENOBIOTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CHEMOPROPHYLAXIS; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; CYTOSOLIC FRACTION; DRUG DETOXIFICATION; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; LIPID PEROXIDATION; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT;

1,2-DIMETHYLHYDRAZINE; ANIMALS; ANTIOXIDANTS; COLON; COLONIC NEOPLASMS; LIPID PEROXIDATION; LIPIDS; LIVER; MALE; RATS; RATS, WISTAR; SILYMARIN; TUMOR BURDEN; XENOBIOTICS;

EID: 84855560688     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.008     Document Type: Article

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