Silibinin triggers apoptosis and cell-cycle arrest of SGC7901 cells

Phytotherapy Research

Volumn 27, Issue 3, 2013, Pages 397-403

  Zhang, Yuanxin ^a,b   Li, Quanshun ^a   Ge, Yakun ^b,c   Chen, Yunpeng ^a   Chen, Jun ^d   Dong, Ying ^d   Shi, Wei ^a  

^a JILIN UNIVERSITY   (China)

^b JILIN INSTITUTE OF CHEMICAL TECHNOLOGY   (China)

^c CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY   (China)

^d JIANGSU UNIVERSITY   (China)

Author keywords

apoptosis; cell cycle arrest; gastric cancer; p21; p53; Silibinin

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; MESSENGER RNA; PROTEIN P21; PROTEIN P53; SILIBININ;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER INHIBITION; CELL CYCLE ARREST; CELL LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN EXPRESSION; STOMACH CANCER;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; HUMANS; SILYMARIN;

EID: 84874930819     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4733     Document Type: Article

References (34)

1. Agarwal R,. 2000. Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochem Pharmacol 60: 1051-1059.
2. Agarwal C, Singh RP, Dhanalakshmi S, et al,. 2003. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene 22: 8271-8282. (Pubitemid 37485520)
3. Braun CJ, Zhang X, Savelyeva I, et al,. 2008. p53-responsive microRNAs 192 and 215 are capable of inducing cell cycle arrest. Cancer Res 68: 10094-10104.
4. Chapla A, Rana PS, Sivanandhan D, et al,. 2003. Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene 22: 8271-8282.
5. Deep G, Agarwal R,. 2010. Antimetastatic efficacy of Silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev 29: 447-463.
6. El-Deiry WS, Tokino T, Velculescu VE, et al,. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75: 817-825. (Pubitemid 23346378)
7. Fischer PM,. 2001. Recent advances and new directions in the discovery and development of cyclin-dependent kinase inhibitors. Curr Opin Drug Discov Devel 4: 623-634. (Pubitemid 32904859)
8. Flora K, Hahn M, Rosen H, Benner K,. 1998. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol 93 (2): 139-143. (Pubitemid 29063954)
9. Hahn G, Lehmann HD, Kürten M, Uebel H, Vogel G,. 1968. On the pharmacology and toxicology of silymarin, an antihepatotoxic active principle from Silybum marianum (L.) Gaertn. Arzneimittelforschung 18 (6): 698-704.
10. Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS,. 2007. Flavonoid, Silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res 143: 58-65. (Pubitemid 47562449)
11. Huang X, Zhang Z, Jia L, Zhao Y, Zhang X, Wu K,. 2010. Endoplasmic reticulum stress contributes to vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells. Cancer Lett 296: 123-131.
12. Jozefa WG, Marieta G, Marcel H,. 2003. Dual action of cyclin-dependent kinase inhibitors: induction of cell cycle arrest and apoptosis. A comparison of the effects exerted by roscovitine and cisplatin. Pol J Pharmacol 55: 895-902.
13. Katiyar SK, Korman NJ, Mukhtar H, Agarwal R,. 1997. Protective effects of silymarin against photocarcinogenesis in a mouse skin model. J Natl Cancer Inst 89: 556-566. (Pubitemid 27172945)
14. Kim HO, Choi HK, Ha ES, et al,. 2010. Silibinin induces apoptosis by downregulating survivin through inhibition of hypoxia-inducible factor-1 alpha in non-small cell lung cancer cells. J Thorac Oncol 5: S248.
15. Kim S, Choi MG, Lee HS, Lee SK, Kim SH, Kim WW,. 2009. Silibinin suppresses TNF-alpha induced MMP-9 expression in gastric cancer cells through inhibition of the MAPK pathway. Molecules 14 (11): 4300-4311.
16. Klaus-Michael D, Delphine P, Guido K,. 2002. Chemotherapy: targeting the mitochondrial cell death pathway. Oncogene 21: 8786-8803.
17. Li L, Gao Y, Zhang L, Zeng J, He D, Sun Y,. 2008. Silinbinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma. Cancer Lett 272: 61-69.
18. Marine JC, Lozano G,. 2010. Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death Differ 17: 93-102.
19. Meyerson M, Harlow E,. 1994. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol 14: 2077-2086.
20. Neehar B, Rajesh A,. 2001. Detrimental effect of cancer preventive phytochemicals silymarin, genistein and epigallocatechin 3-gallate on epigenetic events in human prostate carcinoma DU145 cells. Prostate 46: 98-107.
21. Ohtani S, Kagawa S, Tango Y, et al,. 2004. Quantitative analysis of p53-targeted gene expression and visualization of p53 transcriptional activity following intratumoral administration of adenoviral p53 in vivo. Mol Cancer Ther 3: 93-100. (Pubitemid 39193682)
22. Petak I, Houghton JA,. 2001. Shared pathways: death receptors and cytotoxic drugs in cancer therapy. Pathol Oncol Res 7: 95-106. (Pubitemid 32729759)
23. Samiha M, Alpna T, Chapla A, Rana PS, Rajesh A,. 2010. Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators. Mol Carcinog 49: 247-258.
24. Scott WL, Athena WL,. 2000. Apoptosis in cancer. Carcinogenesis 21: 485-495.
25. Singh RP, Dhanalakshmi S, Agarwal R,. 2002a. Phytochemicals as cell cycle modulators-a less toxic approach in halting human cancers. Cell Cycle 1: 156-161.
26. Singh RP, Dhanalakshmi S, Tyagi AK, Chan DC, Agarwal C, Agarwal R,. 2002b. Dietary feeding of Silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels. Cancer Res 62: 3063-3069. (Pubitemid 34602396)
27. Swanton C., 2004. Cell-cycle targeted therapies. Lancet Oncol 5: 27-36. (Pubitemid 38072557)
28. Tyagi A, Singh RP, Agarwal C, Agarwal R,. 2006. Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: Evidence for a regulatory loop between p53 and caspase 2. Carcinogenesis 27: 2269-2280. (Pubitemid 44644816)
29. Tyagi AK, Singh RP, Agarwal C, Chan DC, Agarwal R,. 2002. Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G2-M arrest, and apoptosis. Clin Cancer Res 8: 3512-3519. (Pubitemid 35340729)
30. Venkateswaran V, Fleshner, NE, Klotz LH,. 2002. Modulation of cell proliferation and cell cycle regulators by vitamin E in human prostate carcinoma cell lines. J Urol 168: 1578-1582. (Pubitemid 35034193)
31. Vogel G, Trost W, Braatz R, et al,. 1975. Pharmacodynamics, site and mechanism of action of silymarin, the antihepatoxic principle from Silybum mar. (L) Gaertn. 1. Acute toxicology or tolerance, general and specific (liver-) pharmacology. Arzneimittelforschung 25 (1): 82-89.
32. Wellington K, Jarvis B,. 2001. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs 15 (7): 465-489. (Pubitemid 32783707)
33. Xing C, Zhu B, Liu H, Yao H, Zhang L,. 2008. Class I phosphatidylinositol 3-kinase inhibitor LY294002 activates autophagy and induces apoptosis through p53 pathway in gastric cancer cell line SGC-7901. Acta Biochim Biophys Sin 40: 194-201. (Pubitemid 351422572)
34. Zhu X, Li J,. 2010. Gastric carcinoma in China: current status and future perspectives (Review). Oncol Lett 3: 407-412.