Alterations in sulfur amino acid metabolism in mice treated with silymarin: A novel mechanism of its action involved in enhancement of the antioxidant defense in liver

Planta Medica

Volumn 79, Issue 12, 2013, Pages 997-1002

  Kwon, Do Young ^a   Jung, Young Suk ^a   Kim, Sun Ju ^a   Kim, Young Soon ^b   Choi, Dal Woong ^b   Kim, Young Chul ^a  

^a Seoul National University   (South Korea)

^b Korea University   (South Korea)

Author keywords

antioxidant; Asteraceae; glutathione; Silybum marianum; silymarin; sulfur amino acid metabolism

Indexed keywords

CYSTATHIONINE; CYSTATHIONINE BETA SYNTHASE; CYSTEINE; CYSTEINE DIOXYGENASE; GLUTATHIONE; HOMOCYSTEINE; HYPOTAURINE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; OXYGEN RADICAL; PEROXY RADICAL; PEROXYNITRITE; S ADENOSYLMETHIONINE; SILYMARIN; SULFUR AMINO ACID; TAURINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVITY; LIPID LIVER LEVEL; LIPID PEROXIDATION; LIVER CYTOSOL; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ASTERACEAE; MUS; SILYBUM MARIANUM;

AMINO ACIDS, SULFUR; ANIMALS; ANTIOXIDANTS; GLUTATHIONE; LIPID PEROXIDATION; LIVER; MALE; METHIONINE ADENOSYLTRANSFERASE; MICE; MILK THISTLE; SILYMARIN; SULFUR; TAURINE;

EID: 84882919360     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0032-1328704     Document Type: Article

References (30)

1. Song Z., Deaciuc I., Song M., Lee D. Y., Liu Y., Ji X., McClain C. Silymarin protects against acute ethanol-induced hepatotoxicity in mice. Alcohol Clin Exp Res: 2006; 30 407 413 (Pubitemid 43341346)
2. Pradeep K., Mohan C. V., Gobianand K., Karthikeyan S. Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. Eur J Pharmacol: 2007; 560 110 116 (Pubitemid 46341309)
3. Lettéron P., Labbe G., Degott C., Berson A., Fromenty B., Delaforge M., Larrey D., Pessayre D. Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice. Evidence that silymarin acts both as an inhibitor of metabolic activation and as a chain-breaking antioxidant. Biochem Pharmacol: 1990; 39 2027 2034 (Pubitemid 20187342)
4. Bindoli A., Cavallini L., Siliprandi N. Inhibitory action of silymarin of lipid peroxide formation in rat liver mitochondria and microsomes. Biochem Pharmacol: 1977; 26 2405 2409 (Pubitemid 8211113)
5. Varga Z., Seres I., Nagy E., Ujhelyi L., Balla G., Balla J., Antus S. Structure prerequisite for antioxidant activity of silybin in different biochemical systems in vitro. Phytomedicine: 2006; 13 85 93 (Pubitemid 41797595)
6. Dehmlow C., Murawski N., de Groot H. Scavenging of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sci: 1996; 58 1591 1600 (Pubitemid 26129234)
7. Comoglio A., Tomasi A., Malandrino S., Poli G., Albano E. Scavenging effect of silipide, a new silybin-phospholipid complex, on ethanol-derived free radicals. Biochem Pharmacol: 1995; 50 1313 1316
8. Valenzuela A., Lagos C., Schmidt K., Videla L. A. Silymarin protection against hepatic lipid peroxidation induced by acute ethanol intoxication in the rat. Biochem Pharmacol: 1985; 34 2209 2212 (Pubitemid 15017088)
9. Valenzuela A., Aspillaga M., Vial S., Guerra R. Selectivity of silymarin on the increase of the glutathione content in different tissues of the rat. Planta Med: 1989; 55 420 422 (Pubitemid 19249809)
10. Kim S. J., Lee J. W., Jung Y. S., Kwon D. Y., Park H. K., Ryu C. S., Kim S. K., Oh G. T., Kim Y. C. Ethanol-induced liver injury and changes in sulfur amino acid metabolomics in glutathione peroxidase and catalase double knockout mice. J Hepatol: 2009; 50 1184 1191
11. Ratnam S., Maclean K. N., Jacobs R. L., Brosnan M. E., Kraus J. P., Brosnan J. T. Hormonal regulation of cystathionine beta-synthase expression in liver. J Biol Chem: 2002; 277 42912 42918 (Pubitemid 35285668)
12. Pradhan S. C., Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res: 2006; 124 491 504 (Pubitemid 46157708)
13. Stipanuk M. H., Hirschberger L. L., Londono M. P., Cresenzi C. L., Yu A. F. The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver. Am J Physiol Endocrinol Metab: 2004; 286 E439 E448 (Pubitemid 38292695)
14. Kwon Y. H., Stipanuk M. H. Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes. Am J Physiol Endocrinol Metab: 2001; 280 E804 E815
15. Ueki I., Stipanuk M. H. 3 T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/ cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways. J Nutr: 2009; 139 207 214
16. Ueki I., Roman H. B., Hirschberger L. L., Junior C., Stipanuk M. H. Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase. Am J Physiol Endocrinol Metab: 2012; 302 E1292 E1299
17. Hosokawa Y., Yamaguchi K., Kohashi N., Kori Y., Ueda I. Decrease of rat liver cysteine dioxygenase (cysteine oxidase) activity mediated by glucagon. J Biochem: 1978; 84 419 424 (Pubitemid 9017134)
18. Crocenzi F. A., Basiglio C. L., Pérez L. M., Portesio M. S., Pozzi E. J., Roma M. G. Silibinin prevents cholestasis-associated retrieval of the bile salt export pump, Bsep, in isolated rat hepatocyte couplets: possible involvement of cAMP. Biochem Pharmacol: 2005; 69 1113 1120 (Pubitemid 40349023)
19. Scharf G., Prustomersky S., Knasmuller S., Schulte-Hermann R., Huber W. W. Enhancement of glutathione and γ -glutamylcysteine synthetase, the rate limiting enzyme of glutathione synthesis, by chemoprotective plant-derived food and beverage components in the human hepatoma cell line HepG2. Nutr Cancer: 2003; 45 74 83 (Pubitemid 36736894)
20. Myhrstad M. C., Carlsen H., Nordström O., Blomhoff R., Moskaug J. O. Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med: 2002; 32 386 393 (Pubitemid 34178348)
21. Griffith O. W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem: 1980; 106 207 212 (Pubitemid 11246585)
22. Gaitonde M. K. A spectrophotometric method for the direct determination of cysteine in the presence of other naturally occurring amino acids. Biochem J: 1976; 104 627 633
23. Rajendra W. High performance liquid chromatographic determination of amino acids in biological samples by precolumn derivatization with O-phthaldehyde. J Liq Chromatogr: 1987; 10 941 955 (Pubitemid 17107395)
24. She Q. B., Nagao I., Hayakawa T., Tsuge H. A simple HPLC method for the determination of S-adenosylmethionine and S-adenosylhomocysteine in rat tissues: the effect of vitamin B6 deficiency on these concentrations in rat liver. Biochem Biophys Res Commun: 1994; 205 1748 1754
25. Nolin T. D., McMenamin M. E., Himmelfarb J. Simultaneous determination of total homocysteine, cysteine, cysteinylglycine, and glutathione in human plasma by high-performance liquid chromatography: application to studies of oxidative stress. J Chromatogr B Analyt Technol Biomed Life Sci: 2007; 852 554 561 (Pubitemid 46830156)
26. Ericson L. E., Harper A. E. Effect of diet on the betaine-homocysteine transmethylase activity of rat liver. I. Amino acids and protein. J Biol Chem: 1956; 219 49 58
27. Kashiwamata S., Greenberg D. M. Studies on cystathionine synthase of rat liver. Properties of the highly purified enzyme. Biochim Biophys Acta: 1970; 212 488 500
28. Matsuo Y., Greenberg D. M. A crystalline enzyme that cleaves homoserine and cystathionine. I. Isolation procedure and some physicochemical properties. J Biol Chem: 1958; 230 545 560
29. Germanò M. P., De Pasquale R., DAngelo V., Catania S., Silvari V., Costa C. Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source. J Agric Food Chem: 2002; 50 1168 1171 (Pubitemid 34194074)
30. Regoli F., Winston G. W. Quantification of total oxidant scavenging capacity of antioxidants for peroxynitrite, peroxyl radicals, and hydroxyl radicals. Toxicol Appl Pharmacol: 1999; 156 96 105 (Pubitemid 29196572)