Silibinin attenuates allergic airway inflammation in mice

Biochemical and Biophysical Research Communications

Volumn 427, Issue 3, 2012, Pages 450-455

  Choi, Yun Ho ^a   Jin, Guang Yu ^b   Guo, Hui Shu ^c   Piao, Hong Mei ^b   Li, Liang chang ^b   Li, Guang Zhao ^b   Lin, Zhen Hua ^b   Yan, Guang Hai ^b  

^a Chonbuk National University   (South Korea)

^b YANBIAN UNIVERSITY   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

Airway inflammation; Asthma; NF B; Silibinin; Th2 cytokine

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; OVALBUMIN; SILIBININ; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC AIRWAY INFLAMMATION; ALLERGIC ASTHMA; ARTICLE; CELLULAR IMMUNITY; DENSITOMETRY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOPATHOLOGY; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH2 CELL;

ANIMALS; ANTIOXIDANTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; FEMALE; MICE; MICE, INBRED BALB C; MILK THISTLE; PNEUMONIA; SILYMARIN; TH2 CELLS;

MUS; SILYBUM MARIANUM;

EID: 84867850255     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.07.112     Document Type: Article

References (29)

1. Galli S.J., Tsai M., Piliponsky A.M. The development of allergic inflammation. Nature 2008, 454:445-454.
2. Medoff B.D., Thomas S.Y., Luster A.D. T cell trafficking in allergic asthma: the ins and outs. Annu. Rev. Immunol. 2008, 26:205-232.
3. Choi Y.H., Yan G.H. Silibinin attenuates mast cell-mediated anaphylaxis-like reactions. Biol. Pharm. Bull. 2009, 32:868-875.
4. Burrows B., Martinez F.D., Halonen M., Barbee R.A., Cline M.G. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N. Engl. J. Med. 1989, 320:271-277.
5. Burrows B. Allergy and the development of asthma and bronchial hyperresponsiveness. Clin. Exp. Allergy 1995, 25(Suppl. 2):15-16.
6. Choi I.W., Kim D.K., Ko H.M., Lee H.K. Administration of antisense phosphorothioate oligonucleotide to the p65 subunit of NF-kappaB inhibits established asthmatic reaction in mice. Int. Immunopharmacol. 2004, 4:1817-1828.
7. Cheung C.W., Gibbons N., Johnson D.W., Nicol D.L. Silibinin - a promising new treatment for cancer. Anticancer Agents Med. Chem. 2010, 10:186-195.
8. Gazak R., Walterova D., Kren V. Silybin and silymarin - new and emerging applications in medicine. Curr. Med. Chem. 2007, 14:315-338.
9. Lecomte J. General pharmacologic properties of silybine and silymarine in the rat. Arch. Int. Pharmacodyn. Ther. 1975, 214:165-176.
10. Miadonna A., Tedeschi A., Leggieri E., Lorini M., Froldi M., Zanussi C. Effects of silybin on histamine release from human basophil leucocytes. Br. J. Clin. Pharmacol. 1987, 24:747-752.
11. Breschi M.C., Martinotti E., Apostoliti F., Nieri P. Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs. Eur. J. Pharmacol. 2002, 437:91-95.
12. Kang J.S., Yoon W.K., Han M.H., Lee H., Lee C.W., Lee K.H., Han S.B., Lee K., Yang K.H., Park S.K., Kim H.M. Inhibition of atopic dermatitis by topical application of silymarin in NC/Nga mice. Int. Immunopharmacol. 2008, 8:1475-1480.
13. Kuo F.H., Jan T.R. Silibinin attenuates antigen-specific IgE production through the modulation of Th1/Th2 balance in ovalbumin-sensitized BALB/c mice. Phytomedicine 2009, 16:271-276.
14. Lee K.S., Kim S.R., Park H.S., Park S.J., Min K.H., Lee K.Y., Choe Y.H., Hong S.H., Han H.J., Lee Y.R., Kim J.S., Atlas D., Lee Y.C. A novel thiol compound, N-acetylcysteine amide, attenuates allergic airway disease by regulating activation of NF-kappaB and hypoxia-inducible factor-1alpha. Exp. Mol. Med. 2007, 39:756-768.
15. Koch M., Witzenrath M., Reuter C., Herma M., Schutte H., Suttorp N., Collins H., Kaufmann S.H. Role of local pulmonary IFN-gamma expression in murine allergic airway inflammation. Am. J. Respir. Cell Mol. Biol. 2006, 35:211-219.
16. Janssen-Heininger Y.M., Poynter M.E., Aesif S.W., Pantano C., Ather J.L., Reynaert N.L., Ckless K., Anathy V., van der Velden J., Irvin C.G., van der Vliet A. Nuclear factor kappaB, airway epithelium, and asthma: avenues for redox control. Proc. Am. Thorac. Soc. 2009, 6:249-255.
17. Jacobsen E.A., Ochkur S.I., Lee N.A., Lee J.J. Eosinophils and asthma. Curr. Allergy Asthma Rep. 2007, 7:18-26.
18. Lukacs N.W. Role of chemokines in the pathogenesis of asthma. Nat. Rev. Immunol. 2001, 1:108-116.
19. Mattes J., Foster P.S. Regulation of eosinophil migration and Th2 cell function by IL-5 and eotaxin. Curr. Drug Targets Inflamm. Allergy 2003, 2:169-174.
20. Renauld J.C. New insights into the role of cytokines in asthma. J. Clin. Pathol. 2001, 54:577-589.
21. Li L., Xia Y., Nguyen A., Lai Y.H., Feng L., Mosmann T.R., Lo D. Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J. Immunol. 1999, 162:2477-2487.
22. Boyce J.A., Broide D., Matsumoto K., Bochner B.S. Advances in mechanisms of asthma, allergy, and immunology in 2008. J. Allergy Clin. Immunol. 2009, 123:569-574.
23. Wegmann M. Th2 cells as targets for therapeutic intervention in allergic bronchial asthma. Expert Rev. Mol. Diagn. 2009, 9:85-100.
24. Cockcroft D.W., Davis B.E. Mechanisms of airway hyperresponsiveness. J. Allergy Clin. Immunol. 2006, 118:551-559. quiz 560-551.
25. Gleich G.J. Mechanisms of eosinophil-associated inflammation. J. Allergy Clin. Immunol. 2000, 105:651-663.
26. Vargaftig B.B., Singer M. Leukotrienes mediate murine bronchopulmonary hyperreactivity, inflammation, and part of mucosal metaplasia and tissue injury induced by recombinant murine interleukin-13. Am. J. Respir. Cell Mol. Biol. 2003, 28:410-419.
27. Brightling C., Berry M., Amrani Y. Targeting TNF-alpha: a novel therapeutic approach for asthma. J. Allergy Clin. Immunol. 2008, 121:5-10. quiz 11-12.
28. Mayr S.I., Zuberi R.I., Zhang M., de Sousa-Hitzler J., Ngo K., Kuwabara Y., Yu L., Fung-Leung W.P., Liu F.T. IgE-dependent mast cell activation potentiates airway responses in murine asthma models. J. Immunol. 2002, 169:2061-2068.
29. Imanifooladi A.A., Yazdani S., Nourani M.R. The role of nuclear factor-kappaB in inflammatory lung disease. Inflamm. Allergy Drug Targets 2010, 9:197-205.